Betulinic acid improves TNF-α-induced insulin resistance by inhibiting negative regulator of insulin signalling and inflammation-activated protein kinase in 3T3-L1 adipocytes

Plant Extracts for Type 2 Diabetes: From Traditional Medicine to Modern Drug Discovery

(2021) Jinjoo Lee et al.   Antioxidants

The Role of JNk Signaling Pathway in Obesity-Driven Insulin Resistance

(2020) Jia Feng et al.   Diabetes Metabolic Syndrome and Obesity-Targets and Therapy

Betulinic acid inhibits high-fat diet-induced obesity and improves energy balance by activating AMPK

(2019) Kyu-Dae Kim et al.   NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES

New Insights into the Inhibition Mechanism of Betulinic Acid on α-Glucosidase

(2018) Huafang Ding et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

New Pharmacological Opportunities for Betulinic Acid

(2017) José Ríos et al.   PLANTA MEDICA

Betulinic acid is a PPARγ antagonist that improves glucose uptake, promotes osteogenesis and inhibits adipogenesis

(2017) Gloria Brusotti et al.   Scientific Reports

JNK at the crossroad of obesity, insulin resistance, and cell stress response

(2017) Giovanni Solinas et al.   Molecular Metabolism

Pentacyclic Triterpenoids from Astilbe rivularis that Enhance Glucose Uptake via the Activation of Akt and Erk1/2 in C2C12 Myotubes

(2015) Joo-Hui Han et al.   JOURNAL OF NATURAL PRODUCTS

Pentacyclic Triterpenoids Inhibit IKKβ Mediated Activation of NF-κB Pathway: In Silico and In Vitro Evidences

(2015) Kalpesh R. Patil et al.   PLoS One

Design and synthesis of lupeol analogues and their glucose uptake stimulatory effect in L6 skeletal muscle cells

(2014) Mohammad Faheem Khan et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Triterpenoid Saponins from Stauntonia chinensis Ameliorate Insulin Resistance via the AMP-Activated Protein Kinase and IR/IRS-1/PI3K/Akt Pathways in Insulin-Resistant HepG2 Cells

(2014) Xin Hu et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Biochemical Basis of the Antidiabetic Activity of Oleanolic Acid and Related Pentacyclic Triterpenes

(2013) J. M. Castellano et al.   DIABETES

Targeting inflammation in the treatment of type 2 diabetes

(2013) M. Y. Donath   DIABETES OBESITY & METABOLISM

Beneficial Effect of Betulinic Acid on Hyperglycemia via Suppression of Hepatic Glucose Production

(2013) Soo Jung Kim et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Natural products possessing protein tyrosine phosphatase 1B (PTP1B) inhibitory activity found in the last decades

(2012) Cheng-shi Jiang et al.   ACTA PHARMACOLOGICA SINICA

Molecular Mechanisms Involved in Inflammation and Insulin Resistance in Chronic Diseases and Possible Interventions

(2012) Renata Gorjão et al.   JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY

JNK Expression by Macrophages Promotes Obesity-Induced Insulin Resistance and Inflammation

(2012) M. S. Han et al.   SCIENCE

Protective role of betulinic acid on TNF-α-induced cell adhesion molecules in vascular endothelial cells

(2009) Jung Joo Yoon et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Inhibition of PTP1B Restores IRS1-Mediated Hepatic Insulin Signaling in IRS2-Deficient Mice

(2009) A. Gonzalez-Rodriguez et al.   DIABETES

Betulinic Acid, a Natural Pentacyclic Triterpenoid, Prevents Abdominal Fat Accumulation in Mice Fed a High-Fat Diet

(2009) Célio L. de Melo et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Inhibition of protein tyrosine phosphatase 1B by lupeol and lupenone isolated fromSorbus commixta

(2009) Minkyun Na et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

Structure−Activity Relationship Study of Betulinic Acid, A Novel and Selective TGR5 Agonist, and Its Synthetic Derivatives: Potential Impact in Diabetes¶

(2009) Cédric Genet et al.   JOURNAL OF MEDICINAL CHEMISTRY

Isolation of Betulinic Acid, its Methyl Ester and Guaiane Sesquiterpenoids with Protein Tyrosine Phosphatase 1B Inhibitory Activity from the Roots of Saussurea lappa C.B.Clarke

(2009) Ji Choi et al.   MOLECULES

Oleanolic acid and its derivatives: New inhibitor of protein tyrosine phosphatase 1B with cellular activities

(2008) Yi-Nan Zhang et al.   BIOORGANIC & MEDICINAL CHEMISTRY

c-Jun N-terminal kinase pathways in diabetes

(2008) Ruojing Yang et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Betulinic acid suppresses constitutive and TNFα-induced NF-κB activation and induces apoptosis in human prostate carcinoma PC-3 cells

(2008) Thangaiyan Rabi et al.   MOLECULAR CARCINOGENESIS

Insulin resistance associated to obesity: the link TNF-alpha

(2008) Iria Nieto-Vazquez et al.   ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY