Induction of T cell exhaustion by JAK1/3 inhibition in the treatment of alopecia areata

Selective inhibition of JAK3 signaling is sufficient to reverse alopecia areata

(2021) Zhenpeng Dai et al.   JCI Insight

Disruption of the endopeptidase ADAM10-Notch signaling axis leads to skin dysbiosis and innate lymphoid cell-mediated hair follicle destruction

(2021) Keiko Sakamoto et al.   IMMUNITY

The γc Family of Cytokines: Basic Biology to Therapeutic Ramifications

(2019) Warren J. Leonard et al.   IMMUNITY

Comprehensive Integration of Single-Cell Data

(2019) Tim Stuart et al.   CELL

TOX transcriptionally and epigenetically programs CD8+ T cell exhaustion

(2019) Omar Khan et al.   NATURE

An Open-Label Pilot Study to Evaluate the Efficacy of Tofacitinib in Moderate to Severe Patch-Type Alopecia Areata, Totalis, and Universalis

(2018) A. Jabbari et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

RNA velocity of single cells

(2018) Gioele La Manno et al.   NATURE

FBXO38 mediates PD-1 ubiquitination and regulates anti-tumour immunity of T cells

(2018) Xiangbo Meng et al.   NATURE

High Levels of Eomes Promote Exhaustion of Anti-tumor CD8+ T Cells

(2018) Jing Li et al.   Frontiers in Immunology

Tofacitinib for the treatment of severe alopecia areata and variants: A study of 90 patients

(2017) Lucy Y. Liu et al.   JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY

JAK inhibitors in dermatology: The promise of a new drug class

(2017) William Damsky et al.   JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY

Alopecia areata

(2017) C. Herbert Pratt et al.   Nature Reviews Disease Primers

Janus kinase inhibition prevents cancer- and myocardial infarction-mediated diaphragm muscle weakness in mice

(2016) Ira J. Smith et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

T cell exhaustion and immune-mediated disease—the potential for therapeutic exhaustion

(2016) Eoin F McKinney et al.   CURRENT OPINION IN IMMUNOLOGY

Efficacy of tofacitinib in treatment of alopecia universalis in two patients

(2016) A.K. Gupta et al.   JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY

JAK3 as an Emerging Target for Topical Treatment of Inflammatory Skin Diseases

(2016) Ana Karina Alves de Medeiros et al.   PLoS One

The role of lymphocytes in the development and treatment of alopecia areata

(2015) Hongwei Guo et al.   Expert Review of Clinical Immunology

T-cell exhaustion, co-stimulation and clinical outcome in autoimmunity and infection

(2015) Eoin F. McKinney et al.   NATURE

Resident memory T cells in human health and disease

(2015) R. A. Clark   Science Translational Medicine

Alopecia areata is driven by cytotoxic T lymphocytes and is reversed by JAK inhibition

(2014) Luzhou Xing et al.   NATURE MEDICINE

JAK and STAT Signaling Molecules in Immunoregulation and Immune-Mediated Disease

(2012) John J. O'Shea et al.   IMMUNITY

Alopecia Areata

(2012)   NEW ENGLAND JOURNAL OF MEDICINE

Placebo-Controlled Trial of Tofacitinib Monotherapy in Rheumatoid Arthritis

(2012) Roy Fleischmann et al.   NEW ENGLAND JOURNAL OF MEDICINE

Significant Reduction of Acute Cardiac Allograft Rejection by Selective Janus Kinase-1/3 Inhibition Using R507 and R545

(2012) Tobias Deuse et al.   TRANSPLANTATION

Jak1 Has a Dominant Role over Jak3 in Signal Transduction through γc-Containing Cytokine Receptors

(2011) Claude Haan et al.   CHEMISTRY & BIOLOGY

Alopecia areata update

(2010) Abdullah Alkhalifah et al.   JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY

Double-Blind, Placebo-Controlled, Dose-Escalation Study to Evaluate the Pharmacologic Effect of CP-690,550 in Patients With Psoriasis

(2009) Mary G. Boy et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY