Passive immunization targeting the N-terminal projection domain of tau decreases tau pathology and improves cognition in a transgenic mouse model of Alzheimer disease and tauopathies
出版年份 2014 全文链接
标题
Passive immunization targeting the N-terminal projection domain of tau decreases tau pathology and improves cognition in a transgenic mouse model of Alzheimer disease and tauopathies
作者
关键词
Aβ, Alzheimer’s disease, Immunotherapy, Tau, Tauopathy
出版物
JOURNAL OF NEURAL TRANSMISSION
Volume 122, Issue 4, Pages 607-617
出版商
Springer Nature
发表日期
2014-09-19
DOI
10.1007/s00702-014-1315-y
参考文献
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注意:仅列出部分参考文献,下载原文获取全部文献信息。- Passive Immunization with Tau Oligomer Monoclonal Antibody Reverses Tauopathy Phenotypes without Affecting Hyperphosphorylated Neurofibrillary Tangles
- (2014) D. L. Castillo-Carranza et al. JOURNAL OF NEUROSCIENCE
- Distinct Tau Prion Strains Propagate in Cells and Mice and Define Different Tauopathies
- (2014) David W. Sanders et al. NEURON
- Two Phase 3 Trials of Bapineuzumab in Mild-to-Moderate Alzheimer's Disease
- (2014) Stephen Salloway et al. NEW ENGLAND JOURNAL OF MEDICINE
- Phase 3 Trials of Solanezumab for Mild-to-Moderate Alzheimer's Disease
- (2014) Rachelle S. Doody et al. NEW ENGLAND JOURNAL OF MEDICINE
- Active immunotherapy options for Alzheimer’s disease
- (2014) Bengt Winblad et al. Alzheimers Research & Therapy
- Intraneuronal tau aggregation precedes diffuse plaque deposition, but amyloid-β changes occur before increases of tau in cerebrospinal fluid
- (2013) Heiko Braak et al. ACTA NEUROPATHOLOGICA
- 2013 Alzheimer's disease facts and figures
- (2013) Alzheimers & Dementia
- Two Novel Tau Antibodies Targeting the 396/404 Region Are Primarily Taken Up by Neurons and Reduce Tau Protein Pathology
- (2013) Jiaping Gu et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Tau immunotherapy targets transcellular propagation
- (2013) Monica Hoyos Flight NATURE REVIEWS DRUG DISCOVERY
- Anti-Tau Antibodies that Block Tau Aggregate Seeding In Vitro Markedly Decrease Pathology and Improve Cognition In Vivo
- (2013) Kiran Yanamandra et al. NEURON
- Tau Passive Immunotherapy in Mutant P301L Mice: Antibody Affinity versus Specificity
- (2013) Cristina d’Abramo et al. PLoS One
- Brain homogenates from human tauopathies induce tau inclusions in mouse brain
- (2013) Florence Clavaguera et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Targeting Phospho-Ser422 by Active Tau Immunotherapy in the THYTau22 Mouse Model: A Suitable Therapeutic Approach
- (2012) Nadege Zommer et al. Current Alzheimer Research
- Passive Immunization with Anti-Tau Antibodies in Two Transgenic Models
- (2011) Xiyun Chai et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Passive immunization targeting pathological phospho-tau protein in a mouse model reduces functional decline and clears tau aggregates from the brain
- (2011) Allal Boutajangout et al. JOURNAL OF NEUROCHEMISTRY
- Implicating Calpain in Tau-Mediated Toxicity In Vivo
- (2011) James B. Reinecke et al. PLoS One
- Tau-Targeted Immunization Impedes Progression of Neurofibrillary Histopathology in Aged P301L Tau Transgenic Mice
- (2011) Mian Bi et al. PLoS One
- Efficacy and safety of immunization with phosphorylated tau against neurofibrillary tangles in mice
- (2010) Moran Boimel et al. EXPERIMENTAL NEUROLOGY
- Immunotherapy Targeting Pathological Tau Prevents Cognitive Decline in a New Tangle Mouse Model
- (2010) A. Boutajangout et al. JOURNAL OF NEUROSCIENCE
- Cleavage of Tau by calpain in Alzheimer's disease: the quest for the toxic 17 kD fragment
- (2010) Sarika Garg et al. NEUROBIOLOGY OF AGING
- Propagation of Tau Misfolding from the Outside to the Inside of a Cell
- (2009) Bess Frost et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Transmission and spreading of tauopathy in transgenic mouse brain
- (2009) Florence Clavaguera et al. NATURE CELL BIOLOGY
- Long-term effects of Aβ42 immunisation in Alzheimer's disease: follow-up of a randomised, placebo-controlled phase I trial
- (2008) Clive Holmes et al. LANCET
- Identification of a caspase-derived N-terminal tau fragment in cellular and animal Alzheimer's disease models
- (2008) V. Corsetti et al. MOLECULAR AND CELLULAR NEUROSCIENCE
- Knock-out and transgenic mouse models of tauopathies
- (2007) Franziska Denk et al. NEUROBIOLOGY OF AGING
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