Aβ Oligomers Dysregulate Calcium Homeostasis by Mechanosensitive Activation of AMPA and NMDA Receptors

Rationally Designed Antibodies as Research Tools to Study the Structure–Toxicity Relationship of Amyloid-β Oligomers

(2020) Ryan Limbocker et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Trodusquemine displaces protein misfolded oligomers from cell membranes and abrogates their cytotoxicity through a generic mechanism

(2020) Ryan Limbocker et al.   Communications Biology

Soluble Prion Peptide 107–120 Protects Neuroblastoma SH-SY5Y Cells against Oligomers Associated with Alzheimer’s Disease

(2020) Elham Rezvani Boroujeni et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

A rationally designed bicyclic peptide remodels Aβ42 aggregation in vitro and reduces its toxicity in a worm model of Alzheimer’s disease

(2020) Tatsuya Ikenoue et al.   Scientific Reports

Trodusquemine enhances Aβ42 aggregation but suppresses its toxicity by displacing oligomers from cell membranes

(2019) Ryan Limbocker et al.   Nature Communications

CRAC Channels And Disease – From Human CRAC Channelopathies And Animal Models To Novel Drugs

(2019) Stefan Feske   CELL CALCIUM

Cellular Prion Protein as a Receptor of Toxic Amyloid-β42 Oligomers Is Important for Alzheimer’s Disease

(2019) Yuan Zhang et al.   Frontiers in Cellular Neuroscience

Differential Interactome and Innate Immune Response Activation of Two Structurally Distinct Misfolded Protein Oligomers

(2019) Benedetta Mannini et al.   ACS Chemical Neuroscience

Stabilization and characterization of cytotoxic Aβ40 oligomers isolated from an aggregation reaction in the presence of zinc ions

(2018) Benedetta Mannini et al.   ACS Chemical Neuroscience

Calcium signaling in Alzheimer's disease & therapies

(2018) Benjamin Chun-Kit Tong et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Elucidating the Interactive Roles of Glia in Alzheimer's Disease Using Established and Newly Developed Experimental Models

(2018) Heejung Chun et al.   Frontiers in Neurology

Soluble Oligomers Require a Ganglioside to Trigger Neuronal Calcium Overload

(2017) Roberta Cascella et al.   JOURNAL OF ALZHEIMERS DISEASE

Role of Glutamate and NMDA Receptors in Alzheimer’s Disease

(2017) Rui Wang et al.   JOURNAL OF ALZHEIMERS DISEASE

Astrocyte dysfunction in Alzheimer disease

(2017) Crystal Acosta et al.   JOURNAL OF NEUROSCIENCE RESEARCH

TRPA1 channels promote astrocytic Ca2+ hyperactivity and synaptic dysfunction mediated by oligomeric forms of amyloid-β peptide

(2017) Anthony Bosson et al.   Molecular Neurodegeneration

Soluble oligomeric amyloid-β induces calcium dyshomeostasis that precedes synapse loss in the living mouse brain

(2017) Michal Arbel-Ornath et al.   Molecular Neurodegeneration

When, where and how? Focus on neuronal calcium dysfunctions in Alzheimer’s Disease

(2016) Mario Agostini et al.   CELL CALCIUM

Ginsenoside Rg1 inhibits high-voltage-activated calcium channel currents in hippocampal neurons of beta-amyloid peptide-exposed rat brain slices

(2016) Qian-kun Quan et al.   Chinese Journal of Integrative Medicine

The amyloid hypothesis of Alzheimer's disease at 25 years

(2016) Dennis J Selkoe et al.   EMBO Molecular Medicine

Local and Use-Dependent Effects of β-Amyloid Oligomers on NMDA Receptor Function Revealed by Optical Quantal Analysis

(2016) Brooke L. Sinnen et al.   JOURNAL OF NEUROSCIENCE

Dysfunction of NMDA receptors in Alzheimer’s disease

(2016) Yan Zhang et al.   NEUROLOGICAL SCIENCES

Binding affinity of amyloid oligomers to cellular membranes is a generic indicator of cellular dysfunction in protein misfolding diseases

(2016) Elisa Evangelisti et al.   Scientific Reports

The Transient Receptor Potential Melastatin 2 (TRPM2) Channel Contributes to  -Amyloid Oligomer-Related Neurotoxicity and Memory Impairment

