Impact of Nuclear De Novo NAD + Synthesis via Histone Dynamics on DNA Repair during Cellular Senescence To Prevent Tumorigenesis

Protecting the Aging Genome

(2020) Michael A. Petr et al.   TRENDS IN CELL BIOLOGY

Evaluation of site-specific homologous recombination activity of BRCA1 by direct quantitation of gene editing efficiency

(2019) Yuki Yoshino et al.   Scientific Reports

Short-term gain, long-term pain: the senescence life cycle and cancer

(2019) Adelyne Sue Li Chan et al.   GENES & DEVELOPMENT

Poly(ADP-ribose) polymerase-1 antagonizes DNA resection at double-strand breaks

(2019) Marie-Christine Caron et al.   Nature Communications

Life or Death after a Break: What Determines the Choice?

(2019) Lenno Krenning et al.   MOLECULAR CELL

NAD metabolism: Implications in aging and longevity

(2018) Keisuke Yaku et al.   AGEING RESEARCH REVIEWS

Quantitative Analysis of NAD Synthesis-Breakdown Fluxes

(2018) Ling Liu et al.   Cell Metabolism

De novo NAD+ biosynthetic impairment in acute kidney injury in humans

(2018) Ali Poyan Mehr et al.   NATURE MEDICINE

De novo NAD+ synthesis enhances mitochondrial function and improves health

(2018) Elena Katsyuba et al.   NATURE

NAD Deficiency, Congenital Malformations, and Niacin Supplementation

(2017) Hongjun Shi et al.   NEW ENGLAND JOURNAL OF MEDICINE

Coordinated Regulation of TIP60 and Poly(ADP-Ribose) Polymerase 1 in Damaged-Chromatin Dynamics

(2016) Masae Ikura et al.   MOLECULAR AND CELLULAR BIOLOGY

NAD+ Metabolism and the Control of Energy Homeostasis: A Balancing Act between Mitochondria and the Nucleus

(2015) Carles Cantó et al.   Cell Metabolism

Secondary NAD+ deficiency in the inherited defect of glutamine synthetase

(2015) Liyan Hu et al.   JOURNAL OF INHERITED METABOLIC DISEASE

Acetylation of Histone H2AX at Lys 5 by the TIP60 Histone Acetyltransferase Complex Is Essential for the Dynamic Binding of NBS1 to Damaged Chromatin

(2015) Masae Ikura et al.   MOLECULAR AND CELLULAR BIOLOGY

Nuclear pyruvate kinase M2 complex serves as a transcriptional coactivator of arylhydrocarbon receptor

(2015) Shun Matsuda et al.   NUCLEIC ACIDS RESEARCH

Inhibition of De Novo NAD + Synthesis by Oncogenic URI Causes Liver Tumorigenesis through DNA Damage

(2014) Krishna S. Tummala et al.   CANCER CELL

Transcriptionally active chromatin recruits homologous recombination at DNA double-strand breaks

(2014) François Aymard et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

PARP-1 mechanism for coupling DNA damage detection to poly(ADP-ribose) synthesis

(2013) Marie-France Langelier et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Replication Stress-Induced Genome Instability: The Dark Side of Replication Maintenance by Homologous Recombination

(2013) Antony M. Carr et al.   JOURNAL OF MOLECULAR BIOLOGY

Activation of the Aryl Hydrocarbon Receptor Sensitizes Mice to Nonalcoholic Steatohepatitis by Deactivating Mitochondrial Sirtuin Deacetylase Sirt3

(2013) J. He et al.   MOLECULAR AND CELLULAR BIOLOGY

Acetylation limits 53BP1 association with damaged chromatin to promote homologous recombination

(2013) Jiangbo Tang et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Regulation of Poly(ADP-ribose) Polymerase-1-dependent Gene Expression through Promoter-directed Recruitment of a Nuclear NAD+Synthase

(2012) Tong Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The dynamic regulation of NAD metabolism in mitochondria

(2012) Liana Roberts Stein et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Methionine Adenosyltransferase II Serves as a Transcriptional Corepressor of Maf Oncoprotein

(2011) Yasutake Katoh et al.   MOLECULAR CELL

Homologous recombination in cancer development, treatment and development of drug resistance

(2010) T. Helleday   CARCINOGENESIS

Enzymes in the NAD+Salvage Pathway Regulate SIRT1 Activity at Target Gene Promoters

(2009) Tong Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Nicotinic Acid, Nicotinamide, and Nicotinamide Riboside: A Molecular Evaluation of NAD+ Precursor Vitamins in Human Nutrition

(2008) Katrina L Bogan et al.   Annual Review of Nutrition

Oncogene-Induced Senescence Relayed by an Interleukin-Dependent Inflammatory Network

(2008) Thomas Kuilman et al.   CELL

Chemokine Signaling via the CXCR2 Receptor Reinforces Senescence

(2008) Juan C. Acosta et al.   CELL

Deadenylation is prerequisite for P-body formation and mRNA decay in mammalian cells

(2008) Dinghai Zheng et al.   JOURNAL OF CELL BIOLOGY