Meiotic defects in human oocytes: Potential causes and clinical implications

Mechanism of spindle pole organization and instability in human oocytes

(2022) Chun So et al.   SCIENCE

Aurora B/C-dependent phosphorylation promotes Rec8 cleavage in mammalian oocytes

(2022) Elvira Nikalayevich et al.   CURRENT BIOLOGY

Aneuploidy in human eggs: contributions of the meiotic spindle

(2021) Christopher Thomas et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Aurora kinase A is essential for meiosis in mouse oocytes

(2021) Cecilia S. Blengini et al.   PLoS Genetics

Loss of centromeric RNA activates the spindle assembly checkpoint in mammalian female meiosis I

(2021) Tianyu Wu et al.   JOURNAL OF CELL BIOLOGY

Age‐dependent integrity of the meiotic spindle assembly checkpoint in females requires Aurora kinase B

(2021) Cecilia S. Blengini et al.   AGING CELL

International Committee for Monitoring Assisted Reproductive Technologies world report: assisted reproductive technology, 2014

(2021) Georgina M Chambers et al.   HUMAN REPRODUCTION

Bi-allelic Missense Pathogenic Variants in TRIP13Cause Female Infertility Characterized by Oocyte Maturation Arrest

(2020) Zhihua Zhang et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Human oocytes harboring damaged DNA can complete meiosis I

(2020) Gaudeline Rémillard-Labrosse et al.   FERTILITY AND STERILITY

Exome sequencing links CEP120 mutation to maternally derived aneuploid conception risk

(2020) Katarzyna M Tyc et al.   HUMAN REPRODUCTION

A liquid-like spindle domain promotes acentrosomal spindle assembly in mammalian oocytes

(2019) Chun So et al.   SCIENCE

Chromosome errors in human eggs shape natural fertility over reproductive life span

(2019) Jennifer R. Gruhn et al.   SCIENCE

Meiotic Kinetochores Fragment into Multiple Lobes upon Cohesin Loss in Aging Eggs

(2019) Agata P. Zielinska et al.   CURRENT BIOLOGY

The Nuclear Matrix Protein SAFB Cooperates with Major Satellite RNAs to Stabilize Heterochromatin Architecture Partially through Phase Separation

(2019) Xiangru Huo et al.   MOLECULAR CELL

Genetic Interactions between the Aurora Kinases Reveal New Requirements for AURKB and AURKC during Oocyte Meiosis

(2018) Alexandra L. Nguyen et al.   CURRENT BIOLOGY

Tri-directional anaphases as a novel chromosome segregation defect in human oocytes

(2017) Jenna Haverfield et al.   HUMAN REPRODUCTION

Human female meiosis revised: new insights into the mechanisms of chromosome segregation and aneuploidies from advanced genomics and time-lapse imaging

(2017) Antonio Capalbo et al.   HUMAN REPRODUCTION UPDATE

Chromosome biorientation and APC activity remain uncoupled in oocytes with reduced volume

(2017) Simon I.R. Lane et al.   JOURNAL OF CELL BIOLOGY

Aurora A kinase phosphorylates Hec1 to regulate metaphase kinetochore–microtubule dynamics

(2017) Keith F. DeLuca et al.   JOURNAL OF CELL BIOLOGY

Error-prone meiotic division and subfertility in mice with oocyte-conditional knockdown of pericentrin

(2017) Claudia Baumann et al.   JOURNAL OF CELL SCIENCE

The tubulin code at a glance

(2017) Sudarshan Gadadhar et al.   JOURNAL OF CELL SCIENCE

Identification and characterization of Aurora kinase B and C variants associated with maternal aneuploidy

(2017) Alexandra L. Nguyen et al.   MOLECULAR HUMAN REPRODUCTION

Actin protects mammalian eggs against chromosome segregation errors

(2017) Binyam Mogessie et al.   SCIENCE

Mechanisms of Aneuploidy in Human Eggs

(2017) Alexandre Webster et al.   TRENDS IN CELL BIOLOGY

Specialize and Divide (Twice): Functions of Three Aurora Kinase Homologs in Mammalian Oocyte Meiotic Maturation

(2017) Alexandra L. Nguyen et al.   TRENDS IN GENETICS

Novel mutations and structural deletions in TUBB8 : expanding mutational and phenotypic spectrum of patients with arrest in oocyte maturation, fertilization or early embryonic development

(2016) Biaobang Chen et al.   HUMAN REPRODUCTION

Mutations in TUBB8 and Human Oocyte Meiotic Arrest

(2016) Ruizhi Feng et al.   NEW ENGLAND JOURNAL OF MEDICINE

Spatial Regulation of Kinetochore Microtubule Attachments by Destabilization at Spindle Poles in Meiosis I

(2015) Lukáš Chmátal et al.   CURRENT BIOLOGY

The spindle checkpoint and chromosome segregation in meiosis

(2015) Gary J. Gorbsky   FEBS Journal

Expression and characterization of three Aurora kinase C splice variants found in human oocytes

(2015) Jessica E. Fellmeth et al.   MOLECULAR HUMAN REPRODUCTION

Error-prone chromosome-mediated spindle assembly favors chromosome segregation defects in human oocytes

(2015) Z. Holubcova et al.   SCIENCE

Bivalent separation into univalents precedes age-related meiosis I errors in oocytes

(2015) Yogo Sakakibara et al.   Nature Communications

A three-step MTOC fragmentation mechanism facilitates bipolar spindle assembly in mouse oocytes

(2015) Dean Clift et al.   Nature Communications

Sister kinetochore splitting and precocious disintegration of bivalents could explain the maternal age effect

(2015) Agata P Zielinska et al.   eLife

Unique geometry of sister kinetochores in human oocytes during meiosis I may explain maternal age-associated increases in chromosomal abnormalities

(2015) Jessica Patel et al.   Biology Open

Stable MCC binding to the APC/C is required for a functional spindle assembly checkpoint

(2014) J. B. Hein et al.   EMBO REPORTS

Thyroid Hormone Receptor Interacting Protein 13 (TRIP13) AAA-ATPase Is a Novel Mitotic Checkpoint-silencing Protein

(2014) Kexi Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Age-Related Decrease of Meiotic Cohesins in Human Oocytes

(2014) Makiko Tsutsumi et al.   PLoS One

Selective Disruption of Aurora C Kinase Reveals Distinct Functions from Aurora B Kinase during Meiosis in Mouse Oocytes

(2014) Ahmed Z. Balboula et al.   PLoS Genetics

Premature dyad separation in meiosis II is the major segregation error with maternal age in mouse oocytes

(2013) Y. Yun et al.   DEVELOPMENT

Molecular causes of aneuploidy in mammalian eggs

(2013) K. T. Jones et al.   DEVELOPMENT

The Spindle Assembly Checkpoint

(2012) Pablo Lara-Gonzalez et al.   CURRENT BIOLOGY

Spindle assembly checkpoint signalling is uncoupled from chromosomal position in mouse oocytes

(2012) L. Gui et al.   DEVELOPMENT

Timing of anaphase-promoting complex activation in mouse oocytes is predicted by microtubule-kinetochore attachment but not by bivalent alignment or tension

(2012) S. I. R. Lane et al.   DEVELOPMENT

Mutation screening of AURKB and SYCP3 in patients with reproductive problems

(2012) A. López-Carrasco et al.   MOLECULAR HUMAN REPRODUCTION

Human aneuploidy: mechanisms and new insights into an age-old problem

(2012) So I. Nagaoka et al.   NATURE REVIEWS GENETICS

Maternally recruited Aurora C kinase is more stable than Aurora B to support mouse oocyte maturation and early development

(2012) K. Schindler et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Complete Kinetochore Tracking Reveals Error-Prone Homologous Chromosome Biorientation in Mammalian Oocytes

(2011) Tomoya S. Kitajima et al.   CELL

Cubism and the cell cycle: the many faces of the APC/C

(2011) Jonathon Pines   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Evidence that Weakened Centromere Cohesion Is a Leading Cause of Age-Related Aneuploidy in Oocytes

(2010) Teresa Chiang et al.   CURRENT BIOLOGY

Age-Related Meiotic Segregation Errors in Mammalian Oocytes Are Preceded by Depletion of Cohesin and Sgo2

(2010) Lisa Martine Lister et al.   CURRENT BIOLOGY

An Smc3 Acetylation Cycle Is Essential for Establishment of Sister Chromatid Cohesion

(2010) Frederic Beckouët et al.   MOLECULAR CELL

Aurora kinase B modulates chromosome alignment in mouse oocytes

(2009) Kristy Shuda et al.   MOLECULAR REPRODUCTION AND DEVELOPMENT

Mouse HORMAD1 and HORMAD2, Two Conserved Meiotic Chromosomal Proteins, Are Depleted from Synapsed Chromosome Axes with the Help of TRIP13 AAA-ATPase

(2009) Lukasz Wojtasz et al.   PLoS Genetics