Mechanisms shared between cancer, heart failure, and targeted anti-cancer therapies

Cancer Incidence and Mortality According to Pre-Existing Heart Failure in a Community-Based Cohort

(2022) Edoardo Bertero et al.   JACC: CardioOncology

Mechanistic and Clinical Overview Cardiovascular Toxicity of BRAF and MEK Inhibitors

(2022) Claire Glen et al.   JACC: CardioOncology

Cardiotoxic effects of angiogenesis inhibitors

(2021) Stephen J.H. Dobbin et al.   CLINICAL SCIENCE

Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

(2021) Hyuna Sung et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Excessive O - GlcNAcylation Causes Heart Failure and Sudden Death

(2021) Priya Umapathi et al.   CIRCULATION

Canakinumab with and without pembrolizumab in patients with resectable non-small-cell lung cancer: CANOPY-N study design

(2021) Pilar Garrido et al.   Future Oncology

The role of short-chain fatty acids in intestinal barrier function, inflammation, oxidative stress, and colonic carcinogenesis

(2021) Pinyi Liu et al.   PHARMACOLOGICAL RESEARCH

New Insights Into the Cancer–Microbiome–Immune Axis: Decrypting a Decade of Discoveries

(2021) Tejeshwar Jain et al.   Frontiers in Immunology

Fat‐1 transgenic mice rich in endogenous omega‐3 fatty acids are protected from lipopolysaccharide‐induced cardiac dysfunction

(2021) Shuai Mao et al.   ESC Heart Failure

Heart Failure With Targeted Cancer Therapies

(2021) Virginia S. Hahn et al.   CIRCULATION RESEARCH

Clonal haematopoiesis of indeterminate potential: intersections between inflammation, vascular disease and heart failure

(2021) Leanne Mooney et al.   CLINICAL SCIENCE

The association between heart failure and incident cancer in women: An analysis of the Women's Health Initiative

(2021) Doug J Leedy et al.   EUROPEAN JOURNAL OF HEART FAILURE

Clonal Hematopoiesis and Risk of Progression of Heart Failure With Reduced Left Ventricular Ejection Fraction

(2021) Domingo A. Pascual-Figal et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

The microbiome and human cancer

(2021) Gregory D. Sepich-Poore et al.   SCIENCE

Succinate Anaplerosis Has an Onco-Driving Potential in Prostate Cancer Cells

(2021) Ana Carolina B. Sant’Anna-Silva et al.   Cancers

Role of microbiota-derived short-chain fatty acids in cancer development and prevention

(2021) Rasoul Mirzaei et al.   BIOMEDICINE & PHARMACOTHERAPY

Role of the CCL2‐CCR2 signalling axis in cancer: Mechanisms and therapeutic targeting

(2021) Maosen Xu et al.   CELL PROLIFERATION

Impaired intestinal function is associated with lower muscle and cognitive health and well‐being in patients with congestive heart failure

(2021) Sarah K. Kirschner et al.   JOURNAL OF PARENTERAL AND ENTERAL NUTRITION

Association of Clonal Hematopoiesis With Incident Heart Failure

(2021) Bing Yu et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Combined landscape of single-nucleotide variants and copy number alterations in clonal hematopoiesis

(2021) Ryunosuke Saiki et al.   NATURE MEDICINE

The Gut Microbiome of Heart Failure With Preserved Ejection Fraction

(2021) Anna L. Beale et al.   Journal of the American Heart Association

Anti-Inflammatory Drugs in Patients with Ischemic Heart Disease

(2021) Ana María Pello Lázaro et al.   Journal of Clinical Medicine

Heart failure is associated with an increased incidence of cancer diagnoses

(2021) Christoph Roderburg et al.   ESC Heart Failure

Evaluation of renal cancer progression in a mouse model of heart failure

(2021) Canxia Shi et al.   Cancer Communications

Belzutifan for Renal Cell Carcinoma in von Hippel–Lindau Disease

(2021) Eric Jonasch et al.   NEW ENGLAND JOURNAL OF MEDICINE

Truncated titin proteins and titin haploinsufficiency are targets for functional recovery in human cardiomyopathy due to TTN mutations

(2021) Andrey Fomin et al.   Science Translational Medicine

Clonal Hematopoiesis Is Associated With Higher Risk of Stroke

(2021) Romit Bhattacharya et al.   STROKE

Associations of plasma trimethylamine N-oxide, choline, carnitine, and betaine with inflammatory and cardiometabolic risk biomarkers and the fecal microbiome in the Multiethnic Cohort Adiposity Phenotype Study

(2020) Benjamin C Fu et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Load-independent effects of empagliflozin contribute to improved cardiac function in experimental heart failure with reduced ejection fraction

(2020) Kim A. Connelly et al.   Cardiovascular Diabetology

Fusobacterium nucleatum promotes epithelial‐mesenchymal transiton through regulation of the lncRNA MIR4435‐2HG/miR‐296‐5p/Akt2/SNAI1 signaling pathway

(2020) Shuwei Zhang et al.   FEBS Journal

Reappraising the role of inflammation in heart failure

(2020) Luigi Adamo et al.   Nature Reviews Cardiology

CCL2/CCR2 signaling in cancer pathogenesis

(2020) Qiongyu Hao et al.   Cell Communication and Signaling

Cardiotoxicity and myocardial hypoperfusion associated with anti‐vascular endothelial growth factor therapies: prospective cardiac magnetic resonance imaging in patients with cancer

(2020) Stephen J.H. Dobbin et al.   EUROPEAN JOURNAL OF HEART FAILURE

Cardiac dysfunction in cancer patients: beyond direct cardiomyocyte damage of anticancer drugs. Novel cardio-oncology insights from the joint 2019 meeting of the ESC Working Groups of Myocardial Function and Cellular Biology of the Heart

(2020) Carlo G Tocchetti et al.   CARDIOVASCULAR RESEARCH

Early Cardiac Remodeling Promotes Tumor Growth and Metastasis

(2020) Shimrit Avraham et al.   CIRCULATION

Gut Microbiota and Cardiovascular Disease

(2020) Marco Witkowski et al.   CIRCULATION RESEARCH

Myocardial infarction accelerates breast cancer via innate immune reprogramming

(2020) Graeme J. Koelwyn et al.   NATURE MEDICINE

Empagliflozin improves post-infarction cardiac remodeling through GTP enzyme cyclohydrolase 1 and irrespective of diabetes status

(2020) Maria del Carmen Asensio Lopez et al.   Scientific Reports

Redox Imbalances in Ageing and Metabolic Alterations: Implications in Cancer and Cardiac Diseases. An Overview from the Working Group of Cardiotoxicity and Cardioprotection of the Italian Society of Cardiology (SIC)

(2020) Valentina Mercurio et al.   Antioxidants

Inflammatory Cytokines and Chemokines as Therapeutic Targets in Heart Failure

(2020) Anis Hanna et al.   CARDIOVASCULAR DRUGS AND THERAPY

Effect of Empagliflozin on the Clinical Stability of Patients with Heart Failure and a Reduced Ejection Fraction: The EMPEROR-Reduced Trial

(2020) Milton Packer et al.   CIRCULATION

Colorectal Cancer, Age, and Obesity-Related Comorbidities: A Large Database Study

(2020) Abbinaya Elangovan et al.   DIGESTIVE DISEASES AND SCIENCES

Common Mechanistic Pathways in Cancer and Heart Failure

(2020) Rudolf A. Boer et al.   EUROPEAN JOURNAL OF HEART FAILURE

Inherited causes of clonal haematopoiesis in 97,691 whole genomes

(2020) Alexander G. Bick et al.   NATURE

Targeting the HIF2–VEGF axis in renal cell carcinoma

(2020) Toni K. Choueiri et al.   NATURE MEDICINE

Gut dysbiosis induced by cardiac pressure overload enhances adverse cardiac remodeling in a T cell-dependent manner

(2020) Francisco J Carrillo-Salinas et al.   Gut Microbes

Immune Checkpoint Inhibitors for the Treatment of Cancer: Clinical Impact and Mechanisms of Response and Resistance

(2020) Sreya Bagchi et al.   Annual Review of Pathology-Mechanisms of Disease

Therapeutic inhibition of HIF2α reverses polycythemia and pulmonary hypertension in murine models of two human diseases

(2020) Manik C Ghosh et al.   BLOOD

Advanced cancer is also a heart failure syndrome – an hypothesis

(2020) Markus S. Anker et al.   EUROPEAN JOURNAL OF HEART FAILURE

The Short-Chain Fatty Acid Propionate Protects from Hypertensive Cardiovascular Damage

