Bardoxolone Methyl Prevents High-Fat Diet-Induced Colon Inflammation in Mice

Bardoxolone methyl prevents fat deposition and inflammation in the visceral fat of mice fed a high-fat diet

(2015) Chi H.L. Dinh et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Bardoxolone methyl prevents insulin resistance and the development of hepatic steatosis in mice fed a high-fat diet

(2015) Danielle Camer et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Bardoxolone methyl prevents high-fat diet-induced alterations in prefrontal cortex signalling molecules involved in recognition memory

(2015) Danielle Camer et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Bardoxolone Methyl Prevents Mesenteric Fat Deposition and Inflammation in High-Fat Diet Mice

(2015) Chi H. L. Dinh et al.   TheScientificWorldJOURNAL

Bardoxolone Methyl Prevents Fat Deposition and Inflammation in Brown Adipose Tissue and Enhances Sympathetic Activity in Mice Fed a High-Fat Diet

(2015) Chi Dinh et al.   Nutrients

Bardoxolone Methyl Prevents Mesenteric Fat Deposition and Inflammation in High-Fat Diet Mice

(2015) Chi H. L. Dinh et al.   Scientific World Journal

Soybean Oil Is More Obesogenic and Diabetogenic than Coconut Oil and Fructose in Mouse: Potential Role for the Liver

(2015) Poonamjot Deol et al.   PLoS One

Oleanolic acid regulates NF-κB signaling by suppressing MafK expression in RAW 264.7 cells

(2014) Yu-Jin Hwang et al.   BMB Reports

Assessing non-digestible compounds in apple cultivars and their potential as modulators of obese faecal microbiota in vitro

(2014) Luis Condezo-Hoyos et al.   FOOD CHEMISTRY

Disequilibrium of M1 and M2 Macrophages Correlates with the Development of Experimental Inflammatory Bowel Diseases

(2014) Wei Zhu et al.   IMMUNOLOGICAL INVESTIGATIONS

Potent anti-inflammatory activity of betulinic acid treatment in a model of lethal endotoxemia

(2014) José Fernando Oliveira Costa et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Cancer incidence and mortality worldwide: Sources, methods and major patterns in GLOBOCAN 2012

(2014) Jacques Ferlay et al.   INTERNATIONAL JOURNAL OF CANCER

Ursolic Acid Isolated from the Seed of Cornus officinalis Ameliorates Colitis in Mice by Inhibiting the Binding of Lipopolysaccharide to Toll-like Receptor 4 on Macrophages

(2014) Se-Eun Jang et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Risk Factors for Heart Failure in Patients With Type 2 Diabetes Mellitus and Stage 4 Chronic Kidney Disease Treated With Bardoxolone Methyl

(2014) Melanie P. Chin et al.   JOURNAL OF CARDIAC FAILURE

Synthetic triterpenoid induces 15-PGDH expression and suppresses inflammation-driven colon carcinogenesis

(2014) Sung Hee Choi et al.   JOURNAL OF CLINICAL INVESTIGATION

Oleanolic acid modulates the immune-inflammatory response in mice with experimental autoimmune myocarditis and protects from cardiac injury. Therapeutic implications for the human disease

(2014) R. Martín et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Intestinal and Systemic Inflammatory Responses Are Positively Associated with Sulfidogenic Bacteria Abundance in High-Fat–Fed Male C57BL/6J Mice

(2014) Wan Shen et al.   JOURNAL OF NUTRITION

Ursolic acid inhibits nuclear factor-κB signaling in intestinal epithelial cells and macrophages, and attenuates experimental colitis in mice

(2014) Jaeyoung Chun et al.   LIFE SCIENCES

Bardoxolone methyl (BARD) ameliorates aristolochic acid (AA)-induced acute kidney injury through Nrf2 pathway

(2014) Juan Wu et al.   TOXICOLOGY

Protection from inflammatory bowel disease and colitis-associated carcinogenesis with 4-vinyl-2,6-dimethoxyphenol (canolol) involves suppression of oxidative stress and inflammatory cytokines

(2013) Jun Fang et al.   CARCINOGENESIS

Linking inflammation to tumorigenesis in a mouse model of high-fat-diet-enhanced colon cancer

(2013) Stani D. Day et al.   CYTOKINE

Extract of Wax Gourd Peel Prevents High-Fat Diet-Induced Hyperlipidemia in C57BL/6 Mice via the Inhibition of the PPARγPathway

(2013) Ming Gu et al.   Evidence-based Complementary and Alternative Medicine

Influence of triterpenoids present in apple peel on inflammatory gene expression associated with inflammatory bowel disease (IBD)

(2013) Dolores Mueller et al.   FOOD CHEMISTRY

Obesity and colorectal cancer

(2013) Marc Bardou et al.   GUT

Immunohistochemical characterization of lymphocytes in microscopic colitis

(2013) C. Göranzon et al.   Journal of Crohns & Colitis

High-Fat Diet-Induced Obesity Exacerbates Inflammatory Bowel Disease in Genetically Susceptible Mdr1a−/− Male Mice

(2013) Jisun Paik et al.   JOURNAL OF NUTRITION

Human colonic crypts in culture: segregation of immunochemical markers in normal versus adenoma-derived

(2013) Michael K Dame et al.   LABORATORY INVESTIGATION

Dietary supplementation withAgaricus blazeimurill extract prevents diet-induced obesity and insulin resistance in rats

(2013) Mylène Vincent et al.   Obesity

Human intestinal microbiota composition is associated with local and systemic inflammation in obesity

(2013) Froukje J. Verdam et al.   Obesity

The Triterpenoid CDDO-Me Inhibits Bleomycin-Induced Lung Inflammation and Fibrosis

(2013) Ajit A. Kulkarni et al.   PLoS One

The synthetic triterpenoid RTA dh404 (CDDO-dhTFEA) restores Nrf2 activity and attenuates oxidative stress, inflammation, and fibrosis in rats with chronic kidney disease

(2013) Mohammad A. Aminzadeh et al.   XENOBIOTICA

Maternal high-fat diet induces hyperproliferation and alters Pten/Akt signaling in prostates of offspring

(2013) Emily C. Benesh et al.   Scientific Reports

Saturated fat stimulates obesity and hepatic steatosis and affects gut microbiota composition by an enhanced overflow of dietary fat to the distal intestine

(2012) Nicole de Wit et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Vanilloid Receptor-1 Regulates Neurogenic Inflammation in Colon and Protects Mice from Colon Cancer

(2012) A. G. Vinuesa et al.   CANCER RESEARCH

The combination of the histone deacetylase inhibitor vorinostat and synthetic triterpenoids reduces tumorigenesis in mouse models of cancer

(2012) Kim Tran et al.   CARCINOGENESIS

A Phase I First-in-Human Trial of Bardoxolone Methyl in Patients with Advanced Solid Tumors and Lymphomas

(2012) D. S. Hong et al.   CLINICAL CANCER RESEARCH

High-Fat Diet Alters Gene Expression in the Liver and Colon: Links to Increased Development of Aberrant Crypt Foci

(2012) Sara Padidar et al.   DIGESTIVE DISEASES AND SCIENCES

RETRACTED: Obesity-Induced Increase in Tumor Necrosis Factor-α Leads to Development of Colon Cancer in Mice

(2012) Marcelo B.S. Flores et al.   GASTROENTEROLOGY

Ursolic acid attenuates lipopolysaccharide-induced acute lung injury in a mouse model

(2012) Xiangjun Chen et al.   Immunotherapy

Inflammation switches the differentiation program of Ly6Chimonocytes from antiinflammatory macrophages to inflammatory dendritic cells in the colon

(2012) Aymeric Rivollier et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The combination of high-fat diet-induced obesity and chronic ulcerative colitis reciprocally exacerbates adipose tissue and colon inflammation

(2012) Lílian G Teixeira et al.   Lipids in Health and Disease

Resident and pro-inflammatory macrophages in the colon represent alternative context-dependent fates of the same Ly6Chi monocyte precursors

(2012) C C Bain et al.   Mucosal Immunology

Green tea powder and Lactobacillus plantarum affect gut microbiota, lipid metabolism and inflammation in high-fat fed C57BL/6J mice

(2012) Ulrika Axling et al.   Nutrition & Metabolism

Increased Gut Permeability and Microbiota Change Associate with Mesenteric Fat Inflammation and Metabolic Dysfunction in Diet-Induced Obese Mice

(2012) Yan Y. Lam et al.   PLoS One

High Fat Diet-Induced Gut Microbiota Exacerbates Inflammation and Obesity in Mice via the TLR4 Signaling Pathway

(2012) Kyung-Ah Kim et al.   PLoS One

Targeting of Nrf2 induces DNA damage signaling and protects colonic epithelial cells from ionizing radiation

(2012) S. B. Kim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Intestinal Mucosal Triacylglycerol Accumulation Secondary to Decreased Lipid Secretion in Obese and High Fat Fed Mice

(2012) John D. Douglass et al.   Frontiers in Physiology

Cytokines, Inflammation and Colon Cancer

(2011) L. Klampfer   CURRENT CANCER DRUG TARGETS

Diet-induced obesity elevates colonic TNF-α in mice and is accompanied by an activation of Wnt signaling: a mechanism for obesity-associated colorectal cancer

(2011) Zhenhua Liu et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Systematic Immunohistochemistry Screening for Lynch Syndrome in Early Age-of-Onset Colorectal Cancer Patients Undergoing Surgical Resection

(2011) Emily Steinhagen et al.   JOURNAL OF THE AMERICAN COLLEGE OF SURGEONS

A high-fat diet increases angiogenesis, solid tumor growth, and lung metastasis of CT26 colon cancer cells in obesity-resistant BALB/c mice

(2011) Heesook Park et al.   MOLECULAR CARCINOGENESIS

Bardoxolone Methyl and Kidney Function in CKD with Type 2 Diabetes

(2011) Pablo E. Pergola et al.   NEW ENGLAND JOURNAL OF MEDICINE

Body Size, Weight Change, and Risk of Colon Cancer

(2010) J. K. Bassett et al.   CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION

Elevated expression of tumor necrosis factor-α signaling molecules in colonic tumors of Zucker obese (fa/fa) rats

(2010) Swati S. Jain et al.   INTERNATIONAL JOURNAL OF CANCER

Cecal and Colonic Responses in Rats Fed 5 or 30% Corn Oil Diets Containing Either 7.5% Broccoli Dietary Fiber or Microcrystalline Cellulose

(2010) Gunaranjan Paturi et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

The Triterpenoid 2-Cyano-3,12-dioxooleana-1,9-dien-28-oic-acid Methyl Ester Has Potent Anti-diabetic Effects in Diet-induced Diabetic Mice andLeprdb/dbMice

(2010) Pradip K. Saha et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Monocyte Chemoattractant Protein-1 Contributes to Gut Homeostasis and Intestinal Inflammation by Composition of IL-10–Producing Regulatory Macrophage Subset

(2010) Yasuhiro Takada et al.   JOURNAL OF IMMUNOLOGY

The Synthetic Triterpenoid, CDDO-Me, Modulates the Proinflammatory Response to In Vivo Lipopolysaccharide Challenge

(2010) Jeffery J. Auletta et al.   JOURNAL OF INTERFERON AND CYTOKINE RESEARCH

Sustained TL1A expression modulates effector and regulatory T-cell responses and drives intestinal goblet cell hyperplasia

(2010) V Y Taraban et al.   Mucosal Immunology

Cancer Chemopreventive Activity of Maslinic Acid: Suppression of COX-2 Expression and Inhibition of NF-κB and AP-1 Activation in Raji Cells

(2010) Yap Hsum et al.   PLANTA MEDICA

High-Fat Diet: Bacteria Interactions Promote Intestinal Inflammation Which Precedes and Correlates with Obesity and Insulin Resistance in Mouse

(2010) Shengli Ding et al.   PLoS One

Impact of diet in shaping gut microbiota revealed by a comparative study in children from Europe and rural Africa

(2010) C. De Filippo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pro-inflammatory cytokines play a key role in the development of radiotherapy-induced gastrointestinal mucositis

(2010) Zhi Ong et al.   Radiation Oncology

CDDO-Me Protects against Space Radiation-Induced Transformation of Human Colon Epithelial Cells

(2010) Ugur Eskiocak et al.   RADIATION RESEARCH

Expression of COX-2, NF-κB-p65, NF-κB-p50 and IKKα in malignant and adjacent normal human colorectal tissue

(2009) M P Charalambous et al.   BRITISH JOURNAL OF CANCER

Therapeutic action and underlying mechanisms of a combination of two pentacyclic triterpenes, α- and β-amyrin, in a mouse model of colitis

(2009) CE Vitor et al.   BRITISH JOURNAL OF PHARMACOLOGY

Triterpenoids CDDO-Methyl Ester or CDDO-Ethyl Amide and Rexinoids LG100268 or NRX194204 for Prevention and Treatment of Lung Cancer in Mice

(2009) K. Liby et al.   Cancer Prevention Research

The Interaction of a High-Fat Diet and Regular Moderate Intensity Exercise on Intestinal Polyp Development in ApcMin/+ Mice

(2009) K. A. Baltgalvis et al.   Cancer Prevention Research

Suppressive effect of COX2 inhibitor on the progression of adipose inflammation in high-fat-induced obese rats

(2009) P.-S. Hsieh et al.   EUROPEAN JOURNAL OF CLINICAL INVESTIGATION

Colon cancer: preventive agents and the present status of chemoprevention

(2009) Elizabeth Half et al.   EXPERT OPINION ON PHARMACOTHERAPY

Western-Style Diets Induce Oxidative Stress and Dysregulate Immune Responses in the Colon in a Mouse Model of Sporadic Colon Cancer

(2009) Ildiko Erdelyi et al.   JOURNAL OF NUTRITION

Interplay Between Weight Loss and Gut Microbiota Composition in Overweight Adolescents

(2009) Arlette Santacruz et al.   Obesity

The role of the small intestine in the development of dietary fat-induced obesity and insulin resistance in C57BL/6J mice

(2008) Nicole JW de Wit et al.   BMC Medical Genomics

Changes in Gut Microbiota Control Metabolic Endotoxemia-Induced Inflammation in High-Fat Diet-Induced Obesity and Diabetes in Mice

(2008) P. D. Cani et al.   DIABETES

Immunomodulatory Activity of Synthetic Triterpenoids: Inhibition of Lymphocyte Proliferation, Cell-Mediated Cytotoxicity, and Cytokine Gene Expression Through Suppression of NF-κB

(2008) Xiaohua Gao et al.   IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY

Real-time PCR and DNA sequencing for detection and identification ofTrichophyton rubrumas a cause of culture negative chronic granulomatous dermatophytosis

(2008) Jean-François Durant et al.   MEDICAL MYCOLOGY

Ursolic acid: An anti- and pro-inflammatory triterpenoid

(2008) Yasutaka Ikeda et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Chemoprevention of Colon Carcinogenesis by Oleanolic Acid and Its Analog in Male F344 Rats and Modulation of COX-2 and Apoptosis in Human Colon HT-29 Cancer Cells

(2008) Naveena B. Janakiram et al.   PHARMACEUTICAL RESEARCH

Quantification of Bifidobacterium spp. and Lactobacillus spp. in rat fecal samples by real-time PCR

(2006) Jean-Marc Delroisse et al.   MICROBIOLOGICAL RESEARCH