Progranulin Controls Sepsis via C/EBPα-RegulatedIl10Transcription and Ubiquitin Ligase/Proteasome-Mediated Protein Degradation

Progranulin deficiency leads to severe inflammation, lung injury and cell death in a mouse model of endotoxic shock

(2016) Yuan Yu et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

C/EBPα regulates macrophage activation and systemic metabolism

(2014) Bonggi Lee et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Interleukin (IL)-32β-mediated CCAAT/Enhancer-binding Protein α (C/EBPα) Phosphorylation by Protein Kinase Cδ (PKCδ) Abrogates the Inhibitory Effect of C/EBPα on IL-10 Production

(2013) Jeong-Woo Kang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

E3 Ubiquitin Ligase E6AP Negatively Regulates Adipogenesis by Downregulating Proadipogenic Factor C/EBPalpha

(2013) Pooja Pal et al.   PLoS One

E6AP, an E3 ubiquitin ligase negatively regulates granulopoiesis by targeting transcription factor C/EBPα for ubiquitin-mediated proteasome degradation

(2013) P Pal et al.   Cell Death & Disease

Insights into the role of progranulin in immunity, infection, and inflammation

(2012) J. Jian et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Prevention of LPS-Induced Acute Lung Injury in Mice by Progranulin

(2012) Zhongliang Guo et al.   MEDIATORS OF INFLAMMATION

Exacerbated inflammatory responses related to activated microglia after traumatic brain injury in progranulin-deficient mice

(2012) Y. Tanaka et al.   NEUROSCIENCE

Neuroprotective effects of progranulin in ischemic mice

(2011) Jiang Tao et al.   BRAIN RESEARCH

Granulin Is a Soluble Cofactor for Toll-like Receptor 9 Signaling

(2011) Boyoun Park et al.   IMMUNITY

HDL/Apolipoprotein A-I Binds to Macrophage-Derived Progranulin and Suppresses its Conversion into Proinflammatory Granulins

(2011) Hanayuki Okura et al.   Journal of Atherosclerosis and Thrombosis

Mal Mediates TLR-Induced Activation of CREB and Expression of IL-10

(2011) M. Mellett et al.   JOURNAL OF IMMUNOLOGY

Cellular Effects of Progranulin in Health and Disease

(2011) Louis De Muynck et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Synaptic dysfunction in progranulin-deficient mice

(2011) Terri L. Petkau et al.   NEUROBIOLOGY OF DISEASE

Progranulin, a Glycoprotein Deficient in Frontotemporal Dementia, Is a Novel Substrate of Several Protein Disulfide Isomerase Family Proteins

(2011) Sandra Almeida et al.   PLoS One

The Growth Factor Progranulin Binds to TNF Receptors and Is Therapeutic Against Inflammatory Arthritis in Mice

(2011) W. Tang et al.   SCIENCE

Nonresolving Inflammation

(2010) Carl Nathan et al.   CELL

Granulin epithelin precursor: a bone morphogenic protein 2-inducible growth factor that activates Erk1/2 signaling and JunB transcription factor in chondrogenesis

(2010) Jian Q. Feng et al.   FASEB JOURNAL

Behavioral deficits and progressive neuropathology in progranulin-deficient mice: a mouse model of frontotemporal dementia

(2010) Fangfang Yin et al.   FASEB JOURNAL

Triptolide Inhibits IL-12/IL-23 Expression in APCs via CCAAT/Enhancer-Binding Protein  

(2010) Y. Zhang et al.   JOURNAL OF IMMUNOLOGY

Common variants at 7p21 are associated with frontotemporal lobar degeneration with TDP-43 inclusions

(2010) Vivianna M Van Deerlin et al.   NATURE GENETICS

Sortilin-Mediated Endocytosis Determines Levels of the Frontotemporal Dementia Protein, Progranulin

(2010) Fenghua Hu et al.   NEURON

The granulin gene family: from cancer to dementia

(2009) Andrew Bateman et al.   BIOESSAYS

Exaggerated inflammation, impaired host defense, and neuropathology in progranulin-deficient mice

(2009) Fangfang Yin et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Immunodesign of experimental sepsis by cecal ligation and puncture

(2009) Daniel Rittirsch et al.   Nature Protocols

Protein Kinase Cδ Stimulates Proteasome-Dependent Degradation of C/EBPα during Apoptosis Induction of Leukemic Cells

(2009) Meng Zhao et al.   PLoS One

C/EBPα S248A mutation reduces granulocytic differentiation in human leukemic K562 cells

(2008) Sheo M. Singh et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS