Anti-Inflammation and Anti-Pyroptosis Activities of Mangiferin via Suppressing NF-κB/NLRP3/GSDMD Signaling Cascades

Clinical effect of Xuebijing combined with thymosinα1 on patients with severe pneumonia complicated with sepsis and its effect on serum inflammatory factors

(2022) Yan Chen et al.   CELLULAR AND MOLECULAR BIOLOGY

Emodin Ameliorates Intestinal Dysfunction by Maintaining Intestinal Barrier Integrity and Modulating the Microbiota in Septic Mice

(2022) Mina Zhang et al.   MEDIATORS OF INFLAMMATION

Dual ligand engagement for noncanonical inflammasome activation

(2022) Zhang-Hua Yang et al.   NATURE IMMUNOLOGY

Caspase-11 interaction with NLRP3 potentiates the noncanonical activation of the NLRP3 inflammasome

(2022) Julien Moretti et al.   NATURE IMMUNOLOGY

A Novel Drug Combination of Mangiferin and Cinnamic Acid Alleviates Rheumatoid Arthritis by Inhibiting TLR4/NFκB/NLRP3 Activation-Induced Pyroptosis

(2022) Weijie Li et al.   Frontiers in Immunology

IP3R1 regulates Ca2+ transport and pyroptosis through the NLRP3/Caspase-1 pathway in myocardial ischemia/reperfusion injury

(2021) Guixi Mo et al.   Cell Death Discovery

Caspase-11 promotes NLRP3 inflammasome activation via the cleavage of pannexin1 in acute kidney disease

(2021) Fan Yin et al.   ACTA PHARMACOLOGICA SINICA

Protective Effect of GM1 Attenuates Hippocampus and Cortex Apoptosis After Ketamine Exposure in Neonatal Rat via PI3K/AKT/GSK3β Pathway

(2021) Zhiheng Zhang et al.   MOLECULAR NEUROBIOLOGY

Mangiferin Promotes Bregs Level, Activates Nrf2 Antioxidant Signaling, and Inhibits Proinflammatory Cytokine Expression in Murine Splenic Mononuclear Cells In Vitro

(2021) Zhi-zhi Qin et al.   Current Medical Science

Caspases in Cell Death, Inflammation, and Gasdermin-Induced Pyroptosis

(2020) Sannula Kesavardhana et al.   Annual Review of Immunology

Mangiferin suppresses human metastatic osteosarcoma cell growth by down-regulating the expression of metalloproteinases-1/2 and parathyroid hormone receptor 1

(2020) Jifeng Wen et al.   AMB Express

Diversity, Mechanisms, and Significance of Macrophage Plasticity

(2019) Massimo Locati et al.   Annual Review of Pathology-Mechanisms of Disease

Lipid Peroxidation Drives Gasdermin D-Mediated Pyroptosis in Lethal Polymicrobial Sepsis

(2018) Rui Kang et al.   Cell Host & Microbe

Ablation of caspase-1 protects against TBI-induced pyroptosis in vitro and in vivo

(2018) Wei Liu et al.   Journal of Neuroinflammation

Molecular mechanisms and functions of pyroptosis, inflammatory caspases and inflammasomes in infectious diseases

(2017) Si Ming Man et al.   IMMUNOLOGICAL REVIEWS

Mangiferin inhibits mastitis induced by LPS via suppressing NF-ĸB and NLRP3 signaling pathways

(2017) Shihui Qu et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Structural and Molecular Mechanisms of Cytokine-Mediated Endocrine Resistance in Human Breast Cancer Cells

(2017) Joshua D. Stender et al.   MOLECULAR CELL

Chemotherapy drugs induce pyroptosis through caspase-3 cleavage of a gasdermin

(2017) Yupeng Wang et al.   NATURE

Pyroptosis: Gasdermin-Mediated Programmed Necrotic Cell Death

(2017) Jianjin Shi et al.   TRENDS IN BIOCHEMICAL SCIENCES

Mangiferin from Pueraria tuberosa reduces inflammation via inactivation of NLRP3 inflammasome

(2017) Ramakrishna K. Bulugonda et al.   Scientific Reports

Anti-inflammatory effects of 6′-O-acetyl mangiferin from Iris rossii Baker via NF-κb signal blocking in lipopolysaccharide-stimulated RAW 264.7 cells

(2016) Ji-Hun Jang et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Lipopolysaccharide-Induced CD300b Receptor Binding to Toll-like Receptor 4 Alters Signaling to Drive Cytokine Responses that Enhance Septic Shock

(2016) Oliver H. Voss et al.   IMMUNITY

Gasdermin D is an executor of pyroptosis and required for interleukin-1β secretion

(2015) Wan-ting He et al.   CELL RESEARCH

Caspase target drives pyroptosis

(2015) Petr Broz   NATURE

Caspase-11 cleaves gasdermin D for non-canonical inflammasome signalling

(2015) Nobuhiko Kayagaki et al.   NATURE

Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death

(2015) Jianjin Shi et al.   NATURE

NLRP3 inflammasome and its inhibitors: a review

(2015) Bo-Zong Shao et al.   Frontiers in Pharmacology

Inflammatory caspases are innate immune receptors for intracellular LPS

(2014) Jianjin Shi et al.   NATURE

Inflammasomes and Their Roles in Health and Disease

(2012) Mohamed Lamkanfi et al.   Annual Review of Cell and Developmental Biology

Combination of Mangiferin and Dipeptidyl Peptidase-4 Inhibitor Sitagliptin Improves Impaired Glucose Tolerance in Streptozotocin-Diabetic Rats

(2012) Jun Hou et al.   PHARMACOLOGY

Mangiferin: A possible strategy for periodontal disease to therapy

(2010) Xing-yu Duang et al.   MEDICAL HYPOTHESES