Ultrasound-mediated delivery of novel tau-specific monoclonal antibody enhances brain uptake but not therapeutic efficacy
出版年份 2022 全文链接
标题
Ultrasound-mediated delivery of novel tau-specific monoclonal antibody enhances brain uptake but not therapeutic efficacy
作者
关键词
-
出版物
JOURNAL OF CONTROLLED RELEASE
Volume 349, Issue -, Pages 634-648
出版商
Elsevier BV
发表日期
2022-07-28
DOI
10.1016/j.jconrel.2022.07.026
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- Transcriptional signature in microglia isolated from an Alzheimer's disease mouse model treated with scanning ultrasound
- (2022) Gerhard Leinenga et al. Bioengineering & Translational Medicine
- Monoclonal Antibodies as Neurological Therapeutics
- (2021) Panagiotis Gklinos et al. Pharmaceuticals
- Tau antibody isotype induces differential effects following passive immunisation of tau transgenic mice
- (2021) Rinie Bajracharya et al. Acta Neuropathologica Communications
- Tau immunotherapy is associated with glial responses in FTLD-tau
- (2021) Boram Kim et al. ACTA NEUROPATHOLOGICA
- A comparative study of the effects of Aducanumab and scanning ultrasound on amyloid plaques and behavior in the APP23 mouse model of Alzheimer disease
- (2021) Gerhard Leinenga et al. Alzheimers Research & Therapy
- Focused ultrasound with anti-pGlu3 Aβ enhances efficacy in Alzheimer's disease-like mice via recruitment of peripheral immune cells
- (2021) Tao Sun et al. JOURNAL OF CONTROLLED RELEASE
- Neurovascular coupling and oxygenation are decreased in hippocampus compared to neocortex because of microvascular differences
- (2021) K. Shaw et al. Nature Communications
- Structure-based classification of tauopathies
- (2021) Yang Shi et al. NATURE
- Current and Emerging Strategies for Enhancing Antibody Delivery to the Brain
- (2021) Rinie Bajracharya et al. Pharmaceutics
- Humanized tau antibodies promote tau uptake by human microglia without any increase of inflammation
- (2020) Monika Zilkova et al. Acta Neuropathologica Communications
- Applications of focused ultrasound in the brain: from thermoablation to drug delivery
- (2020) Ying Meng et al. Nature Reviews Neurology
- Dynamics of Internalization and Intracellular Interaction of Tau Antibodies and Human Pathological Tau Protein in a Human Neuron-Like Model
- (2020) Dov B. Shamir et al. Frontiers in Neurology
- Tau antibody chimerization alters its charge and binding, thereby reducing its cellular uptake and efficacy
- (2019) Erin E. Congdon et al. EBioMedicine
- Prevention of tau seeding and propagation by immunotherapy with a central tau epitope antibody
- (2019) Marie Albert et al. BRAIN
- Ultrasound-mediated blood-brain barrier opening enhances delivery of therapeutically relevant formats of a tau-specific antibody
- (2019) Phillip W. Janowicz et al. Scientific Reports
- Therapeutic antibody targeting microtubule-binding domain prevents neuronal internalization of extracellular tau via masking neuron surface proteoglycans
- (2019) Petronela Weisová et al. Acta Neuropathologica Communications
- The blood-brain barrier: Physiology and strategies for drug delivery
- (2019) Rucha Pandit et al. ADVANCED DRUG DELIVERY REVIEWS
- A Novel Antibody Targeting Tau Phosphorylated at Serine 235 Detects Neurofibrillary Tangles
- (2018) David Brici et al. JOURNAL OF ALZHEIMERS DISEASE
- Tau passive immunization blocks seeding and spread of Alzheimer hyperphosphorylated Tau-induced pathology in 3 × Tg-AD mice
- (2018) Chun-ling Dai et al. Alzheimers Research & Therapy
- Safety and Efficacy of Scanning Ultrasound Treatment of Aged APP23 Mice
- (2018) Gerhard Leinenga et al. Frontiers in Neuroscience
- A common antigenic motif recognized by naturally occurring human VH5–51/VL4–1 anti-tau antibodies with distinct functionalities
- (2018) Adrian Apetri et al. Acta Neuropathologica Communications
- Dynamic assessment of tau immunotherapies in the brains of live animals by two-photon imaging
- (2018) Qian Wu et al. EBioMedicine
- Molecular Pathogenesis of the Tauopathies
- (2018) Jürgen Götz et al. Annual Review of Pathology-Mechanisms of Disease
- Humanized monoclonal antibody armanezumab specific to N-terminus of pathological tau: characterization and therapeutic potency
- (2017) Michael G. Agadjanyan et al. Molecular Neurodegeneration
- Noninvasive and targeted delivery of therapeutics to the brain using focused ultrasound
- (2017) Charissa Poon et al. NEUROPHARMACOLOGY
- Anti-tau antibody administration increases plasma tau in transgenic mice and patients with tauopathy
- (2017) Kiran Yanamandra et al. Science Translational Medicine
- MultiTEP platform-based DNA epitope vaccine targeting N-terminus of tau induces strong immune responses and reduces tau pathology in THY-Tau22 mice
- (2017) Hayk Davtyan et al. VACCINE
- Tau passive immunization inhibits not only tau but also Aβ pathology
- (2017) Chun-ling Dai et al. Alzheimers Research & Therapy
- Co-immunoprecipitation with Tau Isoform-specific Antibodies Reveals Distinct Protein Interactions and Highlights a Putative Role for 2N Tau in Disease
- (2016) Chang Liu et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Pathological conformations involving the amino terminus of tau occur early in Alzheimer's disease and are differentially detected by monoclonal antibodies
- (2016) Benjamin Combs et al. NEUROBIOLOGY OF DISEASE
- Specific Targeting of Tau Oligomers in Htau Mice Prevents Cognitive Impairment and Tau Toxicity Following Injection with Brain-Derived Tau Oligomeric Seeds
- (2016) Diana L. Castillo-Carranza et al. JOURNAL OF ALZHEIMERS DISEASE
- Distinct Therapeutic Mechanisms of Tau Antibodies
- (2015) Kristen E. Funk et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Antibody against early driver of neurodegeneration cis P-tau blocks brain injury and tauopathy
- (2015) Asami Kondo et al. NATURE
- Scanning ultrasound removes amyloid-β and restores memory in an Alzheimer’s disease mouse model
- (2015) Gerhard Leinenga et al. Science Translational Medicine
- Microglial internalization and degradation of pathological tau is enhanced by an anti-tau monoclonal antibody
- (2015) Wenjie Luo et al. Scientific Reports
- Passive Immunization with Phospho-Tau Antibodies Reduces Tau Pathology and Functional Deficits in Two Distinct Mouse Tauopathy Models
- (2015) Sethu Sankaranarayanan et al. PLoS One
- Neuronal uptake of tau/pS422 antibody and reduced progression of tau pathology in a mouse model of Alzheimer‘s disease
- (2014) Ludovic Collin et al. BRAIN
- Use of labeled tomato lectin for imaging vasculature structures
- (2014) Richard T. Robertson et al. HISTOCHEMISTRY AND CELL BIOLOGY
- The Size of Blood–Brain Barrier Opening Induced by Focused Ultrasound is Dictated by the Acoustic Pressure
- (2014) Hong Chen et al. JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
- Passive immunization targeting the N-terminal projection domain of tau decreases tau pathology and improves cognition in a transgenic mouse model of Alzheimer disease and tauopathies
- (2014) Chun-ling Dai et al. JOURNAL OF NEURAL TRANSMISSION
- Antibody-Derived In Vivo Imaging of Tau Pathology
- (2014) S. Krishnaswamy et al. JOURNAL OF NEUROSCIENCE
- Passive Immunization with Tau Oligomer Monoclonal Antibody Reverses Tauopathy Phenotypes without Affecting Hyperphosphorylated Neurofibrillary Tangles
- (2014) D. L. Castillo-Carranza et al. JOURNAL OF NEUROSCIENCE
- p-Tau immunotherapy reduces soluble and insoluble tau in aged 3xTg-AD mice
- (2014) Ken C. Walls et al. NEUROSCIENCE LETTERS
- Open questions for Alzheimer’s disease immunotherapy
- (2014) Todd E Golde Alzheimers Research & Therapy
- Efflux of monoclonal antibodies from rat brain by neonatal Fc receptor, FcRn
- (2013) Philip R. Cooper et al. BRAIN RESEARCH
- Antibody Uptake into Neurons Occurs Primarily via Clathrin-dependent Fcγ Receptor Endocytosis and Is a Prerequisite for Acute Tau Protein Clearance
- (2013) Erin E. Congdon et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Two Novel Tau Antibodies Targeting the 396/404 Region Are Primarily Taken Up by Neurons and Reduce Tau Protein Pathology
- (2013) Jiaping Gu et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Anti-Tau Antibodies that Block Tau Aggregate Seeding In Vitro Markedly Decrease Pathology and Improve Cognition In Vivo
- (2013) Kiran Yanamandra et al. NEURON
- Tau Passive Immunotherapy in Mutant P301L Mice: Antibody Affinity versus Specificity
- (2013) Cristina d’Abramo et al. PLoS One
- Targeting Phospho-Ser422 by Active Tau Immunotherapy in the THYTau22 Mouse Model: A Suitable Therapeutic Approach
- (2012) Nadege Zommer et al. Current Alzheimer Research
- Passive Immunization with Anti-Tau Antibodies in Two Transgenic Models
- (2011) Xiyun Chai et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- The Role of Caveolin-1 in Blood–Brain Barrier Disruption Induced by Focused Ultrasound Combined with Microbubbles
- (2011) Jinmu Deng et al. JOURNAL OF MOLECULAR NEUROSCIENCE
- Passive immunization targeting pathological phospho-tau protein in a mouse model reduces functional decline and clears tau aggregates from the brain
- (2011) Allal Boutajangout et al. JOURNAL OF NEUROCHEMISTRY
- Noninvasive and localized neuronal delivery using short ultrasonic pulses and microbubbles
- (2011) J. J. Choi et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Ultrasound Insertion Loss of Rat Parietal Bone Appears to Be Proportional to Animal Mass at Submegahertz Frequencies
- (2011) Meaghan A. O’Reilly et al. ULTRASOUND IN MEDICINE AND BIOLOGY
- Mechanistic Studies of Antibody-Mediated Clearance of Tau Aggregates Using an ex vivo Brain Slice Model
- (2011) Pavan K. Krishnamurthy et al. Frontiers in Psychiatry
- Antibodies Targeted to the Brain with Image-Guided Focused Ultrasound Reduces Amyloid-β Plaque Load in the TgCRND8 Mouse Model of Alzheimer's Disease
- (2010) Jessica F. Jordão et al. PLoS One
- Sodium selenate mitigates tau pathology, neurodegeneration, and functional deficits in Alzheimer's disease models
- (2010) J. van Eersel et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Tau phosphorylation: the therapeutic challenge for neurodegenerative disease
- (2009) Diane P. Hanger et al. TRENDS IN MOLECULAR MEDICINE
- Parkinsonism and impaired axonal transport in a mouse model of frontotemporal dementia
- (2008) L. M. Ittner et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Effect of Focused Ultrasound Applied With an Ultrasound Contrast Agent on the Tight Junctional Integrity of the Brain Microvascular Endothelium
- (2008) Nickolai Sheikov et al. ULTRASOUND IN MEDICINE AND BIOLOGY
Find Funding. Review Successful Grants.
Explore over 25,000 new funding opportunities and over 6,000,000 successful grants.
ExploreFind the ideal target journal for your manuscript
Explore over 38,000 international journals covering a vast array of academic fields.
Search