(2019) Hendrik Bartolomaeus et al.   CIRCULATION

Anti-Inflammatory Therapy with Canakinumab for the Prevention of Hospitalization for Heart Failure

(2019) Brendan M. Everett et al.   CIRCULATION

A Proinflammatory Gut Microbiota Increases Systemic Inflammation and Accelerates Atherosclerosis

(2019) Eelke Brandsma et al.   CIRCULATION RESEARCH

Breast Cancer Treatment

(2019) Adrienne G. Waks et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Metabolism of the failing heart and the impact of SGLT2 inhibitors

(2019) Alvaro Garcia-Ropero et al.   Expert Opinion on Drug Metabolism & Toxicology

The novel butyrate derivative phenylalanine-butyramide protects from doxorubicin-induced cardiotoxicity

(2019) Michele Russo et al.   EUROPEAN JOURNAL OF HEART FAILURE

Sodium–glucose co‐transporter 2 inhibition with empagliflozin improves cardiac function in non‐diabetic rats with left ventricular dysfunction after myocardial infarction

(2019) Salva R. Yurista et al.   EUROPEAN JOURNAL OF HEART FAILURE

The transcriptional factors HIF-1 and HIF-2 and their novel inhibitors in cancer therapy

(2019) Najah Albadari et al.   Expert Opinion on Drug Discovery

Increased risk of cancer death in patients with chronic heart failure with a special reference to inflammation-A report from the CHART-2 Study

(2019) Takuya Oikawa et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Cancer and heart disease: associations and relations

(2019) Rudolf A. Boer et al.   EUROPEAN JOURNAL OF HEART FAILURE

Trends in modes of death in heart failure over the last two decades: less sudden death but cancer deaths on the rise

(2019) Pedro Moliner et al.   EUROPEAN JOURNAL OF HEART FAILURE

CXCL13/CXCR5 signaling axis in cancer

(2019) Muzammal Hussain et al.   LIFE SCIENCES

The relation between systemic inflammation and incident cancer in patients with stable cardiovascular disease: a cohort study

(2019) Cilie C van’t Klooster et al.   EUROPEAN HEART JOURNAL

Changes in Gut Microbiome Structure and Function of Rats with Isoproterenol-Induced Heart Failure

(2019) Ancai Zheng et al.   International Heart Journal

Dapagliflozin in Patients with Heart Failure and Reduced Ejection Fraction

(2019) John J.V. McMurray et al.   NEW ENGLAND JOURNAL OF MEDICINE

The SGLT2 Inhibitor Canagliflozin Prevents Carcinogenesis in a Mouse Model of Diabetes and Non-Alcoholic Steatohepatitis-Related Hepatocarcinogenesis: Association with SGLT2 Expression in Hepatocellular Carcinoma

(2019) Teruo Jojima et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Noncardiac Versus Cardiac Mortality in Heart Failure With Preserved, Midrange, and Reduced Ejection Fraction

(2019) Giuseppe Vergaro et al.   Journal of the American Heart Association

Gut microbiota from colorectal cancer patients enhances the progression of intestinal adenoma in Apcmin/+ mice

(2019) Lu Li et al.   EBioMedicine

Profiling of the plasma proteome across different stages of human heart failure

(2019) Anna Egerstedt et al.   Nature Communications

Characterization of a mouse model of obesity-related fibrotic cardiomyopathy that recapitulates features of human Heart Failure with Preserved Ejection Fraction

(2018) Linda Alex et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

The Failing Heart Stimulates Tumor Growth by Circulating Factors

(2018) Wouter C. Meijers et al.   CIRCULATION

CRISPR-Mediated Gene Editing to Assess the Roles of Tet2 and Dnmt3a in Clonal Hematopoiesis and Cardiovascular DiseaseNovelty and Significance

(2018) Soichi Sano et al.   CIRCULATION RESEARCH

Gut Microbiota Signature in Heart Failure Defined From Profiling of 2 Independent Cohorts

(2018) Martin Kummen et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Tet2-Mediated Clonal Hematopoiesis Accelerates Heart Failure Through a Mechanism Involving the IL-1β/NLRP3 Inflammasome

(2018) Soichi Sano et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Myocarditis in Patients Treated With Immune Checkpoint Inhibitors

