Sphingosine 1-phosphate signaling in perivascular cells enhances inflammation and fibrosis in the kidney

Discovery of In Vivo Active Sphingosine-1-phosphate Transporter (Spns2) Inhibitors

(2022) Russell Fritzemeier et al.   JOURNAL OF MEDICINAL CHEMISTRY

Functional characterization of the dural sinuses as a neuroimmune interface

(2021) Justin Rustenhoven et al.   CELL

Vagus nerve stimulation activates two distinct neuroimmune circuits converging in the spleen to protect mice from kidney injury

(2021) Shinji Tanaka et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Endothelial Spns2 and ApoM Regulation of Vascular Tone and Hypertension Via Sphingosine‐1‐Phosphate

(2021) Ilaria Del Gaudio et al.   Journal of the American Heart Association

Mechanism of sphingosine 1-phosphate clearance from blood

(2020) Yugesh Kharel et al.   BIOCHEMICAL JOURNAL

Discovery of a Small Side Cavity in Sphingosine Kinase 2 that Enhances Inhibitor Potency and Selectivity

(2020) Christopher D. Sibley et al.   JOURNAL OF MEDICINAL CHEMISTRY

Sphingosine Kinases are Involved in Macrophage NLRP3 Inflammasome Transcriptional Induction

(2020) Shahzad Nawaz Syed et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

A G protein–biased S1P1 agonist, SAR247799, protects endothelial cells without affecting lymphocyte numbers

(2020) Bruno Poirier et al.   Science Signaling

Endothelial S1P 1 Signaling Counteracts Infarct Expansion in Ischemic Stroke

(2020) Anja Nitzsche et al.   CIRCULATION RESEARCH

Ischemic Duration and Frequency Determines AKI-to-CKD Progression Monitored by Dynamic Changes of Tubular Biomarkers in IRI Mice

(2019) Yang Dong et al.   Frontiers in Physiology

Macrophages: versatile players in renal inflammation and fibrosis

(2019) Patrick Ming-Kuen Tang et al.   Nature Reviews Nephrology

Secrets and lyase: Control of sphingosine 1‐phosphate distribution

(2019) Dhaval Dixit et al.   IMMUNOLOGICAL REVIEWS

Sphingosine 1-phosphate: Lipid signaling in pathology and therapy

(2019) Andreane Cartier et al.   SCIENCE

Sphingosine-1-phosphate receptor 1 mediates elevated IL-6 signaling to promote chronic inflammation and multitissue damage in sickle cell disease

(2018) Shushan Zhao et al.   FASEB JOURNAL

Downregulation of the S1P Transporter Spinster Homology Protein 2 (Spns2) Exerts an Anti-Fibrotic and Anti-Inflammatory Effect in Human Renal Proximal Tubular Epithelial Cells

(2018) Olivier Blanchard et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

LPS and palmitate synergistically stimulate sphingosine kinase 1 and increase sphingosine 1 phosphate in RAW264.7 macrophages

(2018) Junfei Jin et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Epithelial and Endothelial Pannexin1 Channels Mediate AKI

(2018) Jakub Jankowski et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Lipid transporter Spns2 promotes microglia pro-inflammatory activation in response to amyloid-beta peptide

(2018) Liansheng Zhong et al.   GLIA

N-cadherin signaling via Trio assembles adherens junctions to restrict endothelial permeability

(2018) Kevin Kruse et al.   JOURNAL OF CELL BIOLOGY

Advantages of Single-Nucleus over Single-Cell RNA Sequencing of Adult Kidney: Rare Cell Types and Novel Cell States Revealed in Fibrosis

(2018) Haojia Wu et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

S1PR1 on tumor-associated macrophages promotes lymphangiogenesis and metastasis via NLRP3/IL-1β

(2017) Benjamin Weichand et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Dynamin-Related Protein 1 Deficiency Promotes Recovery from AKI

(2017) Heather M. Perry et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Chronic Kidney Disease

(2017) Angela C Webster et al.   LANCET

Lymphatic endothelial S1P promotes mitochondrial function and survival in naive T cells

(2017) Alejandra Mendoza et al.   NATURE

Mfsd2b is essential for the sphingosine-1-phosphate export in erythrocytes and platelets

(2017) Thiet M. Vu et al.   NATURE

Augmented sphingosine 1 phosphate receptor-1 signaling in cardiac fibroblasts induces cardiac hypertrophy and fibrosis through angiotensin II and interleukin-6

(2017) Sei-ichiro Ohkura et al.   PLoS One

Vagus nerve stimulation mediates protection from kidney ischemia-reperfusion injury through α7nAChR+ splenocytes

(2016) Tsuyoshi Inoue et al.   JOURNAL OF CLINICAL INVESTIGATION

Pericyte MyD88 and IRAK4 control inflammatory and fibrotic responses to tissue injury

(2016) Irina A. Leaf et al.   JOURNAL OF CLINICAL INVESTIGATION

Endothelial Sphingosine 1-Phosphate Receptor-1 Mediates Protection and Recovery from Acute Kidney Injury

(2016) H. M. Perry et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Sphingosine Kinase 2 Deficiency Attenuates Kidney Fibrosis via IFN- γ

(2016) Amandeep Bajwa et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Emerging biology of sphingosine-1-phosphate: its role in pathogenesis and therapy

(2015) Richard L. Proia et al.   JOURNAL OF CLINICAL INVESTIGATION

Filamin A Expression Negatively Regulates Sphingosine-1-Phosphate-Induced NF-κB Activation in Melanoma Cells by Inhibition of Akt Signaling

(2015) Ludmila Campos et al.   MOLECULAR AND CELLULAR BIOLOGY

HDL-bound sphingosine 1-phosphate acts as a biased agonist for the endothelial cell receptor S1P1to limit vascular inflammation

(2015) Sylvain Galvani et al.   Science Signaling

HDL-bound sphingosine 1-phosphate acts as a biased agonist for the endothelial cell receptor S1P1to limit vascular inflammation

(2015) Sylvain Galvani et al.   Science Signaling

Cardiac and vascular effects of fingolimod: Mechanistic basis and clinical implications

(2014) John Camm et al.   AMERICAN HEART JOURNAL

Fingolimod may support neuroprotection via blockade of astrocyte nitric oxide

(2014) Emanuela Colombo et al.   ANNALS OF NEUROLOGY

Sphingosine 1-Phosphate Receptor-1 Enhances Mitochondrial Function and Reduces Cisplatin-Induced Tubule Injury

(2014) A. Bajwa et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Treatment with the Immunomodulator FTY720 (Fingolimod) Significantly Reduces Renal Inflammation in Murine Unilateral Ureteral Obstruction

(2014) Shobha Thangada et al.   JOURNAL OF UROLOGY

Ultrasound Prevents Renal Ischemia-Reperfusion Injury by Stimulating the Splenic Cholinergic Anti-Inflammatory Pathway

(2013) J. C. Gigliotti et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Evolving importance of kidney disease: from subspecialty to global health burden

(2013) Kai-Uwe Eckardt et al.   LANCET

TLR-2/TLR-4 TREM-1 Signaling Pathway Is Dispensable in Inflammatory Myeloid Cells during Sterile Kidney Injury

(2013) Gabriela Campanholle et al.   PLoS One

KDOQI Clinical Practice Guideline for Diabetes and CKD: 2012 Update

(2012)   AMERICAN JOURNAL OF KIDNEY DISEASES

The sphingosine-1-phosphate transporter Spns2 expressed on endothelial cells regulates lymphocyte trafficking in mice

(2012) Shigetomo Fukuhara et al.   JOURNAL OF CLINICAL INVESTIGATION

Capillary and arteriolar pericytes attract innate leukocytes exiting through venules and 'instruct' them with pattern-recognition and motility programs

(2012) Konstantin Stark et al.   NATURE IMMUNOLOGY

Fingolimod-associated macular edema: Incidence, detection, and management

(2012) N. Jain et al.   NEUROLOGY

The Transporter Spns2 Is Required for Secretion of Lymph but Not Plasma Sphingosine-1-Phosphate

(2012) Alejandra Mendoza et al.   Cell Reports

The Magnitude of Acute Serum Creatinine Increase After Cardiac Surgery and the Risk of Chronic Kidney Disease, Progression of Kidney Disease, and Death

(2011) Areef Ishani et al.   ARCHIVES OF INTERNAL MEDICINE

Pericytes: Developmental, Physiological, and Pathological Perspectives, Problems, and Promises

(2011) Annika Armulik et al.   DEVELOPMENTAL CELL

The severity of acute kidney injury predicts progression to chronic kidney disease

(2011) Lakhmir S. Chawla et al.   KIDNEY INTERNATIONAL

Activation of Sphingosine-1-Phosphate 1 Receptor in the Proximal Tubule Protects Against Ischemia-Reperfusion Injury

(2010) A. Bajwa et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Epithelial cell cycle arrest in G2/M mediates kidney fibrosis after injury

(2010) Li Yang et al.   NATURE MEDICINE

A Placebo-Controlled Trial of Oral Fingolimod in Relapsing Multiple Sclerosis

(2010) Ludwig Kappos et al.   NEW ENGLAND JOURNAL OF MEDICINE

Oral Fingolimod or Intramuscular Interferon for Relapsing Multiple Sclerosis

(2010) Jeffrey A. Cohen et al.   NEW ENGLAND JOURNAL OF MEDICINE

Neural Crest-Derived Pericytes Promote Egress of Mature Thymocytes at the Corticomedullary Junction

(2010) M. A. Zachariah et al.   SCIENCE

Fate Tracing Reveals the Pericyte and Not Epithelial Origin of Myofibroblasts in Kidney Fibrosis

(2009) Benjamin D. Humphreys et al.   AMERICAN JOURNAL OF PATHOLOGY