Activation of γ-globin expression by hypoxia-inducible factor 1α

Identification of novel γ-globin inducers among all potential erythroid druggable targets

(2022) Lei Yu et al.   Blood Advances

β-Thalassemias

(2021) Ali T. Taher et al.   NEW ENGLAND JOURNAL OF MEDICINE

Genetic therapies for the first molecular disease

(2021) Phillip A. Doerfler et al.   JOURNAL OF CLINICAL INVESTIGATION

Hypoxia-inducible factor–prolyl hydroxylase inhibitors in the treatment of anemia of chronic kidney disease

(2021) Volker H. Haase   Kidney International Supplements

Activation of γ-globin gene expression by GATA1 and NF-Y in hereditary persistence of fetal hemoglobin

(2021) Phillip A. Doerfler et al.   NATURE GENETICS

S3norm: simultaneous normalization of sequencing depth and signal-to-noise ratio in epigenomic data

(2020) Guanjue Xiang et al.   NUCLEIC ACIDS RESEARCH

Inactivation of Fbxw7 impairs dsRNA sensing and confers resistance to PD-1 blockade

(2020) Cecile Gstalder et al.   Cancer Discovery

Fetal Hemoglobin in Sickle Cell Anemia

(2020) Martin H Steinberg   BLOOD

Control of fetal globin expression in man: new opportunities to challenge past discoveries

(2020) Thalia Papayannopoulou   EXPERIMENTAL HEMATOLOGY

Fetal hemoglobin rescues ineffective erythropoiesis in sickle cell disease

(2020) Sara El Hoss et al.   HAEMATOLOGICA

FBXO11-mediated proteolysis of BAHD1 relieves PRC2-dependent transcriptional repression in erythropoiesis

(2020) Peng Xu et al.   BLOOD

Highly efficient therapeutic gene editing of human hematopoietic stem cells

(2019) Yuxuan Wu et al.   NATURE MEDICINE

CRISPResso2 provides accurate and rapid genome editing sequence analysis

(2019) Kendell Clement et al.   NATURE BIOTECHNOLOGY

Roxadustat for Anemia in Patients with Kidney Disease Not Receiving Dialysis

(2019) Nan Chen et al.   NEW ENGLAND JOURNAL OF MEDICINE

Transcriptional States and Chromatin Accessibility Underlying Human Erythropoiesis

(2019) Leif S. Ludwig et al.   Cell Reports

Hypoxia-Inducible Factor Activators in Renal Anemia: Current Clinical Experience

(2019) Neil S. Sanghani et al.   ADVANCES IN CHRONIC KIDNEY DISEASE

Direct Promoter Repression by BCL11A Controls the Fetal to Adult Hemoglobin Switch

(2018) Nan Liu et al.   CELL

Targeted in situ genome-wide profiling with high efficiency for low cell numbers

(2018) Peter J Skene et al.   Nature Protocols

Sickle cell disease

(2018) Gregory J. Kato et al.   Nature Reviews Disease Primers

Fetal γ-globin genes are regulated by the BGLT3 long non-coding RNA locus

(2018) Maria Soledad Ivaldi et al.   BLOOD

Comparative analysis of three-dimensional chromosomal architecture identifies a novel fetal hemoglobin regulatory element

(2017) Peng Huang et al.   GENES & DEVELOPMENT

An improved ATAC-seq protocol reduces background and enables interrogation of frozen tissues

(2017) M Ryan Corces et al.   NATURE METHODS

Ever-Changing Landscapes: Transcriptional Enhancers in Development and Evolution

(2016) Hannah K. Long et al.   CELL

A genome-editing strategy to treat β-hemoglobinopathies that recapitulates a mutation associated with a benign genetic condition

(2016) Elizabeth A Traxler et al.   NATURE MEDICINE

Transcription factors LRF and BCL11A independently repress expression of fetal hemoglobin

(2016) T. Masuda et al.   SCIENCE

Multiplexed analysis of chromosome conformation at vastly improved sensitivity

(2015) James O J Davies et al.   NATURE METHODS

limma powers differential expression analyses for RNA-sequencing and microarray studies

(2015) Matthew E. Ritchie et al.   NUCLEIC ACIDS RESEARCH

Occupancy by key transcription factors is a more accurate predictor of enhancer activity than histone modifications or chromatin accessibility

(2015) Nergiz Dogan et al.   Epigenetics & Chromatin

Improved vectors and genome-wide libraries for CRISPR screening

(2014) Neville E Sanjana et al.   NATURE METHODS

Easy quantitative assessment of genome editing by sequence trace decomposition

(2014) Eva K. Brinkman et al.   NUCLEIC ACIDS RESEARCH

Effect of congenital upregulation of hypoxia inducible factors on percentage of fetal hemoglobin in the blood

(2013) J. Salomon-Andonie et al.   BLOOD

Hypoxia and HIFs in regulating the development of the hematopoietic system

(2013) Parisa Imanirad et al.   BLOOD CELLS MOLECULES AND DISEASES

Establishment of Immortalized Human Erythroid Progenitor Cell Lines Able to Produce Enucleated Red Blood Cells

(2013) Ryo Kurita et al.   PLoS One

Ubiquitin and Proteasomes in Transcription

(2012) Fuqiang Geng et al.   Annual Review of Biochemistry

BEDOPS: high-performance genomic feature operations

(2012) Shane Neph et al.   BIOINFORMATICS

High-resolution genome-wide mapping of HIF-binding sites by ChIP-seq

(2011) J. Schodel et al.   BLOOD

Loss of JAK2 regulation via a heterodimeric VHL-SOCS1 E3 ubiquitin ligase underlies Chuvash polycythemia

(2011) Ryan C Russell et al.   NATURE MEDICINE

HIF1  synergizes with glucocorticoids to promote BFU-E progenitor self-renewal

(2010) J. Flygare et al.   BLOOD

Simple Combinations of Lineage-Determining Transcription Factors Prime cis-Regulatory Elements Required for Macrophage and B Cell Identities

(2010) Sven Heinz et al.   MOLECULAR CELL

Oxygen Sensing by Metazoans: The Central Role of the HIF Hydroxylase Pathway

(2008) William G. Kaelin et al.   MOLECULAR CELL

A Gain-of-Function Mutation in theHIF2AGene in Familial Erythrocytosis

(2008) Melanie J. Percy et al.   NEW ENGLAND JOURNAL OF MEDICINE