ExPRSweb: An online repository with polygenic risk scores for common health-related exposures

Portability of 245 polygenic scores when derived from the UK Biobank and applied to 9 ancestry groups from the same cohort

(2022) Florian Privé et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Significant sparse polygenic risk scores across 813 traits in UK Biobank

(2022) Yosuke Tanigawa et al.   PLoS Genetics

Coffee consumption and risk of breast cancer: A Mendelian randomization study

(2021) Merete Ellingjord-Dale et al.   PLoS One

Comparisons of Polyexposure, Polygenic, and Clinical Risk Scores in Risk Prediction of Type 2 Diabetes

(2021) Yixuan He et al.   DIABETES CARE

The Polygenic Score Catalog as an open database for reproducibility and systematic evaluation

(2021) Samuel A. Lambert et al.   NATURE GENETICS

Development of genome-wide polygenic risk scores for lipid traits and clinical applications for dyslipidemia, subclinical atherosclerosis, and diabetes cardiovascular complications among East Asians

(2021) Claudia H. T. Tam et al.   Genome Medicine

A comparison of ten polygenic score methods for psychiatric disorders applied across multiple cohorts

(2021) Guiyan Ni et al.   BIOLOGICAL PSYCHIATRY

Evaluation of polygenic prediction methodology within a reference-standardized framework

(2021) Oliver Pain et al.   PLoS Genetics

A phenome-wide association study of genetically mimicked statins

(2021) Shun Li et al.   BMC Medicine

Genetic prediction of complex traits with polygenic scores: a statistical review

(2021) Ying Ma et al.   TRENDS IN GENETICS

On cross-ancestry cancer polygenic risk scores

(2021) Lars G. Fritsche et al.   PLoS Genetics

Instrumental variable estimation for a time-varying treatment and a time-to-event outcome via structural nested cumulative failure time models

(2021) Joy Shi et al.   BMC Medical Research Methodology

Leukocyte telomere length is associated with aggressive prostate cancer in localized prostate cancer patients

(2020) Junfeng Xu et al.   EBioMedicine

Accurate and Scalable Construction of Polygenic Scores in Large Biobank Data Sets

(2020) Sheng Yang et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Non-parametric Polygenic Risk Prediction via Partitioned GWAS Summary Statistics

(2020) Sung Chun et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Mendelian randomization accounting for correlated and uncorrelated pleiotropic effects using genome-wide summary statistics

(2020) Jean Morrison et al.   NATURE GENETICS

An analytic framework for exploring sampling and observation process biases in genome and phenome‐wide association studies using electronic health records

(2020) Lauren J. Beesley et al.   STATISTICS IN MEDICINE

A phenome-wide association and Mendelian Randomisation study of polygenic risk for depression in UK Biobank

(2020) Xueyi Shen et al.   Nature Communications

Cancer PRSweb: An Online Repository with Polygenic Risk Scores for Major Cancer Traits and Their Evaluation in Two Independent Biobanks

(2020) Lars G. Fritsche et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Causal Associations Between Modifiable Risk Factors and the Alzheimer's Phenome

(2020) Shea J. Andrews et al.   ANNALS OF NEUROLOGY

LDpred2: better, faster, stronger

(2020) Florian Privé et al.   BIOINFORMATICS

15 years of genome-wide association studies and no signs of slowing down

(2020) Ruth J. F. Loos   Nature Communications

Pan-cancer analysis demonstrates that integrating polygenic risk scores with modifiable risk factors improves risk prediction

(2020) Linda Kachuri et al.   Nature Communications

Transethnic Transferability of a Genome-wide Polygenic Score for Coronary Artery Disease

(2020) Akl C. Fahed et al.   Circulation-Genomic and Precision Medicine

Association studies of up to 1.2 million individuals yield new insights into the genetic etiology of tobacco and alcohol use

(2019) Mengzhen Liu et al.   NATURE GENETICS

Clinical use of current polygenic risk scores may exacerbate health disparities

(2019) Alicia R. Martin et al.   NATURE GENETICS

The Missing Diversity in Human Genetic Studies

(2019) Giorgio Sirugo et al.   CELL

Smoking, drinking, diet and physical activity—modifiable lifestyle risk factors and their associations with age to first chronic disease

(2019) Ryan Ng et al.   INTERNATIONAL JOURNAL OF EPIDEMIOLOGY

Polygenic prediction via Bayesian regression and continuous shrinkage priors

(2019) Tian Ge et al.   Nature Communications

An atlas of polygenic risk score associations to highlight putative causal relationships across the human phenome

(2019) Tom G Richardson et al.   eLife

Missing heritability of complex diseases: case solved?

(2019) Emmanuelle Génin   HUMAN GENETICS

Analysis of polygenic risk score usage and performance in diverse human populations

(2019) L. Duncan et al.   Nature Communications

PRSice-2: Polygenic Risk Score software for biobank-scale data

(2019) Shing Wan Choi et al.   GigaScience

Towards clinical utility of polygenic risk scores

(2019) Samuel A Lambert et al.   HUMAN MOLECULAR GENETICS

Improved polygenic prediction by Bayesian multiple regression on summary statistics

(2019) Luke R. Lloyd-Jones et al.   Nature Communications

Making the Most of Clumping and Thresholding for Polygenic Scores

(2019) Florian Privé et al.   AMERICAN JOURNAL OF HUMAN GENETICS

The emerging landscape of health research based on biobanks linked to electronic health records: Existing resources, statistical challenges, and potential opportunities

(2019) Lauren J. Beesley et al.   STATISTICS IN MEDICINE

Association of Polygenic Risk Scores for Multiple Cancers in a Phenome-wide Study: Results from The Michigan Genomics Initiative

(2018) Lars G. Fritsche et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Circulating microRNAs as potential cancer biomarkers: the advantage and disadvantage

(2018) Hao Wang et al.   Clinical Epigenetics

Genome-wide polygenic scores for common diseases identify individuals with risk equivalent to monogenic mutations

(2018) Amit V. Khera et al.   NATURE GENETICS

Efficiently controlling for case-control imbalance and sample relatedness in large-scale genetic association studies

(2018) Wei Zhou et al.   NATURE GENETICS

Genome-wide association analyses identify 143 risk variants and putative regulatory mechanisms for type 2 diabetes

(2018) Angli Xue et al.   Nature Communications

Prospects for the Primary Prevention of Myocardial Infarction and Stroke

(2018) Madison Caldwell et al.   JOURNAL OF CARDIOVASCULAR PHARMACOLOGY AND THERAPEUTICS

Role of the transforming growth factor‐β signaling pathway in the pathogenesis of colorectal cancer

(2018) Atena Soleimani et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

The UK Biobank resource with deep phenotyping and genomic data

(2018) Clare Bycroft et al.   NATURE

The NHGRI-EBI GWAS Catalog of published genome-wide association studies, targeted arrays and summary statistics 2019

(2018) Annalisa Buniello et al.   NUCLEIC ACIDS RESEARCH

Multiethnic polygenic risk scores improve risk prediction in diverse populations

(2017) Carla Márquez-Luna et al.   GENETIC EPIDEMIOLOGY

Polygenic scores via penalized regression on summary statistics

(2017) Timothy Shin Heng Mak et al.   GENETIC EPIDEMIOLOGY

Next-Generation Sequencing in Oncology: Genetic Diagnosis, Risk Prediction and Cancer Classification

(2017) Rick Kamps et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Association analysis identifies 65 new breast cancer risk loci

(2017) Kyriaki Michailidou et al.   NATURE

Risk Factors for Community-Acquired Pneumonia in Adults: A Systematic Review of Observational Studies

(2017) Jordi Almirall et al.   RESPIRATION

Leveraging functional annotations in genetic risk prediction for human complex diseases

(2017) Yiming Hu et al.   PLoS Computational Biology

Treatment of Obesity

(2016) Bruce M. Wolfe et al.   CIRCULATION RESEARCH

Distinguishing Selection Bias and Confounding Bias in Comparative Effectiveness Research

