Target Density, Not Affinity or Avidity of Antigen Recognition, Determines Adoptive T Cell Therapy Outcomes in a Mouse Lymphoma Model

Neoantigens in cancer immunotherapy

(2015) T. N. Schumacher et al.   SCIENCE

Adoptive Immunotherapy for Cancer or Viruses

(2014) Marcela V. Maus et al.   Annual Review of Immunology

Antigen expression level threshold tunes the fate of CD8 T cells during primary hepatic immune responses

(2014) S. S. Tay et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cardiovascular toxicity and titin cross-reactivity of affinity-enhanced T cells in myeloma and melanoma

(2013) G. P. Linette et al.   BLOOD

Rapid Deletion and Inactivation of CTLs upon Recognition of a Number of Target Cells over a Critical Threshold

(2013) S. Prato et al.   JOURNAL OF IMMUNOLOGY

T-cell receptor affinity and avidity defines antitumor response and autoimmunity in T-cell immunotherapy

(2013) S. Zhong et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Transnuclear TRP1-Specific CD8 T Cells with High or Low Affinity TCRs Show Equivalent Antitumor Activity

(2013) S. K. Dougan et al.   Cancer Immunology Research

Autoreactive T cells bypass negative selection and respond to self-antigen stimulation during infection

(2012) Sarah Enouz et al.   JOURNAL OF EXPERIMENTAL MEDICINE

High Avidity Cytotoxic T Lymphocytes Can Be Selected into the Memory Pool but They Are Exquisitely Sensitive to Functional Impairment

(2012) Victoria A. Brentville et al.   PLoS One

Functional differences between low- and high-affinity CD8+T cells in the tumor environment

(2012) Rinke Bos et al.   OncoImmunology

Human T cells expressing affinity-matured TCR display accelerated responses but fail to recognize low density of MHC-peptide antigen

(2011) S. Thomas et al.   BLOOD

Autoimmunity associated with immunotherapy of cancer

(2011) S. M. Amos et al.   BLOOD

Induction of antigen-specific effector-phase tolerance following vaccination against a previously ignored B-cell lymphoma

(2010) Sandro Prato et al.   IMMUNOLOGY AND CELL BIOLOGY

Targeting Antigen to Diverse APCs Inactivates Memory CD8+ T Cells without Eliciting Tissue-Destructive Effector Function

(2009) T. J. Kenna et al.   JOURNAL OF IMMUNOLOGY

Complete but curtailed T-cell response to very low-affinity antigen

(2009) Dietmar Zehn et al.   NATURE

Tissue destruction caused by cytotoxic T lymphocytes induces deletional tolerance

(2009) I. A. Parish et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA