Nose-to-brain delivery of chrysin transfersomal and composite vesicles in doxorubicin-induced cognitive impairment in rats: Insights on formulation, oxidative stress and TLR4/NF-kB/NLRP3 pathways

Evaluation of the Hemocompatibility and Anticancer Potential of Poly(ε-Caprolactone) and Poly(3-Hydroxybutyrate) Microcarriers with Encapsulated Chrysin

(2021) Eleftherios Halevas et al.   Pharmaceutics

Emerging cellular and molecular mechanisms underlying anticancer indications of chrysin

(2021) Marjan Talebi et al.   Cancer Cell International

Polydatin ameliorates chemotherapy-induced cognitive impairment (chemobrain) by inhibiting oxidative stress, inflammatory response, and apoptosis in rats

(2020) Yifan Tong et al.   BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY

Inflammasome and Cognitive Symptoms in Human Diseases: Biological Evidence from Experimental Research

(2020) So Yeong Cheon et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Chrysin attenuates traumatic brain injury-induced recognition memory decline, and anxiety/depression-like behaviors in rats: Insights into underlying mechanisms

(2020) Masome Rashno et al.   PSYCHOPHARMACOLOGY

Cellular mechanisms and treatments for chemobrain: insight from aging and neurodegenerative diseases

(2020) Lien D Nguyen et al.   EMBO Molecular Medicine

Chrysin Protects against Memory and Hippocampal Neurogenesis Depletion in D-Galactose-Induced Aging in Rats

(2020) Ram Prajit et al.   Nutrients

Effect of Metformin on Doxorubicin-Induced Memory Dysfunction

(2020) Ibrahim Alharbi et al.   Brain Sciences

Involvement of ROS/NLRP3 Inflammasome Signaling Pathway in Doxorubicin-Induced Cardiotoxicity

(2020) Shanshan Wei et al.   Cardiovascular Toxicology

Chrysin Attenuates the NLRP3 Inflammasome Cascade to Reduce Synovitis and Pain in KOA Rats

(2020) Taiyang Liao et al.   Drug Design Development and Therapy

QbD-steered development of Biotin-Conjugated Nanostructured Lipid Carriers for Oral Delivery of Chrysin: Role of Surface Modification for Improving Biopharmaceutical Performance

(2020) Teenu Sharma et al.   COLLOIDS AND SURFACES B-BIOINTERFACES

Neuroprotective effect of chrysin on isoniazid-induced neurotoxicity via suppression of oxidative stress, inflammation and apoptosis in rats

(2020) Hamit Çelik et al.   NEUROTOXICOLOGY

Broad-Spectrum Preclinical Antitumor Activity of Chrysin: Current Trends and Future Perspectives

(2020) Ebrahim Rahmani Moghadam et al.   Biomolecules

D-Carvone inhibit cerebral ischemia/reperfusion induced inflammatory response TLR4/NLRP3 signaling pathway

(2020) Mengyuan Dai et al.   BIOMEDICINE & PHARMACOTHERAPY

Ginsenoside Rg1 Prevents Chemotherapy-Induced Cognitive Impairment: Associations with Microglia-Mediated Cytokines, Neuroinflammation, and Neuroplasticity

(2019) Dong-Dong Shi et al.   MOLECULAR NEUROBIOLOGY

Uptake in the Central Nervous System of Geraniol Oil Encapsulated in Chitosan Oleate Following Nasal and Oral Administration

(2019) Maria Bonferoni et al.   Pharmaceutics

Plausible biochemical mechanisms of chemotherapy-induced cognitive impairment (“chemobrain”), a condition that significantly impairs the quality of life of many cancer survivors

(2019) Xiaojia Ren et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Inflammasomes in neuroinflammatory and neurodegenerative diseases

(2019) Sofie Voet et al.   EMBO Molecular Medicine

A novel small molecular NLRP3 inflammasome inhibitor alleviates neuroinflammatory response following traumatic brain injury

(2019) Ram Kuwar et al.   Journal of Neuroinflammation

Chitosan-Based Nanocarriers for Nose to Brain Delivery

(2019) Blessing Atim Aderibigbe et al.   Applied Sciences-Basel

Toll-like receptors in the pathogenesis of neuroinflammation

(2019) V. Kumar   JOURNAL OF NEUROIMMUNOLOGY

Chrysin protects against behavioral, cognitive and neurochemical alterations in a 6-hydroxydopamine model of Parkinson's disease

(2019) Lucian Del Fabbro et al.   NEUROSCIENCE LETTERS

Embryonic stem cell-derived exosomes inhibit doxorubicin-induced TLR4-NLRP3-mediated cell death-pyroptosis

(2019) Zahra Tavakoli Dargani et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Protective effect of chrysin on cyclophosphamide-induced hepatotoxicity and nephrotoxicity via the inhibition of oxidative stress, inflammation, and apoptosis

(2019) Yusuf Temel et al.   NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY

Protective effects of Chrysin against memory impairment, cerebral hyperemia and oxidative stress after cerebral hypoperfusion and reperfusion in rats

(2019) Maryam Khombi Shooshtari et al.   METABOLIC BRAIN DISEASE

Morin attenuates doxorubicin-induced heart and brain damage by reducing oxidative stress, inflammation and apoptosis

(2018) Muslum Kuzu et al.   BIOMEDICINE & PHARMACOTHERAPY

Localized delivery of therapeutic doxorubicin dose across the canine blood–brain barrier with hyperthermia and temperature sensitive liposomes

(2018) Amy Lee Bredlau et al.   DRUG DELIVERY

In vivo cellular and molecular gastroprotective mechanisms of chrysin; Emphasis on oxidative stress, inflammation and angiogenesis

(2018) Mina Y. George et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Doxorubicin-induced elevated oxidative stress and neurochemical alterations in brain and cognitive decline: protection by MESNA and insights into mechanisms of chemotherapy-induced cognitive impairment (“chemobrain”)

(2018) Jeriel T.R. Keeney et al.   Oncotarget

Damage-Associated Molecular Patterns in Inflammatory Diseases

(2018) Jong Seong Roh et al.   Immune Network

Anthracyclines as Topoisomerase II Poisons: From Early Studies to New Perspectives

(2018) Jessica Marinello et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Development and evaluation of Chrysin-phospholipid complex loaded solid lipid nanoparticles - storage stability and in vitro anti-cancer activity

(2018) Shahadali K et al.   JOURNAL OF MICROENCAPSULATION

Antioxidant and Oxidative Stress: A Mutual Interplay in Age-Related Diseases

(2018) Bee Ling Tan et al.   Frontiers in Pharmacology

The significance of drug-to-lipid ratio to the development of optimized liposomal formulation

(2017) Maria Chountoulesi et al.   JOURNAL OF LIPOSOME RESEARCH

Oxidative Stress and Cellular Response to Doxorubicin: A Common Factor in the Complex Milieu of Anthracycline Cardiotoxicity

(2017) Donato Cappetta et al.   Oxidative Medicine and Cellular Longevity

Probenecid protects against oxygen–glucose deprivation injury in primary astrocytes by regulating inflammasome activity

(2016) Zhihong Jian et al.   BRAIN RESEARCH

Effect of low frequency stimulation on impaired spontaneous alternation behavior of kindled rats in Y-maze test

(2016) Samireh Ghafouri et al.   EPILEPSY RESEARCH

Chrysin-piperazine conjugates as antioxidant and anticancer agents

(2016) Rahul V. Patel et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Composite chitosan-transfersomal vesicles for improved transnasal permeation and bioavailability of verapamil

(2016) Mamdouh Abdel Mouez et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Sodium Oleate-Based Nanoemulsion Enhances Oral Absorption of Chrysin through Inhibition of UGT-Mediated Metabolism

(2016) Dong Dong et al.   MOLECULAR PHARMACEUTICS

Mitigating effect of chrysin loaded solid lipid nanoparticles against Amyloid β25–35 induced oxidative stress in rat hippocampal region: An efficient formulation approach for Alzheimer's disease

(2016) Aishwarya Vedagiri et al.   NEUROPEPTIDES

Nanotransfersomes of carvedilol for intranasal delivery: formulation, characterization andin vivoevaluation

(2015) Heba M. Aboud et al.   DRUG DELIVERY

Nose-to-Brain Delivery: Investigation of the Transport of Nanoparticles with Different Surface Characteristics and Sizes in Excised Porcine Olfactory Epithelium

(2015) Alpesh Mistry et al.   MOLECULAR PHARMACEUTICS

Enhanced corneal permeation and antimycotic activity of itraconazole againstCandida albicansvia a novel nanosystem vesicle

(2014) Aliaa N. ElMeshad et al.   DRUG DELIVERY

Decaffeinated coffee prevents scopolamine-induced memory impairment in rats

(2013) Young Jin Jang et al.   BEHAVIOURAL BRAIN RESEARCH

Chemotherapy-related changes in cognitive functioning

(2013) Sanne B. Schagen et al.   EJC SUPPLEMENTS

Insights on the Interactions of Chitosan with Phospholipid Vesicles. Part II: Membrane Stiffening and Pore Formation

(2013) Omar Mertins et al.   LANGMUIR

Toll-Like Receptor 4–Mediated Nuclear Factor Kappa B Activation Is Essential for Sensing Exogenous Oxidants to Propagate and Maintain Oxidative/Nitrosative Cellular Stress

(2013) Rajendra Karki et al.   PLoS One

Brain delivery of olanzapine by intranasal administration of transfersomal vesicles

(2012) Hamed A. Salama et al.   JOURNAL OF LIPOSOME RESEARCH

Chrysin reduces proliferation and induces apoptosis in the human prostate cancer cell line pc-3

(2011) Saeed Samarghandian et al.   Clinics

2-Mercaptoethane sulfonate prevents doxorubicin-induced plasma protein oxidation and TNF-α release: Implications for the reactive oxygen species-mediated mechanisms of chemobrain

(2011) Christopher D. Aluise et al.   FREE RADICAL BIOLOGY AND MEDICINE

The Inflammasomes

(2010) Kate Schroder et al.   CELL

Doxorubicin pathways

(2010) Caroline F. Thorn et al.   Pharmacogenetics and Genomics

Effect of chitosan coating on the characteristics of DPPC liposomes

(2010) Mohsen M. Mady et al.   Journal of Advanced Research

Ethanol injection method for hydrophilic and lipophilic drug-loaded liposome preparation

(2009) Chiraz Jaafar-Maalej et al.   JOURNAL OF LIPOSOME RESEARCH

Comparative effects of different cosurfactants on sterile prednisolone acetate ocular submicron emulsions stability and release

(2008) Shaimaa S. Ibrahim et al.   COLLOIDS AND SURFACES B-BIOINTERFACES