PFKFB3-Driven Macrophage Glycolytic Metabolism Is a Crucial Component of Innate Antiviral Defense

Glycolytic Reprogramming in Myofibroblast Differentiation and Lung Fibrosis

(2015) Na Xie et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Pyruvate Kinase M2 Regulates Hif-1α Activity and IL-1β Induction and Is a Critical Determinant of the Warburg Effect in LPS-Activated Macrophages

(2015) Eva M. Palsson-McDermott et al.   Cell Metabolism

Functional annotation of cis-regulatory elements in human cells by dCas9/sgRNA

(2015) Yinan Du et al.   CELL RESEARCH

Metabolic reprogramming in macrophages and dendritic cells in innate immunity

(2015) Beth Kelly et al.   CELL RESEARCH

Alveolar macrophage–derived type I interferons orchestrate innate immunity to RSV through recruitment of antiviral monocytes

(2015) Michelle Goritzka et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Respiratory Syncytial Virus Infection Upregulates NLRC5 and Major Histocompatibility Complex Class I Expression through RIG-I Induction in Airway Epithelial Cells

(2015) Xuancheng Guo et al.   JOURNAL OF VIROLOGY

Stealing the Keys to the Kitchen: Viral Manipulation of the Host Cell Metabolic Network

(2015) Christopher M. Goodwin et al.   TRENDS IN MICROBIOLOGY

Alveolar Macrophages Contribute to the Pathogenesis of Human Metapneumovirus Infection while Protecting against Respiratory Syncytial Virus Infection

(2014) Deepthi Kolli et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Endothelial PFKFB3 Plays a Critical Role in Angiogenesis

(2014) Yiming Xu et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

The phosphatidylserine receptor TIM4 utilizes integrins as coreceptors to effect phagocytosis

(2014) Ronald S. Flannagan et al.   MOLECULAR BIOLOGY OF THE CELL

Metabolism of stromal and immune cells in health and disease

(2014) Bart Ghesquière et al.   NATURE

TLR-driven early glycolytic reprogramming via the kinases TBK1-IKKɛ supports the anabolic demands of dendritic cell activation

(2014) Bart Everts et al.   NATURE IMMUNOLOGY

Direct Type I IFN but Not MDA5/TLR3 Activation of Dendritic Cells Is Required for Maturation and Metabolic Shift to Glycolysis after Poly IC Stimulation

(2014) Austin Pantel et al.   PLOS BIOLOGY

Role of PFKFB3-Driven Glycolysis in Vessel Sprouting

(2013) Katrien De Bock et al.   CELL

The Relationship between Metabolism and the Autophagy Machinery during the Innate Immune Response

(2013) Jennifer Martinez et al.   Cell Metabolism

Dynamic Adipocyte Phosphoproteome Reveals that Akt Directly Regulates mTORC2

(2013) Sean J. Humphrey et al.   Cell Metabolism

Targeting 6-Phosphofructo-2-Kinase (PFKFB3) as a Therapeutic Strategy against Cancer

(2013) B. F. Clem et al.   MOLECULAR CANCER THERAPEUTICS

Rapamycin-sensitive mTORC1 signaling is involved in physiological primordial follicle activation in mouse ovary

(2013) Yuanyuan Tong et al.   MOLECULAR REPRODUCTION AND DEVELOPMENT

Succinate is an inflammatory signal that induces IL-1β through HIF-1α

(2013) G. M. Tannahill et al.   NATURE

ISG15 Regulates Peritoneal Macrophages Functionality against Viral Infection

(2013) Emilio Yángüez et al.   PLoS Pathogens

The Sedoheptulose Kinase CARKL Directs Macrophage Polarization through Control of Glucose Metabolism

(2012) Arvand Haschemi et al.   Cell Metabolism

Small molecule inhibition of 6-phosphofructo-2-kinase suppresses t cell activation

(2012) Sucheta Telang et al.   Journal of Translational Medicine

The Cell Biology of Phagocytosis

(2011) Ronald S. Flannagan et al.   Annual Review of Pathology-Mechanisms of Disease

Metabolic Connections during Apoptotic Cell Engulfment

(2011) Claudia Z. Han et al.   CELL

Cooperation of Adenosine with Macrophage Toll-4 Receptor Agonists Leads to Increased Glycolytic Flux through the Enhanced Expression ofPFKFB3Gene

(2011) Almudena Ruiz-García et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Continued clearance of apoptotic cells critically depends on the phagocyte Ucp2 protein

(2011) Daeho Park et al.   NATURE

Autophagy in immunity and inflammation

(2011) Beth Levine et al.   NATURE

Regulation of Interleukin-10 Receptor Ubiquitination and Stability by Beta-TrCP-Containing Ubiquitin E3 Ligase

(2011) Hui Jiang et al.   PLoS One

Microtubule-associated protein 1 light chain 3 alpha (LC3)-associated phagocytosis is required for the efficient clearance of dead cells

(2011) J. Martinez et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Divergent Effects of Human Cytomegalovirus and Herpes Simplex Virus-1 on Cellular Metabolism

(2011) Livia Vastag et al.   PLoS Pathogens

Toll-like receptor-induced changes in glycolytic metabolism regulate dendritic cell activation

(2010) C. M. Krawczyk et al.   BLOOD

Pattern Recognition Receptors and Inflammation

(2010) Osamu Takeuchi et al.   CELL

Clearance of apoptotic cells: implications in health and disease

(2010) Michael R. Elliott et al.   JOURNAL OF CELL BIOLOGY

Type I interferon: friend or foe?

(2010) Giorgio Trinchieri   JOURNAL OF EXPERIMENTAL MEDICINE

Substrate Fate in Activated Macrophages: A Comparison between Innate, Classic, and Alternative Activation

(2010) J.-C. Rodriguez-Prados et al.   JOURNAL OF IMMUNOLOGY

Virus-Induced Unfolded Protein Response Attenuates Antiviral Defenses via Phosphorylation-Dependent Degradation of the Type I Interferon Receptor

(2009) Jianghuai Liu et al.   Cell Host & Microbe

Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation

(2009) M. G. Vander Heiden et al.   SCIENCE

Alveolar Macrophages Are a Major Determinant of Early Responses to Viral Lung Infection but Do Not Influence Subsequent Disease Development

(2008) P. K. Pribul et al.   JOURNAL OF VIROLOGY

Systems-level metabolic flux profiling identifies fatty acid synthesis as a target for antiviral therapy

(2008) Joshua Munger et al.   NATURE BIOTECHNOLOGY