Sex hormone binding globulin as a potential drug candidate for liver-related metabolic disorders treatment

Role of PAI-1 in hepatic steatosis and dyslipidemia

(2021) Joshua A. Levine et al.   Scientific Reports

The Role of Hepatic Fat Accumulation in Glucose and Insulin Homeostasis—Dysregulation by the Liver

(2021) Amalie London et al.   Journal of Clinical Medicine

Relationship between de novo lipogenesis and serum sex hormone binding globulin in humans

(2021) Pomme I. H. G. Simons et al.   CLINICAL ENDOCRINOLOGY

Non-alcoholic fatty liver disease

(2021) Elizabeth E Powell et al.   LANCET

Sex Hormone Binding Globulin (SHBG) Mitigates ER Stress in Hepatocytes In Vitro and Ex Vivo

(2021) Katarzyna Kornicka-Garbowska et al.   Cells

Non-alcoholic fatty liver disease, insulin resistance, metabolic syndrome and their association with vascular risk

(2021) Emir Muzurović et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Impact of rare and common genetic variation in the interleukin-1 pathway on human cytokine responses

(2021) Rosanne C. van Deuren et al.   Genome Medicine

Sex hormone-binding globulin overexpression protects against high fat diet induced obesity in transgenic male mice

(2020) Cristina Saez-Lopez et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Potential anti-inflammatory effect of dapagliflozin in HCHF diet- induced fatty liver degeneration through inhibition of TNF-α, IL-1β, and IL-18 in rat liver

(2020) Mohammed Kh. ElMahdy et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Review article: shared disease mechanisms between non-alcoholic fatty liver disease and metabolic syndrome - translating knowledge from systems biology to the bedside

(2019) Silvia Sookoian et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

Osteoprotegerin Promotes Liver Steatosis by Targeting the ERK-PPARγ-CD36 Pathway

(2019) Cheng Zhang et al.   DIABETES

Interleukin-1 Family Cytokines: Keystones in Liver Inflammatory Diseases

(2019) Louise Barbier et al.   Frontiers in Immunology

Molecular insights into how SHBG dimerization exerts changes on ligand molecular recognition

(2019) Concepción Guadarrama-García et al.   JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY

SHBG expression is correlated with PI3K/AKT pathway activity in a cellular model of human insulin resistance

(2018) Chong Feng et al.   GYNECOLOGICAL ENDOCRINOLOGY

Protective Effect of Sex Hormone-Binding Globulin against Metabolic Syndrome: In Vitro Evidence Showing Anti-Inflammatory and Lipolytic Effects on Adipocytes and Macrophages

(2018) Hiroki Yamazaki et al.   MEDIATORS OF INFLAMMATION

The ASK1 inhibitor selonsertib in patients with nonalcoholic steatohepatitis: A randomized, phase 2 trial

(2017) Rohit Loomba et al.   HEPATOLOGY

Low Serum Sex Hormone-Binding Globulin Associated with Insulin Resistance in Men with Nonalcoholic Fatty Liver Disease

(2017) Juan Ye et al.   HORMONE AND METABOLIC RESEARCH

Sex hormone binding globulin - an important biomarker for predicting PCOS risk: A systematic review and meta-analysis

(2017) Ritu Deswal et al.   Systems Biology in Reproductive Medicine

Non-alcoholic fatty liver disease in women with polycystic ovary syndrome: systematic review and meta-analysis

(2017) A. L. L. Rocha et al.   JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION

Shedding light on FGF21: A potential negative regulator of PCSK9

(2016) Yuan Guo et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Nonalcoholic fatty liver disease is associated with an almost twofold increased risk of incident type 2 diabetes and metabolic syndrome. Evidence from a systematic review and meta-analysis

(2016) Stefano Ballestri et al.   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

Management of NAFLD: a stage-based approach

(2016) Mary E. Rinella et al.   Nature Reviews Gastroenterology & Hepatology

Sex hormone-binding globulin regulation of androgen bioactivity in vivo: validation of the free hormone hypothesis

(2016) Michaël R. Laurent et al.   Scientific Reports

PRDX1 is involved in palmitate induced insulin resistance via regulating the activity of p38MAPK in HepG2 cells

(2015) Zhuqi Tang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Hepatokines: unlocking the multi-organ network in metabolic diseases

(2015) Alison Iroz et al.   DIABETOLOGIA

KPNβ1 promotes palmitate-induced insulin resistance via NF-κB signaling in hepatocytes

(2015) Suxin Wang et al.   JOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY

Novel insights in SHBG regulation and clinical implications

(2015) Rafael Simó et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Non-alcoholic fatty liver disease as a cause and a consequence of metabolic syndrome

(2014) Hannele Yki-Järvinen   Lancet Diabetes & Endocrinology

The role of hepatokines in metabolism

(2013) Norbert Stefan et al.   Nature Reviews Endocrinology

Diverse Roles for Sex Hormone-Binding Globulin in Reproduction

(2011) G. L. Hammond   BIOLOGY OF REPRODUCTION

Potential Role of Tumor Necrosis Factor-  in Downregulating Sex Hormone-Binding Globulin

(2011) R. Simo et al.   DIABETES

Fatty acid and endotoxin activate inflammasomes in mouse hepatocytes that release danger signals to stimulate immune cells

(2011) Timea Csak et al.   HEPATOLOGY

Sex hormone-binding globulin and type 2 diabetes mellitus

(2011) Trang N. Le et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Obesity and nonalcoholic fatty liver disease: Biochemical, metabolic, and clinical implications

(2009) Elisa Fabbrini et al.   HEPATOLOGY

Thyroid hormones act indirectly to increase sex hormone-binding globulin production by liver via hepatocyte nuclear factor-4α

(2009) David M Selva et al.   JOURNAL OF MOLECULAR ENDOCRINOLOGY

Genetic variants of sex hormone-binding globulin and their biological consequences

(2009) Nectaria Xita et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY