Article
Food Science & Technology
Jaskiran Kaur, Monica Gulati, Sachin Kumar Singh, Gowthamarajan Kuppusamy, Bhupinder Kapoor, Vijay Mishra, Saurabh Gupta, Mohammed F. Arshad, Omji Porwal, Niraj Kumar Jha, M. V. N. L. Chaitanya, Dinesh Kumar Chellappan, Gaurav Gupta, Piyush Kumar Gupta, Kamal Dua, Rubiya Khursheed, Ankit Awasthi, Leander Corrie
Summary: Vanillic acid exhibits diverse therapeutic effects against cancer, diabetes, obesity, neurodegenerative, cardiovascular, and hepatic diseases. Its derivatives also show potential in treating autoimmune diseases and fungal/bacterial infections. However, its limited oral bioavailability due to rapid metabolism hampers its delivery via conventional formulations. Efforts are required to develop nanoformulations of vanillic acid to overcome these challenges.
TRENDS IN FOOD SCIENCE & TECHNOLOGY
(2022)
Article
Endocrinology & Metabolism
Kai On Chu, Kwok Ping Chan, Yolanda Wong Ying Yip, Wai Kit Chu, Chi Chiu Wang, Chi Pui Pang
Summary: The study showed that GTE indirectly induced systemic phosphorylcholine lipids to suppress inflammatory responses, hepatic damage, and respiratory mitochondrial stress in EIU rats induced by LPS. Phospholipids may be a therapeutic target of GTE for anterior chamber inflammation.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Review
Immunology
Lydia J. Bradley, Amy Ward, Madeleine C. Y. Hsue, Jian Liu, David A. Copland, Andrew D. Dick, Lindsay B. Nicholson
Summary: Ocular inflammation imposes significant burden on patients and healthcare systems, with classification of uveitis severity remaining a challenge. Experimental autoimmune uveitis models can replicate clinical features and provide insights into tissue changes, offering potential for new approaches to monitoring tissue health with modern image processing techniques.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Nanoscience & Nanotechnology
Eman Alaaeldin, Heba A. Abou-Taleb, Soad A. Mohamad, Mahmoud Elrehany, Shereen S. Gaber, Heba F. Mansour
Summary: The study aimed to develop a site-specific delivery system for Celecoxib using spanlastic nanovesicles or niosomes, to improve therapeutic outcomes while avoiding systemic administration of large doses. The developed spanlastic nano-vesicle formulation showed higher transdermal flux and permeability coefficient compared to other investigated formulations, effectively reducing inflammation markers in a rat model of arthritis.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2021)
Article
Pharmacology & Pharmacy
Meghna Bains, Jaspreet Kaur, Ansab Akhtar, Anurag Kuhad, Sangeeta Pilkhwal Sah
Summary: The study found that ellagic acid (EA) and vanillic acid (VA) have neuroprotective effects in the Huntington disease (HD) model. These substances can improve motor and cognitive functions, reduce oxidative stress and neuroinflammation, and improve mitochondrial function.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2022)
Review
Gastroenterology & Hepatology
Janaki Shah, Aaditya Shah, Lynn Hassman, Alexandra Gutierrez
Summary: IBD is not only associated with intestinal inflammation, but can also manifest in ocular symptoms such as keratopathy. Investigating and treating ocular symptoms in IBD patients is crucial in preventing ocular complications.
INFLAMMATORY BOWEL DISEASES
(2021)
Review
Ophthalmology
Sean Ming Sheng Ng, Rebecca Low, Clara Pak, SerSei Lai, Bernett Lee, Peter McCluskey, Richard Symes, Alessandro Invernizzi, Edmund Tsui, Ranju Kharel Sitaula, Muna Kharel, Anadi Khatri, Anna Nur Utami, Rina La Distia Nora, Ikhwanuliman Putera, Alok Sen, Manisha Agarwal, Padmamalini H. Mahendradas, Jyotirmay Biswas, Carlos Pavesio, Luca Cimino, Lucia Sobrin, John Kempen, Vishali Gupta, Rupesh Agrawal
Summary: In the current literature, there is a lack of clinical registry cohorts related to ocular inflammation, especially those involving multinational data. Existing registries are limited in scope and may not provide robust data for prognostication or epidemiological conclusions in the field of uveitis. To address this, the Ocular Autoimmune Systemic Inflammatory Infectious Study (OASIS) Clinical Registry has been developed. OASIS collects comprehensive clinical data from patients with ocular inflammatory conditions worldwide, aiming to create a well-organized dataset for analysis and various applications such as epidemiological analysis and treatment guidelines development.
