A rare human centenarian variant of SIRT6 enhances genome stability and interaction with Lamin A

Restoration of energy homeostasis by SIRT6 extends healthy lifespan

(2021) A. Roichman et al.   Nature Communications

SIRT6 mono-ADP ribosylates KDM2A to locally increase H3K36me2 at DNA damage sites to inhibit transcription and promote repair

(2020) Sarallah Rezazadeh et al.   Aging-US

L1 drives IFN in senescent cells and promotes age-associated inflammation

(2019) Marco De Cecco et al.   NATURE

An advanced strategy for comprehensive profiling of ADP-ribosylation sites using mass spectrometry-based proteomics

(2019) Ivo A Hendriks et al.   MOLECULAR & CELLULAR PROTEOMICS

LINE1 Derepression in Aged Wild-Type and SIRT6-Deficient Mice Drives Inflammation

(2019) Matthew Simon et al.   Cell Metabolism

SIRT6 Is Responsible for More Efficient DNA Double-Strand Break Repair in Long-Lived Species

(2019) Xiao Tian et al.   CELL

One minute analysis of 200 histone post-translational modifications by direct injection mass spectrometry

(2019) Simone Sidoli et al.   GENOME RESEARCH

SIRT6 promotes transcription of a subset of NRF2 targets by mono-ADP-ribosylating BAF170

(2019) Sarallah Rezazadeh et al.   NUCLEIC ACIDS RESEARCH

Therapeutic Potential of NAD-Boosting Molecules: The In Vivo Evidence

(2018) Luis Rajman et al.   Cell Metabolism

Comprehensive ADP‐ribosylome analysis identifies tyrosine as an ADP‐ribose acceptor site

(2018) Deena M Leslie Pedrioli et al.   EMBO REPORTS

An inactivating mutation in the histone deacetylase SIRT6 causes human perinatal lethality

(2018) Christina M. Ferrer et al.   GENES & DEVELOPMENT

Effective discovery of rare variants by pooled target capture sequencing: A comparative analysis with individually indexed target capture sequencing

(2018) Seungjin Ryu et al.   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS

SIRT6 deficiency results in developmental retardation in cynomolgus monkeys

(2018) Weiqi Zhang et al.   NATURE

Natural polyphenols as sirtuin 6 modulators

(2018) Minna Rahnasto-Rilla et al.   Scientific Reports

The BioGRID interaction database: 2019 update

(2018) Rose Oughtred et al.   NUCLEIC ACIDS RESEARCH

The RNA processing factors THRAP3 and BCLAF1 promote the DNA damage response through selective mRNA splicing and nuclear export

(2017) Jekaterina Vohhodina et al.   NUCLEIC ACIDS RESEARCH

A conserved NAD + binding pocket that regulates protein-protein interactions during aging

(2017) Jun Li et al.   SCIENCE

PICKLE 2.0: A human protein-protein interaction meta-database employing data integration via genetic information ontology

(2017) Aris Gioutlakis et al.   PLoS One

SIRT6 safeguards human mesenchymal stem cells from oxidative stress by coactivating NRF2

(2016) Huize Pan et al.   CELL RESEARCH

SIRT6 deacetylates H3K18ac at pericentric chromatin to prevent mitotic errors and cellular senescence

(2016) Luisa Tasselli et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

ADPriboDB: The database of ADP-ribosylated proteins

(2016) Christina A. Vivelo et al.   NUCLEIC ACIDS RESEARCH

Proteome-wide identification of the endogenous ADP-ribosylome of mammalian cells and tissue

(2016) Rita Martello et al.   Nature Communications

SIRT6 deacetylates H3K18ac at pericentric chromatin to prevent mitotic errors and cellular senescence

(2016) Luisa Tasselli et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

A continuous sirtuin activity assay without any coupling to enzymatic or chemical reactions

(2016) Sabine Schuster et al.   Scientific Reports

JNK Phosphorylates SIRT6 to Stimulate DNA Double-Strand Break Repair in Response to Oxidative Stress by Recruiting PARP1 to DNA Breaks

(2016) Michael Van Meter et al.   Cell Reports

The BioPlex Network: A Systematic Exploration of the Human Interactome

(2015) Edward L. Huttlin et al.   CELL

Cell Fate by SIRT6 and TETs

(2015) Jean-Pierre Etchegaray et al.   CELL CYCLE

Sequential Window Acquisition of all Theoretical Mass Spectra (SWATH) Analysis for Characterization and Quantification of Histone Post-translational Modifications

