Notch activation drives adipocyte dedifferentiation and tumorigenic transformation in mice

Involvement of tumor suppressors PTEN and p53 in the formation of multiple subtypes of liposarcoma

(2015) A M Puzio-Kuter et al.   CELL DEATH AND DIFFERENTIATION

Increased H3K9me3 drives dedifferentiated phenotype via KLF6 repression in liposarcoma

(2015) Emily Z. Keung et al.   JOURNAL OF CLINICAL INVESTIGATION

Developmental origins of neurotransmitter and transcriptome alterations in adult female zebrafish exposed to atrazine during embryogenesis

(2015) Sara E. Wirbisky et al.   TOXICOLOGY

Notch signaling as a novel regulator of metabolism

(2015) Pengpeng Bi et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Selective enhancement of insulin sensitivity in the mature adipocyte is sufficient for systemic metabolic improvements

(2015) Thomas S. Morley et al.   Nature Communications

HDACi inhibits liposarcoma via targeting of the MDM2-p53 signaling axis and PTEN, irrespective of p53 mutational status

(2015) Wen-Bin Ou et al.   Oncotarget

Notch intracellular domain overexpression in adipocytes confers lipodystrophy in mice

(2015) Dionysios V. Chartoumpekis et al.   Molecular Metabolism

Notch Activation as a Driver of Osteogenic Sarcoma

(2014) Jianning Tao et al.   CANCER CELL

Lineage of origin in rhabdomyosarcoma informs pharmacological response

(2014) J. Abraham et al.   GENES & DEVELOPMENT

Lightening up a notch: Notch regulation of energy metabolism

(2014) Thomas Gridley et al.   NATURE MEDICINE

Inhibition of Notch signaling promotes browning of white adipose tissue and ameliorates obesity

(2014) Pengpeng Bi et al.   NATURE MEDICINE

Advances in our understanding of adipose tissue homeostasis

(2014) Jennifer H. Stern et al.   Nature Reviews Endocrinology

Characterization of Cre recombinase models for the study of adipose tissue

(2014) Elise Jeffery et al.   Adipocyte

Novel Dedifferentiated Liposarcoma Xenograft Models Reveal PTEN Down-Regulation as a Malignant Signature and Response to PI3K Pathway Inhibition

(2013) Kathleen B. Smith et al.   AMERICAN JOURNAL OF PATHOLOGY

Non-degradative ubiquitination of the Notch1 receptor by the E3 ligase MDM2 activates the Notch signalling pathway

(2013) Susanne Pettersson et al.   BIOCHEMICAL JOURNAL

Hepatic Notch Signaling Correlates With Insulin Resistance and Nonalcoholic Fatty Liver Disease

(2013) L. Valenti et al.   DIABETES

Lessons on Conditional Gene Targeting in Mouse Adipose Tissue

(2013) K. Y. Lee et al.   DIABETES

Liposarcomas: diagnostic pitfalls and new insights

(2013) Angelo P Dei Tos   HISTOPATHOLOGY

Notch Signaling in Osteocytes Differentially Regulates Cancellous and Cortical Bone Remodeling

(2013) Ernesto Canalis et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The liver diseases of lipodystrophy: The long-term effect of leptin treatment

(2013) Elika Safar Zadeh et al.   JOURNAL OF HEPATOLOGY

Characterization of the adipocyte cellular lineage in vivo

(2013) Ryan Berry et al.   NATURE CELL BIOLOGY

Inhibition of Notch uncouples Akt activation from hepatic lipid accumulation by decreasing mTorc1 stability

(2013) Utpal B Pajvani et al.   NATURE MEDICINE

PPARγ signaling and metabolism: the good, the bad and the future

(2013) Maryam Ahmadian et al.   NATURE MEDICINE

Novel Systemic Therapies in Advanced Liposarcoma: A Review of Recent Clinical Trial Results

(2013) William Tseng et al.   Cancers

Diagnostic Utility of p16, CDK4, and MDM2 as an Immunohistochemical Panel in Distinguishing Well-differentiated and Dedifferentiated Liposarcomas From Other Adipocytic Tumors

(2012) Khin Thway et al.   AMERICAN JOURNAL OF SURGICAL PATHOLOGY

A Mouse Model of Rhabdomyosarcoma Originating from the Adipocyte Lineage

(2012) Mark E. Hatley et al.   CANCER CELL

MiR-155 Is a Liposarcoma Oncogene That Targets Casein Kinase-1  and Enhances  -Catenin Signaling

(2012) P. Zhang et al.   CANCER RESEARCH

Membrane-Tethered Delta-Like 1 Homolog (DLK1) Restricts Adipose Tissue Size by Inhibiting Preadipocyte Proliferation

(2012) S. B. Mortensen et al.   DIABETES

Metabolic Syndrome and Risk of Cancer: A systematic review and meta-analysis

(2012) K. Esposito et al.   DIABETES CARE

Notch Signaling Is Activated in Human Hepatocellular Carcinoma and Induces Tumor Formation in Mice

(2012) Augusto Villanueva et al.   GASTROENTEROLOGY

mtDNA lineage analysis of mouse L-cell lines reveals the accumulation of multiple mtDNA mutants and intermolecular recombination

(2012) W. Fan et al.   GENES & DEVELOPMENT

MDM2 Protein-mediated Ubiquitination of NUMB Protein

(2012) Matylda Sczaniecka et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Novel Adipose-Specific Gene Deletion Model Demonstrates Potential Pitfalls of Existing Methods

(2012) Shannon E. Mullican et al.   MOLECULAR ENDOCRINOLOGY

The Notch signalling system: recent insights into the complexity of a conserved pathway

(2012) K. G. Guruharsha et al.   NATURE REVIEWS GENETICS

PPARs are a unique set of fatty acid regulated transcription factors controlling both lipid metabolism and inflammation

(2011) Tamas Varga et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Transcriptional Control of Adipose Lipid Handling by IRF4

(2011) Jun Eguchi et al.   Cell Metabolism

Notch signaling: simplicity in design, versatility in function

(2011) E. R. Andersson et al.   DEVELOPMENT

Intramuscular adipose is derived from a non-Pax3 lineage and required for efficient regeneration of skeletal muscles

(2011) Weiyi Liu et al.   DEVELOPMENTAL BIOLOGY

Notch Initiates the Endothelial-to-Mesenchymal Transition in the Atrioventricular Canal through Autocrine Activation of Soluble Guanylyl Cyclase

(2011) Alex C.Y. Chang et al.   DEVELOPMENTAL CELL

Lipodystrophies: Genetic and Acquired Body Fat Disorders

(2011) Abhimanyu Garg   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Oncogenic and tumor suppressor functions of Notch in cancer: it’s NOTCH what you think: Table I.

(2011) Camille Lobry et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Nonalcoholic fatty liver disease and hepatocellular carcinoma: A weighty connection

(2010) Brad Q. Starley et al.   HEPATOLOGY

Lipodystrophy: metabolic insights from a rare disorder

(2010) Isabel Huang-Doran et al.   JOURNAL OF ENDOCRINOLOGY

An experimental model for the study of well-differentiated and dedifferentiated liposarcoma; deregulation of targetable tyrosine kinase receptors

(2010) Tingsheng Peng et al.   LABORATORY INVESTIGATION

Lipodystrophy: pathophysiology and advances in treatment

(2010) Christina G. Fiorenza et al.   Nature Reviews Endocrinology

Notch signaling contributes to the pathogenesis of human osteosarcomas

(2009) F. Engin et al.   HUMAN MOLECULAR GENETICS

A robust and high-throughput Cre reporting and characterization system for the whole mouse brain

(2009) Linda Madisen et al.   NATURE NEUROSCIENCE

Notch Signaling in Leukemia

(2008) Jon C. Aster et al.   Annual Review of Pathology-Mechanisms of Disease