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Rheb Is Essential for Murine Development

MOLECULAR AND CELLULAR BIOLOGY (2011)

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MOLECULAR AND CELLULAR BIOLOGY
卷 31, 期 8, 页码 1672-1678

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AMER SOC MICROBIOLOGY
DOI: 10.1128/MCB.00985-10

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Biochemistry & Molecular Biology Cell Biology

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  1. Netherlands Organization for Scientific Research

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Ras homolog enriched in brain (Rheb) couples growth factor signaling to activation of the target of rapamycin complex 1 (TORC1). To study its role in mammals, we generated a Rheb knockout mouse. In contrast to mTOR or regulatory-associated protein of mTOR (Raptor) mutants, the inner cell mass of Rheb(-/-) embryos differentiated normally. Nevertheless, Rheb(-/-) embryos died around midgestation, most likely due to impaired development of the cardiovascular system. Rheb(-/-) embryonic fibroblasts showed decreased TORC1 activity, were smaller, and showed impaired proliferation. Rheb heterozygosity extended the life span of tuberous sclerosis complex 1-deficient (Tsc1(-/-)) embryos, indicating that there is a genetic interaction between the Tsc1 and Rheb genes in mouse.

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