Rheb1 promotes tumor progression through mTORC1 in MLL-AF9-initiated murine acute myeloid leukemia

Cancer stem cells in basic science and in translational oncology: can we translate into clinical application?

(2015) Axel Schulenburg et al.   Journal of Hematology & Oncology

Current treatment strategies for inhibiting mTOR in cancer

(2015) Francesca Chiarini et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Identification of a novel MTOR activator and discovery of a competing endogenous RNA regulating autophagy in vascular endothelial cells

(2014) Di Ge et al.   Autophagy

CD44 standard and CD44v10 isoform expression on leukemia cells distinctly influences niche embedding of hematopoietic stem cells

(2014) Ulrike Erb et al.   Journal of Hematology & Oncology

Notch1-induced T cell leukemia can be potentiated by microenvironmental cues in the spleen

(2014) Shihui Ma et al.   Journal of Hematology & Oncology

Two Faces of TGF-Beta1 in Breast Cancer

(2014) Joanna Magdalena Zarzynska   MEDIATORS OF INFLAMMATION

Discovery and saturation analysis of cancer genes across 21 tumour types

(2014) Michael S. Lawrence et al.   NATURE

Anticancer effects of lactoferrin: underlying mechanisms and future trends in cancer therapy

(2014) Yunlei Zhang et al.   NUTRITION REVIEWS

C/EBPα is an essential collaborator in Hoxa9/Meis1-mediated leukemogenesis

(2014) Cailin Collins et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

mTOR Signaling in Growth Control and Disease

(2012) Mathieu Laplante et al.   CELL

mTORC1 is essential for leukemia propagation but not stem cell self-renewal

(2012) Takayuki Hoshii et al.   JOURNAL OF CLINICAL INVESTIGATION

Leukemia Gene Atlas – A Public Platform for Integrative Exploration of Genome-Wide Molecular Data

(2012) Katja Hebestreit et al.   PLoS One

Rheb1 Is Required for mTORC1 and Myelination in Postnatal Brain Development

(2011) Jia Zou et al.   DEVELOPMENTAL CELL

Non-canonical functions of the tuberous sclerosis complex-Rheb signalling axis

(2011) Nicole A. Neuman et al.   EMBO Molecular Medicine

Obesity, inflammation, and liver cancer

(2011) Beicheng Sun et al.   JOURNAL OF HEPATOLOGY

Rheb Is Essential for Murine Development

(2011) S. M. I. Goorden et al.   MOLECULAR AND CELLULAR BIOLOGY

mTOR couples cellular nutrient sensing to organismal metabolic homeostasis

(2011) Jessica J. Howell et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Inhibition of MEK/ERK signaling induces apoptosis of acute myelogenous leukemia cells via inhibition of eukaryotic initiation factor 4E-binding protein 1 and down-regulation of Mcl-1

(2010) Chie Nishioka et al.   APOPTOSIS

Ras homologue enriched in brain is a critical target of farnesyltransferase inhibitors in non-small cell lung cancer cells

(2010) Hang Zheng et al.   CANCER LETTERS

Protective roles of matrix metalloproteinases: From mouse models to human cancer

(2010) Carlos López-Otín et al.   CELL CYCLE

Rheb activates AMPK and reduces p27Kip1 levels in Tsc2-null cells via mTORC1-independent mechanisms: implications for cell proliferation and tumorigenesis

(2010) M D Lacher et al.   ONCOGENE

The Wnt/ -Catenin Pathway Is Required for the Development of Leukemia Stem Cells in AML

(2010) Y. Wang et al.   SCIENCE

Spectrum of Phosphatidylinositol 3-Kinase Pathway Gene Alterations in Bladder Cancer

(2009) F. M. Platt et al.   CLINICAL CANCER RESEARCH

Molecular mechanisms of mTOR-mediated translational control

(2009) Xiaoju Max Ma et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

HOXA9 is required for survival in human MLL-rearranged acute leukemias

(2008) J. Faber et al.   BLOOD

Functional proteomic profiling of AML predicts response and survival

(2008) S. M. Kornblau et al.   BLOOD

Stem cell concepts renew cancer research

(2008) J. E. Dick   BLOOD

Tumorigenic activity and therapeutic inhibition of Rheb GTPase

(2008) K. J. Mavrakis et al.   GENES & DEVELOPMENT

TSC–mTOR maintains quiescence and function of hematopoietic stem cells by repressing mitochondrial biogenesis and reactive oxygen species

(2008) Chong Chen et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Contributions of the Raf/MEK/ERK, PI3K/PTEN/Akt/mTOR and Jak/STAT pathways to leukemia

(2008) L S Steelman et al.   LEUKEMIA

RHEB expression in fibroadenomas of the breast

(2008) Minseob Eom et al.   PATHOLOGY INTERNATIONAL

The BCL-2 protein family: opposing activities that mediate cell death

(2007) Richard J. Youle et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY