Article
Oncology
Jeong A. Park, Madelyn Espinosa-Cotton, Hong-fen Guo, Sebastien Monette, Nai-Kong Cheung
Summary: This study demonstrates that using anti-VEGF antibodies can significantly improve the therapeutic efficacy of T cell immunotherapies by increasing HEVs and promoting the infiltration of cytotoxic CD8(+) TILs.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2023)
Article
Oncology
Julien Balzeau, Anindita Ravindran, Xin Wang, Jinal Maisuria, Anna Lucchesi, Hui Yao, Satoko Matsueda
Summary: Tumor infiltrating lymphocytes (TIL) have shown efficacy in treating various solid cancers. However, most clinical trials exclude patients who have received systemic therapy before tumor tissue resection. In this study, we investigated whether patients who underwent chemotherapy prior to surgery can still benefit from TIL therapy. We found that TILs from tumor tissues can be successfully expanded ex vivo regardless of prior chemotherapy, suggesting that patients with recent chemotherapy history can be recruited for TIL therapy trials.
CANCER IMMUNOLOGY IMMUNOTHERAPY
(2023)
Article
Oncology
Anders Handrup Kverneland, Christopher Aled Chamberlain, Troels Holz Borch, Morten Nielsen, Sofie Kirial Mork, Julie Westerlin Kjeldsen, Cathrine Lund Lorentzen, Lise Pyndt Jorgensen, Lene Buhl Riis, Christina Westmose Yde, Ozcan Met, Marco Donia, Inge Marie Svane
Summary: This study demonstrated high success rates of TIL expansion and tumor regressions in multiple solid cancer types when combining TIL ACT with CPIs. In vitro tumor reactivity was positively associated with treatment outcomes.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2021)
Article
Oncology
Hannah M. Knochelmann, Amalia M. Rivera-Reyes, Megan M. Wyatt, Aubrey S. Smith, Reilley Chamness, Connor J. Dwyer, Michael Bobian, Guillermo O. Rangel Rivera, Joshuva D. Horton, Michael Lilly, Martin J. Romeo, Cynthia D. Timmers, Mark P. Rubinstein, David M. Neskey, Chrystal M. Paulos
Summary: The study found that murine TIL are similar to human TIL in the expression of inhibitory receptors and can be expanded ex vivo, providing a platform for studying TIL across different malignancies. This research will help to draw parallels between mouse and human tumor-infiltrating lymphocytes and evaluate relationships between inhibitory receptor expression and function.
Article
Biochemistry & Molecular Biology
Claire Y. Li, Hyeung Ju Park, Jinyeon Shin, Jung Eun Baik, Babak J. Mehrara, Raghu P. Kataru
Summary: This study suggests that lymphatic endothelial cells (LECs) can act as immunosuppressive cells in the tumor microenvironment (TME) in an MHC-II dependent manner. LECs in the TME increase MHC-II expression and co-inhibitory signals, suppressing the immune response. This finding highlights the importance of understanding the role of LECs in tumor immunity and opens up new avenues for therapeutic interventions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Oncology
Veronica Finisguerra, Tereza Dvorakova, Matteo Formenti, Pierre Van Meerbeeck, Lionel Mignion, Bernard Gallez, Benoit J. van den Eynde
Summary: Despite limitations in certain tumor types and patients, immunotherapies have achieved revolutionary success in cancer treatment. However, the efficacy of immunotherapies is dependent on the viability and functionality of tumor antigen-specific CD8 T cells within the immunosuppressive tumor microenvironment, where oxygen levels are often low. This study reveals that the antidiabetic drug metformin can improve CD8 T cell fitness in hypoxia, increasing their proliferation and cytokine production, and enhancing their infiltration and survival in hypoxic tumor areas. This presents a promising strategy to overcome resistance to immunotherapy in hypoxic and immunosuppressive tumors.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2023)
Article
Oncology
Francesco De Sanctis, Alessia Lamolinara, Federico Boschi, Chiara Musiu, Simone Caligola, Rosalinda Trovato, Alessandra Fiore, Cristina Frusteri, Cristina Anselmi, Ornella Poffe, Tiziana Cestari, Stefania Cane, Silvia Sartoris, Rosalba Giugno, Giulia Del Rosario, Barbara Zappacosta, Francesco Del Pizzo, Matteo Fassan, Erica Dugnani, Lorenzo Piemonti, Emanuela Bottani, Ilaria Decimo, Salvatore Paiella, Roberto Salvia, Rita Teresa Lawlor, Vincenzo Corbo, Youngkyu Park, David A. Tuveson, Claudio Bassi, Aldo Scarpa, Manuela Iezzi, Stefano Ugel, Vincenzo Bronte
Summary: PDAC tumors exhibit strong immunosuppressive characteristics that limit the success of immunotherapy. Research shows that reprogramming the tumor microenvironment by intervening in RNS production can enhance the efficacy of immune-based treatments.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2022)
Article
Oncology
Samantha M. Fix, Marie-Andree Forget, Donastas Sakellariou-Thompson, Yunfei Wang, Tamara M. Griffiths, Minjung Lee, Cara L. Haymaker, Ana Lucia Dominguez, Rafet Basar, Christopher Reyes, Sanjay Kumar, Larissa A. Meyer, Patrick Hwu, Chantale Bernatchez, Amir A. Jazaeri
Summary: In this study, we optimized CRISPR/Cas9-mediated knockout of TGF-beta receptor 2 (TGFBR2) in patient-derived ovarian cancer TIL. TGFBR2 knockout TIL showed resistance to immunosuppression and improved cytotoxicity. This lays the groundwork for clinical translation of CRISPR-modified TIL for the treatment of ovarian cancer and other solid cancers.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2022)
Article
Oncology
Julia Karbach, Dragan Kiselicki, Kathrin Brand, Claudia Wahle, Evgueni Sinelnikov, Dirk Gustavus, Hans Hoffmeister, Hans-Bernd Prisack, Akin Atmaca, Elke Jaeger
Summary: Adoptive transfer of autologous tumor-specific lymphocytes in conjunction with IL-2 and immune-checkpoint blockade led to complete and durable tumor remission in a patient with metastatic hormone-refractory NY-ESO-1 expressing prostate cancer. The treatment resulted in a decrease of tumor-driven NY-ESO-1 serum antibody and prostate-specific antigen, demonstrating the effectiveness of this method for advanced malignancies.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2023)
Article
Oncology
Chaoting Zhang, Yizhe Sun, Shance Li, Luyan Shen, Xia Teng, Yefei Xiao, Nan Wu, Zheming Lu
Summary: The study found that restoring autophagic flux of exhausted TILs through spermidine treatment can enhance the diversity of TCR repertoire, reduce the expression of inhibitory immunoreceptors (PD1, TIM3, or LAG3), improve proliferation and effector functions, leading to superior in vitro and in vivo antitumor activity.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2022)
Article
Oncology
Jose Manuel Casanova, Jani-Sofia Almeida, John David Reith, Luana Madalena Sousa, Ruben Fonseca, Paulo Freitas-Tavares, Manuel Santos-Rosa, Paulo Rodrigues-Santos
Summary: Osteosarcoma is a common high-grade primary bone tumor that mainly affects young adults. The presence of tumor-infiltrating CD4+ cells is protective for patients, while CD8+ cells have a significant impact on overall survival and progression-free survival. There is a strong association between tumor-infiltrating CD4+ cells and CD44s expression in tumor samples, highlighting the importance of considering TIL and tumor markers for improving OST treatment.
Article
Oncology
Aubrey S. Smith, Hannah M. Knochelmann, Megan M. Wyatt, Guillermo O. Rangel Rivera, Amalia M. Rivera-Reyes, Connor J. Dwyer, Michael B. Ware, Anna C. Cole, David M. Neskey, Mark P. Rubinstein, Bei Liu, Jessica E. Thaxton, Eric Bartee, Chrystal M. Paulos
Summary: TLR agonists can be repurposed ex vivo to condition T cells, improving immunotherapy and revealing the vital role of B cells in the generation of potent CD8(+) T cell-based therapies.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2022)
Article
Oncology
Surbhi Bansil, Anthony Silva, Alana Taniguchi, Christina Wiedmer, Mayumi Fernandez, Ian Pagano, Koah Vierkoetter, Jeffrey Killeen, Jami Fukui
Summary: Tumor-infiltrating lymphocytes (TILs) have emerged as predictors of breast cancer treatment response and patient outcomes. This study provides preliminary data on the breast cancer tumor microenvironment for Asian and Native Hawaiian/Pacific Islander racial/ethnic groups, which are underrepresented in the literature.
Article
Oncology
MacLean S. Hall, Jamie K. Teer, Xiaoqing Yu, Holly Branthoover, Sebastian Snedal, Madeline Rodriguez-Valentin, Luz Nagle, Ellen Scott, Ben Schachner, Patrick Innamarato, Amy M. Hall, Jamie Blauvelt, Carolyn J. Rich, Allison D. Richards, Jake Ceccarelli, T. J. Langer, Sean J. Yoder, Matthew S. Beatty, Cheryl A. Cox, Jane L. Messina, Daniel Abate-Daga, James J. Mule, John E. Mullinax, Amod A. Sarnaik, Shari Pilon-Thomas
Summary: This study highlights the importance of neoantigen-specific CD4(+)T cells within tumor-infiltrating lymphocytes (TILs) as a potent source of tumor-specific effectors. The findings suggest that these CD4(+)T cells play a significant role in antitumor immunity and should be included in future adoptive cell therapy (ACT) protocols to improve treatment efficacy.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2023)
Article
Biochemistry & Molecular Biology
Kosuke Imamura, Yusuke Tomita, Ryo Sato, Tokunori Ikeda, Shinji Iyama, Takayuki Jodai, Misako Takahashi, Akira Takaki, Kimitaka Akaike, Shohei Hamada, Shinya Sakata, Koichi Saruwatari, Sho Saeki, Koei Ikeda, Makoto Suzuki, Takuro Sakagami
Summary: This study found that the infiltration of drebrin-expressing T cells within the tumor cell nest in resectable squamous cell lung cancer patients is associated with short relapse-free survival and overall survival. The in vitro induced drebrin(+) T cells co-express multiple exhaustion-associated molecules. Single-cell RNA-sequencing analysis confirmed that exhausted tumor-infiltrating CD8(+) T cells specifically expressed drebrin.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Oncology
Edjah K. Nduom, Jun Wei, Nasser K. Yaghi, Neal Huang, Ling-Yuan Kong, Konrad Gabrusiewicz, Xiaoyang Ling, Shouhao Zhou, Cristina Ivan, Jie Qing Chen, Jared K. Burks, Greg N. Fuller, George A. Calin, Charles A. Conrad, Caitlin Creasy, Krit Ritthipichai, Laszlo Radvanyi, Amy B. Heimberger
Article
Oncology
Weiyi Peng, Jie Qing Chen, Chengwen Liu, Shruti Malu, Caitlin Creasy, Michael T. Tetzlaff, Chunyu Xu, Jodi A. McKenzie, Chunlei Zhang, Xiaoxuan Liang, Leila J. Williams, Wanleng Deng, Guo Chen, Rina Mbofung, Alexander J. Lazar, Carlos A. Torres-Cabala, Zachary A. Cooper, Pei-Ling Chen, Trang N. Tieu, Stefani Spranger, Xiaoxing Yu, Chantale Bernatchez, Marie-Andree Forget, Cara Haymaker, Rodabe Amaria, Jennifer L. McQuade, Isabella C. Glitza, Tina Cascone, Haiyan S. Li, Lawrence N. Kwong, Timothy P. Heffernan, Jianhua Hu, Roland L. Bassett, Marcus W. Bosenberg, Scott E. Woodman, Willem W. Overwijk, Gregory Lizee, Jason Roszik, Thomas F. Gajewski, Jennifer A. Wargo, Jeffrey E. Gershenwald, Laszlo Radvanyi, Michael A. Davies, Patrick Hwu
Article
Oncology
Geok Choo Sim, Chengwen Liu, Ena Wang, Hui Liu, Caitlin Creasy, Zhimin Dai, WillemW. Overwijk, Jason Roszik, Francesco Marincola, Patrick Hwu, Elizabeth Grimm, Laszlo Radvanyi
CANCER IMMUNOLOGY RESEARCH
(2016)
Article
Oncology
Guo Chen, Jennifer L. McQuade, David J. Panka, Courtney W. Hudgens, Ali Amin-Mansour, Xinmeng Jasmine Mu, Samira Bahl, Judit Jane-Valbuena, Khalida M. Wani, Alexandre Reuben, Caitlyn A. Creasy, Hong Jiang, Zachary A. Cooper, Jason Roszik, Roland L. Bassett, Aron Y. Joon, Lauren M. Simpson, Rosalind D. Mouton, Isabella C. Glitza, Sapna P. Patel, Wen-Jen Hwu, Rodabe N. Amaria, Adi Diab, Patrick Hwu, Alexander J. Lazar, Jennifer A. Wargo, Levi A. Garraway, Michael T. Tetzlaff, Ryan J. Sullivan, Kevin B. Kim, Michael A. Davies
Article
Oncology
Jungsun Park, Amjad H. Talukder, Seon A. Lim, Kwanghee Kim, Ke Pan, Brenda Melendez, Sherille D. Bradley, Kyle R. Jackson, Jahan S. Khalili, Junmei Wang, Caitlin Creasy, Bih-Fang Pan, Scott E. Woodman, Chantale Bernatchez, David Hawke, Patrick Hwu, Kyung-Mi Lee, Jason Roszik, Gregory Lizee, Cassian Yee
CANCER IMMUNOLOGY RESEARCH
(2017)
Article
Oncology
Cara L. Haymaker, DaeWon Kim, Marc Uemura, Luis M. Vence, Ann Phillip, Natalie McQuail, Paul D. Brown, Irina Fernandez, Courtney W. Hudgens, Caitlin Creasy, Wen-Jen Hwu, Padmanee Sharma, Michael T. Tetzlaff, James P. Allison, Patrick Hwu, Chantale Bernatchez, Adi Diab
CANCER IMMUNOLOGY RESEARCH
(2017)
Article
Cell Biology
Tina Cascone, Jodi A. McKenzie, Rina M. Mbofung, Simone Punt, Zhe Wang, Chunyu Xu, Leila J. Williams, Zhiqiang Wang, Christopher A. Bristow, Alessandro Carugo, Michael D. Peoples, Lerong Li, Tatiana Karpinets, Lu Huang, Shruti Malu, Caitlin Creasy, Sara E. Leahey, Jiong Chen, Yuan Chen, Helen Pelicano, Chantale Bernatchez, Y. N. Vashisht Gopal, Timothy P. Heffernan, Jianhua Hu, Jing Wang, Rodabe N. Amaria, Levi A. Garraway, Peng Huang, Peiying Yang, Ignacio I. Wistuba, Scott E. Woodman, Jason Roszik, R. Eric Davis, Michael A. Davies, John V. Heymach, Patrick Hwu, Weiyi Peng
Article
Oncology
Marie-Andree Forget, Cara Haymaker, Kenneth R. Hess, Yuzhong Jeff Meng, Caitlin Creasy, Tatiana Karpinets, Orenthial J. Fulbright, Jason Roszik, Scott E. Woodman, Young Uk Kim, Donastas Sakellariou-Thompson, Ankit Bhatta, Arely Wahl, Esteban Flores, Shawne T. Thorsen, Rene J. Tavera, Renjith Ramachandran, Audrey M. Gonzalez, Christopher L. Toth, Seth Wardell, Rahmatu Mansaray, Vruti Patel, Destiny Joy Carpio, Carol Vaughn, Chantell M. Farinas, Portia G. Velasquez, Wen-Jen Hwu, Sapna P. Patel, Michael A. Davies, Adi Diab, Isabella C. Glitza, Hussein Tawbi, Michael K. Wong, Suzanne Cain, Merrick I. Ross, Jeffrey E. Lee, Jeffrey E. Gershenwald, Anthony Lucci, Richard Royal, Janice N. Cormier, Jennifer A. Wargo, Laszlo G. Radvanyi, Carlos A. Torres-Cabala, Rameen Beroukhim, Patrick Hwu, Rodabe N. Amaria, Chantale Bernatchez
CLINICAL CANCER RESEARCH
(2018)
Article
Oncology
Rene J. Tavera, Marie-Andree Forget, Young Uk Kim, Donastas Sakellariou-Thompson, Caitlin A. Creasy, Ankit Bhatta, Orenthial J. Fulbright, Renjith Ramachandran, Shawne T. Thorsen, Esteban Flores, Arely Wahl, Audrey M. Gonzalez, Christopher Toth, Seth Wardell, Rahmatu Mansaray, Laszlo G. Radvanyi, Dan S. Gombos, Sapna P. Patel, Patrick Hwu, Rodabe N. Amaria, Chantale Bernatchez, Cara Haymaker
JOURNAL OF IMMUNOTHERAPY
