The human disease gene LYSET is essential for lysosomal enzyme transport and viral infection

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SARS-CoV-2 Omicron variant replication in human bronchus and lung ex vivo

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Comprehensive draft of the mouse embryonic fibroblast lysosomal proteome by mass spectrometry based proteomics

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SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor

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An Infectious cDNA Clone of SARS-CoV-2

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Disease-causing missense mutations within the N-terminal transmembrane domain of GlcNAc-1-phosphotransferase impair endoplasmic reticulum translocation or Golgi retention

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The mutational constraint spectrum quantified from variation in 141,456 humans

(2020) Konrad J. Karczewski et al.   NATURE

A Replication-Competent Vesicular Stomatitis Virus for Studies of SARS-CoV-2 Spike-Mediated Cell Entry and Its Inhibition

(2020) M. Eugenia Dieterle et al.   Cell Host & Microbe

Optimal Dissociation Methods Differ for N- and O-Glycopeptides

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Mucolipidoses Overview: Past, Present, and Future

(2020) Shaukat A. Khan et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Genetic Screens Identify Host Factors for SARS-CoV-2 and Common Cold Coronaviruses

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Biallelic TMEM251 variants in patients with severe skeletal dysplasia and extreme short stature

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SARS-CoV-2 structure and replication characterized by in situ cryo-electron tomography

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Simply Extending the Mass Range in Electron Transfer Higher Energy Collisional Dissociation Increases Confidence in N-Glycopeptide Identification

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Enterovirus pathogenesis requires the host methyltransferase SETD3

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S-Trap, an Ultrafast Sample-Preparation Approach for Shotgun Proteomics

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Targeted analysis of lysosomal directed proteins and their sites of mannose-6-phosphate modification

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PANTHER version 14: more genomes, a new PANTHER GO-slim and improvements in enrichment analysis tools

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UniProt: a worldwide hub of protein knowledge

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The Skyline ecosystem: Informatics for quantitative mass spectrometry proteomics

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Systematic Evaluation of Protein Reduction and Alkylation Reveals Massive Unspecific Side Effects by Iodine-containing Reagents

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A proteomic atlas of the legume Medicago truncatula and its nitrogen-fixing endosymbiont Sinorhizobium meliloti

(2016) Harald Marx et al.   NATURE BIOTECHNOLOGY

Optimized sgRNA design to maximize activity and minimize off-target effects of CRISPR-Cas9

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The Perseus computational platform for comprehensive analysis of (prote)omics data

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Lrp1/LDL Receptor Play Critical Roles in Mannose 6-Phosphate-Independent Lysosomal Enzyme Targeting

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Novel LC-MS2 Product Dependent Parallel Data Acquisition Function and Data Analysis Workflow for Sequencing and Identification of Intact Glycopeptides

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Megabase-scale deletion using CRISPR/Cas9 to generate a fully haploid human cell line

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Improved vectors and genome-wide libraries for CRISPR screening

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Mislocalization of phosphotransferase as a cause of mucolipidosis III αβ

(2014) Eline van Meel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mucolipidosis II-Related Mutations Inhibit the Exit from the Endoplasmic Reticulum and Proteolytic Cleavage of GlcNAc-1-Phosphotransferase Precursor Protein (GNPTAB)

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Improved Quenched Fluorescent Probe for Imaging of Cysteine Cathepsin Activity

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Middle East Respiratory Syndrome Coronavirus Infection Mediated by the Transmembrane Serine Protease TMPRSS2

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Genome engineering using the CRISPR-Cas9 system

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In Search of Cathepsins: How Reovirus Enters Host Cells

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Transport of the GlcNAc-1-phosphotransferase α/β-Subunit Precursor Protein to the Golgi Apparatus Requires a Combinatorial Sorting Motif

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Higher Energy Collision Dissociation (HCD) Product Ion-Triggered Electron Transfer Dissociation (ETD) Mass Spectrometry for the Analysis of N-Linked Glycoproteins

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Vacuolization of mucolipidosis type II mouse exocrine gland cells represents accumulation of autolysosomes

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Ebola virus entry requires the cholesterol transporter Niemann–Pick C1

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A Key Enzyme in the Biogenesis of Lysosomes Is a Protease That Regulates Cholesterol Metabolism

(2011) K. Marschner et al.   SCIENCE

A Novel Single-Chain Antibody Fragment for Detection of Mannose 6-Phosphate-Containing Proteins

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Virus Entry by Endocytosis

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Skyline: an open source document editor for creating and analyzing targeted proteomics experiments

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A Forward Genetic Strategy Reveals Destabilizing Mutations in the Ebolavirus Glycoprotein That Alter Its Protease Dependence during Cell Entry

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A Versatile Viral System for Expression and Depletion of Proteins in Mammalian Cells

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Sorting of lysosomal proteins

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MaxQuant enables high peptide identification rates, individualized p.p.b.-range mass accuracies and proteome-wide protein quantification

(2008) Jürgen Cox et al.   NATURE BIOTECHNOLOGY