Targeted protein S-nitrosylation of ACE2 inhibits SARS-CoV-2 infection

A TMPRSS2 inhibitor acts as a pan-SARS-CoV-2 prophylactic and therapeutic

(2022) Tirosh Shapira et al.   NATURE

Structural insight into SARS-CoV-2 neutralizing antibodies and modulation of syncytia

(2021) Daniel Asarnow et al.   CELL

Characteristics of SARS-CoV-2 variants of concern B.1.1.7, B.1.351 or P.1: data from seven EU/EEA countries, weeks 38/2020 to 10/2021

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Bispecific antibodies targeting distinct regions of the spike protein potently neutralize SARS-CoV-2 variants of concern

(2021) Hyeseon Cho et al.   Science Translational Medicine

Potential for the Repurposing of Adamantane Antivirals for COVID-19

(2021) Roger F. Butterworth   DRUGS IN R&D

Lung epithelial and endothelial damage, loss of tissue repair, inhibition of fibrinolysis, and cellular senescence in fatal COVID-19

(2021) Felice D’Agnillo et al.   Science Translational Medicine

Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) in vitro

(2020) Manli Wang et al.   CELL RESEARCH

Structural basis for the recognition of the SARS-CoV-2 by full-length human ACE2

(2020) Renhong Yan et al.   SCIENCE

SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor

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Structure of the SARS-CoV-2 spike receptor-binding domain bound to the ACE2 receptor

(2020) Jun Lan et al.   NATURE

Characterization of spike glycoprotein of SARS-CoV-2 on virus entry and its immune cross-reactivity with SARS-CoV

(2020) Xiuyuan Ou et al.   Nature Communications

Structural and functional properties of SARS-CoV-2 spike protein: potential antivirus drug development for COVID-19

(2020) Yuan Huang et al.   ACTA PHARMACOLOGICA SINICA

Scalable molecular dynamics on CPU and GPU architectures with NAMD

(2020) James C. Phillips et al.   JOURNAL OF CHEMICAL PHYSICS

Isolation of potent SARS-CoV-2 neutralizing antibodies and protection from disease in a small animal model

(2020) Thomas F. Rogers et al.   SCIENCE

Distinct conformational states of SARS-CoV-2 spike protein

(2020) Yongfei Cai et al.   SCIENCE

SARS-CoV-2 E protein is a potential ion channel that can be inhibited by Gliclazide and Memantine

(2020) Prabhat Pratap Singh Tomar et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Gene of the month: TMPRSS2 (transmembrane serine protease 2)

(2020) Michelle Thunders et al.   JOURNAL OF CLINICAL PATHOLOGY

Harnessing nitric oxide for preventing, limiting and treating the severe pulmonary consequences of COVID-19

(2020) Nagasai C. Adusumilli et al.   NITRIC OXIDE-BIOLOGY AND CHEMISTRY

Mitigation of the replication of SARS-CoV-2 by nitric oxide in vitro

(2020) Dario Akaberi et al.   Redox Biology

Noncanonical transnitrosylation network contributes to synapse loss in Alzheimer’s disease

(2020) Tomohiro Nakamura et al.   SCIENCE

MEK inhibitors reduce cellular expression of ACE2, pERK, pRb while stimulating NK-mediated cytotoxicity and attenuating inflammatory cytokines relevant to SARS-CoV-2 infection

(2020) Lanlan Zhou et al.   Oncotarget

The flexibility of ACE2 in the context of SARS-CoV-2 infection

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Membrane Lipid Composition: Effect on Membrane and Organelle Structure, Function and Compartmentalization and Therapeutic Avenues

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Coronavirus envelope protein: current knowledge

(2019) Dewald Schoeman et al.   Virology Journal

Mechanisms of hyperexcitability in Alzheimer’s disease hiPSC-derived neurons and cerebral organoids vs isogenic controls

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Protein S-Nitrosylation: Determinants of Specificity and Enzymatic Regulation of S-Nitrosothiol-Based Signaling

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Bayesian noninferiority test for 2 binomial probabilities as the extension of Fisher exact test

(2017) Masaaki Doi et al.   STATISTICS IN MEDICINE

NitroSynapsin therapy for a mouse MEF2C haploinsufficiency model of human autism

(2017) Shichun Tu et al.   Nature Communications

CHARMM36m: an improved force field for folded and intrinsically disordered proteins

(2016) Jing Huang et al.   NATURE METHODS

Extracting Accurate Precursor Information for Tandem Mass Spectra by RawConverter

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MDTraj: A Modern Open Library for the Analysis of Molecular Dynamics Trajectories

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ProLuCID: An improved SEQUEST-like algorithm with enhanced sensitivity and specificity

(2015) T. Xu et al.   Journal of Proteomics

Pharmacologically targeted NMDA receptor antagonism by NitroMemantine for cerebrovascular disease

(2015) Hiroto Takahashi et al.   Scientific Reports

A  induces astrocytic glutamate release, extrasynaptic NMDA receptor activation, and synaptic loss

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Mechanisms of S-nitrosothiol formation and selectivity in nitric oxide signaling

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Automation of the CHARMM General Force Field (CGenFF) II: Assignment of Bonded Parameters and Partial Atomic Charges

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Automation of the CHARMM General Force Field (CGenFF) I: Bond Perception and Atom Typing

(2012) K. Vanommeslaeghe et al.   Journal of Chemical Information and Modeling

Extension of the CHARMM general force field to sulfonyl-containing compounds and its utility in biomolecular simulations

(2012) Wenbo Yu et al.   JOURNAL OF COMPUTATIONAL CHEMISTRY

Viroporins: structure and biological functions

(2012) José Luis Nieva et al.   NATURE REVIEWS MICROBIOLOGY

Where does amantadine bind to the influenza virus M2 proton channel?

(2010) Dima Kozakov et al.   TRENDS IN BIOCHEMICAL SCIENCES

CHARMM Additive All-Atom Force Field for Glycosidic Linkages between Hexopyranoses

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Balance between synaptic versus extrasynaptic NMDA receptor activity influences inclusions and neurotoxicity of mutant huntingtin

(2009) Shu-ichi Okamoto et al.   NATURE MEDICINE

Structure and Inhibition of the SARS Coronavirus Envelope Protein Ion Channel

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Membrane lipids: where they are and how they behave

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