MTCH2 is a mitochondrial outer membrane protein insertase

Combinatorial GxGxE CRISPR screen identifies SLC25A39 in mitochondrial glutathione transport linking iron homeostasis to OXPHOS

(2022) Xiaojian Shi et al.   Nature Communications

Mapping information-rich genotype-phenotype landscapes with genome-scale Perturb-seq

(2022) Joseph M. Replogle et al.   CELL

Highly accurate protein structure prediction with AlphaFold

(2021) John Jumper et al.   NATURE

A proximity-dependent biotinylation map of a human cell

(2021) Christopher D. Go et al.   NATURE

Sequence‐based features that are determinant for tail‐anchored membrane protein sorting in eukaryotes

(2021) Michelle Y. Fry et al.   TRAFFIC

An engineered transcriptional reporter of protein localization identifies regulators of mitochondrial and ER membrane protein trafficking in high-throughput CRISPRi screens

(2021) Robert Coukos et al.   eLife

Genome-wide CRISPRi screening identifies OCIAD1 as a prohibitin client and regulatory determinant of mitochondrial Complex III assembly in human cells

(2021) Maxence Le Vasseur et al.   eLife

Quantitative high-confidence human mitochondrial proteome and its dynamics in cellular context

(2021) Marcel Morgenstern et al.   Cell Metabolism

The modified mitochondrial outer membrane carrier MTCH2 links mitochondrial fusion to lipogenesis

(2021) Katherine Labbé et al.   JOURNAL OF CELL BIOLOGY

Mitochondria dysfunction in the pathogenesis of Alzheimer’s disease: recent advances

(2020) Wenzhang Wang et al.   Molecular Neurodegeneration

Combinatorial single-cell CRISPR screens by direct guide RNA capture and targeted sequencing

(2020) Joseph M. Replogle et al.   NATURE BIOTECHNOLOGY

Structural basis for membrane insertion by the human ER membrane protein complex

(2020) Tino Pleiner et al.   SCIENCE

Differential Modes of Orphan Subunit Recognition for the WRB/CAML Complex

(2020) Alison J. Inglis et al.   Cell Reports

The Mitochondrial Import Complex MIM Functions as Main Translocase for α-Helical Outer Membrane Proteins

(2020) Kim Nguyen Doan et al.   Cell Reports

Structure of the ER membrane complex, a transmembrane-domain insertase

(2020) Lin Bai et al.   NATURE

UCSF ChimeraX : Structure visualization for researchers, educators, and developers

(2020) Eric F. Pettersen et al.   PROTEIN SCIENCE

Structural and mechanistic basis of the EMC-dependent biogenesis of distinct transmembrane clients

(2020) Lakshmi E Miller-Vedam et al.   eLife

Engineered SUMO/protease system identifies Pdr6 as a bidirectional nuclear transport receptor

(2019) Arturo Vera Rodriguez et al.   JOURNAL OF CELL BIOLOGY

Compromised function of the ESCRT pathway promotes endolysosomal escape of tau seeds and propagation of tau aggregation

(2019) John J. Chen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Armadillo repeat-containing protein 1 is a dual localization protein associated with mitochondrial intermembrane space bridging complex

(2019) Fabienne Wagner et al.   PLoS One

The SLC25 Mitochondrial Carrier Family: Structure and Mechanism

(2019) Jonathan J. Ruprecht et al.   TRENDS IN BIOCHEMICAL SCIENCES

The ALFA-tag is a highly versatile tool for nanobody-based bioscience applications

(2019) Hansjörg Götzke et al.   Nature Communications

Independent evolution of functionally exchangeable mitochondrial outer membrane import complexes

(2018) Daniela G Vitali et al.   eLife

Histidine catabolism is a major determinant of methotrexate sensitivity

(2018) Naama Kanarek et al.   NATURE

EMC Is Required to Initiate Accurate Membrane Protein Topogenesis

(2018) Patrick J. Chitwood et al.   CELL

A toolbox of anti–mouse and anti–rabbit IgG secondary nanobodies

(2017) Tino Pleiner et al.   JOURNAL OF CELL BIOLOGY

Combined CRISPRi/a-Based Chemical Genetic Screens Reveal that Rigosertib Is a Microtubule-Destabilizing Agent

(2017) Marco Jost et al.   MOLECULAR CELL

MTCH2 is a conserved regulator of lipid homeostasis

(2017) Veerle Rottiers et al.   Obesity

The ER membrane protein complex is a transmembrane domain insertase

(2017) Alina Guna et al.   SCIENCE

Mitochondria and Cancer

(2016) Sejal Vyas et al.   CELL

Mitochondrial dysfunction in Parkinson's disease

(2016) Anindita Bose et al.   JOURNAL OF NEUROCHEMISTRY

Ubiquilins Chaperone and Triage Mitochondrial Membrane Proteins for Degradation

(2016) Eisuke Itakura et al.   MOLECULAR CELL

Outer membrane protein functions as integrator of protein import and DNA inheritance in mitochondria

(2016) Sandro Käser et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Versatile protein tagging in cells with split fluorescent protein

(2016) Daichi Kamiyama et al.   Nature Communications

Compact and highly active next-generation libraries for CRISPR-mediated gene repression and activation

(2016) Max A Horlbeck et al.   eLife

Multiple selection filters ensure accurate tail-anchored membrane protein targeting

(2016) Meera Rao et al.   eLife

Alzheimer’s Disease Risk Polymorphisms Regulate Gene Expression in the ZCWPW1 and the CELF1 Loci

(2016) Celeste M. Karch et al.   PLoS One

Nanobodies: site-specific labeling for super-resolution imaging, rapid epitope-mapping and native protein complex isolation

(2015) Tino Pleiner et al.   eLife

Genome-Scale CRISPR-Mediated Control of Gene Repression and Activation

(2014) Luke A. Gilbert et al.   CELL

DNAJC19, a Mitochondrial Cochaperone Associated with Cardiomyopathy, Forms a Complex with Prohibitins to Regulate Cardiolipin Remodeling

(2014) Ricarda Richter-Dennerlein et al.   Cell Metabolism

A new set of highly efficient, tag-cleaving proteases for purifying recombinant proteins

(2014) Steffen Frey et al.   JOURNAL OF CHROMATOGRAPHY A

Proteomic Mapping of the Human Mitochondrial Intermembrane Space in Live Cells via Ratiometric APEX Tagging

(2014) Victoria Hung et al.   MOLECULAR CELL

Mitochondrial form and function

(2014) Jonathan R. Friedman et al.   NATURE

Structural basis of Sec-independent membrane protein insertion by YidC

(2014) Kaoru Kumazaki et al.   NATURE

Deciphering key features in protein structures with the new ENDscript server

(2014) Xavier Robert et al.   NUCLEIC ACIDS RESEARCH

Gene-Wide Analysis Detects Two New Susceptibility Genes for Alzheimer's Disease

(2014) Valentina Escott-Price et al.   PLoS One

A crucial role for Mim2 in the biogenesis of mitochondrial outer membrane proteins

(2012) K. S. Dimmer et al.   JOURNAL OF CELL SCIENCE

The mitochondrial transporter family SLC25: Identification, properties and physiopathology

(2012) Ferdinando Palmieri   MOLECULAR ASPECTS OF MEDICINE

The mechanism of membrane-associated steps in tail-anchored protein insertion

(2011) Malaiyalam Mariappan et al.   NATURE

Accelerated Profile HMM Searches

(2011) Sean R. Eddy   PLoS Computational Biology

MTCH2/MIMP is a major facilitator of tBID recruitment to mitochondria

(2010) Yehudit Zaltsman et al.   NATURE CELL BIOLOGY

Two Modular Forms of the Mitochondrial Sorting and Assembly Machinery Are Involved in Biogenesis of α-Helical Outer Membrane Proteins

(2009) Nicolas Thornton et al.   JOURNAL OF MOLECULAR BIOLOGY

The Transmembrane Segment of Tom20 Is Recognized by Mim1 for Docking to the Mitochondrial TOM Complex

(2008) Joanne M. Hulett et al.   JOURNAL OF MOLECULAR BIOLOGY