(2018) Syed S. Mahmood et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Increased reporting of fatal immune checkpoint inhibitor-associated myocarditis

(2018) Javid J Moslehi et al.   LANCET

Metabolic remodelling in heart failure

(2018) Edoardo Bertero et al.   Nature Reviews Cardiology

Combined BRAF, EGFR, and MEK Inhibition in Patients with BRAF V600E -Mutant Colorectal Cancer

(2018) Ryan B. Corcoran et al.   Cancer Discovery

Canagliflozin, an SGLT2 inhibitor, attenuates the development of hepatocellular carcinoma in a mouse model of human NASH

(2018) Kumiko Shiba et al.   Scientific Reports

The Association of Obesity and Cardiometabolic Traits With Incident HFpEF and HFrEF

(2018) Nazir Savji et al.   JACC-Heart Failure

Carfilzomib-Associated Cardiovascular Adverse Events

(2018) Adam J. Waxman et al.   JAMA Oncology

Linking Heart Failure to Cancer

(2018) Edoardo Bertero et al.   CIRCULATION

Gut microbe-derived metabolite trimethylamine N-oxide induces cardiac hypertrophy and fibrosis

(2018) Zehua Li et al.   LABORATORY INVESTIGATION

Environment dominates over host genetics in shaping human gut microbiota

(2018) Daphna Rothschild et al.   NATURE

Sodium butyrate induces autophagy in colorectal cancer cells through LKB1/AMPK signaling

(2018) Shunli Luo et al.   JOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY

Dietary metabolism, the gut microbiome, and heart failure

(2018) W. H. Wilson Tang et al.   Nature Reviews Cardiology

Association of Obesity With Risk of Early-Onset Colorectal Cancer Among Women

(2018) Po-Hong Liu et al.   JAMA Oncology

Association of Mutations Contributing to Clonal Hematopoiesis With Prognosis in Chronic Ischemic Heart Failure

(2018) Lena Dorsheimer et al.   JAMA Cardiology

Myocardial infarction and future risk of cancer in the general population—the Tromsø Study

(2017) Ludvig B. Rinde et al.   EUROPEAN JOURNAL OF EPIDEMIOLOGY

Gavage of Fecal Samples From Patients With Colorectal Cancer Promotes Intestinal Carcinogenesis in Germ-Free and Conventional Mice

(2017) Sunny H. Wong et al.   GASTROENTEROLOGY

Sodium glucose cotransporter 2 inhibitor canagliflozin attenuates liver cancer cell growth and angiogenic activity by inhibiting glucose uptake

(2017) Kosuke Kaji et al.   INTERNATIONAL JOURNAL OF CANCER

Sodium Butyrate Protects ­Against High Fat Diet-Induced Cardiac Dysfunction and Metabolic Disorders in Type II Diabetic Mice

(2017) Ling Zhang et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Trimethylamine-N-oxide and Heart Failure With Reduced Versus Preserved Ejection Fraction

(2017) Katharina Schuett et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Effect of interleukin-1β inhibition with canakinumab on incident lung cancer in patients with atherosclerosis: exploratory results from a randomised, double-blind, placebo-controlled trial

(2017) Paul M Ridker et al.   LANCET

Antiinflammatory Therapy with Canakinumab for Atherosclerotic Disease

(2017) Paul M Ridker et al.   NEW ENGLAND JOURNAL OF MEDICINE

Cancer-induced cardiac cachexia: Pathogenesis and impact of physical activity

(2017) Yassine Belloum et al.   ONCOLOGY REPORTS

The gut microbiome in atherosclerotic cardiovascular disease

(2017) Zhuye Jie et al.   Nature Communications

Gut‐Derived Serum Lipopolysaccharide is Associated With Enhanced Risk of Major Adverse Cardiovascular Events in Atrial Fibrillation: Effect of Adherence to Mediterranean Diet

(2017) Daniele Pastori et al.   Journal of the American Heart Association

Statin therapy causes gut dysbiosis in mice through a PXR-dependent mechanism

(2017) Jose A. Caparrós-Martín et al.   Microbiome

Obesity, Inflammation, and Cancer

(2016) Tuo Deng et al.   Annual Review of Pathology-Mechanisms of Disease

ErbB2 signaling at the crossing between heart failure and cancer

(2016) Zarha Vermeulen et al.   BASIC RESEARCH IN CARDIOLOGY

Molecular Mechanisms of the Cardiotoxicity of the Proteasomal-Targeted Drugs Bortezomib and Carfilzomib

