Article
Biochemistry & Molecular Biology
Li Zhang, Ying Lan, Yan Wang, Yiying Yang, Wenzheng Han, Jingyan Li, Yutang Wang, Xuebo Liu
Summary: Secoisolariciresinol diglucoside (SDG) has a strong anti-inflammatory effect, which is partly dependent on gut microbiota. Both the single compound and extract of SDG can improve colon inflammation by ameliorating morphologic damage and enhancing intestinal barrier integrity. SDG also suppresses the expression of inflammatory cytokines in the colon, with the single compound having a stronger effect. The composition of gut microbiota and the concentration of short-chain fatty acids (SCFAs) are also affected by SDG, with the extract exhibiting a greater effect. Nutritional intervention with SDG shows promise for chronic intestinal inflammation.
Article
Pharmacology & Pharmacy
Sami A. Algaidi, Khadija A. Faddladdeen, Ghadeer I. Alrefaei, Safa H. Qahl, Emad A. Albadawi, Hailah M. ALmohaimeed, Nasra N. Ayuob
Summary: This study demonstrates that Thymoquinone (TQ) can limit the structural changes in the testis caused by hypothyroidism by upregulating SIRT1 expression, and it shows promising antioxidant, anti-inflammatory, and antiapoptotic effects. TQ is recommended as a safe adjuvant supplement for managing hypothyroidism.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Chemistry, Medicinal
Ashwag S. Alanazi, Mohammed M. Alanazi, Engy Elekhnawy, Nashwah G. M. Attallah, Walaa A. Negm, Aya H. El-Kadem
Summary: In this study, the effects of Encephalartos villosus (EV) extract on acetic acid-induced ulcerative colitis (UC) were evaluated. The results showed that EV improved UC through its antioxidative effects, modulation of pro-inflammatory cytokines, and restoration of mucosal integrity.
Article
Dentistry, Oral Surgery & Medicine
Jiahao Zeng, Ni Jia, Chunlan Ji, Sulan Zhong, Qiaoxue Chai, Chuan Zou, Lei Chen
Summary: This study aimed to evaluate the influence of experimental periodontitis on renal damage in obese rats. The results showed that periodontitis induced dysfunction and structural destruction of the kidney in obese rats, while plaque control relieved renal damage.
Review
Endocrinology & Metabolism
Yue Wu, Yunjiao Yang, Lan Wang, Yiding Chen, Xuke Han, Lisha Sun, Huizhen Chen, Qiu Chen
Summary: Osteoporosis is a bone disease characterized by low bone quality and density, causing bone fragility and vulnerability to fractures. Increased osteoclast differentiation and activity contribute to bone loss, a common manifestation of osteoporosis. The TNF-a/NF-κB inflammatory pathway plays a key role in regulating osteoclast formation, along with the classical RANKL/RANK/OPG pathway. Probiotics, particularly Bifidobacterium, have shown potential beneficial effects on bone health by modulating this pathway. This review discusses the molecular mechanisms of the TNF-a/NF-κB pathway in osteoclast formation and explores the secretions produced by Bifidobacterium, providing new directions for future research.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Patricia Garcia-Fernandez, Colette Reinhold, Nurcan Ueceyler, Claudia Sommer
Summary: Polyneuropathy (PNP) refers to diseases of the peripheral nervous system, with 50% of cases presenting with neuropathic pain. Certain types of PNP show pain restricted to the distal leg skin, indicating a local regulatory process leading to pain. This study suggests that a pro-inflammatory pathway mediated by NF-κB may contribute to pain development in patients with painful PNP. Our findings support the hypothesis of local inflammatory processes involved in pain in PNP, and suggest disrupted anti-inflammatory pathways in inflammatory PNP involving TRPV1 and SIRT1.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, Research & Experimental
Huanhuan Xu, Chunxia Gan, Zemin Xiang, Ting Xiang, Jin Li, Xueqin Huang, Xiangdong Qin, Titi Liu, Jun Sheng, Xuanjun Wang
Summary: The tumor necrosis factor alpha (TNF-a)-TNF-a receptor (TNFR) interaction is crucial in the development of autoimmune diseases like rheumatoid arthritis, making it an important target for drug discovery. This study found that (-)-Epigallocatechin-3-gallate (EGCG), a polyphenolic compound found in green tea, can bind to TNF-a, TNFR1, and TNFR2 and disrupt their interactions. This leads to inhibition of TNF-a-induced cell death and NF-kB signaling pathway, suggesting that regular consumption of EGCG in green tea could potentially be used as a therapeutic agent for TNF-a-associated diseases.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Biochemistry & Molecular Biology
Zhenzhen Yan, Jingwei Dai, Jiayue Wang, Qianxi Feng, Yaguang Wang, Tongye Han, Chen Wu
Summary: In this study, the post-translational modification of Tollip by ubiquitination was identified. Tollip interacts with RNF167 and RNF167 functions as the E3 ligase to attach poly-ubiquitin chains to Tollip. The ubiquitination of Tollip plays a crucial role in TNF-alpha signaling.
Article
Biochemistry & Molecular Biology
Zhenzhen Yan, Jingwei Dai, Jiayue Wang, Qianxi Feng, Yaguang Wang, Tongye Han, Chen Wu
Summary: In this study, ubiquitination was identified as a post-translational modification on Tollip, and RNF167 was found to be the potential E3 ligase for Tollip. Tollip's ubiquitination plays a crucial role in TNF-a signaling.
Article
Pharmacology & Pharmacy
Weiwei Yuan, Jinxi Huang, Shanshan Hou, Huahua Li, Liangyu Bie, Beibei Chen, Gaofeng Li, Yang Zhou, Xiaobing Chen
Summary: The study found that pretreatment of gastric cancer cells with triptolide can enhance its anti-tumor effect. This effect is dependent on the disruption of the H19/miR-204-5p/NF-kappa B/FLIP axis.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Immunology
Yuying Li, Huiping Qiu, Shuihong Yao, Qunfeng Li, Yuemin Ding, Yanhui Cao, Xuming Chen, Xiaoping Zhu
Summary: The study shows that Gen can promote the recovery of SCI rats, reduce inflammation, and enhance motor function and axon regeneration by inhibiting the IKKs/NF-κB signaling pathway.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Immunology
Chang-hong Li, Zhen-zhen Ma, Lei-lei Jian, Xin-yu Wang, Lin Sun, Xiang-yuan Liu, Zhong-qiang Yao, Jin-xia Zhao
Summary: Iguratimod has been shown to inhibit osteoclast formation and bone resorption by interfering with signaling pathways, preventing bone loss in animal models. It also dampened TNF-alpha-induced osteoclastogenesis and disrupted nuclear translocation, providing promising evidence for its therapeutic application against RA and bone loss prevention.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Sho Inoue, Yuki Inahashi, Makoto Itakura, Gen Inoue, Kyoko Muneshige, Tomoyasu Hirose, Masato Iwatsuki, Masashi Takaso, Masayuki Miyagi, Kentaro Uchida
Summary: This study found that Medermycin (MED) can reduce inflammatory reactions in synovial cells and inhibit the expression of proinflammatory cytokines. Further experiments demonstrated that MED can also inhibit the activation of NF?B and Akt, thereby modulating the inflammatory response. These results highlight the potential therapeutic value of MED in managing inflammatory conditions in osteoarthritis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Food Science & Technology
Rania M. Salama, Samar F. Darwish, Ismail El Shaffei, Noura F. Elmongy, Nouran M. Fahmy, Manal S. Afifi, Ghada A. Abdel-Latif
Summary: In this study, we investigated the protective effect of MFE in an AA-induced UC rat model. The results showed that MFE could alleviate UC pathology and inflammatory reactions, and increase the expression of miRNA-223. These findings suggest that MFE may be a promising protective agent for UC patients.
FOOD AND CHEMICAL TOXICOLOGY
(2022)
Article
Cell Biology
James M. Murphy, Kyuho Jeong, Donna L. Cioffi, Pamela Moore Campbell, Hanjoong Jo, Eun-Young Erin Ahn, Ssang-Taek Steve Lim
Summary: The study reveals that focal adhesion kinase (FAK) plays a crucial role in regulating sustained NF-kappa B activation in endothelial cells (ECs) stimulated by tumor necrosis factor-alpha (TNF-alpha). Inhibition of FAK disrupts the formation of TNF-alpha receptor complex-I (TNFRC-I) and diminishes recruitment of downstream proteins, leading to reduced NF-kappa B activity. Targeting FAK may hold promise for treating chronic inflammatory diseases.
Article
Oncology
Yuxin Liu, Swati Bhardwaj, Keith Sigel, John Winters, Joseph Terlizzi, Michael M. Gaisa
Summary: This study investigated the prevalence and severity of anal HPV disease among MSM LWH under the age of 35, finding a high prevalence of HPV infection and precancer but no cases of invasive anal cancer. This supports the adoption of age-based anal cancer screening for this population.
INTERNATIONAL JOURNAL OF CANCER
(2024)
Correction
Oncology
J. Gu, S. Xie, S. Wang
INTERNATIONAL JOURNAL OF CANCER
(2024)