Characterization of SIGIRR/IL-1R8 Homolog from Zebrafish Provides New Insights into Its Inhibitory Role in Hepatic Inflammation

IL-37 requires the receptors IL-18Rα and IL-1R8 (SIGIRR) to carry out its multifaceted anti-inflammatory program upon innate signal transduction

(2015) Claudia A Nold-Petry et al.   NATURE IMMUNOLOGY

Extracellular forms of IL-37 inhibit innate inflammation in vitro and in vivo but require the IL-1 family decoy receptor IL-1R8

(2015) Suzhao Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Zebrafish TRIF, a Golgi-Localized Protein, Participates in IFN Induction and NF- B Activation

(2014) S. Fan et al.   JOURNAL OF IMMUNOLOGY

Teleost TLR22 Recognizes RNA Duplex to Induce IFN and Protect Cells from Birnaviruses

(2014) A. Matsuo et al.   JOURNAL OF IMMUNOLOGY

B Cells in Teleost Fish Act as Pivotal Initiating APCs in Priming Adaptive Immunity: An Evolutionary Perspective on the Origin of the B-1 Cell Subset and B7 Molecules

(2014) L.-y. Zhu et al.   JOURNAL OF IMMUNOLOGY

The Interleukin-1 Family: Back to the Future

(2013) Cecilia Garlanda et al.   IMMUNITY

Toll IL-1R8/Single Ig IL-1-Related Receptor Regulates Psoriasiform Inflammation through Direct Inhibition of Innate IL-17A Expression by    T Cells

(2013) S. E. Russell et al.   JOURNAL OF IMMUNOLOGY

IL-16 Induces Intestinal Inflammation via PepT1 Upregulation in a Pufferfish Model: New Insights into the Molecular Mechanism of Inflammatory Bowel Disease

(2013) P. Wang et al.   JOURNAL OF IMMUNOLOGY

Recruitment of TLR adapter TRIF to TLR4 signaling complex is mediated by the second helical region of TRIF TIR domain

(2013) W. Piao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The interleukin-1 receptor family

(2013) Diana Boraschi et al.   SEMINARS IN IMMUNOLOGY

SIGIRR, a Negative Regulator of TLR/IL-1R Signalling Promotes Microbiota Dependent Resistance to Colonization by Enteric Bacterial Pathogens

(2013) Ho Pan Sham et al.   PLoS Pathogens

The Toll Interleukin-1 Receptor (IL-1R) 8/Single Ig Domain IL-1R-Related Molecule Modulates the Renal Response to Bacterial Infection

(2012) Jaklien C. Leemans et al.   INFECTION AND IMMUNITY

Structural insights of rohu TLR3, its binding site analysis with fish reovirus dsRNA, poly I:C and zebrafish TRIF

(2012) Bikash R. Sahoo et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Scavenger Receptor in Fish Is a Lipopolysaccharide Recognition Molecule Involved in Negative Regulation of NF- B Activation by Competing with TNF Receptor-Associated Factor 2 Recruitment into the TNF-  Signaling Pathway

(2012) Z. Meng et al.   JOURNAL OF IMMUNOLOGY

Characterization of a PIAS4 Homologue from Zebrafish: Insights into Its Conserved Negative Regulatory Mechanism in the TRIF, MAVS, and IFN Signaling Pathways during Vertebrate Evolution

(2012) R. Xiong et al.   JOURNAL OF IMMUNOLOGY

TIR8/SIGIRR is an Interleukin-1 Receptor/Toll Like Receptor Family Member with Regulatory Functions in Inflammation and Immunity

(2012) Federica Riva et al.   Frontiers in Immunology

Lack of TIR8/SIGIRR triggers progression of chronic lymphocytic leukemia in mouse models

(2011) M. T. S. Bertilaccio et al.   BLOOD

GADD45A Protein Plays an Essential Role in Active DNA Demethylation during Terminal Osteogenic Differentiation of Adipose-derived Mesenchymal Stem Cells

(2011) Rui-peng Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Discovery of the DIGIRR Gene from Teleost Fish: A Novel Toll-IL-1 Receptor Family Member Serving as a Negative Regulator of IL-1 Signaling

(2011) Y.-f. Gu et al.   JOURNAL OF IMMUNOLOGY

MEGA5: Molecular Evolutionary Genetics Analysis Using Maximum Likelihood, Evolutionary Distance, and Maximum Parsimony Methods

(2011) K. Tamura et al.   MOLECULAR BIOLOGY AND EVOLUTION

SIGIRR/TIR-8 is an inhibitor of toll-like receptor signaling in primary human cells and regulates inflammation in models of rheumatoid arthritis

(2010) Stefan K. Drexler et al.   ARTHRITIS AND RHEUMATISM

SIGIRR modulates the inflammatory response in the brain

(2010) Melanie B. Watson et al.   BRAIN BEHAVIOR AND IMMUNITY

Down-regulation of single immunoglobulin interleukin-1R-related molecule (SIGIRR)/TIR8 expression in intestinal epithelial cells during inflammation

(2010) C. Kadota et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

SIGIRR inhibits toll-like receptor 4, 5, 9-mediated immune responses in human airway epithelial cells

(2010) Chun Zhang et al.   MOLECULAR BIOLOGY REPORTS

Enhanced Expression of Single Immunoglobulin IL-1 Receptor-Related Molecule Ameliorates LPS-Induced Acute Lung Injury in Mice

(2010) XuXin Chen et al.   SHOCK

Limb regeneration is impaired in an adult zebrafish model of diabetes mellitus

(2010) Ansgar S. Olsen et al.   WOUND REPAIR AND REGENERATION

Immunological and Inflammatory Functions of the Interleukin-1 Family

(2009) Charles A. Dinarello   Annual Review of Immunology

Toll-like receptors as targets in chronic liver diseases

(2009) A Mencin et al.   GUT

The interleukin-1 receptor/Toll-like receptor superfamily: 10 years of progress

(2009) Luke A. J. O'Neill   IMMUNOLOGICAL REVIEWS

Inflammatory Regulation by TLR3 in Acute Hepatitis

(2009) X. Xiao et al.   JOURNAL OF IMMUNOLOGY

The Essential Role of Single Ig IL-1 Receptor-Related Molecule/Toll IL-1R8 in Regulation of Th2 Immune Response

(2009) K. Bulek et al.   JOURNAL OF IMMUNOLOGY

Lack of SIGIRR/TIR8 aggravates hydrocarbon oil-induced lupus nephritis

(2009) Maciej Lech et al.   JOURNAL OF PATHOLOGY

The expression pattern of TIR8 is conserved among vertebrates

(2009) Federica Riva et al.   VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY

NKG2D-retinoic acid early inducible-1 recognition between natural killer cells and kupffer cells in a novel murine natural killer cell-dependent fulminant hepatitis

(2008) Xin Hou et al.   HEPATOLOGY

Hepatic steatosis in response to acute alcohol exposure in zebrafish requires sterol regulatory element binding protein activation

(2008) Michael J. Passeri et al.   HEPATOLOGY

Toll‐like receptors and adaptor molecules in liver disease: Update

(2008) Ekihiro Seki et al.   HEPATOLOGY

Tir8/Sigirr prevents murine lupus by suppressing the immunostimulatory effects of lupus autoantigens

(2008) Maciej Lech et al.   JOURNAL OF EXPERIMENTAL MEDICINE

TLR-dependent cross talk between human Kupffer cells and NK cells

(2008) Zhengkun Tu et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Thioacetamide accelerates steatohepatitis, cirrhosis and HCC by expressing HCV core protein in transgenic zebrafish Danio rerio

(2007) Ravikumar Deepa Rekha et al.   TOXICOLOGY