Article
Plant Sciences
Juntaro Negi, Tomoki Obata, Sakura Nishimura, Boseok Song, Sho Yamagaki, Yuhei Ono, Makoto Okabe, Natsumi Hoshino, Kohei Fukatsu, Ryo Tabata, Katsushi Yamaguchi, Shuji Shigenobu, Masashi Yamada, Mitsuyasu Hasebe, Shinichiro Sawa, Toshinori Kinoshita, Ikuo Nishida, Koh Iba
Summary: A mutant of Arabidopsis, cdi4, was found to have impaired stomatal responses to CO2 and light. This mutation is associated with a gene called PECT1, which encodes CTP:phosphorylethanolamine cytidylyltransferase. By suppressing the expression of PECT1 in guard cells, it was discovered that these mutant lines also exhibited impaired stomatal responses to low-CO2 concentrations or light.
Article
Multidisciplinary Sciences
Chonnikan Hanpaibool, Phornphimon Maitarad, Thanyada Rungrotmongkol
Summary: Colistin has become a last-resort therapy for AMR diseases, but the presence of the mcr gene in Enterobacteriaceae has resulted in colistin resistance. By utilizing Deep Learning, researchers predicted the structures of MCR-1 to 10 proteins and identified six conserved residues at the active site. They also determined the possible substrate entry path into MCR proteins.
Article
Chemistry, Medicinal
Elliot D. Mock, Ioli Kotsogianni, Wouter P. F. Driever, Carmen S. Fonseca, Jelle M. Vooijs, Hans den Dulk, Constant A. A. van Boeckel, Mario van der Stelt
Summary: The study described the structure-activity relationship of a library of pyrimidine-4-carboxamides as NAPE-PLD inhibitors and identified LEI-401 as a potent inhibitor. LEI-401 is a nanomolar potent inhibitor with drug-like properties, suitable for investigating NAPE-PLD function in vitro and in vivo.
JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Article
Multidisciplinary Sciences
Jian-Bo Song, Rui-Ke Huang, Miao-Jie Guo, Qian Zhou, Rui Guo, Shu-Yuan Zhang, Jing-Wen Yao, Ya-Ni Bai, Xuan Huang
Summary: This study identified lipid metabolites associated with plant basal resistance and systemic acquired resistance (SAR) using a metabolomics approach. The findings provide valuable insights for future research on the molecular mechanisms of SAR.
Article
Multidisciplinary Sciences
Justin E. Silpe, Joel W. H. Wong, Sian Owen, Michael Baym, Emily P. Balskus
Summary: Colibactin is a chemically unstable small-molecule genotoxin produced by various bacteria, and it induces bacterial cell death by targeting bacteria containing prophages. Exogenous DNA or expression of Colibactin resistance protein can protect bacteria from the toxic effects of Colibactin. This study reveals the potential impact of Colibactin production on microbiomes and highlights the role of microbial natural products in influencing population-level events.
Article
Chemistry, Physical
Tzong-Hsien Lee, Vinzenz Hofferek, Marc-Antoine Sani, Frances Separovic, Gavin E. Reid, Marie-Isabel Aguilar
Summary: The impact of Mac1 on bacterial membrane properties showed significant differences between lipid membranes derived from different growth phases, with Mac1 binding strongly and disrupting membrane structures, especially with a faster disruption rate observed for bilayers derived from stationary growth phase (SGP).
FARADAY DISCUSSIONS
(2021)
Article
Infectious Diseases
Jerzy Karczewski, Christine M. Brown, Yukari Maezato, Stephen P. Krasucki, Stephen J. Streatfield
Summary: CMB001 maintained stable antibacterial activity in the presence of blood or plasma, efficiently killed S. aureus within the biofilm, and showed equivalent efficacy to vancomycin in treating MRSA infection in neutropenic mice. Further evaluation of its efficacy against other pathogens and expansion of its pharmacokinetic/pharmacodynamic parameters and safety profile are warranted.
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
(2021)
Article
Endocrinology & Metabolism
Toshie Saito, Yue Wei, Li Wen, Chaitanya Srinivasan, Benjamin O. Wolthers, Cheng-Yu Tsai, Marian H. Harris, Kristen Stevenson, Craig Byersdorfer, Judy-April Oparaji, Christian Fernandez, Amitava Mukherjee, Maisam Abu-El-Haija, Sameer Agnihotri, Kjeld Schmiegelow, Megan R. Showalter, Paul W. Fogle, Scott McCulloch, Kevin Contrepois, Lewis B. Silverman, Ying Ding, Sohail Z. Husain
Summary: Metabolomic profiling in ALL patients showed significant alterations in metabolism, particularly in lipid metabolism, following induction chemotherapy.
