Ion Mobility-Mass Spectrometry Coupled to Droplet Microfluidics for Rapid Protein Structure Analysis and Drug Discovery

Femtoliter-Droplet Mass Spectrometry Interface Utilizing Nanofluidics for Ultrasmall and High-Sensitivity Analysis

(2022) Yuto Takagi et al.   ANALYTICAL CHEMISTRY

Pharmacological and genetic perturbation establish SIRT5 as a promising target in breast cancer

(2021) Yashira L. Negrón Abril et al.   ONCOGENE

Coupling Droplet Microfluidics with Ion Mobility Spectrometry for Monitoring Chemical Conversions at Nanoliter Scale

(2021) Nora T. Hartner et al.   ANALYTICAL CHEMISTRY

Protein X-ray Crystallography and Drug Discovery

(2020) Laurent Maveyraud et al.   MOLECULES

Native mass spectrometry - a valuable tool in structural biology

(2020) Marie Barth et al.   JOURNAL OF MASS SPECTROMETRY

Coupling droplet microfluidics with mass spectrometry for ultra-high-throughput analysis of complex mixtures up to and above 30Hz.

(2020) Emily E. Kempa et al.   ANALYTICAL CHEMISTRY

Acoustic Mist Ionization Platform for Direct and Contactless Ultrahigh-Throughput Mass Spectrometry Analysis of Liquid Samples

(2019) Ian Sinclair et al.   ANALYTICAL CHEMISTRY

CIUSuite 2: Next-Generation Software for the Analysis of Gas-Phase Protein Unfolding Data

(2019) Daniel A. Polasky et al.   ANALYTICAL CHEMISTRY

High-Throughput Nanoelectrospray Ionization-Mass Spectrometry Analysis of Microfluidic Droplet Samples

(2019) Daniel J. Steyer et al.   ANALYTICAL CHEMISTRY

Advances in MS Based Strategies for Probing Ligand-Target Interactions: Focus on Soft Ionization Mass Spectrometric Techniques

(2019) Guilin Chen et al.   Frontiers in Chemistry

Understanding protein–drug interactions using ion mobility–mass spectrometry

(2018) Claire E Eyers et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Collision induced unfolding of isolated proteins in the gas phase: past, present, and future

(2018) Sugyan M Dixit et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Conformational landscapes of ubiquitin, cytochrome c, and myoglobin: Uniform field ion mobility measurements in helium and nitrogen drift gas

(2018) Jody C. May et al.   INTERNATIONAL JOURNAL OF MASS SPECTROMETRY

Potent and Selective Inhibitors of Human Sirtuin 5

(2018) Diana Kalbas et al.   JOURNAL OF MEDICINAL CHEMISTRY

Cryo-EM in drug discovery: achievements, limitations and prospects

(2018) Jean-Paul Renaud et al.   NATURE REVIEWS DRUG DISCOVERY

A droplet-chip/mass spectrometry approach to study organic synthesis at nanoliter scale

(2017) R. J. Beulig et al.   LAB ON A CHIP

Mass spectrometry captures off-target drug binding and provides mechanistic insights into the human metalloprotease ZMPSTE24

(2016) Shahid Mehmood et al.   Nature Chemistry

Biophysics in drug discovery: impact, challenges and opportunities

(2016) Jean-Paul Renaud et al.   NATURE REVIEWS DRUG DISCOVERY

Identification of sirtuin 5 inhibitors by ultrafast microchip electrophoresis using nanoliter volume samples

(2015) Erik D. Guetschow et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

Microfluidics-to-mass spectrometry: A review of coupling methods and applications

(2015) Xue Wang et al.   JOURNAL OF CHROMATOGRAPHY A

Quantifying the stabilizing effects of protein–ligand interactions in the gas phase

(2015) Timothy M. Allison et al.   Nature Communications

Mass Spectrometry Quantifies Protein Interactions-From Molecular Chaperones to Membrane Porins

(2014) Jonathan T. S. Hopper et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

SIRT5 facilitates cancer cell growth and drug resistance in non-small cell lung cancer

(2014) Weidong Lu et al.   TUMOR BIOLOGY

Analytical detection techniques for droplet microfluidics—A review

(2013) Ying Zhu et al.   ANALYTICA CHIMICA ACTA

NMR-based analysis of protein–ligand interactions

(2013) Olivier Cala et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

Sensitive, High Throughput Detection of Proteins in Individual, Surfactant-Stabilized Picoliter Droplets Using Nanoelectrospray Ionization Mass Spectrometry

(2013) Clive A. Smith et al.   ANALYTICAL CHEMISTRY

Activation State-Selective Kinase Inhibitor Assay Based on Ion Mobility-Mass Spectrometry

(2013) Jessica N. Rabuck et al.   ANALYTICAL CHEMISTRY

Carboxylic Acid (Bio)Isosteres in Drug Design

(2013) Carlo Ballatore et al.   ChemMedChem

Evidence for a Common Mechanism of SIRT1 Regulation by Allosteric Activators

(2013) B. P. Hubbard et al.   SCIENCE

Quantifying Protein-Ligand Binding Constants using Electrospray Ionization Mass Spectrometry: A Systematic Binding Affinity Study of a Series of Hydrophobically Modified Trypsin Inhibitors

(2012) Dragana Cubrilovic et al.   JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY

Proteolysis in microfluidic droplets: an approach to interface protein separation and peptide mass spectrometry

(2012) Ji Ji et al.   LAB ON A CHIP

Small-Molecule Allosteric Activators of Sirtuins

(2011) David A. Sinclair et al.   Annual Review of Pharmacology and Toxicology

Surfactants in droplet-based microfluidics

(2011) Jean-Christophe Baret   LAB ON A CHIP

Analysis of Samples Stored as Individual Plugs in a Capillary by Electrospray Ionization Mass Spectrometry

(2009) Jian Pei et al.   ANALYTICAL CHEMISTRY

Coupling Microdroplet Microreactors with Mass Spectrometry: Reading the Contents of Single Droplets Online

(2009) Luis M. Fidalgo et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

The Thermodynamics of Protein–Ligand Interaction and Solvation: Insights for Ligand Design

(2008) Tjelvar S.G. Olsson et al.   JOURNAL OF MOLECULAR BIOLOGY