标题
Pharmacological inhibition of LSD1 for the treatment of MLL-rearranged leukemia
作者
关键词
MLL-rearranged leukemia, Lysine-specific demethylase 1, Enzyme inhibitor, Drug discovery, Leukemia therapeutics
出版物
Journal of Hematology & Oncology
Volume 9, Issue 1, Pages -
出版商
Springer Nature
发表日期
2016-03-12
DOI
10.1186/s13045-016-0252-7
参考文献
相关参考文献
注意：仅列出部分参考文献，下载原文获取全部文献信息。- Chromosomal rearrangement involving 11q23 locus in chronic myelogenous leukemia: a rare phenomenon frequently associated with disease progression and poor prognosis
- (2015) Wei Wang et al. Journal of Hematology & Oncology
- High expression of myocyte enhancer factor 2C (MEF2C) is associated with adverse-risk features and poor outcome in pediatric acute myeloid leukemia: a report from the Children’s Oncology Group
- (2015) George S. Laszlo et al. Journal of Hematology & Oncology
- A Selective Phenelzine Analogue Inhibitor of Histone Demethylase LSD1
- (2014) Polina Prusevich et al. ACS Chemical Biology
- Strategies for modern biomarker and drug development in oncology
- (2014) Alan D Smith et al. Journal of Hematology & Oncology
- Highly effective combination of LSD1 (KDM1A) antagonist and pan-histone deacetylase inhibitor against human AML cells
- (2014) W Fiskus et al. LEUKEMIA
- DOT1L Inhibition Sensitizes MLL-Rearranged AML to Chemotherapy
- (2014) Wei Liu et al. PLoS One
- Potent inhibition of DOT1L as treatment of MLL-fusion leukemia
- (2013) S. R. Daigle et al. BLOOD
- Triazole–Dithiocarbamate Based Selective Lysine Specific Demethylase 1 (LSD1) Inactivators Inhibit Gastric Cancer Cell Growth, Invasion, and Migration
- (2013) Yi-Chao Zheng et al. JOURNAL OF MEDICINAL CHEMISTRY
- High-Throughput Virtual Screening Identifies Novel N′-(1-Phenylethylidene)-benzohydrazides as Potent, Specific, and Reversible LSD1 Inhibitors
- (2013) Venkataswamy Sorna et al. JOURNAL OF MEDICINAL CHEMISTRY
- A Novel Application of Furazolidone: Anti-Leukemic Activity in Acute Myeloid Leukemia
- (2013) Xueqing Jiang et al. PLoS One
- Synthesis, activity and metabolic stability of non-ribose containing inhibitors of histone methyltransferase DOT1L
- (2013) Lisheng Deng et al. MedChemComm
- Histone demethylase Lsd1 represses hematopoietic stem and progenitor cell signatures during blood cell maturation
- (2013) Marc A Kerenyi et al. eLife
- The Histone Demethylase KDM1A Sustains the Oncogenic Potential of MLL-AF9 Leukemia Stem Cells
- (2012) William J. Harris et al. CANCER CELL
- Conformational Adaptation Drives Potent, Selective and Durable Inhibition of the Human Protein Methyltransferase DOT1L
- (2012) Aravind Basavapathruni et al. Chemical Biology & Drug Design
- LSD1 inhibition: a therapeutic strategy in cancer?
- (2012) James T Lynch et al. EXPERT OPINION ON THERAPEUTIC TARGETS
- Synthesis and Structure–Activity Relationship Investigation of Adenosine-Containing Inhibitors of Histone Methyltransferase DOT1L
- (2012) Justin L. Anglin et al. JOURNAL OF MEDICINAL CHEMISTRY
- Lysine-specific demethylase 1 restricts hematopoietic progenitor proliferation and is essential for terminal differentiation
- (2012) A Sprüssel et al. LEUKEMIA
- Catalytic site remodelling of the DOT1L methyltransferase by selective inhibitors
- (2012) Wenyu Yu et al. Nature Communications
- Brain-Penetrant LSD1 Inhibitors Can Block Memory Consolidation
- (2011) Ramesh Neelamegam et al. ACS Chemical Neuroscience
- Selective Killing of Mixed Lineage Leukemia Cells by a Potent Small-Molecule DOT1L Inhibitor
- (2011) Scott R. Daigle et al. CANCER CELL
- Lysine Demethylases Inhibitors
- (2011) Takayoshi Suzuki et al. JOURNAL OF MEDICINAL CHEMISTRY
- Selective Inhibitors of Histone Methyltransferase DOT1L: Design, Synthesis, and Crystallographic Studies
- (2011) Yuan Yao et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- MLL-AF9-Induced Leukemogenesis Requires Coexpression of the Wild-Type Mll Allele
- (2010) Austin T. Thiel et al. CANCER CELL
- (Bis)urea and (Bis)thiourea Inhibitors of Lysine-Specific Demethylase 1 as Epigenetic Modulators
- (2010) Shiv K. Sharma et al. JOURNAL OF MEDICINAL CHEMISTRY
- Biochemical, Structural, and Biological Evaluation of Tranylcypromine Derivatives as Inhibitors of Histone Demethylases LSD1 and LSD2
- (2010) Claudia Binda et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Lysine-Specific Demethylase 1 Is Strongly Expressed in Poorly Differentiated Neuroblastoma: Implications for Therapy
- (2009) J. H. Schulte et al. CANCER RESEARCH
- Lysine-specific demethylase 1 (LSD1) is highly expressed in ER-negative breast cancers and a biomarker predicting aggressive biology
- (2009) Soyoung Lim et al. CARCINOGENESIS
- H3K79 Methylation Profiles Define Murine and Human MLL-AF4 Leukemias
- (2008) Andrei V. Krivtsov et al. CANCER CELL
- Targeting the leukemic stem cell: the Holy Grail of leukemia therapy
- (2008) N Misaghian et al. LEUKEMIA
- The lysine demethylase LSD1 (KDM1) is required for maintenance of global DNA methylation
- (2008) Jing Wang et al. NATURE GENETICS
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