Lineage tracing reveals B cell antibody class switching is stochastic, cell-autonomous, and tuneable

Clonal multi-omics reveals Bcor as a negative regulator of emergency dendritic cell development

(2021) Luyi Tian et al.   IMMUNITY

Fate mapping of single NK cells identifies a type 1 innate lymphoid-like lineage that bridges innate and adaptive recognition of viral infection

(2021) Sophie Flommersfeld et al.   IMMUNITY

Lineage tracing on transcriptional landscapes links state to fate during differentiation

(2020) Caleb Weinreb et al.   SCIENCE

Antibody-secreting cell destiny emerges during the initial stages of B-cell activation

(2020) Christopher D. Scharer et al.   Nature Communications

Distinct Surface Expression of Activating Receptor Ly49H Drives Differential Expansion of NK Cell Clones upon Murine Cytomegalovirus Infection

(2019) Simon Grassmann et al.   IMMUNITY

Two modes of cis-activation of switch transcription by the IgH superenhancer

(2019) Joana M. Santos et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

TET enzymes augment activation-induced deaminase (AID) expression via 5-hydroxymethylcytosine modifications at the Aicda superenhancer

(2019) Chan-Wang J. Lio et al.   Science Immunology

Fundamental roles of chromatin loop extrusion in antibody class switching

(2019) Xuefei Zhang et al.   NATURE

Multiplexed Division Tracking Dyes for Proliferation-Based Clonal Lineage Tracing

(2018) Miles B. Horton et al.   JOURNAL OF IMMUNOLOGY

Nongenetic origins of cell-to-cell variability in B lymphocyte proliferation

(2018) Simon Mitchell et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Principles of nucleosome organization revealed by single-cell micrococcal nuclease sequencing

(2018) Binbin Lai et al.   NATURE

Single-cell mapping of lineage and identity in direct reprogramming

(2018) Brent A. Biddy et al.   NATURE

PinMol: Python application for designing molecular beacons for live cell imaging of endogenous mRNAs

(2018) Livia V. Bayer et al.   RNA

Diverse continuum of CD4+T-cell states is determined by hierarchical additive integration of cytokine signals

(2017) Inbal Eizenberg-Magar et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

T Cell Fate at the Single-Cell Level

(2016) Veit R. Buchholz et al.   Annual Review of Immunology

Single-molecule detection and tracking of RNA transcripts in living cells using phosphorothioate-optimized 2′- O -methyl RNA molecular beacons

(2016) Dan Zhao et al.   BIOMATERIALS

Role of TET enzymes in DNA methylation, development, and cancer

(2016) Kasper Dindler Rasmussen et al.   GENES & DEVELOPMENT

Intrinsic transcriptional heterogeneity in B cells controls early class switching to IgE

(2016) Yee Ling Wu et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Plasma cell differentiation is coupled to division-dependent DNA hypomethylation and gene regulation

(2016) Benjamin G Barwick et al.   NATURE IMMUNOLOGY

T-cell stimuli independently sum to regulate an inherited clonal division fate

(2016) J. M. Marchingo et al.   Nature Communications

Apoptosis and antigen affinity limit effector cell differentiation of a single naive B cell

(2015) J. J. Taylor et al.   SCIENCE

IgH Chain Class Switch Recombination: Mechanism and Regulation

(2014) Janet Stavnezer et al.   JOURNAL OF IMMUNOLOGY

Molecular beacon–enabled purification of living cells by targeting cell type–specific mRNAs

(2014) Brian M Wile et al.   Nature Protocols

Environmental Cues Dictate the Fate of Individual CD8+ T Cells Responding to Infection

(2013) Courtney R. Plumlee et al.   IMMUNITY

Phenotypic CD8+ T Cell Diversification Occurs before, during, and after the First T Cell Division

(2013) F. Lemaitre et al.   JOURNAL OF IMMUNOLOGY

Heterogeneous Differentiation Patterns of Individual CD8+ T Cells

(2013) C. Gerlach et al.   SCIENCE

Regulation of asymmetric cell division and polarity by Scribble is not required for humoral immunity

(2013) Edwin D. Hawkins et al.   Nature Communications

Mapping Differentiation under Mixed Culture Conditions Reveals a Tunable Continuum of T Cell Fates

(2013) Yaron E. Antebi et al.   PLOS BIOLOGY

RT-qPCR work-flow for single-cell data analysis

(2012) Anders Ståhlberg et al.   METHODS

Activation-Induced B Cell Fates Are Selected by Intracellular Stochastic Competition

(2012) K. R. Duffy et al.   SCIENCE

Amplification efficiency: linking baseline and bias in the analysis of quantitative PCR data

(2009) J. M. Ruijter et al.   NUCLEIC ACIDS RESEARCH

Mechanism and Regulation of Class Switch Recombination

(2008) Janet Stavnezer et al.   Annual Review of Immunology

Enhanced B-cell activation mediated by TLR4 and BCR crosstalk

(2008) Susana Minguet et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Instructive Role of the Transcription Factor E2A in Early B Lymphopoiesis and Germinal Center B Cell Development

(2008) Kyongrim Kwon et al.   IMMUNITY