The NLRP3 Inflammasome and IL-1β Accelerate Immunologically Mediated Pathology in Experimental Viral Fulminant Hepatitis

C5aR, TNF-α, and FGL2 contribute to coagulation and complement activation in virus-induced fulminant hepatitis

(2015) Jianjun Liu et al.   JOURNAL OF HEPATOLOGY

C5a/C5aR pathway is essential for the pathogenesis of murine viral fulminant hepatitis by way of potentiating Fgl2/fibroleukin expression

(2014) Gui-lian Xu et al.   HEPATOLOGY

P2X7 Receptor Differentially Couples to Distinct Release Pathways for IL-1  in Mouse Macrophage

(2014) P. Pelegrin et al.   JOURNAL OF IMMUNOLOGY

IL-18 in inflammatory and autoimmune disease

(2013) Saikiran K. Sedimbi et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Tumor necrosis factor α (TNF-α) receptor-I is required for TNF-α-mediated fulminant virus hepatitis caused by murine hepatitis virus strain-3 infection

(2013) Huan Xu et al.   IMMUNOLOGY LETTERS

Gene Deletion of Gabarap Enhances Nlrp3 Inflammasome-Dependent Inflammatory Responses

(2013) Z. Zhang et al.   JOURNAL OF IMMUNOLOGY

TNF-α Upregulates Fgl2 Expression in Rat Myocardial Ischemia/Reperfusion Injury

(2013) Peng Jia et al.   MICROCIRCULATION

Cell death by pyroptosis drives CD4 T-cell depletion in HIV-1 infection

(2013) Gilad Doitsh et al.   NATURE

HCV and Oxidative Stress in the Liver

(2013) Alexander Ivanov et al.   Viruses-Basel

Expression of B and T lymphocyte attenuator (BTLA) in macrophages contributes to the fulminant hepatitis caused by murine hepatitis virus strain-3

(2012) Chengying Yang et al.   GUT

IL-1 receptor antagonist ameliorates inflammasome-dependent alcoholic steatohepatitis in mice

(2012) Jan Petrasek et al.   JOURNAL OF CLINICAL INVESTIGATION

NLRs, inflammasomes, and viral infection

(2012) S. R. Jacobs et al.   JOURNAL OF LEUKOCYTE BIOLOGY

IL-1β Signaling Promotes CNS-Intrinsic Immune Control of West Nile Virus Infection

(2012) Hilario J. Ramos et al.   PLoS Pathogens

Interleukin-1 in the pathogenesis and treatment of inflammatory diseases

(2011) C. A. Dinarello   BLOOD

Mitochondrial reactive oxygen species promote production of proinflammatory cytokines and are elevated in TNFR1-associated periodic syndrome (TRAPS)

(2011) Ariel C. Bulua et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Suppressing production of reactive oxygen species (ROS) for influenza A virus therapy

(2011) Ross Vlahos et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Inhibition of Nox2 Oxidase Activity Ameliorates Influenza A Virus-Induced Lung Inflammation

(2011) Ross Vlahos et al.   PLoS Pathogens

Human NLRP3 inflammasome activation is Nox1-4 independent

(2010) R. van Bruggen et al.   BLOOD

Signaling by ROS drives inflammasome activation

(2010) Fabio Martinon   EUROPEAN JOURNAL OF IMMUNOLOGY

Toll-Like Receptor 9 Promotes Steatohepatitis by Induction of Interleukin-1β in Mice

(2010) Kouichi Miura et al.   GASTROENTEROLOGY

Type I Interferons Protect From Toll-Like Receptor 9–Associated Liver Injury and Regulate IL-1 Receptor Antagonist in Mice

(2010) Jan Petrasek et al.   GASTROENTEROLOGY

A role for mitochondria in NLRP3 inflammasome activation

(2010) Rongbin Zhou et al.   NATURE

Reactive oxygen species-independent activation of the IL-1  inflammasome in cells from patients with chronic granulomatous disease

(2010) F. L. van de Veerdonk et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Interleukin-1 participates in the progression from liver injury to fibrosis

(2009) Roben G. Gieling et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Macrophage interleukin-6 and tumour necrosis factor-α are induced by coronavirus fixation to Toll-like receptor 2/heparan sulphate receptors but not carcinoembryonic cell adhesion antigen 1a

(2009) Alexandre Jacques et al.   IMMUNOLOGY

AIM2 recognizes cytosolic dsDNA and forms a caspase-1-activating inflammasome with ASC

(2009) Veit Hornung et al.   NATURE

Recognition of RNA virus by RIG-I results in activation of CARD9 and inflammasome signaling for interleukin 1β production

(2009) Hendrik Poeck et al.   NATURE IMMUNOLOGY

Interleukin-1β and the Autoinflammatory Diseases

(2009) Charles A. Dinarello   NEW ENGLAND JOURNAL OF MEDICINE

The novel CD4+CD25+ regulatory T cell effector molecule fibrinogen-like protein 2 contributes to the outcome of murine fulminant viral hepatitis

(2008) Itay Shalev et al.   HEPATOLOGY

Acute-on-chronic liver failure: consensus recommendations of the Asian Pacific Association for the study of the liver (APASL)

(2008) Shiv Kumar Sarin et al.   Hepatology International

Superoxide dismutase 1 regulates caspase-1 and endotoxic shock

(2008) Felix Meissner et al.   NATURE IMMUNOLOGY

Silica crystals and aluminum salts activate the NALP3 inflammasome through phagosomal destabilization

(2008) Veit Hornung et al.   NATURE IMMUNOLOGY

Innate Immune Activation Through Nalp3 Inflammasome Sensing of Asbestos and Silica

(2008) C. Dostert et al.   SCIENCE