Article
Medicine, General & Internal
Alix Cuny, Lucas Guillo, Cedric Baumann, Patrick Netter, Silvio Danese, Benedicte Caron, Laurent Peyrin-Biroulet, Karine Angioi
Summary: This study assessed the prevalence of ocular manifestations in patients with inflammatory bowel disease (IBD) and found that dry eye and uveitis were the most common ocular diagnoses. There were no statistically significant differences in disease characteristics of IBD associated with ocular manifestations.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Chemistry, Multidisciplinary
Xinyu Liu, Zhongxing Chen, Jieyi Bai, Xin Li, Xin Chen, Zheng Li, Hongxian Pan, Siheng Li, Qingyi Gao, Nan Zhao, Aodong Chen, Huilin Xu, Yinuo Wen, Lan Du, Mei Yang, Xingtao Zhou, Jinhai Huang
Summary: In this study, multifunctional hydrogel eye drops were developed for the synergistic treatment of uveitis. These eye drops offer improved ocular bioavailability and unexpected anti-inflammatory efficacy. By mitigating the ophthalmic inflammatory reaction and suppressing inflammatory cytokines, the eye drops demonstrated superior efficacy in treating endotoxin-induced uveitis.
Article
Pharmacology & Pharmacy
Ifedolapo M. Oke, Limpho M. Ramorobi, Samson S. Mashele, Susanna L. Bonnet, Tshepiso J. Makhafola, Kenneth C. Eze, Anwar E. M. Noreljaleel, Chika Chukwuma
Summary: The study synthesized a new Zn-vanillic acid complex with enhanced antioxidative and antihyperglycaemic properties compared to vanillic acid alone. The complex demonstrated significant bioactivity in cell-based and ex vivo models.
JOURNAL OF PHARMACY AND PHARMACOLOGY
(2021)
Article
Biotechnology & Applied Microbiology
Ping Fei, Huazhang Feng, Jing Li, Miaomiao Liu, Jia Luo, Hongfei Ye, Peiquan Zhao
Summary: This retrospective study reports potential vaccine-induced inflammatory ocular adverse events following inactivated COVID-19 vaccination. The study included 5 patients with uveitis and other ocular complications, such as anterior uveitis, herpetic keratitis and iridocyclitis, and posterior uveitis. Treatment with steroids resulted in good visual outcomes for all patients.
HUMAN VACCINES & IMMUNOTHERAPEUTICS
(2022)
Review
Biotechnology & Applied Microbiology
Jing Wei, Jinyu Mu, Yong Tang, Dalian Qin, Junguo Duan, Anguo Wu
Summary: This review investigates the potential of advanced nanomaterials in revolutionizing ocular anti-inflammatory drug interventions. It explores different categories of nanomaterials and their unique properties for drug delivery, while also discussing the challenges and advantages of these systems. The review emphasizes the importance of interdisciplinary collaborations in advancing this field.
JOURNAL OF NANOBIOTECHNOLOGY
(2023)
Article
Biology
Samantha C. Pendleton, Luke T. Slater, Andreas Karwath, Rose M. Gilbert, Nicola Davis, Konrad Pesudovs, Xiaoxuan Liu, Alastair K. Denniston, Georgios Gkoutos, Tasanee Braithwaite
Summary: This study developed an ontology for ocular immune-mediated inflammatory diseases (OcIMIDo) to extract and analyze data from online patient support forum. The ontology includes 661 classes, 1661 relationships and axioms, 2851 annotations, and 187 patient-preferred synonyms. The language sentiment analysis of forum posts showed generally positive sentiment, with first posts having higher odds of expressing negative sentiment compared to replies.
COMPUTERS IN BIOLOGY AND MEDICINE
(2021)
Review
Ophthalmology
Joao M. Furtado, Milena Simoes, Daniel Vasconcelos-Santos, Genevieve F. Oliver, Mudit Tyagi, Heloisa Nascimento, David L. Gordon, Justine R. Smith
Summary: Multiple studies suggest the re-emergence of syphilis worldwide. Ocular syphilis, with various presentations mostly categorized as subtypes of uveitis, has become a common cause of ocular inflammation in the past 20 years. The increasing incidence, diagnostic complexity, and recently characterized manifestations make ocular syphilis relevant from public health, clinical, and scientific perspectives.
SURVEY OF OPHTHALMOLOGY
(2022)
Review
Pharmacology & Pharmacy
Sean Teabagy, Emma Wood, Evan Bilsbury, Sean Doherty, Priya Janardhana, Darren J. Lee
Summary: Ocular immune privilege refers to the ability of foreign tissue grafts placed in the eye to survive indefinitely. This privilege is maintained by various mechanisms, including the blood-ocular barrier, lack of lymphatics in the eye, production of immune-suppressing molecules in the ocular microenvironment, and induction of systemic regulatory immunity. Failure of ocular immune privilege can lead to uveitis, which is a group of inflammatory disorders that can cause vision loss. Current treatments for uveitis involve immunosuppressive and anti-inflammatory medications. Research on ocular immune privilege mechanisms and the development of novel uveitis treatments is ongoing.
ADVANCED DRUG DELIVERY REVIEWS
(2023)
Review
Pharmacology & Pharmacy
Shaimaa S. Ibrahim, Rihab Osman, Gehanne A. S. Awad, Nahed D. Mortada, Ahmed-Shawky Geneidy
Article
Pharmacology & Pharmacy
Shaimaa S. Ibrahim, Rihab Osman, Gehanne A. S. Awad, Nahed D. Mortada, Ahmed-Shawky Geneidi
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2017)
Article
Biophysics
Shaimaa S. Ibrahim, Gehanne A. S. Awad, Ahmed Geneidi, Nahed D. Mortada
COLLOIDS AND SURFACES B-BIOINTERFACES
(2009)
Review
Chemistry, Medicinal
Shaimaa S. Ibrahim
JOURNAL OF PHARMACEUTICAL SCIENCES
(2019)
Article
Neurosciences
Shaimaa S. Ibrahim, Omar G. Abo Elseoud, Mohamed H. Mohamedy, Mohamed M. Amer, Youssef Y. Mohamed, Shehab A. Elmansy, Mohamed M. Kadry, Ahmed A. Attia, Ragy A. Fanous, Mahmoud S. Kamel, Youssef A. Solyman, Mazen S. Shehata, Mina Y. George
Summary: The study successfully formulated chrysin as transfersomal lipid vesicles and chitosan composite vesicles, which showed nanometric size range, high drug entrapment efficiency, and controlled release over a 72h period. Intranasal administration of optimized chrysin formulations improved doxorubicin-induced memory impairment in rats by inhibiting acetylcholinesterase, oxidative stress, and inflammatory pathways. Chrysin formulations demonstrated enhanced therapeutic potential against chemotherapy-induced cognitive impairment.
Article
Chemistry, Medicinal
Shaimaa S. Ibrahim
Summary: The aim of this study was to develop nanostructured lipid carriers (NLC) to improve the therapeutic outcome of prednisolone acetate (PA) by altering its pharmacokinetic profile and/or allowing preferential targeting to inflammatory tissues. Optimized PA-loaded NLCs showed superior anti-inflammatory activity and good stability.
JOURNAL OF PHARMACEUTICAL SCIENCES
(2023)
Article
Chemistry, Multidisciplinary
A. H. Lotfallah, J. J. Andreu, R. M. Hathout, D. H. Kassem, S. S. Ibrahim, B. Altava, E. Garcia-Verdugo, S. V. Luis
Summary: Nanovesicles based on tripodal amphiphilic pseudopeptides were developed as carriers for p-coumaric acid (p-CA) delivery. The nanovesicles obtained through thin film hydration and ethanol injection methods showed positive Z-potential values. The ethanol injection method resulted in smaller particle sizes and better polydispersity index. In vitro release experiments demonstrated interesting results under different external stimuli. The loaded pseudopeptide nanovesicles exhibited enhanced cytotoxicity against brain cancer cells, and the observed biological activity was associated with an enhanced permeability and retention effect.
MATERIALS TODAY CHEMISTRY
(2023)
Article
Pharmacology & Pharmacy
Shaimaa S. Ibrahim, Rihab Osman, Nahed D. Mortada, Ahmed-Shawky Geneidy, Gehanne A. S. Awad
Article
Pharmacology & Pharmacy
Greta Camilla Magnano, Marika Quadri, Elisabetta Palazzo, Roberta Lotti, Francesca Loschi, Stefano Dall'Acqua, Michela Abrami, Francesca Larese Filon, Alessandra Marconi, Dritan Hasa
Summary: This study aimed to investigate the loading of sildenafil citrate in three commercial transdermal vehicles using 3D full-thickness skin equivalent and compare the results with permeability experiments using porcine skin. The results showed that the results obtained using the 3D skin equivalent were comparable to those obtained using porcine skin, suggesting that the 3D skin model can be a valid alternative for ex-vivo skin absorption experiments.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2024)
Article
Pharmacology & Pharmacy
James W. Mckeage, Andrew Z. H. Tan, Andrew J. Taberner
Summary: Needle-free jet injection is a promising alternative drug delivery technique that offers rapid, non-invasive, and large-volume injections. The study presents a prototype multi-orifice nozzle and a computational fluid dynamic model to demonstrate the feasibility and effectiveness of this technology.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2024)