(2015) Simone Sidoli et al.   MOLECULAR & CELLULAR PROTEOMICS

Lamin A Is an Endogenous SIRT6 Activator and Promotes SIRT6-Mediated DNA Repair

(2015) Shrestha Ghosh et al.   Cell Reports

The interplay between DNA damage response and RNA processing: the unexpected role of splicing factors as gatekeepers of genome stability

(2015) Chiara Naro et al.   Frontiers in Genetics

GWAS of Longevity in CHARGE Consortium Confirms APOE and FOXO3 Candidacy

(2014) Linda Broer et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

SIRT6 Minor Allele Genotype Is Associated with >5-Year Decrease in Lifespan in an Aged Cohort

(2014) Mindi J. TenNapel et al.   PLoS One

SIRT6 represses LINE1 retrotransposons by ribosylating KAP1 but this repression fails with stress and age

(2014) Michael Van Meter et al.   Nature Communications

Lamins are rapamycin targets that impact human longevity: a study in centenarians

(2013) G. Lattanzi et al.   JOURNAL OF CELL SCIENCE

Proteome-wide Identification of Poly(ADP-Ribosyl)ation Targets in Different Genotoxic Stress Responses

(2013) Stephanie Jungmichel et al.   MOLECULAR CELL

SIRT6 regulates TNF-α secretion through hydrolysis of long-chain fatty acyl lysine

(2013) Hong Jiang et al.   NATURE

Pre-mRNA processing factors meet the DNA damage response

(2013) Alessandra Montecucco et al.   Frontiers in Genetics

Human longevity and common variations in the LMNA gene: a meta-analysis

(2012) Karen N. Conneely et al.   AGING CELL

DNA Sequence-Dependent Compartmentalization and Silencing of Chromatin at the Nuclear Lamina

(2012) Joseph M. Zullo et al.   CELL

The Histone Deacetylase SIRT6 Is a Tumor Suppressor that Controls Cancer Metabolism

(2012) Carlos Sebastián et al.   CELL

Proteomic Investigations Reveal a Role for RNA Processing Factor THRAP3 in the DNA Damage Response

(2012) Petra Beli et al.   MOLECULAR CELL

The sirtuin SIRT6 regulates lifespan in male mice

(2012) Yariv Kanfi et al.   NATURE

Liver cancer initiation is controlled by AP-1 through SIRT6-dependent inhibition of survivin

(2012) Lihua Min et al.   NATURE CELL BIOLOGY

An Abundance of Rare Functional Variants in 202 Drug Target Genes Sequenced in 14,002 People

(2012) M. R. Nelson et al.   SCIENCE

Genome-wide association study identifies a single major locus contributing to survival into old age; the APOE locus revisited

(2011) Joris Deelen et al.   AGING CELL

SIRT6 overexpression induces massive apoptosis in cancer cells but not in normal cells

(2011) Michael Van Meter et al.   CELL CYCLE

Correlation of Tryptophan Fluorescence Spectral Shifts and Lifetimes Arising Directly from Heterogeneous Environment

(2011) Chia-Pin Pan et al.   JOURNAL OF PHYSICAL CHEMISTRY B

SIRT6 Promotes DNA Repair Under Stress by Activating PARP1

(2011) Z. Mao et al.   SCIENCE

Dynamic Chromatin Localization of Sirt6 Shapes Stress- and Aging-Related Transcriptional Networks

(2011) Tiara L. A. Kawahara et al.   PLoS Genetics

Molecular Maps of the Reorganization of Genome-Nuclear Lamina Interactions during Differentiation

(2010) Daan Peric-Hupkes et al.   MOLECULAR CELL

Human SIRT6 Promotes DNA End Resection Through CtIP Deacetylation

(2010) Abderrahmane Kaidi et al.   SCIENCE

SIRT6 Links Histone H3 Lysine 9 Deacetylation to NF-κB-Dependent Gene Expression and Organismal Life Span

(2009) Tiara L.A. Kawahara et al.   CELL

Comparison of nonhomologous end joining and homologous recombination in human cells

(2008) Z MAO et al.   DNA REPAIR

SIRT6 is a histone H3 lysine 9 deacetylase that modulates telomeric chromatin

(2008) Eriko Michishita et al.   NATURE