(2016) Brian B. Hasinoff et al.   Cardiovascular Toxicology

Evidence for Intramyocardial Disruption of Lipid Metabolism and Increased Myocardial Ketone Utilization in Advanced Human Heart Failure

(2016) Kenneth C. Bedi et al.   CIRCULATION

The Failing Heart Relies on Ketone Bodies as a Fuel

(2016) Gregory Aubert et al.   CIRCULATION

Body Mass Index, Abdominal Fatness, and Heart Failure Incidence and MortalityCLINICAL PERSPECTIVE

(2016) Dagfinn Aune et al.   CIRCULATION

Myocardial VHL-HIF Signaling Controls an Embryonic Metabolic Switch Essential for Cardiac Maturation

(2016) Ivan Menendez-Montes et al.   DEVELOPMENTAL CELL

Incidence of cancer in patients with chronic heart failure: a long-term follow-up study

(2016) Ann Banke et al.   EUROPEAN JOURNAL OF HEART FAILURE

TrimethylamineN-oxide and prognosis in acute heart failure

(2016) Toru Suzuki et al.   HEART

Models of Heart Failure Based on the Cardiotoxicity of Anticancer Drugs

(2016) Valentina Mercurio et al.   JOURNAL OF CARDIAC FAILURE

Cardiovascular Disease Among Survivors of Adult-Onset Cancer: A Community-Based Retrospective Cohort Study

(2016) Saro H. Armenian et al.   JOURNAL OF CLINICAL ONCOLOGY

Cardenolides from Calotropis gigantea as potent inhibitors of hypoxia-inducible factor-1 transcriptional activity

(2016) Supawadee Parhira et al.   JOURNAL OF ETHNOPHARMACOLOGY

Heart Failure After Myocardial Infarction Is Associated With Increased Risk of Cancer

(2016) Tal Hasin et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Dabrafenib plus trametinib in patients with previously treated BRAF V600E -mutant metastatic non-small cell lung cancer: an open-label, multicentre phase 2 trial

(2016) David Planchard et al.   LANCET ONCOLOGY

Trastuzumab, but Not Pertuzumab, Dysregulates HER2 Signaling to Mediate Inhibition of Autophagy and Increase in Reactive Oxygen Species Production in Human Cardiomyocytes

(2016) Nishant Mohan et al.   MOLECULAR CANCER THERAPEUTICS

Blocking the CCL2–CCR2 Axis Using CCL2-Neutralizing Antibody Is an Effective Therapy for Hepatocellular Cancer in a Mouse Model

(2016) Kun-Yu Teng et al.   MOLECULAR CANCER THERAPEUTICS

Mechanisms and regulation of endothelial VEGF receptor signalling

(2016) Michael Simons et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Body Fatness and Cancer — Viewpoint of the IARC Working Group

(2016) Béatrice Lauby-Secretan et al.   NEW ENGLAND JOURNAL OF MEDICINE

Oncometabolite d-2-hydroxyglutarate impairs α-ketoglutarate dehydrogenase and contractile function in rodent heart

(2016) Anja Karlstaedt et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Population-based metagenomics analysis reveals markers for gut microbiome composition and diversity

(2016) Alexandra Zhernakova et al.   SCIENCE

Breast Cancer-Derived Lung Metastases Show Increased Pyruvate Carboxylase-Dependent Anaplerosis

(2016) Stefan Christen et al.   Cell Reports

Obesity and Subtypes of Incident Cardiovascular Disease

(2016) Chiadi E. Ndumele et al.   Journal of the American Heart Association

Pathogenic Gut Flora in Patients With Chronic Heart Failure

(2016) Evasio Pasini et al.   JACC-Heart Failure

Fundamentals of cancer metabolism

(2016) R. J. DeBerardinis et al.   Science Advances

Cardiotoxicity associated with CTLA4 and PD1 blocking immunotherapy

(2016) Lucie Heinzerling et al.   Journal for ImmunoTherapy of Cancer

Mucosal adherent bacterial dysbiosis in patients with colorectal adenomas

(2016) Yingying Lu et al.   Scientific Reports

NMR (1H and 13C) based signatures of abnormal choline metabolism in oral squamous cell carcinoma with no prominent Warburg effect

(2015) Swarnendu Bag et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

PI3K/Akt signaling mediated Hexokinase-2 expression inhibits cell apoptosis and promotes tumor growth in pediatric osteosarcoma

(2015) Baobiao Zhuo et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Supporting Aspartate Biosynthesis Is an Essential Function of Respiration in Proliferating Cells

(2015) Lucas B. Sullivan et al.   CELL

Genomic Classification of Cutaneous Melanoma

(2015) Rehan Akbani et al.   CELL

Congestive heart failure with vascular endothelial growth factor receptor tyrosine kinase inhibitors

(2015) Pooja Ghatalia et al.   CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY

Cardiac LXR  protects against pathological cardiac hypertrophy and dysfunction by enhancing glucose uptake and utilization

(2015) M. V. Cannon et al.   EMBO Molecular Medicine

Metabolomic analysis of prostate cancer risk in a prospective cohort: The alpha-tocopherol, beta-carotene cancer prevention (ATBC) study

(2015) Alison M. Mondul et al.   INTERNATIONAL JOURNAL OF CANCER

Genetically induced moderate inhibition of 20S proteasomes in cardiomyocytes facilitates heart failure in mice during systolic overload

(2015) Mark J. Ranek et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Global burden of cancer attributable to high body-mass index in 2012: a population-based study

(2015) Melina Arnold et al.   LANCET ONCOLOGY

The Histone Methyltransferase Inhibitor BIX01294 Inhibits HIF-1α Stability and Angiogenesis

(2015) Su Young Oh et al.   MOLECULES AND CELLS

Obesity and Diabetes: The Increased Risk of Cancer and Cancer-Related Mortality

(2015) Emily Jane Gallagher et al.   PHYSIOLOGICAL REVIEWS

Functional expression of sodium-glucose transporters in cancer

(2015) Claudio Scafoglio et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The future of immune checkpoint therapy

(2015) P. Sharma et al.   SCIENCE

The Genomic Landscape of Renal Oncocytoma Identifies a Metabolic Barrier to Tumorigenesis

(2015) Shilpy Joshi et al.   Cell Reports

Hypertension Due to Antiangiogenic Cancer Therapy With Vascular Endothelial Growth Factor Inhibitors: Understanding and Managing a New Syndrome

(2014) Heather Yvonne Small et al.   CANADIAN JOURNAL OF CARDIOLOGY

Plasma Choline Metabolites and Colorectal Cancer Risk in the Women's Health Initiative Observational Study

(2014) S. Bae et al.   CANCER RESEARCH

The Bacteroides fragilis Toxin Gene Is Prevalent in the Colon Mucosa of Colorectal Cancer Patients

(2014) Annemarie Boleij et al.   CLINICAL INFECTIOUS DISEASES

Risk of coronary artery disease in patients with systemic sclerosis: a systematic review and meta-analysis

(2014) Patompong Ungprasert et al.   CLINICAL RHEUMATOLOGY

D-2-hydroxyglutarate produced by mutant IDH2 causes cardiomyopathy and neurodegeneration in mice

(2014) E. A. Akbay et al.   GENES & DEVELOPMENT

Macrophages, Immunity, and Metabolic Disease

(2014) Joanne C. McNelis et al.   IMMUNITY

Adipose tissue-resident regulatory T cells: phenotypic specialization, functions and therapeutic potential

(2014) Daniela Cipolletta   IMMUNOLOGY

Microbiota-dependent metabolite trimethylamine-N-oxide is associated with disease severity and survival of patients with chronic heart failure

(2014) M. Trøseid et al.   JOURNAL OF INTERNAL MEDICINE

Prognostic Value of Elevated Levels of Intestinal Microbe-Generated Metabolite Trimethylamine-N-Oxide in Patients With Heart Failure

(2014) W.H. Wilson Tang et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

CXCL13-CXCR5 axis promotes the growth and invasion of colon cancer cells via PI3K/AKT pathway

(2014) Zhenyu Zhu et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Age-Related Clonal Hematopoiesis Associated with Adverse Outcomes

(2014) Siddhartha Jaiswal et al.   NEW ENGLAND JOURNAL OF MEDICINE

Incidence and Risk of Cardiotoxicity Associated with Bortezomib in the Treatment of Cancer: A Systematic Review and Meta-Analysis

(2014) Yi Xiao et al.   PLoS One

Chronic Inflammation and Cytokines in the Tumor Microenvironment

(2014) Glauben Landskron et al.   Journal of Immunology Research

Adipokines as mediators of endothelial function and atherosclerosis

(2013) George Ntaios et al.   ATHEROSCLEROSIS

Carfilzomib

(2013) K. M. Kortuem et al.   BLOOD

PKM2 Isoform-Specific Deletion Reveals a Differential Requirement for Pyruvate Kinase in Tumor Cells

(2013) William J. Israelsen et al.   CELL

Cardiac Metabolism in Heart Failure

(2013) Torsten Doenst et al.   CIRCULATION RESEARCH

Ketogenic Diets Enhance Oxidative Stress and Radio-Chemo-Therapy Responses in Lung Cancer Xenografts

(2013) B. G. Allen et al.   CLINICAL CANCER RESEARCH

Butyrate and Colorectal Cancer: The Role of Butyrate Transport

(2013) Pedro Gonçalves et al.   CURRENT DRUG METABOLISM

Glutamine and cancer: cell biology, physiology, and clinical opportunities

(2013) Christopher T. Hensley et al.   JOURNAL OF CLINICAL INVESTIGATION

Patients With Heart Failure Have an Increased Risk of Incident Cancer

(2013) Tal Hasin et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Human Gut Microbiome and Risk for Colorectal Cancer

(2013) Jiyoung Ahn et al.   JNCI-Journal of the National Cancer Institute

Dysbiosis Signature of Fecal Microbiota in Colorectal Cancer Patients

(2013) Na Wu et al.   MICROBIAL ECOLOGY

Intestinal microbiota metabolism of l-carnitine, a nutrient in red meat, promotes atherosclerosis

(2013) Robert A Koeth et al.   NATURE MEDICINE

Proteotoxicity and Cardiac Dysfunction — Alzheimer's Disease of the Heart?

(2013) Monte S. Willis et al.   NEW ENGLAND JOURNAL OF MEDICINE

Recurrent Exposure to Subclinical Lipopolysaccharide Increases Mortality and Induces Cardiac Fibrosis in Mice

(2013) Wilbur Y. W. Lew et al.   PLoS One

Olfactory receptor responding to gut microbiota-derived signals plays a role in renin secretion and blood pressure regulation

(2013) Jennifer L. Pluznick et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Tumour-associated mutant p53 drives the Warburg effect

(2013) Cen Zhang et al.   Nature Communications

Oncogenic Kras Maintains Pancreatic Tumors through Regulation of Anabolic Glucose Metabolism

(2012) Haoqiang Ying et al.   CELL

Cardiac-Specific Deletion of Acetyl CoA Carboxylase 2 Prevents Metabolic Remodeling During Pressure-Overload Hypertrophy

(2012) Stephen C. Kolwicz et al.   CIRCULATION RESEARCH

Macrophages in Tumor Microenvironments and the Progression of Tumors

(2012) Ning-Bo Hao et al.   Clinical & Developmental Immunology

Epidemiology of Viral Hepatitis and Hepatocellular Carcinoma

(2012) Hashem B. El-Serag   GASTROENTEROLOGY

Metabolic effects of glutamine on the heart: Anaplerosis versus the hexosamine biosynthetic pathway

(2012) Benjamin Lauzier et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Risk of Heart Failure in Breast Cancer Patients After Anthracycline and Trastuzumab Treatment: A Retrospective Cohort Study

(2012) E. J. A. Bowles et al.   JNCI-Journal of the National Cancer Institute

Adipose tissue inflammation in diabetes and heart failure

(2012) Ippei Shimizu et al.   MICROBES AND INFECTION

The Warburg Effect Dictates the Mechanism of Butyrate-Mediated Histone Acetylation and Cell Proliferation

(2012) Dallas R. Donohoe et al.   MOLECULAR CELL

Cancer-Associated Adipocytes Exhibit an Activated Phenotype and Contribute to Breast Cancer Invasion

(2011) B. Dirat et al.   CANCER RESEARCH

Structural segregation of gut microbiota between colorectal cancer patients and healthy volunteers

(2011) Tingting Wang et al.   ISME Journal

Mild hypoxia-induced cardiomyocyte hypertrophy via up-regulation of HIF-1α-mediated TRPC signalling

(2011) Wenfeng Chu et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Reductive glutamine metabolism by IDH1 mediates lipogenesis under hypoxia

(2011) Christian M. Metallo et al.   NATURE

Resistance to BRAF Inhibition in Melanomas

(2011) David B. Solit et al.   NEW ENGLAND JOURNAL OF MEDICINE

Biology of Human Sodium Glucose Transporters

(2011) Ernest M. Wright et al.   PHYSIOLOGICAL REVIEWS

Hypoxia promotes isocitrate dehydrogenase-dependent carboxylation of  -ketoglutarate to citrate to support cell growth and viability

(2011) D. R. Wise et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Eosinophils Sustain Adipose Alternatively Activated Macrophages Associated with Glucose Homeostasis

(2011) D. Wu et al.   SCIENCE

Role of adipokines in obesity-associated hypertension

(2010) M. Vlasova et al.   Acta Physiologica

Cancer Causes Cardiac Atrophy and Autophagy in a Sexually Dimorphic Manner

(2010) P. F. Cosper et al.   CANCER RESEARCH

Risk of cardiac dysfunction with trastuzumab in breast cancer patients: A meta-analysis

(2010) Tao Chen et al.   CANCER TREATMENT REVIEWS

Ketones and lactate “fuel” tumor growth and metastasis

(2010) Gloria Bonuccelli et al.   CELL CYCLE

Ubiquitin Proteasome Dysfunction in Human Hypertrophic and Dilated Cardiomyopathies

(2010) Jaime M. Predmore et al.   CIRCULATION

Analysis of Metabolic Remodeling in Compensated Left Ventricular Hypertrophy and Heart Failure

(2010) Takao Kato et al.   Circulation-Heart Failure

Interleukin-6 promotes tumorigenesis by altering DNA methylation in oral cancer cells

(2010) Jacqueline A. Gasche et al.   INTERNATIONAL JOURNAL OF CANCER

Deregulation of HIF1-alpha and hypoxia-regulated pathways in hepatocellular carcinoma and corresponding non-malignant liver tissue—influence of a modulated host stroma on the prognosis of HCC

(2010) Frank Simon et al.   LANGENBECKS ARCHIVES OF SURGERY

Mitogen-Activated Protein Kinase Signaling in the Heart: Angels Versus Demons in a Heart-Breaking Tale

(2010) Beth A. Rose et al.   PHYSIOLOGICAL REVIEWS

Mitochondrial metabolism and ROS generation are essential for Kras-mediated tumorigenicity

(2010) F. Weinberg et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Macrophage-modulating cytokines predict adverse outcome in heart failure

(2010) Philipp Hohensinner et al.   THROMBOSIS AND HAEMOSTASIS

Decreased rates of substrate oxidation ex vivo predict the onset of heart failure and contractile dysfunction in rats with pressure overload

(2009) T. Doenst et al.   CARDIOVASCULAR RESEARCH

Activation of a HIF1α-PPARγ Axis Underlies the Integration of Glycolytic and Lipid Anabolic Pathways in Pathologic Cardiac Hypertrophy

(2009) Jaya Krishnan et al.   Cell Metabolism

HIF-1: upstream and downstream of cancer metabolism

(2009) Gregg L Semenza   CURRENT OPINION IN GENETICS & DEVELOPMENT

Helicobacter pylori in Health and Disease

(2009) Timothy L. Cover et al.   GASTROENTEROLOGY

Cachexia: A new definition

(2008) William J. Evans et al.   CLINICAL NUTRITION

Microbes in Gastrointestinal Health and Disease

(2008) Andrew S. Neish   GASTROENTEROLOGY

Transketolase-like protein 1 (TKTL1) is required for rapid cell growth and full viability of human tumor cells

(2008) Xiaojun Xu et al.   INTERNATIONAL JOURNAL OF CANCER

Blockade of the erbB2 Receptor Induces Cardiomyocyte Death through Mitochondrial and Reactive Oxygen Species-dependent Pathways

(2008) Leo I. Gordon et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Hypoxia-Inducible Factor-Dependent Degeneration, Failure, and Malignant Transformation of the Heart in the Absence of the von Hippel-Lindau Protein

(2008) L. Lei et al.   MOLECULAR AND CELLULAR BIOLOGY

A core gut microbiome in obese and lean twins

(2008) Peter J. Turnbaugh et al.   NATURE