Progress in ciliary ion channel physiology

The Structure of the Polycystic Kidney Disease Channel PKD2 in Lipid Nanodiscs

(2016) Peter S. Shen et al.   CELL

The primary cilium as a cellular receiver: organizing ciliary GPCR signaling

(2016) Keren I Hilgendorf et al.   CURRENT OPINION IN CELL BIOLOGY

Permeability barriers for generating a unique ciliary protein and lipid composition

(2016) Kristen J Verhey et al.   CURRENT OPINION IN CELL BIOLOGY

The intraflagellar transport machinery in ciliary signaling

(2016) André Mourão et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Primary cilia are not calcium-responsive mechanosensors

(2016) M. Delling et al.   NATURE

A single polycystic kidney disease 2-like 1 channel opening acts as a spike generator in cerebrospinal fluid-contacting neurons of adult mouse brainstem

(2016) Adeline Orts-Del'Immagine et al.   NEUROPHARMACOLOGY

Cilia have high cAMP levels that are inhibited by Sonic Hedgehog-regulated calcium dynamics

(2016) Bryn S. Moore et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Function and regulation of TRPP2 ion channel revealed by a gain-of-function mutant

(2016) Mahmud Arif Pavel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cilia-based flow network in the brain ventricles

(2016) R. Faubel et al.   SCIENCE

Endocytic Control of Cellular Signaling at the Primary Cilium

(2016) Lotte B. Pedersen et al.   TRENDS IN BIOCHEMICAL SCIENCES

The Intraflagellar Transport Machinery

(2016) Michael Taschner et al.   Cold Spring Harbor Perspectives in Biology

Genetic Analysis Reveals a Hierarchy of Interactions between Polycystin-Encoding Genes and Genes Controlling Cilia Function during Left-Right Determination

(2016) Daniel T. Grimes et al.   PLoS Genetics

Atypical calcium regulation of the PKD2-L1 polycystin ion channel

(2016) Paul G DeCaen et al.   eLife

The Role of G-Protein-Coupled Receptor Proteolysis Site Cleavage of Polycystin-1 in Renal Physiology and Polycystic Kidney Disease

(2016) Marie Trudel et al.   Cells

Phosphoinositides regulate ion channels

(2015) Bertil Hille et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Flagellar ion channels of sperm: similarities and differences between species

(2015) Melissa R. Miller et al.   CELL CALCIUM

Intraciliary Calcium Oscillations Initiate Vertebrate Left-Right Asymmetry

(2015) Shiaulou Yuan et al.   CURRENT BIOLOGY

Modulation of Ciliary Phosphoinositide Content Regulates Trafficking and Sonic Hedgehog Signaling Output

(2015) Marcelo Chávez et al.   DEVELOPMENTAL CELL

Phosphoinositides Regulate Ciliary Protein Trafficking to Modulate Hedgehog Signaling

(2015) Francesc R. Garcia-Gonzalo et al.   DEVELOPMENTAL CELL

Polycystin-1 maturation requires polycystin-2 in a dose-dependent manner

(2015) Vladimir G. Gainullin et al.   JOURNAL OF CLINICAL INVESTIGATION

Ion channels and calcium signaling in motile cilia

(2015) Julia F Doerner et al.   eLife

Structurally Distinct Ca2+ Signaling Domains of Sperm Flagella Orchestrate Tyrosine Phosphorylation and Motility

(2014) Jean-Ju Chung et al.   CELL

Altered trafficking and stability of polycystins underlie polycystic kidney disease

(2014) Yiqiang Cai et al.   JOURNAL OF CLINICAL INVESTIGATION

Early Evolution of the Eukaryotic Ca2+ Signaling Machinery: Conservation of the CatSper Channel Complex

(2014) Xinjiang Cai et al.   MOLECULAR BIOLOGY AND EVOLUTION

The Ca2+-activated Cl− channel ANO1/TMEM16A regulates primary ciliogenesis

(2014) Chelsey Chandler Ruppersburg et al.   MOLECULAR BIOLOGY OF THE CELL

Morphology, Distribution and Phenotype of Polycystin Kidney Disease 2-like 1-Positive Cerebrospinal Fluid Contacting Neurons in The Brainstem of Adult Mice

(2014) Adeline Orts-Del’Immagine et al.   PLoS One

Intestinal cell kinase, a protein associated with endocrine-cerebro-osteodysplasia syndrome, is a key regulator of cilia length and Hedgehog signaling

(2014) H. Moon et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ciliary membrane proteins traffic through the Golgi via a Rabep1/GGA1/Arl3-dependent mechanism

(2014) Hyunho Kim et al.   Nature Communications

The Genomic and Cellular Foundations of Animal Origins

(2013) Daniel J. Richter et al.   Annual Review of Genetics

Shear stress-induced Ca2+ mobilization in MDCK cells is ATP dependent, no matter the primary cilium

(2013) Lise Rodat-Despoix et al.   CELL CALCIUM

Direct recording and molecular identification of the calcium channel of primary cilia

(2013) Paul G. DeCaen et al.   NATURE

Primary cilia are specialized calcium signalling organelles

(2013) Markus Delling et al.   NATURE

TRPP2 and TRPV4 Form an EGF-Activated Calcium Permeable Channel at the Apical Membrane of Renal Collecting Duct Cells

(2013) Zhi-Ren Zhang et al.   PLoS One

Spatial mismatch between the Na+ flux and spike initiation in axon initial segment

(2013) G. Baranauskas et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Kinocilia Mediate Mechanosensitivity in Developing Zebrafish Hair Cells

(2012) Katie S. Kindt et al.   DEVELOPMENTAL CELL

A novel evolutionarily conserved domain of cell-adhesion GPCRs mediates autoproteolysis

(2012) Demet Araç et al.   EMBO JOURNAL

Cilia at the Node of Mouse Embryos Sense Fluid Flow for Left-Right Determination via Pkd2

(2012) S. Yoshiba et al.   SCIENCE

Modeling Human Disease in Humans: The Ciliopathies

(2011) Gaia Novarino et al.   CELL

Protein kinase A acts at the basal body of the primary cilium to prevent Gli2 activation and ventralization of the mouse neural tube

(2011) M. Tuson et al.   DEVELOPMENT

Primary cilia as biomechanical sensors in regulating endothelial function

(2011) Anastasia D. Egorova et al.   DIFFERENTIATION

Epithelial sodium channels (ENaC) are uniformly distributed on motile cilia in the oviduct and the respiratory airways

(2011) Yehoshua Enuka et al.   HISTOCHEMISTRY AND CELL BIOLOGY

Progesterone activates the principal Ca2+ channel of human sperm

(2011) Polina V. Lishko et al.   NATURE

The CatSper channel mediates progesterone-induced Ca2+ influx in human sperm

(2011) Timo Strünker et al.   NATURE

Sour Taste Responses in Mice Lacking PKD Channels

(2011) Nao Horio et al.   PLoS One

A novel gene required for male fertility and functional CATSPER channel formation in spermatozoa

(2011) Jean-Ju Chung et al.   Nature Communications

Atomic Force Microscopy Reveals the Alternating Subunit Arrangement of the TRPP2-TRPV4 Heterotetramer

(2010) Andrew P. Stewart et al.   BIOPHYSICAL JOURNAL

Sensory reception is an attribute of both primary cilia and motile cilia

(2010) R. A. Bloodgood   JOURNAL OF CELL SCIENCE

Polycystin-1 Surface Localization Is Stimulated by Polycystin-2 and Cleavage at the G Protein-coupled Receptor Proteolytic Site

(2010) Hannah C. Chapin et al.   MOLECULAR BIOLOGY OF THE CELL

Molecular diagnostics for autosomal dominant polycystic kidney disease

(2010) Peter C. Harris et al.   Nature Reviews Nephrology

The multimeric structure of polycystin-2 (TRPP2): structural-functional correlates of homo- and hetero-multimers with TRPC1

(2009) P. Zhang et al.   HUMAN MOLECULAR GENETICS

Polycystin-1 C-terminal Cleavage Is Modulated by Polycystin-2 Expression

(2009) Claudia A. Bertuccio et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Transient Receptor Potential Channels TRPP2 and TRPC1 Form a Heterotetramer with a 2:2 Stoichiometry and an Alternating Subunit Arrangement

(2009) Toshiro Kobori et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Lateral transport of Smoothened from the plasma membrane to the membrane of the cilium

(2009) Ljiljana Milenkovic et al.   JOURNAL OF CELL BIOLOGY

Inactivation of Chibby affects function of motile airway cilia

(2009) Vera A. Voronina et al.   JOURNAL OF CELL BIOLOGY

Localization of inner hair cell mechanotransducer channels using high-speed calcium imaging

(2009) Maryline Beurg et al.   NATURE NEUROSCIENCE

Morphogenesis of the node and notochord: The cellular basis for the establishment and maintenance of left-right asymmetry in the mouse

(2008) Jeffrey D. Lee et al.   DEVELOPMENTAL DYNAMICS

Formation of a new receptor-operated channel by heteromeric assembly of TRPP2 and TRPC1 subunits

(2008) Chang-Xi Bai et al.   EMBO REPORTS

Identification and Functional Characterization of an N-terminal Oligomerization Domain for Polycystin-2

(2008) Shuang Feng et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

TRPP2 and TRPV4 form a polymodal sensory channel complex

(2008) Michael Köttgen et al.   JOURNAL OF CELL BIOLOGY

TRPV4 channel participates in receptor-operated calcium entry and ciliary beat frequency regulation in mouse airway epithelial cells

(2008) I. M. Lorenzo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA