Article
Multidisciplinary Sciences
Veronika Ecker, Martina Stumpf, Lisa Brandmeier, Tanja Neumayer, Lisa Pfeuffer, Thomas Engleitner, Ingo Ringshausen, Nina Nelson, Manfred Juecker, Stefan Wanninger, Thorsten Zenz, Clemens Wendtner, Katrin Manske, Katja Steiger, Roland Rad, Markus Mueschen, Juergen Ruland, Maike Buchner
Summary: Current therapeutic approaches in CLL focus on suppressing the PI3K/AKT signaling pathway, but research shows that CLL cells are vulnerable to hyperactivation of this pathway, which may be a promising concept for CLL therapy.
NATURE COMMUNICATIONS
(2021)
Article
Genetics & Heredity
Huajie Mao, Ya Zhao, Li Lei, Yanxia Hu, Hangrui Zhu, Runzhi Wang, Dongsheng Ni, Jianing Liu, Lei Xu, Hua Xia, Zaikuan Zhang, Meng Ma, Zheng Pan, Qin Zhou, Yajun Xie
Summary: SELS is highly expressed in clear cell renal cell carcinoma (ccRCC) and associated with multiple pathological features. SELS overexpression promotes cell proliferation and inhibits apoptosis, while silence of SELS has the opposite effect. Mechanistically, SELS activates AKT/GSK3 beta/NF-kappa B signaling pathway to enhance cell proliferation and inhibit apoptosis, and stabilizes c-Myc by preventing ubiquitin-proteasome-mediated degradation. Furthermore, SELS inhibits ccRCC cell migration likely through repressing epithelial-mesenchymal transition (EMT).
Article
Biochemistry & Molecular Biology
Jiayao Qu, Jia Li, Yaming Zhang, Rongzhang He, Xiangting Liu, Ke Gong, Lili Duan, Weihao Luo, Zheng Hu, Gengsheng Wang, Chenglai Xia, Dixian Luo
Summary: Elevated expression of AKR1B10 in breast cancer tissues was associated with lymph node metastasis, tumor size, Ki67 expression, and p53 expression, while inversely correlated with overall and disease-free survival rates. AKR1B10 promotes proliferation, migration, and invasion of breast cancer cells via the PI3K/AKT/NF-kappa B signaling pathway, indicating its potential as a prognostic indicator and therapeutic target in breast cancer.
CELL AND BIOSCIENCE
(2021)
Article
Plant Sciences
Yun-Mi Kang, Minho Lee, Hyo-Jin An
Summary: OA exhibits potential therapeutic effects in suppressing allergic inflammatory responses by regulating multiple signaling pathways, alleviating symptoms associated with allergies, and may serve as a promising therapeutic agent for allergic diseases including anaphylaxis.
Article
Biochemistry & Molecular Biology
Sang Eun Ha, Seong Min Kim, Preethi Vetrivel, Hun Hwan Kim, Pritam Bhagwan Bhosale, Jeong Doo Heo, Ho Jeong Lee, Gon Sup Kim
Summary: SCU as a potential agent for HCC therapy inhibits cell proliferation and metastasis in HepG2 cells through upregulation of PTEN and inhibition of the PI3K/Akt/NF-kappa B signaling pathway. It is a natural based agent that shows promise in improving therapeutic outcomes for HCC treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Yuxin Zhang, Jing Wang, Chenxu Jing, Ming-Xue Zhou, Wenqi Jin, Xiuci Yan, Huanhuan Hou, Kai Shi, Wan-Chun Sun, Liwei Sun
Summary: Purple tea extract (PTE) was found to suppress osteoclast formation in bone marrow macrophages (BMMs) stimulated by RANKL, possibly through modulation of the Blimp1-Irf8 and Akt/GSK3 beta signaling pathways. In addition, PTE administration showed improvement in bone loss in LPS-treated mice.
Article
Chemistry, Medicinal
Yuyan Bai, Jin Zhou, Han Zhu, Yanlin Tao, Lupeng Wang, Liu Yang, Hui Wu, Fei Huang, Hailian Shi, Xiaojun Wu
Summary: This study found that Isoliquiritigenin (ISL) can inhibit microglia-mediated neuroinflammation in Parkinson's disease (PD) by deactivating JNK/AKT/NFκB signaling pathways. These findings suggest the therapeutic potential of ISL for microglia-mediated neuroinflammation in PD.
PHYTOTHERAPY RESEARCH
(2023)
Article
Food Science & Technology
Haiyan Wen, Siqi Zhou, Jianping Li, Fei Peng, Xiaotao Han, Haohuan Li
Summary: The study highlights the protective effect of Nuciferine (Nuf) against osteoarthritis (OA) by reducing extracellular matrix degradation and inhibiting the production of inflammatory cytokines. Nuf attenuates OA progression by targeting the PI3K/Akt/NF-kappa B signaling pathway.
JOURNAL OF FUNCTIONAL FOODS
(2021)
Article
Immunology
Zijian Liu, Zhihao Li, Guozhi Yan, Can Lin, Yaosheng Luo, Yanshi Ye, Xiaokang Zeng, Jie Yao
Summary: We found that MIF, IL-17A, and HVEM were up-regulated in HT patients, and the proportion of Th17 cells was positively correlated with the serum MIF protein level. Further studies showed that MIF promotes Th17 cell differentiation through HVEM and NF-kappa B signaling pathways.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Environmental Sciences
Laura O. Walter, Mariana F. Maioral, Lisandra O. Silva, Douglas B. Speer, Sanjay C. Campbell, Winklet Gallimore, Miriam B. Falkenberg, Maria Claudia Santos-Silva
Summary: This study evaluated the cytotoxicity of the o-quinone stypoldione isolated from brown algae on multiple myeloma cells (MM) and found it to have potential for MM treatment.
ENVIRONMENTAL TOXICOLOGY
(2022)
Article
Agriculture, Multidisciplinary
Qi Zhang, Guowan Su, Qing Yang, Zhengpeng Wei, Jinmei Wang, Lin Zheng, Mouming Zhao
Summary: The study revealed that WCPFSRSF could ameliorate oxidative stress, promote the Nrf2-mediated defense system, and potentially reduce ROS generation by inhibiting NF kappa B. Additionally, WCPFSRSF showed potential as a radical scavenger and Nrf2 activator, with its antioxidant and anti-inflammatory effects possibly related to the presence of Cys and Trp. Furthermore, WCPFSRSF exhibited memory-improving effects in sleep-deprived mice, highlighting its potential as a candidate against neurotoxicity and memory deficits.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2021)
Article
Pediatrics
Xia Zhang, Cun Liu, Yi Cao, Li Liu, Fusheng Sun, Lin Hou
Summary: This study found that RRS1 plays a role in regulating proliferation and cell cycle in neuroblastoma, and knockdown of RRS1 can inhibit cell proliferation through the PI3K/Akt/NF-kappa B pathway. Therefore, RRS1 may be a potential target for neuroblastoma treatment.
PEDIATRIC RESEARCH
(2022)
Article
Environmental Sciences
Hao-Min Wu, Chen-Yu Chiang, Wen-Ying Chen, Chun-Jung Chen, Ching-Chi Tseng, Yu-Chi Chang, Wen-Min Cheng, Yu-Hsiang Kuan
Summary: Cyclizine exhibits sedation and treatment of nausea, vomiting, and motion sickness due to its antihistaminic and antimuscarinic effects. However, it has the potential for abuse due to its hallucinogenic and euphoric effects. Overdose and illegal abuse of Cyclizine can result in confusion, tremors, chest pain, ataxia, seizures, and even suicide.
ENVIRONMENTAL TOXICOLOGY
(2023)
Article
Immunology
Linjie He, Yinan Pan, Jiapei Yu, Ben Wang, Gaole Dai, Xiaozhou Ying
Summary: This study found that DE could inhibit inflammatory responses mediated by IL-1 beta by reducing the secretion of inflammatory factors and preventing extracellular matrix collapse. Molecular docking analysis indicated strong binding affinity of DE with PI3K inhibitory targets. In an animal model of OA, DE treatment improved articular cartilage destruction and reduced serum inflammatory factors, suggesting potential for osteoarthritis treatment.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Cell Biology
Yan-Lin Chen, De-Yi Yan, Chen-Yu Wu, Jiang-Wei Xuan, Chen-Qiang Jin, Xin-Li Hu, Guo-Dong Bao, Yu-Jie Bian, Zhi-Chao Hu, Zhong-Hai Shen, Wen-Fei Ni
Summary: OA is characterized by destruction of articular cartilage and inflammation plays a key role in its progression. Maslinic acid (MA) from olive fruit has been shown to have anti-inflammatory effects. In in vitro and in vivo experiments, MA was found to attenuate inflammatory mediators and inhibit the progression of OA disease.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Article
Multidisciplinary Sciences
Mahtab Ghadiri, Ayman Rezk, Rui Li, Ashley Evans, Paul S. Giacomini, Michael H. Barnett, Jack Antel, Amit Bar-Or
SCIENTIFIC REPORTS
(2020)
Article
Biochemistry & Molecular Biology
Xize Guo, Wanping Zhang, Chun Wang, Bo Zhang, Rui Li, Lie Zhang, Kai Zhao, Yu Li, Linlu Tian, Bo Li, Huakun Cheng, Lixian Li, Chunying Pei, Hongwei Xu
Article
Multidisciplinary Sciences
Ayman Rezk, Rui Li, Amit Bar-Or
SCIENTIFIC REPORTS
(2020)
Article
Multidisciplinary Sciences
Daniel E. Morales-Mantilla, Xinyan Huang, Philip Erice, Paul Porter, Yun Zhang, Mary Figueroa, Joya Chandra, Katherine Y. King, Farrah Kheradmand, Antony Rodriguez
JOVE-JOURNAL OF VISUALIZED EXPERIMENTS
(2020)
Article
Oncology
Linlu Tian, Hongxue Meng, Xiao Dong, Xinlei Li, Zilin Shi, Hulun Li, Lie Zhang, Yue Yang, Ruijie Liu, Chunying Pei, Bo Li, Hongwei Xu, Rui Li
Summary: Studies have shown that overexpression of IRGM is associated with human melanoma progression and poor patient survival. Specifically, IRGMb is responsible for this correlation, and the mechanism by which IRGM promotes melanoma cell survival is mainly through autophagy.
MOLECULAR THERAPY-ONCOLYTICS
(2021)
Article
Clinical Neurology
Mukanthu H. Nyirenda, Giulia Fadda, Luke M. Healy, Ina Mexhitaj, Laurence Poliquin-Lasnier, Heather Hanwell, Alexander W. Saveriano, Ayal Rozenberg, Rui Li, Craig S. Moore, Chahrazed Belabani, Trina Johnson, Julia O'Mahony, Douglas L. Arnold, E. Ann Yeh, Ruth Ann Marrie, Shannon Dunn, Brenda Banwell, Amit Bar-Or
Summary: This study investigated serum adiponectin levels and their effects on immune responses and microglia in pediatric-onset MS. The results showed that children with MS had higher serum adiponectin levels, which were associated with pro-inflammatory states and activation of CNS microglia.
MULTIPLE SCLEROSIS JOURNAL
(2021)
Review
Clinical Neurology
Amit Bar-Or, Rui Li
Summary: The pathogenesis of multiple sclerosis is being redefined by new insights from basic and translational studies, indicating involvement of various cell types and subsets in the inflammatory responses. Imbalanced interactions between T cells, myeloid cells, B cells, and their subpopulations play a crucial role in relapsing multiple sclerosis, with patient-specific contributors to these imbalances. Single-cell immune cell profiling techniques reveal functional heterogeneity and plasticity that could impact disease progression and treatment response. Clinical trials with different agents have helped to elucidate disease mechanisms, clarify immune therapy modes of action, and set the stage for new therapeutic strategies.
Article
Biochemistry & Molecular Biology
Sokratis A. Apostolidis, Mihir Kakara, Mark M. Painter, Rishi R. Goel, Divij Mathew, Kerry Lenzi, Ayman Rezk, Kristina R. Patterson, Diego A. Espinoza, Jessy C. Kadri, Daniel M. Markowitz, Clyde E. Markowitz, Ina Mexhitaj, Dina Jacobs, Allison Babb, Michael R. Betts, Eline T. Luning Prak, Daniela Weiskopf, Alba Grifoni, Kendall A. Lundgreen, Sigrid Gouma, Alessandro Sette, Paul Bates, Scott E. Hensley, Allison R. Greenplate, E. John Wherry, Rui Li, Amit Bar-Or
Summary: Patients with multiple sclerosis on anti-CD20 monotherapy exhibit significantly reduced SARS-CoV-2-specific antibodies and memory B cells, while CD4(+) and CD8(+) T cells are robustly activated compared to healthy controls after receiving BNT162b2 or mRNA-1273 mRNA vaccination.
Article
Clinical Neurology
Rui Li, Thomas Francis Tropea, Laura Rosa Baratta, Leah Zuroff, Maria E. Diaz-Ortiz, Bo Zhang, Koji Shinoda, Ayman Rezk, Roy N. Alcalay, Alice Chen-Plotkin, Amit Bar-Or
Summary: This study comprehensively characterized phenotypic and functional profiles of circulating immune cells in patients with Parkinson disease (PD) compared to controls. B cells appeared to be preferentially affected in PD, with decreased proliferating B cell counts, reduced proportions of B-cell subsets with regulatory capacity, and increased proportions of proinflammatory cytokine-producing B cells. Unsupervised principal component analysis revealed increased expression of TNF alpha and GM-CSF by both B cells and T cells in patients with PD. These findings suggest aberrant Tfh:B-cell interactions in PD.
NEUROLOGY-NEUROIMMUNOLOGY & NEUROINFLAMMATION
(2022)
Article
Clinical Neurology
Rui Li, Hao Tang, Jeremy C. Burns, Brian T. Hopkins, Carole Le Coz, Bo Zhang, Isabella Peixoto de Barcelos, Neil Romberg, Amy C. Goldstein, Brenda L. Banwell, Eline T. Luning Prak, Michael Mingueneau, Amit Bar-Or
Summary: Inhibition of Bruton's Tyrosine Kinase (BTKi) is a promising therapy for autoimmune diseases. This study demonstrates that BTKi attenuates B-cell:T-cell interactions by modulating B-cell metabolic pathways and mediates an anti-inflammatory modulation of B cells. The study suggests that targeting B-cell metabolism may be a viable therapeutic approach for pro-inflammatory B cells.
ACTA NEUROPATHOLOGICA
(2022)
Article
Medicine, General & Internal
Leah Zuroff, Ayman Rezk, Koji Shinoda, Diego A. Espinoza, Yehezqel Elyahu, Bo Zhang, Andrew A. Chen, Russell T. Shinohara, Dina Jacobs, Roy N. Alcalay, Thomas F. Tropea, Alice Chen-Plotkin, Alon Monsonego, Rui Li, Amit Bar-Or
Summary: In the study comparing untreated MS patients with normal controls, it was found that MS patients exhibited early and persistent redistribution of naive and memory CD4 T-cell compartments. While most CD4 and CD8 T-cell aging trajectories were similar between groups, MS patients demonstrated abnormal age-associated increases, particularly in patients over 60.
Review
Physiology
Farrah Kheradmand, Yun Zhang, David B. Corry
Summary: The pathophysiology of chronic obstructive pulmonary disease (COPD) has long focused on innate immune cells, but recent data suggests that adaptive immune cells also contribute to lung destruction. The presence of activated and organized adaptive immune cells in emphysematous lungs indicates their role in COPD. Experimental models have shown that Th1 and Th17 subsets activate innate immune cells, confirming their involvement in emphysema pathogenesis.
PHYSIOLOGICAL REVIEWS
(2023)
Article
Medicine, General & Internal
Hanane Touil, Rui Li, Leah Zuroff, Craig S. Moore, Luke Healy, Francesca Cignarella, Laura Piccio, Samuel Ludwin, Alexandre Prat, Jennifer Gommerman, Frederick C. Bennett, Dina Jacobs, Joyce A. Benjamins, Robert P. Lisak, Jack P. Antel, Amit Bar-Or
Summary: B-cell-myeloid cell interactions may contribute to the progression of multiple sclerosis by inducing pro-inflammatory responses in microglia and macrophages, and modulating their phagocytosis and expression of quiescence-associated molecules. Targeting these interactions could be a potential therapeutic strategy.
Meeting Abstract
Clinical Neurology
D. A. Espinoza, I. Mexhitaj, J. Smiler, F. Thompson, R. A. Pellegrino Da Silva, G. Fadda, A. Yeh, R. Marrie, D. L. Arnold, R. Li, B. Banwell, A. Bar-Or
MULTIPLE SCLEROSIS JOURNAL
(2023)
Article
Respiratory System
Yuying Zeng, Yun Zhang, Xinyan Huang, Lizhen Song, Katherine Polsky, Yifan Wu, Farrah Kheradmand, Yubiao Guo, Linda K. Green, David B. Corry, John M. Knight
Summary: The study found that high dose inhalation of LPS can alleviate asthma-like features induced by allergenic mold Aspergillus niger, replacing them with a phenotype more consistent with acute hypersensitivity pneumonitis (HP).
RESPIRATORY RESEARCH
(2021)