(2015) V. G. Ostapchenko et al.   JOURNAL OF NEUROSCIENCE

Tissue-based map of the human proteome

(2015) M. Uhlen et al.   SCIENCE

Lipid Rafts Mediate Amyloid-Induced Calcium Dyshomeostasis and Oxidative Stress in Alzheimer’s Disease

(2013) Elisa Evangelisti et al.   Current Alzheimer Research

Calcium channelopathies and Alzheimer's disease: Insight into therapeutic success and failures

(2013) Shreaya Chakroborty et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Tracking pathophysiological processes in Alzheimer's disease: an updated hypothetical model of dynamic biomarkers

(2013) Clifford R Jack et al.   LANCET NEUROLOGY

Amyloid-β oligomer synaptotoxicity is mimicked by oligomers of the model protein HypF-N

(2013) Francesca Tatini et al.   NEUROBIOLOGY OF AGING

Nature of the neurotoxic membrane actions of amyloid-β on hippocampal neurons in Alzheimer's disease

(2013) Fernando J. Sepúlveda et al.   NEUROBIOLOGY OF AGING

A  induces astrocytic glutamate release, extrasynaptic NMDA receptor activation, and synaptic loss

(2013) M. Talantova et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The mitochondrial Na+/Ca2+ exchanger

(2012) Raz Palty et al.   CELL CALCIUM

CXCL12/CXCR4 Protein Signaling Axis Induces Sonic Hedgehog Expression in Pancreatic Cancer Cells via Extracellular Regulated Kinase- and Akt Kinase-mediated Activation of Nuclear Factor κB

(2012) Ajay P. Singh et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Membrane lipid composition and its physicochemical properties define cell vulnerability to aberrant protein oligomers

(2012) E. Evangelisti et al.   JOURNAL OF CELL SCIENCE

The toxic Aβ oligomer and Alzheimer's disease: an emperor in need of clothes

(2012) Iryna Benilova et al.   NATURE NEUROSCIENCE

Alzheimer amyloid-β oligomer bound to postsynaptic prion protein activates Fyn to impair neurons

(2012) Ji Won Um et al.   NATURE NEUROSCIENCE

Amyloid β peptide oligomers directly activate NMDA receptors

(2011) Laura Texidó et al.   CELL CALCIUM

Squalamine as a broad-spectrum systemic antiviral agent with therapeutic potential

(2011) M. Zasloff et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Amyloid β oligomers induce Ca2+ dysregulation and neuronal death through activation of ionotropic glutamate receptors

(2010) Elena Alberdi et al.   CELL CALCIUM

A comparison of the biochemical modifications caused by toxic and non-toxic protein oligomers in cells

(2010) Mariagioia Zampagni et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

N-Methyl-d-aspartate receptors are required for synaptic targeting of Alzheimer’s toxic amyloid-β peptide oligomers

(2010) Helena Decker et al.   JOURNAL OF NEUROCHEMISTRY

CGP-37157 Inhibits the Sarcoplasmic Reticulum Ca2+ ATPase and Activates Ryanodine Receptor Channels in Striated Muscle

(2010) J. T. Neumann et al.   MOLECULAR PHARMACOLOGY

A causative link between the structure of aberrant protein oligomers and their toxicity

(2010) Silvia Campioni et al.   Nature Chemical Biology

Early neuronal dysfunction by amyloid β oligomers depends on activation of NR2B-containing NMDA receptors

(2010) Raik Rönicke et al.   NEUROBIOLOGY OF AGING

Inhibition of Calcineurin-mediated Endocytosis and α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid (AMPA) Receptors Prevents Amyloid β Oligomer-induced Synaptic Disruption

(2009) Wei-Qin Zhao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Role for Synaptic Zinc in Activity-Dependent A  Oligomer Formation and Accumulation at Excitatory Synapses

(2009) A. Deshpande et al.   JOURNAL OF NEUROSCIENCE

Nonspecific Interaction of Prefibrillar Amyloid Aggregates with Glutamatergic Receptors Results in Ca2+Increase in Primary Neuronal Cells

(2008) Francesca Pellistri et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Vaccination with soluble Aβ oligomers generates toxicity-neutralizing antibodies

(2003) Mary P. Lambert et al.   JOURNAL OF NEUROCHEMISTRY