Thiazole derivatives in medicinal chemistry: Recent advancements in synthetic strategies, structure activity relationship and pharmacological outcomes
出版年份 2022 全文链接
标题
Thiazole derivatives in medicinal chemistry: Recent advancements in synthetic strategies, structure activity relationship and pharmacological outcomes
作者
关键词
-
出版物
JOURNAL OF MOLECULAR STRUCTURE
Volume 1266, Issue -, Pages 133479
出版商
Elsevier BV
发表日期
2022-06-08
DOI
10.1016/j.molstruc.2022.133479
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注意:仅列出部分参考文献,下载原文获取全部文献信息。- Cancer statistics, 2022
- (2022) Rebecca L. Siegel et al. CA-A CANCER JOURNAL FOR CLINICIANS
- Design, synthesis, and biological evaluation of isatin‐indole‐3‐carboxaldehyde hybrids as a new class of xanthine oxidase inhibitors
- (2022) Atamjit Singh et al. ARCHIV DER PHARMAZIE
- An Overview of the Synthesis and Antimicrobial, Antiprotozoal, and Antitumor Activity of Thiazole and Bisthiazole Derivatives
- (2021) Anca-Maria Borcea et al. MOLECULES
- Design, synthesis and docking studies of novel thiazole derivatives incorporating pyridine moiety and assessment as antimicrobial agents
- (2021) Rizk E. Khidre et al. Scientific Reports
- Antiproliferative activity of thiazole and oxazole derivatives: A systematic review of in vitro and in vivo studies
- (2021) Nancy Y. Guerrero-Pepinosa et al. BIOMEDICINE & PHARMACOTHERAPY
- Design, synthesis and anti-influenza virus activity of furan-substituted spirothiazolidinones
- (2021) Çağla Begüm Apaydın et al. BIOORGANIC CHEMISTRY
- Insights into the structure activity relationship of nitrogen-containing heterocyclics for the development of antidepressant compounds: An updated review
- (2021) Karanvir Singh et al. JOURNAL OF MOLECULAR STRUCTURE
- Recent advances on drug development and emerging therapeutic agents for Alzheimer’s disease
- (2021) Teeba Athar et al. MOLECULAR BIOLOGY REPORTS
- Comparative study of cefixime and tetracycline as an evaluation policy driven by the antibiotic resistance crisis in Indonesia
- (2021) Danni Ramdhani et al. Scientific Reports
- Cefdinir and β-Lactamase Inhibitor Independent Efficacy Against Mycobacterium tuberculosis
- (2021) Shashikant Srivastava et al. Frontiers in Pharmacology
- Ixabepilone: Overview of Effectiveness, Safety, and Tolerability in Metastatic Breast Cancer
- (2021) Nuhad K. Ibrahim Frontiers in Oncology
- Cefiderocol-Based Combination Therapy for “Difficult-to-Treat” Gram-Negative Severe Infections: Real-Life Case Series and Future Perspectives
- (2021) Davide Fiore Bavaro et al. Antibiotics-Basel
- Design, synthesis, and biological evaluation of novel morpholinated isatin–quinoline hybrids as potent anti‐breast cancer agents
- (2021) Atamjit Singh et al. ARCHIV DER PHARMAZIE
- The clinical and microbiological efficacy of temocillin versus cefotaxime in adults with febrile urinary tract infection, and its effects on the intestinal microbiota: a randomised multicentre clinical trial in Sweden
- (2021) Charlotta Edlund et al. LANCET INFECTIOUS DISEASES
- Novel class of benzimidazole-thiazole hybrids: The privileged scaffolds of potent anti-inflammatory activity with dual inhibition of cyclooxygenase and 15-lipoxygenase enzymes
- (2020) Mohammed T.-E. Maghraby et al. BIOORGANIC & MEDICINAL CHEMISTRY
- Discovery of 4-hydroxy-2-oxo-1,2-dihydroquinolines as potential inhibitors of Streptococcus pneumoniae, including drug-resistant strains
- (2020) Srigouri Huddar et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Drug-Like Property Optimization: Discovery of Orally Bioavailable Quinazoline-Based Multi-Targeted Kinase Inhibitors
- (2020) Shu-Yu Lin et al. BIOORGANIC CHEMISTRY
- Synthesis, Anti-convulsant activity and Molecular Docking Study of novel Thiazole Pyridazinone Hybrid Analogues
- (2020) Aness Ahmad Siddiqui et al. BIOORGANIC CHEMISTRY
- Novel pyrazine based anti-tubercular agents: Design, synthesis, biological evaluation and in silico studies
- (2020) Nayera W. Hassan et al. BIOORGANIC CHEMISTRY
- Novel distamycin analogues that block the cell cycle of African trypanosomes with high selectivity and potency
- (2020) Jaime Franco et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- Oxadiazolylthiazoles as novel and selective antifungal agents
- (2020) Mohamed Hagras et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- Design, synthesis and evaluation of phenylthiazole and phenylthiophene pyrimidindiamine derivatives targeting the bacterial membrane
- (2020) Tingting Fan et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- Design, synthesis, antitumor activity and theoretical calculation of novel PI3Ka inhibitors
- (2020) Ru-Yi Jin et al. BIOORGANIC CHEMISTRY
- Discovery of thiazole-based-chalcones and 4-hetarylthiazoles as potent anticancer agents: Synthesis, docking study and anticancer activity
- (2020) Thoraya A. Farghaly et al. BIOORGANIC CHEMISTRY
- Key Takeaways From the U.S. CDC’s 2019 Antibiotic Resistance Threats Report for Frontline Providers
- (2020) Sameer S. Kadri CRITICAL CARE MEDICINE
- Discovery of T-1101 tosylate as a first-in-class clinical candidate for Hec1/Nek2 inhibition in cancer therapy
- (2020) Shih-Hsien Chuang et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- Synthesis, modelling and molecular docking of new 5-arylazo-2-chloroacetamido thiazole derivatives as antioxidant agent
- (2020) Aisha SM. Hossan JOURNAL OF MOLECULAR STRUCTURE
- Synthesis and antimicrobial evaluation of new thiazolyl-1,2,3-triazolyl-alcohol derivatives
- (2020) Shivaji Jagadale et al. MEDICINAL CHEMISTRY RESEARCH
- Assessment of Deaths From COVID-19 and From Seasonal Influenza
- (2020) Jeremy Samuel Faust et al. JAMA Internal Medicine
- Optimization and biological evaluation of thiazole-bis-amide inverse agonists of RORγt
- (2020) Christian Gege et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Discovery and optimization of new oxadiazole substituted thiazole RORγt inverse agonists through a bioisosteric amide replacement approach
- (2020) Christoph Steeneck et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- The rational design, synthesis, and antimicrobial investigation of 2-Amino-4-Methylthiazole analogues inhibitors of GlcN-6-P synthase
- (2020) Abdelsattar M. Omar et al. BIOORGANIC CHEMISTRY
- Dual mechanisms suppress meloxicam bioactivation relative to sudoxicam
- (2020) Dustyn A. Barnette et al. TOXICOLOGY
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- (2020) Ning Chen et al. Frontiers in Pharmacology
- New coumarin-benzotriazole based hybrid molecules as inhibitors of acetylcholinesterase and amyloid aggregation
- (2020) Atamjit Singh et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Synthesis and molecular modeling of novel bio-functional moieties derived from 2-cyanoacetamide-3,4,5-substituted thiophene as human carcinoma growth inhibitors
- (2020) Mohamed E. Khalifa JOURNAL OF MOLECULAR STRUCTURE
- Lopinavir–ritonavir in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial
- (2020) Peter W Horby et al. LANCET
- Discovery of 2-phenylthiazole-4-carboxylic acid, a novel and potent scaffold as xanthine oxidase inhibitors
- (2019) Xue Xu et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
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- (2019) Somaia S. Abd El-Karim et al. BIOORGANIC CHEMISTRY
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- (2019) Weiyang Dai et al. JOURNAL OF MEDICINAL CHEMISTRY
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- (2019) Xiaojing Wang et al. JOURNAL OF MEDICINAL CHEMISTRY
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- (2019) Xiaofeng Guo et al. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
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- (2019) Ting Pan et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
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- (2019) Sushma J. Takate et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
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- (2019) Attila Egyed et al. BIOORGANIC & MEDICINAL CHEMISTRY
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- (2019) Krisztián Tóth et al. BIOORGANIC & MEDICINAL CHEMISTRY
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- (2019) Zhongzhong Yan et al. BIOORGANIC & MEDICINAL CHEMISTRY
- Synthesis, anticancer effect and molecular modeling of new thiazolylpyrazolyl coumarin derivatives targeting VEGFR-2 kinase and inducing cell cycle arrest and apoptosis
- (2019) Tahia K. Mohamed et al. BIOORGANIC CHEMISTRY
- Synthesis and structure-activity relationship of tyrosinase inhibiting novel bi-heterocyclic acetamides: Mechanistic insights through enzyme inhibition, kinetics and computational studies
- (2019) Abdul Rehman Sadiq Butt et al. BIOORGANIC CHEMISTRY
- Synthesis and structure-activity relationship of elastase inhibiting novel ethylated thiazole-triazole acetamide hybrids: Mechanistic insights through kinetics and computational contemplations
- (2019) Abdul Rehman Sadiq Butt et al. BIOORGANIC CHEMISTRY
- Design, synthesis and molecular docking of pyrazolo [3,4d] thiazole hybrids as potential anti-HIV-1 NNRT inhibitors
- (2019) H.M. Kasralikar et al. BIOORGANIC CHEMISTRY
- Pharmacological investigation of quinoxaline-bisthiazoles as multitarget-directed ligands for the treatment of Alzheimer’s disease
- (2019) Sneha R. Sagar et al. BIOORGANIC CHEMISTRY
- The in vivo antinociceptive and μ-opioid receptor activating effects of the combination of N-phenyl-2′,4′-dimethyl-4,5′-bi-1,3-thiazol-2-amines and naloxone
- (2019) Shu-Yu Lin et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- Design and synthesis of aminothiazolyl norfloxacin analogues as potential antimicrobial agents and their biological evaluation
- (2019) Liang-Liang Wang et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- A novel, potent, and orally bioavailable thiazole HCV NS5A inhibitor for the treatment of hepatitis C virus
- (2019) Teng-Kuang Yeh et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- 4-Imidazo[2,1-b]thiazole-1,4-DHPs and neuroprotection: preliminary study in hits searching
- (2019) Alberto Leoni et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- Identification of 5-Substituted 2-Acylaminothiazoles That Activate Tat-Mediated Transcription in HIV-1 Latency Models
- (2019) William Nguyen et al. JOURNAL OF MEDICINAL CHEMISTRY
- Identifying novel anti-osteoporosis leads with a chemotype-assembly approach
- (2019) Chao Zhao et al. JOURNAL OF MEDICINAL CHEMISTRY
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- (2019) Shimaa M. Abd El-Gilil JOURNAL OF MOLECULAR STRUCTURE
- Gentamicin compared with ceftriaxone for the treatment of gonorrhoea (G-ToG): a randomised non-inferiority trial
- (2019) Jonathan D C Ross et al. LANCET
- Synthesis and antimycobacterial evaluation of new 5-(1-benzyl-1H-1,2,3-triazol-4-yl)-4-methyl-2-arylthiazole derivatives
- (2019) Vikas Shinde et al. MEDICINAL CHEMISTRY RESEARCH
- Design, synthesis, bioactivity, and DFT calculation of 2-thiazolyl-hydrazone derivatives as influenza neuraminidase inhibitors
- (2019) Man-Ying Cui et al. MEDICINAL CHEMISTRY RESEARCH
- Neurological, Psychiatric, and Biochemical Aspects of Thiamine Deficiency in Children and Adults
- (2019) Shibani Dhir et al. Frontiers in Psychiatry
- Alkynamide phthalazinones as a new class of TbrPDEB1 inhibitors (Part 2)
- (2019) Erik de Heuvel et al. BIOORGANIC & MEDICINAL CHEMISTRY
- Preparation and biological evaluation of soluble tetrapeptide epoxyketone proteasome inhibitors
- (2019) Meng Lei et al. BIOORGANIC & MEDICINAL CHEMISTRY
- Synthesis and biological evaluation of 2-chloro-3-[(thiazol-2-yl)amino]-1,4-naphthoquinones
- (2019) Emmanuel O. Olawode et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Synthesis, fungicidal activity and SAR of 3,4-dichloroisothiazole-based cycloalkylsulfonamides
- (2019) Yumeng Zhang et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Design, synthesis, and carbonic anhydrase inhibition activity of benzenesulfonamide-linked novel pyrazoline derivatives
- (2019) Alaa A.-M. Abdel-Aziz et al. BIOORGANIC CHEMISTRY
- Design, synthesis and biological evaluation of Trinary Benzocoumarin-Thiazoles-Azomethines derivatives as Effective and Selective Inhibitors of Alkaline Phosphatase
- (2019) Pervaiz Ali Channar et al. BIOORGANIC CHEMISTRY
- Novel synthesized SLC-0111 thiazole and thiadiazole analogues: Determination of their carbonic anhydrase inhibitory activity and molecular modeling studies
- (2019) Mahmoud F. Abo-Ashour et al. BIOORGANIC CHEMISTRY
- Thiazolidinone/thiazole based hybrids – New class of antitrypanosomal agents
- (2019) Anna Kryshchyshyn et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- Synthesis, in vitro assays, molecular docking, theoretical ADMET prediction, and evaluation of 4-methoxy-phenylthiazole-2-amine derivatives as acetylcholinesterase inhibitors
- (2019) Xiao-Zhong Zhang et al. MEDICINAL CHEMISTRY RESEARCH
- Discovery of 3-(thiophen/thiazole-2-ylthio)pyridine derivatives as multitarget anticancer agents
- (2019) Jiankang Zhang et al. MEDICINAL CHEMISTRY RESEARCH
- Low-dose ritonavir-boosted darunavir once daily versus ritonavir-boosted lopinavir for participants with less than 50 HIV RNA copies per mL (WRHI 052): a randomised, open-label, phase 3, non-inferiority trial
- (2019) Willem D F Venter et al. Lancet HIV
- Design, Synthesis, Antimicrobial Evaluation, and Molecular Modeling Studies of Novel Indolinedione–Coumarin Molecular Hybrids
- (2019) Kavita Bhagat et al. ACS Omega
- Monocarbonyl Curcumin-Based Molecular Hybrids as Potent Antibacterial Agents
- (2019) Atamjit Singh et al. ACS Omega
- Structure-activity relationship study of thiazolyl-hydroxamate derivatives as selective histone deacetylase 6 inhibitors
- (2019) Gibeom Nam et al. BIOORGANIC & MEDICINAL CHEMISTRY
- Discovery of a novel orally active TRPV4 inhibitor: Part 1. Optimization from an HTS hit
- (2019) Yuichi Sami et al. BIOORGANIC & MEDICINAL CHEMISTRY
- Thiazolidinedione and thiazole derivatives potentiate norfloxacin activity against NorA efflux pump over expression in Staphylococcus aureus 1199B strains
- (2019) Pedro Silvino Pereira et al. BIOORGANIC & MEDICINAL CHEMISTRY
- Thiazole orange – Spermine conjugate: A potent human telomerase inhibitor comparable to BRACO-19
- (2019) Siwen Wang et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- Design, synthesis and biological evaluation of bromophenol-thiazolylhydrazone hybrids inhibiting the interaction of translation initiation factors eIF4E/eIF4G as multifunctional agents for cancer treatment
- (2019) Lijun Wang et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- Novel 99mTc-2-arylimidazo[2,1-b]benzothiazole derivatives as SPECT imaging agents for amyloid-β plaques
- (2019) Sajjad Molavipordanjani et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- Discovery and structure-activity relationship of novel diphenylthiazole derivatives as BTK inhibitor with potent activity against B cell lymphoma cell lines
- (2019) Xiaofeng Guo et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- Lipophilic efficient phenylthiazoles with potent undecaprenyl pyrophosphatase inhibitory activity
- (2019) Mohamed M. Elsebaei et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- Discovery of tropinone-thiazole derivatives as potent caspase 3/7 activators, and noncompetitive tyrosinase inhibitors with high antiproliferative activity: Rational design, one-pot tricomponent synthesis, and lipophilicity determination
- (2019) Katarzyna Piechowska et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- Synthesis and biological evaluation of 2,4,5-trisubstituted thiazoles as antituberculosis agents effective against drug-resistant tuberculosis
- (2019) Uttam B. Karale et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- Synthesis and evaluation of new pyrazoline‐thiazole derivatives as monoamine oxidase inhibitors
- (2019) Ulviye Acar Çevik et al. JOURNAL OF HETEROCYCLIC CHEMISTRY
- Bleomycin use in the treatment of Hodgkin lymphoma (HL): toxicity and outcomes in the modern era
- (2019) Kekoa Taparra et al. LEUKEMIA & LYMPHOMA
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- (2019) Shrinivas D. Joshi et al. MEDICINAL CHEMISTRY RESEARCH
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- (2019) Anna Biernasiuk et al. MEDICINAL CHEMISTRY RESEARCH
- Recent Advances in Exploration and Biotechnological Production of Bioactive Compounds in Three Cyanobacterial Genera: Nostoc, Lyngbya, and Microcystis
- (2019) Nguyen Huy Thuan et al. Frontiers in Chemistry
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- (2019) Baijayantimala Swain et al. BIOORGANIC & MEDICINAL CHEMISTRY
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- (2019) Mohd Adil Shareef et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
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- (2019) Florian M. Dato et al. BIOORGANIC CHEMISTRY
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- (2019) Muhammad Tariq Shehzad et al. BIOORGANIC CHEMISTRY
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- (2019) Liang-Liang Wang et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
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- (2019) David Furman et al. NATURE MEDICINE
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- (2018) Cleudiomar Inácio Lino et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
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- (2018) Nulgumnalli Manjunathaiah Raghavendra et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- Synthesis, anticancer activity and mechanism of action of new thiazole derivatives
- (2018) Temístocles Italo de Santana et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- Turning natural products into insecticide candidates: Design and semisynthesis of novel fraxinellone-based N-(1,3-thiazol-2-yl)carboxamides against two crop-threatening insect pests
- (2018) Yong Guo et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
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- (2018) Andrew S. Felts et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
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- (2018) Hervé Geneste et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Development of 2-amino-4-phenylthiazole analogues to disrupt myeloid differentiation factor 88 and prevent inflammatory responses in acute lung injury
- (2018) Lingfeng Chen et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- Novel tyrosyl-DNA phosphodiesterase 1 inhibitors enhance the therapeutic impact of topoteсan on in vivo tumor models
- (2018) A.L. Zakharenko et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- Effectiveness of empiric aztreonam compared to other beta-lactams for treatment of Pseudomonas aeruginosa infections
- (2018) Michael Hogan et al. Infection and Drug Resistance
- Novel stilbene analogues containing thiazole moiety: Synthesis, biological evaluation and docking study
- (2018) Qi Lu et al. JOURNAL OF MOLECULAR STRUCTURE
- Synthesis, chemical and biological investigations of new Ru(III) and Se(IV) complexes containing 1,3,5-triazine chelating derivatives
- (2018) Fatima A.I. Al-Khodir et al. JOURNAL OF MOLECULAR STRUCTURE
- Thiazole fused thiosemicarbazones: Microwave-assisted synthesis, biological evaluation and molecular docking study
- (2018) Neelam P. Prajapati et al. JOURNAL OF MOLECULAR STRUCTURE
- Discovery of first-in-class thiazole-based dual FFA1/PPARδ agonists as potential anti-diabetic agents
- (2018) Zheng Li et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- Design, synthesis and biological evaluation of novel β-pinene-based thiazole derivatives as potential anticancer agents via mitochondrial-mediated apoptosis pathway
- (2018) Yunyun Wang et al. BIOORGANIC CHEMISTRY
- Synthesis of novel N-(1,3-thiazol-2-yl)benzamide clubbed oxadiazole scaffolds: Urease inhibition, Lipinski rule and molecular docking analyses
- (2018) Muhammad Athar Abbasi et al. BIOORGANIC CHEMISTRY
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- (2018) Usman Ghani BIOORGANIC CHEMISTRY
- Synthesis and anti-proliferative activity of some new quinoline based 4,5-dihydropyrazoles and their thiazole hybrids as EGFR inhibitors
- (2018) Riham F. George et al. BIOORGANIC CHEMISTRY
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- (2018) Begüm Nurpelin Sağlık et al. BIOORGANIC CHEMISTRY
- Ravuconazole self-emulsifying delivery system: in vitro activity against Trypanosoma cruzi amastigotes and in vivo toxicity
- (2017) Pollyanna Álvaro Ferreira Spósito et al. International Journal of Nanomedicine
- Antibacterial and β-Lactamase Inhibitory Activity of Monocyclic β-Lactams
- (2017) Lena Decuyper et al. MEDICINAL RESEARCH REVIEWS
- Therapies for acute myeloid leukemia: vosaroxin
- (2017) Hamid Sayar et al. OncoTargets and Therapy
- Synthesis and Carbonic Anhydrase Inhibition of Novel 2-(4-(Aryl)thiazole-2-yl)-3a,4,7,7a-tetrahydro-1H-4,7-methanoisoindole-1,3(2H)-dione Derivatives
- (2016) Umit M. Kocyigit et al. ARCHIV DER PHARMAZIE
- Design, synthesis and antimalarial evaluation of novel thiazole derivatives
- (2016) José María Bueno et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Rational design, synthesis, anti-HIV-1 RT and antimicrobial activity of novel 3-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-1-(piperazin-1-yl)propan-1-one derivatives
- (2016) Subhash Chander et al. BIOORGANIC CHEMISTRY
- Coordination chemistry of thiazoles, isothiazoles and thiadiazoles
- (2016) Luís M.T. Frija et al. COORDINATION CHEMISTRY REVIEWS
- Thiazole: A Review on Chemistry, Synthesis and Therapeutic Importance of its Derivatives
- (2016) Mahesh T. Chhabria et al. CURRENT TOPICS IN MEDICINAL CHEMISTRY
- Recent applications of 1,3-thiazole core structure in the identification of new lead compounds and drug discovery
- (2015) Adile Ayati et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- Faldaprevir for the Treatment of Hepatitis C
- (2015) Tatsuo Kanda et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Simeprevir versus telaprevir with peginterferon and ribavirin in previous null or partial responders with chronic hepatitis C virus genotype 1 infection (ATTAIN): a randomised, double-blind, non-inferiority phase 3 trial
- (2015) K Rajender Reddy et al. LANCET INFECTIOUS DISEASES
- Synthesis, biological evaluation and molecular docking studies of thiazole-based pyrrolidinones and isoindolinediones as anticonvulsant agents
- (2015) Hazem A. Ghabbour et al. MEDICINAL CHEMISTRY RESEARCH
- Antimicrobial resistance: a global multifaceted phenomenon
- (2015) Francesca Prestinaci et al. Pathogens and Global Health
- Ceftaroline in the management of complicated skin and soft tissue infections and community acquired pneumonia
- (2015) Mbiye Mpenge et al. Therapeutics and Clinical Risk Management
- Cyclooxygenase-2 selective non-steroidal anti-inflammatory drugs (etodolac, meloxicam, celecoxib, rofecoxib, etoricoxib, valdecoxib and lumiracoxib) for osteoarthritis and rheumatoid arthritis: a systematic review and economic evaluation
- (2014) Y Chen et al. HEALTH TECHNOLOGY ASSESSMENT
- Improved Total Synthesis and Biological Evaluation of Potent Apratoxin S4 Based Anticancer Agents with Differential Stability and Further Enhanced Activity
- (2014) Qi-Yin Chen et al. JOURNAL OF MEDICINAL CHEMISTRY
- A model study on the photochemical isomerization of isothiazoles and thiazoles
- (2014) Ming-Der Su PHYSICAL CHEMISTRY CHEMICAL PHYSICS
- Nicotinamide mononucleotide adenylyltransferase2 overexpression enhances colorectal cancer cell-kill by Tiazofurin
- (2013) P Kusumanchi et al. CANCER GENE THERAPY
- Cobicistat: A Review of Its Use as a Pharmacokinetic Enhancer of Atazanavir and Darunavir in Patients with HIV-1 Infection
- (2013) Emma D. Deeks DRUGS
- Synthesis and biological evaluation of some novel thiazole compounds as potential anti-inflammatory agents
- (2013) M.H.M. Helal et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- Pramipexole in patients with early Parkinson's disease (PROUD): a randomised delayed-start trial
- (2013) Anthony HV Schapira et al. LANCET NEUROLOGY
- Synthesis, anti-inflammatory evaluation, and docking studies of some new thiazole derivatives
- (2013) Pran Kishore Deb et al. MEDICINAL CHEMISTRY RESEARCH
- A review on various heterocyclic moieties and their antitubercular activity
- (2011) S. Sharma et al. BIOMEDICINE & PHARMACOTHERAPY
- Is cefepime safe for clinical use? A Bayesian viewpoint
- (2011) A. C. Kalil JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
- Terminal Alkene Formation by the Thioesterase of Curacin A Biosynthesis
- (2011) Jennifer J. Gehret et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Thiazoles: having diverse biological activities
- (2011) Shiv Jee Kashyap et al. MEDICINAL CHEMISTRY RESEARCH
- Larval papulonodular dermatitis treated with topical tiabendazole
- (2010) Vincent Lönngren et al. LANCET INFECTIOUS DISEASES
- SYNTHESIS AND BIOLOGICAL EVALUATION OF SOME SUBSTITUTED AMINO THIAZOLE DERIVATIVES
- (2010) A. K PRAJAPATI et al. JOURNAL OF THE CHILEAN CHEMICAL SOCIETY
- The H2 Receptor Antagonist Nizatidine is a P-Glycoprotein Substrate: Characterization of its Intestinal Epithelial Cell Efflux Transport
- (2009) Arik Dahan et al. AAPS Journal
- Participation of mitochondrial respiratory complex III in neutrophil activation and lung injury
- (2009) Jaroslaw W. Zmijewski et al. AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY
- Discovery of 4-Substituted Methoxybenzoyl-aryl-thiazole as Novel Anticancer Agents: Synthesis, Biological Evaluation, and Structure−Activity Relationships
- (2009) Yan Lu et al. JOURNAL OF MEDICINAL CHEMISTRY
- Famotidine for the prevention of peptic ulcers and oesophagitis in patients taking low-dose aspirin (FAMOUS): a phase III, randomised, double-blind, placebo-controlled trial
- (2009) Ali S Taha et al. LANCET
- Synthesis, Antibacterial Activity of 2,4-Disubstituted Oxazoles and Thiazoles as Bioisosteres
- (2009) Mohamed Kaspady et al. Letters in Drug Design & Discovery
- Modes of Action of the New Arylguanidine Abafungin beyond Interference with Ergosterol Biosynthesis and in vitro Activity against Medically Important Fungi
- (2008) C. Borelli et al. CHEMOTHERAPY
- Imidazo[2,1-b]thiazole System: A Scaffold Endowing Dihydropyridines with Selective Cardiodepressant Activity
- (2008) Roberta Budriesi et al. JOURNAL OF MEDICINAL CHEMISTRY
- The Neglected Tropical Diseases of Latin America and the Caribbean: A Review of Disease Burden and Distribution and a Roadmap for Control and Elimination
- (2008) Peter J. Hotez et al. PLoS Neglected Tropical Diseases
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