(2018)
Article
Oncology
Shelly Kalaora, Yochai Wolf, Tali Feferman, Eilon Barnea, Erez Greenstein, Dan Reshef, Itay Tirosh, Alexandre Reuben, Sushant Patkar, Ronen Levy, Juliane Quinkhardt, Tana Omokoko, Nouar Qutob, Ofra Golani, Jianhua Zhang, Xizeng Mao, Xingzhi Song, Chantale Bernatchez, Cara Haymaker, Marie-Andree Forget, Caitlin Creasy, Polina Greenberg, Brett W. Carter, Zachary A. Cooper, Steven A. Rosenberg, Michal Lotem, Ugur Sahin, Guy Shakhar, Eytan Ruppin, Jennifer A. Wargo, Nir Friedman, Arie Admon, Yardena Samuels
Article
Immunology
Caitlin A. Creasy, Marie-Andree Forget, Gopal Singh, Coya Tapia, Mingxuan Xu, Bettzy Stephen, Sharjeel Sabir, Funda Meric-Bernstam, Cara Haymaker, Chantale Bernatchez, Aung Naing
EUROPEAN JOURNAL OF IMMUNOLOGY
(2019)
Article
Multidisciplinary Sciences
Meenu Sharma, Hiep Khong, Faisal Fa'ak, Salah-Eddine Bentebibel, Louise M. E. Janssen, Brent C. Chesson, Caitlin A. Creasy, Marie-Andree Forget, Laura Maria S. Kahn, Barbara Pazdrak, Binisha Karki, Yared Hailemichael, Manisha Singh, Christina Vianden, Srinivas Vennam, Uddalak Bharadwaj, David J. Tweardy, Cara Haymaker, Chantale Bernatchez, Shixia Huang, Kimal Rajapakshe, Cristian Coarfa, Michael E. Hurwitz, Mario Sznol, Patrick Hwu, Ute Hoch, Murali Addepalli, Deborah H. Charych, Jonathan Zalevsky, Adi Diab, Willem W. Overwijk
NATURE COMMUNICATIONS
(2020)
Article
Oncology
Caitlin A. Creasy, Yuzhong Jeff Meng, Marie-Andree Forget, Tatiana Karpinets, Katarzyna Tomczak, Chip Stewart, Carlos A. Torres-Cabala, Shari Pilon-Thomas, Amod A. Sarnaik, James J. Mule, Levi Garraway, Matias Bustos, Jianhua Zhang, Sapna P. Patel, Adi Diab, Isabella C. Glitza, Cassian Yee, Hussein Tawbi, Michael K. Wong, Jennifer McQuade, Dave S. B. Hoon, Michael A. Davies, Patrick Hwu, Rodabe N. Amaria, Cara Haymaker, Rameen Beroukhim, Chantale Bernatchez
Summary: This study found that transcriptional features of melanomas are correlated with outcomes after TIL therapy, and there is a positive correlation between neoantigen load and overall survival. Furthermore, the high expression of PDE1C, RTKN2, and NGFR is associated with favorable response to therapy, while the high expression of ELFN1 is associated with unfavorable response and poor prognosis. Tumor-associated fibroblasts and endothelial cells may play a role in the outcome of TIL therapy.
CLINICAL CANCER RESEARCH
(2022)
Article
Oncology
Donastas Sakellariou-Thompson, Marie-Andree Forget, Caitlin Creasy, Vincent Bernard, Li Zhao, Young Uk Kim, Mark W. Hurd, Naohiro Uraoka, Edwin Roger Parra, Ya'an Kang, Christopher A. Bristow, Jaime Rodriguez-Canales, Jason B. Fleming, Gauri Varadhachary, Milind Javle, Michael J. Overman, Hector A. Alvarez, Timothy P. Heffernan, Jianhua Zhang, Patrick Hwu, Anirban Maitra, Cara Haymaker, Chantale Bernatchez
CLINICAL CANCER RESEARCH
(2017)
Article
Medicine, General & Internal
Lisa M. Hodge, Caitlin Creasy, KiahRae Carter, Ashley Orlowski, Artur Schander, Hollis H. King
JOURNAL OF THE AMERICAN OSTEOPATHIC ASSOCIATION
(2015)