Selective IRAK4 Inhibition Attenuates Disease in Murine Lupus Models and Demonstrates Steroid Sparing Activity

Suppression of IRAK1 or IRAK4 Catalytic Activity, but Not Type 1 IFN Signaling, Prevents Lupus Nephritis in Mice Expressing a Ubiquitin Binding–Defective Mutant of ABIN1

(2016) Sambit K. Nanda et al.   JOURNAL OF IMMUNOLOGY

Comprehensive RNAi-based screening of human and mouse TLR pathways identifies species-specific preferences in signaling protein use

(2016) Jing Sun et al.   Science Signaling

Comprehensive RNAi-based screening of human and mouse TLR pathways identifies species-specific preferences in signaling protein use

(2016) Jing Sun et al.   Science Signaling

Toll-like receptors: potential targets for lupus treatment

(2015) Yan-wei Wu et al.   ACTA PHARMACOLOGICA SINICA

Selective interleukin-1 receptor–associated kinase 4 inhibitors for the treatment of autoimmune disorders and lymphoid malignancy

(2015) Priscilla N. Kelly et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Potent and Selective Amidopyrazole Inhibitors of IRAK4 That Are Efficacious in a Rodent Model of Inflammation

(2015) William T. McElroy et al.   ACS Medicinal Chemistry Letters

Renoprotective effects of novel interleukin-1 receptor-associated kinase 4 inhibitor AS2444697 through anti-inflammatory action in 5/6 nephrectomized rats

(2014) Mitsuhiro Kondo et al.   NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY

Neutrophil gelatinase-associated lipocalin as a biomarker for lupus nephritis

(2014) M. T. Torres-Salido et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

A novel antagonist of Toll-like receptors 7, 8 and 9 suppresses lupus disease-associated parameters in NZBW/F1 mice

(2013) Fu-Gang Zhu et al.   AUTOIMMUNITY

Signals via the Adaptor MyD88 in B Cells and DCs Make Distinct and Synergistic Contributions to Immune Activation and Tissue Damage in Lupus

(2013) Lino L. Teichmann et al.   IMMUNITY

TLR4-mediated pro-inflammatory dendritic cell differentiation in humans requires the combined action of MyD88 and TRIF

(2013) Sonja THM Kolanowski et al.   Innate Immunity

Inhibition of type I interferon signalling prevents TLR ligand-mediated proteinuria

(2013) Sevgi Gurkan et al.   JOURNAL OF PATHOLOGY

Experimental and natural infections in MyD88- and IRAK-4-deficient mice and humans

(2012) Horst von Bernuth et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Epigallocatechin-3-gallate prevents lupus nephritis development in mice via enhancing the Nrf2 antioxidant pathway and inhibiting NLRP3 inflammasome activation

(2011) Pei-Yi Tsai et al.   FREE RADICAL BIOLOGY AND MEDICINE

The interleukin-1 receptor-associated kinases: Critical regulators of innate immune signalling

(2010) Sinead Flannery et al.   BIOCHEMICAL PHARMACOLOGY

TLR recognition of self nucleic acids hampers glucocorticoid activity in lupus

(2010) Cristiana Guiducci et al.   NATURE

Helical assembly in the MyD88–IRAK4–IRAK2 complex in TLR/IL-1R signalling

(2010) Su-Chang Lin et al.   NATURE

The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors

(2010) Taro Kawai et al.   NATURE IMMUNOLOGY

Regulation of autoreactive B cell responses to endogenous TLR ligands

(2009) Ana Maria Avalos et al.   AUTOIMMUNITY

Interleukin-1 Receptor-associated Kinase 2 Is Critical for Lipopolysaccharide-mediated Post-transcriptional Control

(2009) Youzhong Wan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Fibrinogen That Appears in Bowman’s Space of Proteinuric Kidneys in vivo Activates Podocyte Toll-Like Receptors 2 and 4 in vitro

(2009) Masaru Motojima et al.   NEPHRON EXPERIMENTAL NEPHROLOGY

IRAK-4 kinase activity-dependent and -independent regulation of lipopolysaccharide-inducible genes

(2008) Magdalena Koziczak-Holbro et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

The Kinase Activity of IL-1 Receptor-associated Kinase 4 Is Required for Interleukin-1 Receptor/Toll-like Receptor-induced TAK1-dependent NFκB Activation

(2008) Jerzy Frączek et al.   JOURNAL OF BIOLOGICAL CHEMISTRY