Canagliflozin interrupts mTOR-mediated inflammatory signaling and attenuates DMBA-induced mammary cell carcinoma in rats

A review of fertility preservation in patients with breast cancer

(2022) Nicole D. Ulrich et al.   BEST PRACTICE & RESEARCH CLINICAL OBSTETRICS & GYNAECOLOGY

Protective Effect of Crocin on Immune Checkpoint Inhibitors-Related Myocarditis Through Inhibiting NLRP3 Mediated Pyroptosis in Cardiomyocytes via NF-κB Pathway

(2022) Hui Zhang et al.   Journal of Inflammation Research

SGLT2 inhibitor, canagliflozin, ameliorates cardiac inflammation in experimental autoimmune myocarditis

(2022) Qi Long et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

(2021) Hyuna Sung et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Anti-cancer effect of metformin on the metastasis and invasion of primary breast cancer cells through mediating NF-kB activity

(2021) Guven Yenmis et al.   ACTA HISTOCHEMICA

Changing profiles of cancer burden worldwide and in China: a secondary analysis of the global cancer statistics 2020

(2021) Wei Cao et al.   CHINESE MEDICAL JOURNAL

Pancancer survival analysis of cancer hallmark genes

(2021) Ádám Nagy et al.   Scientific Reports

Canagliflozin attenuates lipotoxicity in cardiomyocytes and protects diabetic mouse hearts by inhibiting the mTOR/HIF-1α pathway

(2021) Pengbo Sun et al.   iScience

Brucine promotes apoptosis in cervical cancer cells ( ME ‐180) via suppression of inflammation and cell proliferation by regulating PI3K / AKT / mTOR signaling pathway

(2021) Vidya Devanathadesikan Seshadri   ENVIRONMENTAL TOXICOLOGY

mTOR in Alzheimer disease and its earlier stages: Links to oxidative damage in the progression of this dementing disorder

(2021) M. Perluigi et al.   FREE RADICAL BIOLOGY AND MEDICINE

Transcriptome Profiling and Metagenomic Analysis Help to Elucidate Interactions in an Inflammation-Associated Cancer Mouse Model

(2021) Kazuko Sakai et al.   Cancers

SGLT2 inhibitor counteracts NLRP3 inflammasome via tubular metabolite itaconate in fibrosis kidney

(2021) Qingqing Ke et al.   FASEB JOURNAL

Canagliflozin Modulates Hypoxia-Induced Metastasis, Angiogenesis and Glycolysis by Decreasing HIF-1α Protein Synthesis via AKT/mTOR Pathway

(2021) Jingyi Luo et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Distinct Roles of mTOR Targets S6K1 and S6K2 in Breast Cancer

(2020) Savitha Sridharan et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

25-LB: SGLT2 Inhibitor Attenuates Inflammatory Response in Diabetic Kidney Disease by Inhibiting GSDMD-Related Pyroptosis

(2020) SHIJING REN et al.   DIABETES

Beneficial effects of combination therapy of canagliflozin and teneligliptin on diabetic polyneuropathy and β-cell volume density in spontaneously type 2 diabetic Goto-Kakizaki rats

(2020) Danyang Guo et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Diallyl trisulfide potentiates chemotherapeutic efficacy of doxorubicin in experimentally induced mammary carcinoma: Role of Notch signaling

(2020) Nehal M. Elsherbiny et al.   PATHOLOGY RESEARCH AND PRACTICE

Sodium-glucose co-transporter-2 (SGLT-2) inhibition reduces glucose uptake to induce breast cancer cell growth arrest through AMPK/mTOR pathway

(2020) Jun Zhou et al.   BIOMEDICINE & PHARMACOTHERAPY

PI3K/AKT/mTOR Signaling Pathway in Breast Cancer: From Molecular Landscape to Clinical Aspects

(2020) Daniela Miricescu et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Assessment of Ki67 in Breast Cancer: Updated Recommendations From the International Ki67 in Breast Cancer Working Group

(2020) Torsten O Nielsen et al.   JNCI-Journal of the National Cancer Institute

Sodium-glucose cotransporters: new targets of cancer therapy?

(2019) Ivana Vrhovac Madunić et al.   Arhiv za Higijenu Rada i Toksikologiju-Archives of Industrial Hygiene and Toxicology

Decreased incidence of Kaposi sarcoma after kidney transplant in Italy and role of mTOR-inhibitors: 1997-2016

(2019) Pierluca Piselli et al.   INTERNATIONAL JOURNAL OF CANCER

Canagliflozin review – safety and efficacy profile in patients with T2DM

(2019) Haroon Jakher et al.   Diabetes Metabolic Syndrome and Obesity-Targets and Therapy

Pyranocarbazole derivatives as potent anti-cancer agents triggering tubulin polymerization stabilization induced activation of caspase-dependent apoptosis and downregulation of Akt/mTOR in breast cancer cells

(2019) Om P.S. Patel et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Polyphenols from mango (Mangifera indica L.) modulate PI3K/AKT/mTOR-associated micro-RNAs and reduce inflammation in non-cancer and induce cell death in breast cancer cells

(2019) Shirley H. Arbizu-Berrocal et al.   Journal of Functional Foods

The role of pyroptosis in cancer: pro-cancer or pro-“host”?

(2019) Xiaojing Xia et al.   Cell Death & Disease

The SGLT2 Inhibitor Canagliflozin Prevents Carcinogenesis in a Mouse Model of Diabetes and Non-Alcoholic Steatohepatitis-Related Hepatocarcinogenesis: Association with SGLT2 Expression in Hepatocellular Carcinoma

(2019) Teruo Jojima et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

P1.14-33 Canagliflozin Inhibits Lung Cancer Survival and Enhances Its Response to Radiotherapy; Effective Blockade of mTOR Pathway, HIF1a, and Mitosis

(2019) E. Tsakiridis et al.   Journal of Thoracic Oncology

Transcriptional regulation in model organisms: recent progress and clinical implications

(2019) Jiaqi Tang et al.   Open Biology

Combined SGLT2 and DPP4 Inhibition Reduces the Activation of the Nlrp3/ASC Inflammasome and Attenuates the Development of Diabetic Nephropathy in Mice with Type 2 Diabetes

(2018) Yochai Birnbaum et al.   CARDIOVASCULAR DRUGS AND THERAPY

Vitamin D nanoemulsion enhances hepatoprotective effect of conventional vitamin D in rats fed with a high-fat diet

(2018) Mohamed El-Sherbiny et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Sodium Glucose Cotransporter 2 Inhibition Combined With Cetuximab Significantly Reduced Tumor Size and Carcinoembryonic Antigen Level in Colon Cancer Metastatic to Liver

(2018) Junichi Okada et al.   Clinical Colorectal Cancer

Activation of WNT/β-catenin signaling results in resistance to a dual PI3K/mTOR inhibitor in colorectal cancer cells harboring PIK3CA mutations

(2018) Ye-Lim Park et al.   INTERNATIONAL JOURNAL OF CANCER

Effects of canagliflozin versus glimepiride on adipokines and inflammatory biomarkers in type 2 diabetes

(2018) W. Timothy Garvey et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Mitigation of cisplatin-induced peripheral neuropathy by canagliflozin in rats

(2018) Ahmed A. Abdelsameea et al.   NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY

Sodium glucose cotransporter 2 inhibitor canagliflozin attenuates liver cancer cell growth and angiogenic activity by inhibiting glucose uptake

(2017) Kosuke Kaji et al.   INTERNATIONAL JOURNAL OF CANCER

Anticancer activity of salicin and fenofibrate

(2017) Marwa Sabaa et al.   NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY

The Role of Oxidative Stress Modulators in Breast Cancer

(2017) Hande Gurer-Orhan et al.   CURRENT MEDICINAL CHEMISTRY

Inhibition of PI3K/AKT/mTOR axis disrupts oxidative stress-mediated survival of melanoma cells

(2015) Heather G. Hambright et al.   Oncotarget

BRCA1, a ‘complex’ protein involved in the maintenance of genomic stability

(2014) Kienan I. Savage et al.   FEBS Journal

Pharmacodynamic Effects of Canagliflozin, a Sodium Glucose Co-Transporter 2 Inhibitor, from a Randomized Study in Patients with Type 2 Diabetes

(2014) Sue Sha et al.   PLoS One

Targeting the Akt/mTOR pathway in Brca1-deficient cancers

(2011) T Xiang et al.   ONCOGENE

Nutrient transporters in cancer: Relevance to Warburg hypothesis and beyond

(2008) Vadivel Ganapathy et al.   PHARMACOLOGY & THERAPEUTICS