Article
Endocrinology & Metabolism
Marieh Salavatizadeh, Samira Soltanieh, Amirhossein Ataei Kachouei, Zahra Abdollahi Fallahi, Hamed Kord-Varkaneh, Hossein Poustchi, Asieh Mansour, Mohammad E. Khamseh, Fariba Alaei-Shahmiri, Heitor O. Santos, Azita Hekmatdoost
Summary: Dietary glycemic index (GI) is associated with the odds of non-alcoholic fatty liver disease (NAFLD) in patients with type 2 diabetes mellitus (T2DM). Higher GI diets are associated with increased risk of NAFLD in individuals with T2DM.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Hongyan Li, Yanzhi Zeng, Xinyu Zheng, Guangjun Wang, Jingjing Tian, Wangbao Gong, Yun Xia, Kai Zhang, Zhifei Li, Wenping Xie, Jun Xie, Ermeng Yu
Summary: The study found that betaine promotes the growth of mandarin fish and can alleviate oxidative stress and ER stress caused by a high-carbohydrate diet, as well as reduce autophagy and apoptosis.
Article
Endocrinology & Metabolism
Chun Zhou, Zhuxian Zhang, Mengyi Liu, Yuanyuan Zhang, Huan Li, Panpan He, Qinqin Li, Chengzhang Liu, Xianhui Qin
Summary: The study found a U-shaped association between the percentage of energy from carbohydrate intake and new-onset diabetes, with the lowest risk at 49-56% of carbohydrate intake. There was an L-shaped association between high-quality carbohydrate intake and new-onset diabetes, and a J-shaped association of low-quality carbohydrate intake with new-onset diabetes. The findings suggest that consuming high-quality carbohydrates and substituting plant-based products for low-quality carbohydrates may help prevent diabetes.
METABOLISM-CLINICAL AND EXPERIMENTAL
(2021)
Review
Oncology
Lin Qian, Fan Zhang, Miao Yin, Qunying Lei
Summary: Metabolic remodeling is a key feature in cancer development, leading malignant cells to favor specialized fermentation. Targeted cancer therapies based on reprogramming nutrient or metabolite metabolism have gained substantial attention, as well as the management of nutrient availability becoming more appealing.
CANCER BIOLOGY & MEDICINE
(2022)
Review
Nutrition & Dietetics
Qianying Zuo, Nicole Hwajin Park, Jenna Kathryn Lee, Zeynep Madak Erdogan
Summary: The median overall survival of patients with metastatic breast cancer is short, requiring more effective anti-cancer strategies. Diet can influence tumor progression, but there is currently limited evidence to support the role of diet in cancer treatment.
Article
Immunology
Junseok Jeon, Kyungho Lee, Kyeong Eun Yang, Jung Eun Lee, Ghee Young Kwon, Wooseong Huh, Dae Joong Kim, Yoon-Goo Kim, Hye Ryoun Jang
Summary: The study suggests that high-salt or high-fat diets may enhance susceptibility to ischemic AKI by inducing proinflammatory changes to the intrarenal immunologic micromilieu.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Neurosciences
Carolyn E. Keating, Kevin D. Browne, D. Kacy Cullen
Summary: The study investigated the impact of different diets on acute neuronal damage mechanism in TBI, showing that a high fat diet beneficially modulated acute plasma membrane permeability and resulted in a smaller lesion size.
EXPERIMENTAL NEUROLOGY
(2021)
Article
Biochemistry & Molecular Biology
Sunil K. Panchal, Naga K. R. Ghattamaneni, Marie Magnusson, Andrew Cole, David Roberts, Nicolas Neveux, Lindsay Brown, Nicholas A. Paul
Summary: This study found that macroalgae biomass cultivated in different wastewater sources contain different nutrients and may have different effects in the development of metabolic syndrome induced by a high-carbohydrate, high-fat diet. Macroalgae biomass cultured in treated municipal wastewater may improve blood glucose responses, while biomass grown in ash dam water from a coal-fired power station may decrease abdominal fat deposition.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Nutrition & Dietetics
Bahareh Sasanfar, Fatemeh Toorang, Elham Mohebbi, Kazem Zendehdel, Leila Azadbakht
Summary: The study revealed a positive association between GI and the risk of BC, as well as a negative association between CQI and the risk of BC, especially among premenopausal women.
Article
Cardiac & Cardiovascular Systems
Michinari Nakamura, Natalija Odanovic, Yasuki Nakada, Satomi Dohi, Peiyong Zhai, Andreas Ivessa, Zhi Yang, Maha Abdellatif, Junichi Sadoshima
Summary: This study demonstrates that a high-fat or high-protein low-carbohydrate diet can inhibit pathological cardiac growth and heart failure after pressure overload through different mechanisms. The high-fat diet provides cardioprotection, while the high-protein diet does not have a significant effect in this aspect.
CARDIOVASCULAR RESEARCH
(2021)
Article
Oncology
Liang Zhu, Juntao Ji, Jianjia Ma, Dan Wang, Muyun Liu, James Xianxing Du, Rong Chen, Wei Hou, James L. Abbruzzese, Craig D. Logsdon, Vincent W. Yang, Yongde Luo, Weiqin Lu
Summary: PDAC is a lethal disease with prevalent KRAS mutations. This study investigated the effects of different macronutrient diets on PDAC development in mice expressing mutant KRAS. The study showed that a high-carbohydrate diet (HCD) promoted pancreatic metaplasia and neoplasia with increased inflammation, while a high-protein diet (HPD) did not show adverse effects. Ablation of cyclooxygenase 2 (Cox-2) in pancreatic cells eliminated the adverse effects induced by HCD, suggesting that diet-induced inflammation plays a critical role in promoting oncogenic KRAS-mediated neoplasia. Managing macronutrient intake to prevent inflammation is an important strategy for patients with oncogenic KRAS mutations.
Article
Nutrition & Dietetics
Shanshan Mei, Jie Ding, Kaili Wang, Zhexin Ni, Jin Yu
Summary: The results of this study suggest that the MED/LC diet model is an effective treatment for overweight PCOS patients. It significantly restores their menstrual cycle, improves their anthropometric parameters, corrects their disturbed endocrine levels, and has better overall effectiveness compared to the LF diet model. Therefore, the MED/LC diet model is recommended for clinical treatment of overweight PCOS patients.
FRONTIERS IN NUTRITION
(2022)
Review
Nutrition & Dietetics
Helen Chauhan, Regina Belski, Eleanor Bryant, Matthew Cooke
Summary: Metabolic syndrome is associated with chronic diseases, and lifestyle interventions are crucial for its treatment. While weight reduction is commonly used, it may not address all risk factors. Diet quality and novel strategies like carbohydrate restriction and modifying meal timing have shown promise. Dietary assessment tools are necessary for personalized advice, but existing tools may not capture all relevant dietary patterns.
Article
Nutrition & Dietetics
Krystle C. Kalafut, Sarah J. Mitchell, Michael R. MacArthur, James R. Mitchell
Summary: This study investigated the potential relationship between protein restriction and ketogenic diet, revealing that while both have effects on weight loss and metabolic health, they may operate through different mechanisms.
FRONTIERS IN NUTRITION
(2022)
Article
Nutrition & Dietetics
Deaglan McCullough, Tanja Harrison, Lynne M. Boddy, Kevin J. Enright, Farzad Amirabdollahian, Michael A. Schmidt, Katrina Doenges, Kevin Quinn, Nichole Reisdorph, Mohsen Mazidi, Katie E. Lane, Claire E. Stewart, Ian G. Davies
Summary: This study investigated the effects of LCHF and HCLF diets on CMD markers, the metabolome, and insulin resistance markers. The results showed that both diets improved insulin resistance markers and CMD markers. LCHF diet may enhance insulin sensitivity by increasing lipid oxidation.
Meeting Abstract
Neurosciences
Zhonghua Hu, Shouguo Gao, Joel Kleinman, Jun Zhu, Zheng Li
BIOLOGICAL PSYCHIATRY
(2019)
Article
Biochemistry & Molecular Biology
Zhonghua Hu, Xiao Xiao, Zhuohua Zhang, Ming Li
MOLECULAR PSYCHIATRY
(2019)
Article
Psychiatry
Huijuan Li, Dong-Sheng Zhou, Hong Chang, Lu Wang, Weipeng Liu, Shao-Xing Dai, Chen Zhang, Jun Cai, Weiqing Liu, Xingxing Li, Weixing Fang, Wei Tang, Wenxin Tang, Fang Liu, Yuanfang He, Yan Bai, Zhonghua Hu, Xiao Xiao, Lei Gao, Ming Li
JOURNAL OF PSYCHIATRIC RESEARCH
(2019)
Article
Psychiatry
Zhonghua Hu, Shuoguo Gao, Daniel Lindberg, Debabrata Panja, Yoshi Wakabayashi, Keshen Li, Joel E. Kleinman, Jun Zhu, Zheng Li
TRANSLATIONAL PSYCHIATRY
(2019)
Correction
Psychiatry
Zhonghua Hu, Shouguo Gao, Daniel Lindberg, Debabrata Panja, Yoshi Wakabayashi, Keshen Li, Joel E. Kleinman, Jun Zhu, Zheng Li
TRANSLATIONAL PSYCHIATRY
(2019)
Article
Biochemistry & Molecular Biology
Chu-Yi Zhang, Xiao Xiao, Zhuohua Zhang, Zhonghua Hu, Ming Li
Summary: Transcriptomic and long-read sequencing analyses have revealed alternative splicing characteristics of schizophrenia risk genes, identifying new spliced isoforms and providing examples for investigating these isoforms in vitro and in vivo.
MOLECULAR PSYCHIATRY
(2022)
Article
Medicine, General & Internal
Milin Peng, Fuxing Deng, Desheng Qi, Zhonghua Hu, Lina Zhang
Summary: This retrospective study analyzed the impact of hyperbilirubinemia on long-term outcomes in patients with sepsis, finding that TBIL levels ≥5 mg/dl were associated with increased long-term mortality risk. The study suggests potential cutoff values for early intervention in sepsis patients, which could improve prognosis.
FRONTIERS IN MEDICINE
(2021)
Review
Biochemistry & Molecular Biology
Xiao Xiao, Chu-Yi Zhang, Zhuohua Zhang, Zhonghua Hu, Ming Li, Tao Li
Summary: GWAS have identified genetic components in psychiatric disorders, but tandem repeats, often overlooked by GWAS, may hold missing pieces of heritability. These repeats may regulate gene expression and human phenotypes, modulating biological traits related to psychiatric disorders.
MOLECULAR PSYCHIATRY
(2022)
Review
Biochemistry & Molecular Biology
Ming Li, Tao Li, Xiao Xiao, Jun Chen, Zhonghua Hu, Yiru Fang
Summary: GWAS studies have identified BD risk genes that have been shown to affect clinical manifestations of BD and provide insights into the neurobiology of the disorder.
MOLECULAR PSYCHIATRY
(2022)
Article
Neurosciences
Panlin Liao, Yanchun Yuan, Zhen Liu, Xiaorong Hou, Wanzhen Li, Jin Wen, Kexuan Zhang, Bin Jiao, Lu Shen, Hong Jiang, Jifeng Guo, Beisha Tang, Zhuohua Zhang, Zhonghua Hu, Junling Wang
Summary: This study identified rare damage variants (RDVs) in the KIF1A gene associated with ALS and delineated the clinical characteristics of ALS patients with KIF1A RDVs. The majority of these variants are located at the C-terminal cargo-binding region of the KIF1A protein and enhance the binding of specific vesicles. KIF1A is highlighted as an important player in the pathogenesis of ALS.
TRANSLATIONAL NEURODEGENERATION
(2022)
Article
Neurosciences
Kexuan Zhang, Panlin Liao, Jin Wen, Zhonghua Hu
Summary: Schizophrenia is a severe neuropsychiatric syndrome with genetic and environmental factors contributing to its onset. The exploration of synaptopathy and dysregulated synaptic plasticity as biological mechanisms of schizophrenia pathogenesis is becoming increasingly intriguing. Understanding the molecular and cellular mechanisms of synaptic plasticity, as well as the impact of disease-risk genes and environmental alterations on synaptic plasticity, can advance our understanding of schizophrenia pathology.
IBRO NEUROSCIENCE REPORTS
(2022)
Article
Neurosciences
Kexuan Zhang, Panlin Liao, Jin Wen, Zhonghua Hu
Summary: Schizophrenia is a severe neuropsychiatric syndrome characterized by psychotic behavioral abnormalities and cognitive deficits. The role of genetic and environmental factors in its development is widely recognized, but the underlying etiology and pathology remain largely unknown. Recent research has focused on synaptopathology and dysfunctional synaptic plasticity as potential biological mechanisms contributing to schizophrenia. Understanding the molecular and cellular mechanisms of synaptic plasticity, as well as the impact of disease-risk genes and environmental alterations on synaptic transmission and plasticity, may provide valuable insights into the pathology of schizophrenia.
IBRO NEUROSCIENCE REPORTS
(2023)
Article
Biochemistry & Molecular Biology
Qingtao Gao, Runyi Tian, Hailong Han, Jesse Slone, Caifang Wang, Xiao Ke, Tongmei Zhang, Xiangyu Li, Yuhong He, Panlin Liao, Fang Wang, Ye Chen, Shiqing Fu, Kexuan Zhang, Fangfang Zeng, Yingxuan Yang, Zhuo Li, Jieqiong Tan, Jiada Li, Youming Lu, Taosheng Huang, Zhonghua Hu, Zhuohua Zhang
Summary: This study reveals the importance of mitochondrial morphology and distribution in neural circuitry formation and synaptic efficacy and identifies the essential role of PINK1-Drp1(S616) phosphorylation coupling in regulating mitochondrial dynamics and neural circuitry formation.
SIGNAL TRANSDUCTION AND TARGETED THERAPY
(2022)
Article
Dermatology
Ling Yang, Zhonghua Hu, Yanxia Jin, Ning Huang, Su Xu
Summary: UVB radiation significantly increased the expression of miR-4497 in HaCaT cells, inhibiting cell proliferation and promoting cell apoptosis. Additionally, UVB radiation led to the upregulation of cytokines TNF-a, IL-18, IL-6, and IL-113, as well as the promotion of ROS production and inhibition of SOD activity in the cells.
ITALIAN JOURNAL OF DERMATOLOGY AND VENEREOLOGY
(2022)