Article
Agriculture, Dairy & Animal Science
Yunyun Luo, Mengyang Zhang, Zhengang Guo, Dwi Wijayanti, Hongwei Xu, Fugui Jiang, Xianyong Lan
Summary: In this study, two InDel polymorphic loci were identified in the PDGFD gene, and the 13bp deletion mutation was found to be significantly associated with sheep body size. Yearling rams with the ID genotype in the LXBH breed had larger body length, chest depth, and body weight than those with the wild genotype. Adult ewes with the DD genotype in the GSFW breed had smaller chest width, and yearling ewes with the same genotype had lower body weight, chest width, and cannon circumference compared to other individuals. These findings suggest that PDGFD InDel polymorphisms could serve as effective molecular markers for improving morphological traits in Chinese sheep.
Article
Genetics & Heredity
Haixia Li, Hongwei Xu, Zhanerke Akhatayeva, Hongfei Liu, Chunjian Lin, Xufei Han, Xiaofang Lu, Xianyong Lan, Qingfeng Zhang, Chuanying Pan
Summary: Research shows that various indels in the FecB gene are associated with sheep litter size, with the 10-bp indel having a significant correlation and the 12-bp indel being linked to the 17-bp indel. The DD genotype is harmful for fecundity. These findings offer new insights into accelerating molecular breeding in sheep.
Article
Agriculture, Dairy & Animal Science
Hongfei Liu, Haixia Li, Cui Mao, Fugui Jiang, Kunjie Hao, Xufei Han, Xiaofang Lu, Chuanying Pan, Qingfeng Zhang, Xianyong Lan
Summary: IGF2BP1 plays a crucial role in cellular growth, proliferation, and embryonic development, and the 5-bp and 9-bp InDel mutations associated with sheep reproductive traits significantly affect litter size. The combined genotype ID-II is identified as the best genotype for large litter size.
SMALL RUMINANT RESEARCH
(2021)
Article
Reproductive Biology
Yangming Huang, Peng Su, Zhanerke Akhatayeva, Chuanying Pan, Qingfeng Zhang, Xianyong Lan
Summary: This study investigates the polymorphisms of the Cry2 gene in Australian White ewes and finds two novel deletion mutations that are significantly associated with litter size. These findings may contribute to molecular breeding strategies in sheep.
Article
Agriculture, Dairy & Animal Science
Fengyan Wang, Mingxing Chu, Linxiang Pan, Xiangyu Wang, Xiaoyun He, Rensen Zhang, Lin Tao, Yongfu La, Lin Ma, Ran Di
Summary: GDF9 and BMPR1B are important reproduction genes. This study sequenced the entire coding region of GDF9 and identified mutations in Luzhong mutton sheep, with two SNPs being associated with litter size. The missense mutation g.41768485 G > A in GDF9 is predicted to affect the protein's tertiary structure. These mutations could potentially serve as genetic markers for improving litter size in sheep.
Article
Agriculture, Dairy & Animal Science
Xinwei Zhang, Rongrong Yuan, Yangyang Bai, Yuta Yang, Xiaoyue Song, Xianyong Lan, Chuanying Pan
Summary: AKAP13 gene is a candidate gene for regulating female fertility and its 16-bp indel locus is significantly associated with litter size in goats, making it a potential DNA molecular marker for molecular marker-assisted selection in goat breeding.
ANIMAL BIOTECHNOLOGY
(2023)
Article
Agriculture, Dairy & Animal Science
Hongying Ren, Qi Tang, Tao Xue, Qian Wang, Hongwei Xu, Qingfeng Zhang, Chuanying Pan
Summary: The 24-bp indel mutation of the sheep AHR gene is significantly associated with litter size and live litter size in AuW sheep, indicating its potential for marker-assisted selection breeding and improving reproductive performance in sheep.
ANIMAL BIOTECHNOLOGY
(2022)
Article
Reproductive Biology
Linxiu Yue, Wenjie Li, Yejun Pan, Xianyong Lan, Qingfeng Zhang, Chuanying Pan
Summary: Several loci of the GTF2A1 gene were found to be significantly correlated with litter size in sheep, providing new insights for accelerating sheep molecular breeding through molecular marker-assisted selection (MAS).
Article
Agriculture, Dairy & Animal Science
Dwi Wijayanti, Yangyang Bai, Quratulain Hanif, Hong Chen, Haijing Zhu, Lei Qu, Zhengang Guo, Xianyong Lan
Summary: This study identified a significant correlation between a 16-bp deletion within the CLSTN2 gene and first-born litter size in goats.
ANIMAL BIOTECHNOLOGY
(2022)
Article
Agriculture, Dairy & Animal Science
Zhiying Wang, Xinyu Wang, Xianyong Lan, Haijing Zhu, Lei Qu, Chuanying Pan
Summary: This study identified a significant correlation between the P4-Del-8bp polymorphism of the goat GATA4 gene and litter size, and two polymorphic indels were found. These findings provide a potential molecular marker for marker-assisted selection breeding to improve the goat industry.
ANIMAL BIOTECHNOLOGY
(2022)
Article
Agriculture, Dairy & Animal Science
Ruizhe Sun, Mingming Li, Na He, Xiaocheng Wen, Junxia Zhang
Summary: This study investigated the expression, sequence characteristics, and polymorphisms of SMAD4, SMAD5, and SMAD7 in Tibetan sheep. The results showed widespread expression of these genes in various tissues, with differences in expression levels. Bioinformatics analysis revealed sequence similarities with other species, and SNP analysis detected two mutations. However, no significant associations were found between these genes and litter size in Tibetan sheep.
Article
Agriculture, Dairy & Animal Science
Yuta Yang, Huina Hu, Cui Mao, Fugui Jiang, Xiaofang Lu, Xufei Han, Kunjie Hao, Xianyong Lan, Qingfeng Zhang, Chuanying Pan
Summary: This study identified a 23-bp nucleotide sequence mutation in intron 1 of the RORA gene in Australian White Sheep and found associations with litter size. The ID genotype showed significantly better performance in second and third born litter size.
ANIMAL BIOTECHNOLOGY
(2022)
Article
Genetics & Heredity
Jiaqiang Zhang, Zhansaya Toremurat, Yilin Liang, Jie Cheng, Zhenzhen Sun, Yangming Huang, Junxia Liu, B. U. R. E. N. Chaogetu, Gang Ren, Hong Chen
Summary: Marker-assisted selection is an important method for improving body conformation traits in livestock breeding. This study evaluated the association between genetic variations of the LRRC8B gene and body conformation traits in two native sheep breeds. The results showed that the LRRC8B gene polymorphism was significantly associated with chest depth in Small-Tailed Han sheep, suggesting its potential as a candidate gene for marker-assisted selection in this breed.
Article
Agriculture, Dairy & Animal Science
Pinggui Yang, Gaofu Wang, Shihai Jiang, Minghua Chen, Jie Zeng, Qian Pang, Dan Du, Mingliang Zhou
Summary: This study investigated DNA copy number variations (CNVs) between Tibetan sheep and White Suffolk sheep using high-throughput sequencing. The results revealed that these CNVs may be associated with differential biological characteristics between the two breeds, including energy metabolism, seasonal reproduction, and litter size. Furthermore, the identified CNVRs overlapped with known quantitative trait loci related to growth, testis weight, and reproductive seasonality.
ANIMAL BIOTECHNOLOGY
(2023)
Article
Agriculture, Dairy & Animal Science
Ruolan Wang, Zhen Wang, Xinyu Wang, Yicheng Li, Lei Qu, Xianyong Lan
Summary: The CFAP43/ WDR96 gene is associated with goat fertility, and a novel 4-bp insertion mutation in intron 7 was found to be significantly linked to litter size in this study. The DD genotype showed superior fertility compared to ID carriers, and there was a significant difference in genotype distribution between single lamb mothers and multi-lamb mothers. The 4-bp insertion within the CFAP43 gene could serve as a molecular marker for improving goat litter size.
SMALL RUMINANT RESEARCH
(2021)
Article
Multidisciplinary Sciences
Hong Yan, Jixiong Zhang, Jingxian Gao, Yangming Huang, Yanmei Xiong, Shungeng Min
SCIENTIFIC REPORTS
(2018)
Article
Spectroscopy
Jingjing Xia, Jixiong Zhang, Yueting Zhao, Yangming Huang, Yanmei Xiong, Shungeng Min
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2019)
Article
Automation & Control Systems
Yangming Huang, Yue Huang, Xiangzhong Song, Jingxian Gao, Yanmei Xiong, Shungeng Min
Summary: The study introduces a novel PLS-DA strategy, showing its superior performance in multi-class problems, especially in NIR and Raman spectral datasets. The method achieves high prediction accuracy through selecting representative samples and building qualitative models.
CHEMOMETRICS AND INTELLIGENT LABORATORY SYSTEMS
(2021)
Article
Chemistry, Applied
Xi He, Huang Yangming, Elzbieta Gorska-Horczyczak, Agnieszka Wierzbicka, Henryk H. Jelen
Summary: Solid-phase microextraction-mass spectrometry (SPME-MS) and fast gas chromatography based electronic nose (GC-E-Nose) were compared for their ability to distinguish Baijiu of various aroma types and geographical origin. It was found that the SPME-MS method had better fitness and prediction ability compared with the GC-E-Nose method in classifying aroma and regional origins of the Baijiu samples.
Article
Reproductive Biology
Yangming Huang, Peng Su, Zhanerke Akhatayeva, Chuanying Pan, Qingfeng Zhang, Xianyong Lan
Summary: This study investigates the polymorphisms of the Cry2 gene in Australian White ewes and finds two novel deletion mutations that are significantly associated with litter size. These findings may contribute to molecular breeding strategies in sheep.
Article
Energy & Fuels
Zongliang Yu, Shunxiang Wang, Yangming Huang, Yongjin Zou, Fen Xu, Cuili Xiang, Jian Zhang, Jingjing Xie, Lixian Sun
Summary: In this study, NiCo2O4 nanoneedles coated with Bi2O3 nanosheets were successfully prepared and investigated as electrode materials for supercapacitors. The proposed NiCo2O4@Bi2O3 heterostructure exhibited high capacitance, energy density, and cycling stability, showing great potential for application in high-performance supercapacitors.
JOURNAL OF ENERGY STORAGE
(2022)
Article
Genetics & Heredity
Jiaqiang Zhang, Zhansaya Toremurat, Yilin Liang, Jie Cheng, Zhenzhen Sun, Yangming Huang, Junxia Liu, B. U. R. E. N. Chaogetu, Gang Ren, Hong Chen
Summary: Marker-assisted selection is an important method for improving body conformation traits in livestock breeding. This study evaluated the association between genetic variations of the LRRC8B gene and body conformation traits in two native sheep breeds. The results showed that the LRRC8B gene polymorphism was significantly associated with chest depth in Small-Tailed Han sheep, suggesting its potential as a candidate gene for marker-assisted selection in this breed.
Article
Cell Biology
Yangming Huang, Kejing Zhang, Yafang Li, Sihuan Zhang, Zhanerke Akhatayeva, Fugui Jiang, Enliang Song, Xianyong Lan
Summary: The study analyzed the mRNA expression level and genetic variations of the HOXA11 gene in different tissues and cells. The results showed that HOXA11 is highly expressed in fat and muscle and may be involved in the differentiation of myoblasts and adipocytes in cattle. Two InDel polymorphisms in the HOXA11 gene were identified and genotyped, and they were found to be significantly correlated with various beef traits. These findings provide a new perspective for marker-assisted selection (MAS) strategies in molecular breeding of cattle.