Article
Biochemistry & Molecular Biology
Beatriz Tlatelpa-Romero, David Atahualpa Contreras-Cruz, Gabriel Guerrero-Luna, Maria Guadalupe Hernandez-Linares, Sinuhe Ruiz-Salgado, Criselda Mendoza-Milla, Yair Romero, Rene de-la-Rosa Paredes, Luis F. Oyarzabal, Diego Alejandro Mendoza-Samano, Jiovani Alfredo Galvan-Leon, Luis G. Vazquez-de-Lara
Summary: This study successfully obtained PE through an organic synthesis pathway and demonstrated a significant apoptotic effect in normal human lung fibroblasts. The apoptosis rate varied with different concentrations of PE, showing a dose-dependent relationship.
CHEMISTRY AND PHYSICS OF LIPIDS
(2023)
Article
Multidisciplinary Sciences
Xin Yang, Xuegao Wei, Jing Yang, Tianhua Du, Cheng Yin, Buli Fu, Mingjiao Huang, Jinjin Liang, Peipan Gong, Shaonan Liu, Wen Xie, Zhaojiang Guo, Shaoli Wang, Qingjun Wu, Ralf Nauen, Xuguo Zhou, Chris Bass, Youjun Zhang
Summary: The study reveals the significant role of m(6)A modification in regulating a gene associated with insecticide resistance in the global whitefly pest Bemisia tabaci. This finding sheds light on the biological function of m(6)A in insects and provides a new avenue for investigating the development of insecticide resistance.
Article
Chemistry, Analytical
Justyna Walczak-Skierska, Fernanda Monedeiro, Ewelina Maslak, Michal Zloch
Summary: Lipidomic profiling using MALDI-TOF MS was conducted to analyze bacterial strains isolated from diabetic foot infections. The study identified distinct lipidomic signatures among Gram-positive and Gram-negative bacteria, emphasizing the utility of MALDI-TOF MS in bacterial lipidomics. These findings provide valuable insights into the lipidomic adaptations of bacteria in diabetic foot infections and lay the groundwork for future studies aimed at enhancing bacterial identification.
ANALYTICAL CHEMISTRY
(2023)
Article
Endocrinology & Metabolism
Domagoj Cikes, Kareem Elsayad, Erdinc Sezgin, Erika Koitai, Torma Ferenc, Michael Orthofer, Rebecca Yarwood, Leonhard X. Heinz, Vitaly Sedlyarov, Nasser Darwish Miranda, Adrian Taylor, Sophie Grapentine, Fathiya al-Murshedi, Anne Abot, Adelheid Weidinger, Candice Kutchukian, Colline Sanchez, Shane J. F. Cronin, Maria Novatchkova, Anoop Kavirayani, Thomas Schuetz, Bernhard Haubner, Lisa Haas, Astrid Hagelkruys, Suzanne Jackowski, Andrey Kozlov, Vincent Jacquemond, Claude Knauf, Giulio Superti-Furga, Eric Rullman, Thomas Gustafsson, John McDermot, Martin Lowe, Zsolt Radak, Jeffrey S. Chamberlain, Marica Bakovic, Siddharth Banka, Josef M. Penninger
Summary: Muscle degeneration is a common cause of frailty and dependency in inherited diseases and ageing. The enzyme PCYT2/ECT plays a critical role in muscle health. Deficiency in PCYT2 leads to severe disease and muscle weakness. Mechanistically, PCYT2 deficiency affects cellular bioenergetics and membrane lipid bilayer structure. PCYT2 activity declines in ageing muscles and therapeutic delivery of PCYT2 improves muscle weakness.
Article
Biochemistry & Molecular Biology
John B. Bruce, Sebastien Lion, Angus Buckling, Edze R. Westra, Sylvain Gandon
Summary: Viruses utilize molecular communication to regulate their infection strategies, with some viruses using signaling molecules to enter dormant infections. Understanding these mechanisms can help manipulate host and phage population dynamics in natural environments.
Review
Immunology
Yanpeng Feng, Zhiyuan Chen, Yi Xu, Yuxuan Han, Xiujuan Jia, Zixuan Wang, Nannan Zhang, Wenjing Lv
Summary: NFKBIZ, encoded by NFKBIZ, is a recently identified IkappaB family protein that has been the focus of studies due to its role in inflammation. It is a key gene in the regulation of inflammatory factors in the NF-KB pathway, affecting the progression of related diseases. The investigation of NFKBIZ has led to a better understanding of its functions.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Plant Sciences
Shasmita, Barsha Bhushan Swain, Pradipta Kumar Mohapatra, Soumendra Kumar Naik, Arup Kumar Mukherjee
Summary: This review critically evaluates the potential of different biotic agents to protect rice yield from pathogenicity and highlights unexplored areas for managing rice diseases. It emphasizes the need for safe and eco-friendly alternatives to agrochemicals in order to combat pathogen resistance and increase rice production. The review also analyzes the use of bacterial and fungal agents in inducing defense against rice pathogens and examines their effects on rice yield.