(2016) Sebastien Haneuse   MEDICAL CARE

A reference panel of 64,976 haplotypes for genotype imputation

(2016)   NATURE GENETICS

Developing and evaluating polygenic risk prediction models for stratified disease prevention

(2016) Nilanjan Chatterjee et al.   NATURE REVIEWS GENETICS

Genetically Predicted Body Mass Index and Breast Cancer Risk: Mendelian Randomization Analyses of Data from 145,000 Women of European Descent

(2016) Yan Guo et al.   PLOS MEDICINE

Joint Analysis of Psychiatric Disorders Increases Accuracy of Risk Prediction for Schizophrenia, Bipolar Disorder, and Major Depressive Disorder

(2015) Robert Maier et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Modeling Linkage Disequilibrium Increases Accuracy of Polygenic Risk Scores

(2015) Bjarni J. Vilhjálmsson et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Genetic variance estimation with imputed variants finds negligible missing heritability for human height and body mass index

(2015) Jian Yang et al.   NATURE GENETICS

Relation between BMI and Diabetes Mellitus and Its Complications among US Older Adults

(2015) Natallia Gray et al.   SOUTHERN MEDICAL JOURNAL

UK Biobank: An Open Access Resource for Identifying the Causes of a Wide Range of Complex Diseases of Middle and Old Age

(2015) Cathie Sudlow et al.   PLOS MEDICINE

PRSice: Polygenic Risk Score software

(2014) Jack Euesden et al.   BIOINFORMATICS

Ancestry estimation and control of population stratification for sequence-based association studies

(2014) Chaolong Wang et al.   NATURE GENETICS

Índice triglicéridos y glucosa: un indicador útil de insulinorresistencia

(2014) Gisela Unger et al.   Endocrinologia y Nutricion

A New Equation to Estimate Glomerular Filtration Rate

(2013) Andrew S. Levey et al.   ANNALS OF INTERNAL MEDICINE

Lifestyle Factors and Risk for New-Onset Diabetes

(2013) Jared P. Reis et al.   ANNALS OF INTERNAL MEDICINE

Mendelian Randomization Analysis With Multiple Genetic Variants Using Summarized Data

(2013) Stephen Burgess et al.   GENETIC EPIDEMIOLOGY

TGF-β – an excellent servant but a bad master

(2012) Lenka Kubiczkova et al.   Journal of Translational Medicine

Genome-wide efficient mixed-model analysis for association studies

(2012) Xiang Zhou et al.   NATURE GENETICS

Estimating Missing Heritability for Disease from Genome-wide Association Studies

(2011) Sang Hong Lee et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Genetic risk prediction in complex disease

(2011) Luke Jostins et al.   HUMAN MOLECULAR GENETICS

Central Obesity and Survival in Subjects With Coronary Artery Disease

(2011) Thais Coutinho et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Robust relationship inference in genome-wide association studies

(2010) Ani Manichaikul et al.   BIOINFORMATICS

The dynamic relationship between systolic and diastolic blood pressure: yet another marker of vascular aging?

(2010) Giuseppe Schillaci et al.   HYPERTENSION RESEARCH

C-reactive protein levels and body mass index: elucidating direction of causation through reciprocal Mendelian randomization

(2010) N J Timpson et al.   INTERNATIONAL JOURNAL OF OBESITY

Common SNPs explain a large proportion of the heritability for human height

(2010) Jian Yang et al.   NATURE GENETICS

Fast model-based estimation of ancestry in unrelated individuals

(2009) D. H. Alexander et al.   GENOME RESEARCH

Linear relationship between systolic and diastolic blood pressure monitored over 24 h: assessment and correlates

(2009) Benjamin Gavish et al.   JOURNAL OF HYPERTENSION

Finding the missing heritability of complex diseases

(2009) Teri A. Manolio et al.   NATURE

Common polygenic variation contributes to risk of schizophrenia and bipolar disorder

(2009) Shaun M. Purcell et al.   NATURE

Heritability in the genomics era — concepts and misconceptions

(2008) Peter M. Visscher et al.   NATURE REVIEWS GENETICS

Worldwide Human Relationships Inferred from Genome-Wide Patterns of Variation

(2008) J. Z. Li et al.   SCIENCE