Article
Agriculture, Dairy & Animal Science
Peng Su, Hui Wu, Yangming Huang, Xiaofang Lu, Jing Yin, Qingfeng Zhang, Xianyong Lan
Summary: Studying the characteristics of mammalian hoof colors is important for genetic improvements in animals. In this study, a specific single-nucleotide polymorphism (SNP) in the MITF gene was found to be significantly associated with hoof color in Australian White sheep. This research provides novel insights into hoof color genetics and offers molecular markers for selecting sheep with desired hoof color.
Article
Chemistry, Analytical
Yuan He, Yang-Ming Huang, Yao Wang, Yue-Ting Zhao, Xiao-Bin Li, Feng-Xia Zhang, Lei Xu, Jun-Gang Peng, Shun-Geng Min
CHINESE JOURNAL OF ANALYTICAL CHEMISTRY
(2020)
Article
Genetics & Heredity
Xiangge Meng, Chengping Li, Yu Hei, Xiang Zhou, Guoli Zhou
Summary: The study used IVT-SAPAS sequencing to analyze the dynamic changes of APA sites during adipogenesis in bovine subcutaneous preadipocytes and intramuscular preadipocytes. The results showed that APA plays an important role in adipocyte differentiation, and UTR-APA switching genes have different trends, with intramuscular preadipocytes tending to use shorter 3'UTR for differentiation. TRIB3, WWTR1, and INSIG1 play important roles in intramuscular preadipocyte differentiation.
Article
Genetics & Heredity
S. Alizadeh, S. Khamse, N. Tajeddin, H. R. Khorram Khorshid, A. Delbari, M. Ohadi
Summary: This study identifies a specific genotype at a CG-rich trinucleotide short tandem repeat (STR) locus that is associated with late-onset neurocognitive disorders such as Alzheimer's disease (AD).
Article
Genetics & Heredity
Shougang Liu, Zhe Zhuang, Fanghua Liu, Xiuqing Yuan, Zeqiao Zhang, Xiaoqian Liang, Xinhui Li, Yongfeng Chen
Summary: This study investigated the effect and mechanism of RPL9 and TIFA in scalp psoriasis, and identified RPL9 as a potential therapeutic target for scalp psoriasis.
Article
Genetics & Heredity
Shiting Wang, Jiaqi Chen, Zhichao Jin, Ying Xing, Ruiping Wang
Summary: This study suggests a causal association between hair color and skin cancers, with light hair colors (red, blonde, and light brown) being associated with an increased risk and dark brown hair being associated with a decreased risk.
Article
Genetics & Heredity
Joseph Hawadak, Loick Pradel Kojom Foko, Rodrigue Roman Dongang Nana, Karmveer Yadav, Veena Pande, Aparup Das, Vineeta Singh
Summary: This study investigates the genetic diversity and natural selection of the Pfama-1 gene in Plasmodium falciparum isolates from Cameroon. The study finds a considerable nucleotide and haplotype diversity, as well as specific mutations in Cameroonian isolates. Positive diversifying selection and the identification of selected codon sites suggest the potential implication of these genetic variations in host immune pressure and parasite-binding complex modulation. The findings provide valuable baseline data for malaria vaccine design.
Article
Genetics & Heredity
Emily Biernat, Mansi Verma, Chhabi K. Govind
Summary: RSC is an essential ATP-dependent chromatin remodeling complex in Saccharomyces cerevisiae. It regulates nucleosome-depleted regions (NDRs) by sliding flanking nucleosomes away from NDRs. Depletion of RSC leads to nucleosome encroachment in NDRs and transcription initiation defects. The study compared the effects of catalytic-dead Sth1 and rapid depletion of Sth1 on transcription. Rapid depletion of Sth1 reduces recruitment of TBP and Pol II, while the catalytic-dead mutant exhibits a severe reduction in TBP binding but accumulates Pol II in coding regions. The results suggest a role for RSC in transcription elongation and termination processes.
Article
Genetics & Heredity
Yunxiao Wei, Yuhan Song, Muhammad Aamir Khan, Chengzhen Liang, Zhigang Meng, Yuan Wang, Sandui Guo, Rui Zhang
Summary: This study analyzed the GhTPP protein family in upland cotton for the first time and identified the important role of GhTPPA_2 in regulating sugar metabolism, improving soluble sugar accumulation, and drought stress tolerance.
Article
Genetics & Heredity
Yannan Geng, Rui Shao, Tiantong Xu, Lilong Zhang
Summary: A novel risk model based on SCUBE3, TNNC1, SPON1, SEPT12 and ULBP1 genes was developed for predicting PMOP risk, with higher risk score indicating higher risk of suffering from PMOP. Significant differences in signaling pathway activities were observed between the high-risk score group and the low-risk score group.
Article
Genetics & Heredity
Randy P. Williams, Corina Lesseur, Haoxiang Cheng, Qian Li, Maya Deyssenroth, Christopher D. Molteno, Ernesta M. Meintjes, Sandra W. Jacobson, Joseph L. Jacobson, Helen Wainwright, Ke Hao, Jia Chen, R. Colin Carter
Summary: The study suggests that heavy alcohol exposure during pregnancy may impact the proportion of fetal placental villi macrophages and increase the expression of inflammatory genes. Further research is needed to explore these effects and evaluate the potential functional roles of placental inflammation in FASD.
Article
Genetics & Heredity
Lvjing Luo, Lishuang Sun, Shu Li, Huiting Liu, Zhengyu Chen, Shi Huang, Yinyin Mo, Genliang Li
Summary: This study analyzed the expression of Ptpn1 and miR-124-3p in testicular tissues of mice and investigated their regulatory relationship. The results showed that Ptpn1 expression was up-regulated in adult mouse testis compared to juvenile mouse testis, while miR-124-3p expression showed an opposite pattern. Further analysis suggested that the down-regulation of miR-124-3p may contribute to the high expression of Ptpn1 in adult mouse testis.
Article
Genetics & Heredity
Gairui Li, Dan Zhao, Xiaolin Peng, Yashuang Zhao
Summary: MiRNA-22 shows potential as a candidate for early diagnosis of colorectal cancer (CRC). The study found higher miR-22 expression levels in the CRC and CRA groups, suggesting its potential as a biomarker for CRC early screening.
Article
Genetics & Heredity
Zhongqiu Zhu, Qianting Yang, Xiaoying Tian, Da Man, Jian Wang, Junfang Zhang, Bingshe Han
Summary: This study constructed a ceRNA network mediated by lncRNAs in cold-acclimated zebrafish ZF4 cells and revealed that upregulation of MSTRG3207 promotes apoptosis by sponging dre-miR-736 during cold acclimation.
Article
Genetics & Heredity
Weitao Chen, Denggao Xiang, Shang Gao, Shuli Zhu, Zhi Wu, Yuefei Li, Jie Li
Summary: Dam construction has negatively impacted the genetic diversity and structure of fish populations. This case study on the endangered Hemibagrus guttatus found low genetic diversity, high levels of inbreeding, and decreasing population size in fragmented populations. Genetic structure and differentiation were also observed, indicating the influence of dams on these fish populations.
Article
Genetics & Heredity
Pooja Singh, Debleena Guin, Bijay Pattnaik, Ritushree Kukreti
Summary: Through systematic literature review and meta-analysis, it was found that idiopathic pulmonary fibrosis is significantly associated with 222 polymorphisms in 118 genes. Four polymorphisms - rs35705950/MUC5B, rs2736100/TERT, rs2076295/DSP, and rs111521887/TOLLIP, exhibited substantial epidemiological evidence supporting their association with IPF risk.
Article
Genetics & Heredity
Jianping Zhang, Zhijun Cai, Fanzhe Feng, Yufeng Peng, Yi Cui, Yongiqing Xu
Summary: This study found that exosomes secreted by young BMSCs can promote the healing of tendon-bone interface after rotator cuff tears. These exosomes can improve extracellular matrix remodeling, osteogenic differentiation, angiogenesis, and stemness of tendon-derived stem cells (TDSCs). The exosomes from young BMSCs have better effects compared to those from aged BMSCs.
