Article
Toxicology
Jin Jia, Shi-Qi Chen, Wei-Zhe Pan, Sheng-Nan Yu, Xiao-Tian Zhao, Yan Hao, Yong-Mei Shen, Ying Cheng, Cai-Ling Wei, Feng-Jie Tian, Xiao-Yan Yan, Yu-Lan Qiu
Summary: The study found that exposure to vinyl chloride can exacerbate hepatic steatosis in high-fat diet mice, leading to oxidative stress and endoplasmic reticulum stress. Upregulation of de novo lipogenesis-related proteins expression may be associated with the occurrence of hepatic steatosis.
JOURNAL OF APPLIED TOXICOLOGY
(2022)
Article
Pharmacology & Pharmacy
Yu-Hao Wang, Ya-Ping Liu, Jia-Quan Zhu, Guang Hai Zhou, Feng Zhang, Qi An, Jie Yang, Kyung Woo Cho, Song Nan Jin, Jin Fu Wen
Summary: Physcion has a protective effect on high-fat diet-induced endothelial dysfunction, which is related to the inhibition of oxidative stress and ER stress through activation of eNOS/Nrf2 signaling pathway.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)
Article
Environmental Sciences
Sitong Zhou, Xiaohong Zhang, Qin Fu, Zheng Cheng, Wenbo Ji, Honggui Liu
Summary: This study evaluated the toxic effect of NH3 exposure on the spleen and investigated the protective effect of selenomethionine against ammonia-induced immunotoxicity. The results showed that NH3 inhalation caused autophagy in the pig spleen, decreased lymphocytes, increased autophagic vesicles, decreased antioxidant enzyme activity, and increased expression of genes related to oxidative stress and endoplasmic reticulum stress. Selenomethionine mitigated ammonia toxicity in pigs.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2022)
Article
Biochemistry & Molecular Biology
Naymel Alejandra Guzman Mendoza, Kohei Homma, Hideto Osada, Eriko Toda, Norimitsu Ban, Norihiro Nagai, Kazuno Negishi, Kazuo Tsubota, Yoko Ozawa
Summary: This study demonstrated that administration of an ER-stress inhibitor, 4-phenylbutyric acid (4-PBA), effectively suppressed light-induced visual function impairment and reduced photoreceptor cell apoptosis. Induction of ER stress in the light-exposed retina was attenuated by 4-PBA treatment, leading to suppression of oxidative stress and mitochondrial apoptosis.
Article
Engineering, Environmental
Huanliang Liu, Wenqing Lai, Xiaohua Liu, Honglian Yang, Yanjun Fang, Lei Tian, Kang Li, Huipeng Nie, Wei Zhang, Yue Shi, Liping Bian, Susu Ding, Jun Yan, Bencheng Lin, Zhuge Xi
Summary: The research investigated the mechanism of hepatotoxicity and apoptosis caused by Nano-CuO through oxidative stress and ER-stress. Both in vivo and in vitro experiments confirmed that Nano-CuO induced oxidative stress, leading to ER-stress pathway activation and subsequently cell death.
JOURNAL OF HAZARDOUS MATERIALS
(2021)
Article
Biochemistry & Molecular Biology
Wenrong Feng, Shengyan Su, Changyou Song, Fan Yu, Jun Zhou, Jianlin Li, Rui Jia, Pao Xu, Yongkai Tang
Summary: High concentrations of copper pose a threat to aquatic animals, but the response mechanisms of crustaceans to Cu2+ exposure are not well understood. This study investigated the physiological and molecular changes in Chinese mitten crabs after Cu2+ exposure. The results showed that Cu2+ exposure decreased antioxidative capacity and promoted lipid peroxidation in different tissues. It also induced apoptosis and autophagy, and triggered an immune response. The toxicity of Cu2+ may be associated with the activation of ERK, AMPK, and TLR2-MyD88-NF-kappa B pathways.
Article
Food Science & Technology
Jing Wu, You Wu, Hui Fan, Chenglin Yang, Mengran Yang, Xiangyi Kong, Can Ning, Siqi Wang, Wenguang Xiao, Naidong Wang, Jine Yi, Zhihang Yuan
Summary: This study investigated the mechanism of Citrinin (CTN) exposure on male infertility. The results showed that CTN exposure caused disorder of androgen, decreased sperm quality, and histopathological damage of testis. The expression of blood-testis barrier (BTB) related proteins were inhibited, and oxidative and ER stress damage were observed in the testis. Additionally, treatment with 4-Phenylbutyric acid blocked the adverse effects of CTN exposure on male reproduction.
Article
Environmental Sciences
Mingdan You, Siyao Li, Siyu Yan, Dianqi Yao, Tingyu Wang, Yi Wang
Summary: Early-life exposure to environmental endocrine disruptors (EDCs) is a potential risk factor for autism spectrum disorder (ASD). This study found that exposure to nonylphenol (NP), a typical EDC, in early life can cause mild ASD-like behaviors. Additionally, the activation of endoplasmic reticulum (ER) stress triggered by oxidative stress may contribute to synaptic dysfunction, underlying the neurobehavioral abnormalities induced by early-life exposure to NP.
ENVIRONMENT INTERNATIONAL
(2023)
Article
Environmental Sciences
Huanliang Liu, Susu Ding, Huipeng Nie, Yue Shi, Wenqing Lai, Xuan Liu, Kang Li, Lei Tian, Zhuge Xi, Bencheng Lin
Summary: This study elucidates the molecular mechanisms of PM2.5 exposure in the male reproductive system, identifying a possible relationship between endoplasmic reticulum stress (ERS), oxidative stress, and reproductive toxicity. It shows that PM2.5 triggers ERS pathway activation and induces DNA damage and apoptosis in testicular cells through oxidative stress. Moreover, high-concentration intermittent inhalation poses greater harm than low-concentration continuous inhalation.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2022)
Article
Biochemistry & Molecular Biology
Shaoqing Yang, Yuzhuan Hou, Hengwei Zhang, Ying Hao, Yanli Zhang, Zanyan Zhao, Wenyan Ruan, Xiaohong Duan
Summary: This study found that ATP6V1H deficiency worsens fatty acid-induced glucose intolerance and increases endoplasmic reticulum stress in beta-cells. Alternative splicing of ATP6V1H might be involved in this process, increasing susceptibility to T2DM.
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
(2022)
Article
Biochemistry & Molecular Biology
Xiaoli Zhang, Weiwei Li, Yiming Ma, Xinhua Zhao, Longmei He, Peng Sun, Hongying Wang
Summary: A high-fat diet exacerbates colorectal cancer by suppressing lipid peroxidation and iron-dependent cell death, known as ferroptosis. Ferroptosis is negatively correlated with tumor number in colorectal cancer. A lipid mixture can block ferroptosis, offering a new potential approach for colorectal cancer prevention.
FREE RADICAL BIOLOGY AND MEDICINE
(2021)
Article
Nutrition & Dietetics
Tian An, Jia-Xian Liu, Xiu-yan Yang, Bo-han Lv, Yan-xiang Wu, Guang-jian Jiang
Summary: The quinoa diet significantly reduced blood glucose, triglyceride, cholesterol, and low-density lipoprotein levels, improved glucose tolerance, and histological changes in liver tissues in obese mice. Additionally, quinoa improved oxidative stress indicators and down-regulated ER stress markers in the liver of obese mice.
NUTRITION & METABOLISM
(2021)
Article
Agriculture, Dairy & Animal Science
Jing Wang, Xin-Qin Wang, Rong-Ping Liu, Ying-Hua Li, Xue-Rui Yao, Nam-Hyung Kim, Yong-Nan Xu
Summary: Research has found that imidacloprid, a widely used neonicotinoid insecticide in agriculture, can affect oocyte maturation in livestock, but the extent of its toxicity and potential countermeasures are unclear. This study demonstrates that imidacloprid can impair oocyte maturation, but supplementation with melatonin can alleviate oxidative stress and endoplasmic reticulum stress, thereby restoring oocyte maturation and offsetting the toxic effects of imidacloprid on pig oocytes. These findings suggest that melatonin may be a promising drug to improve the quality of oocytes exposed to imidacloprid.
Article
Biochemistry & Molecular Biology
Fangzhou Cheng, Yaoshan Dun, Jing Cheng, Jeffrey W. Ripley-Gonzalez, Wenlong Jiang, Baiyang You, Suixin Liu
Summary: This study investigates how exercise training acts on insulin resistance (IR) through the mechanism of endoplasmic reticulum (ER) stress and blocked autophagy caused by a high-fat diet (HFD). The findings suggest that exercise training can facilitate HFD-blocked protective autophagy via the activation of the AMPK/PGC1 alpha pathway to relieve insulin resistance in mice.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Article
Multidisciplinary Sciences
Jun Shunzi Chen, Peng Fei Xie, Hong Feng
Summary: A diet high in sugar and fat is a precursor to chronic diseases, particularly hyperlipidemia, which causes increased plasma free fatty acids and ectopic lipid accumulation. The kidney is significantly impacted by hyperlipidemia, and recent studies have focused on renal injury caused by the disease. The main pathological mechanism is related to renal lipotoxicity, but different kidney cells have varying reaction mechanism due to differing lipid receptor affinities. In addition to lipotoxicity, oxidative stress, endoplasmic reticulum stress, and inflammatory reactions are closely related to hyperlipidemia-induced renal injury. Exercise has been shown to play a vital role in preventing various chronic diseases and recent research has suggested its positive effects on renal injury caused by hyperlipidemia. However, there is limited research summarizing the effects of exercise on this disease and further exploration of specific mechanisms is needed. This article summarizes the cellular mechanisms of hyperlipidemia-induced renal injury and discusses exercise as a potential means of regulation, providing theoretical support and novel approaches for intervention targeting hyperlipidemia-induced renal injury.
Article
Biochemistry & Molecular Biology
Wenhao Zhou, Samad Rahimnejad, Kangle Lu, Lina Wang, Wenbin Liu
FISH PHYSIOLOGY AND BIOCHEMISTRY
(2019)
Article
Fisheries
Xiao Li, Samad Rahimnejad, Ling Wang, Kangle Lu, Kai Song, Chunxiao Zhang
Article
Fisheries
Wenhao Zhou, Samad Rahimnejad, Douglas R. Tocher, Kangle Lu, Chunxiao Zhang, Yunzhang Sun
Article
Physiology
Xiaojun Song, Samad Rahimnejad, Wenhao Zhou, Linsen Cai, Kangle Lu
FRONTIERS IN PHYSIOLOGY
(2019)
Article
Fisheries
Manqi Yang, Samad Rahimnejad, Chunxiao Zhang, Kai Song, Kangle Lu, Ling Wang
AQUACULTURE RESEARCH
(2020)
Article
Fisheries
Lin-Sen Cai, Ling Wang, Kai Song, Kang-Le Lu, Chun-Xiao Zhang, Samad Rahimnejad
Article
Biochemistry & Molecular Biology
Kangle Lu, Tomas Policar, Xiaojun Song, Samad Rahimnejad
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Article
Agriculture, Multidisciplinary
Yan-Zou Dong, Lei Li, Marit Espe, Kang-Le Lu, Samad Rahimnejad
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2020)
Article
Fisheries
Kang-Le Lu, Lin-Sen Cai, Ling Wang, Kai Song, Chun-Xiao Zhang, Samad Rahimnejad
AQUACULTURE NUTRITION
(2020)
Article
Biochemistry & Molecular Biology
Yanzou Dong, Manhan Yu, Youlin Wu, Tian Xia, Ling Wang, Kai Song, Chunxiao Zhang, Kangle Lu, Samad Rahimnejad
Summary: Hydroxytyrosol can alleviate symptoms of non-alcoholic fatty liver disease by activating mitophagy through the AMPK/PINK1 pathway, including reducing fat accumulation, oxidative stress, and mitochondrial dysfunction.
Article
Agriculture, Dairy & Animal Science
Jian Zhang, Yanzou Dong, Kai Song, Ling Wang, Xueshan Li, Beiping Tan, Kangle Lu, Chunxiao Zhang
Summary: This study suggests that replacing fish meal with defatted yellow mealworm as a protein source in large yellow croaker feed can improve immune response and intestinal health without affecting growth.
Article
Biochemistry & Molecular Biology
Tian Xia, Yan-Qin Liao, Lei Li, Lu-Yu Sun, Neng-Shui Ding, You-Lin Wu, Kang-Le Lu
Summary: Excessive fat accumulation is common in cultured fish. This study investigates the role of endoplasmic reticulum stress in fat deposition and finds that 4-PBA, an endoplasmic reticulum stress inhibitor, can reduce fat accumulation caused by a high-fat diet.
Article
Fisheries
Jian Zhang, Yanzou Dong, Kai Song, Ling Wang, Xueshan Li, Kangle Lu, Beiping Tan, Chunxiao Zhang
Summary: This study investigated the effects of replacing fish meal with Clostridium autoethanogenum protein (CAP) on the growth performance, digestive enzyme activity, humoral immunity, and liver and intestinal health of large yellow croakers. The results showed that a 15% replacement level of CAP had beneficial effects on humoral immunity and intestinal health without adverse effects on growth. However, higher replacement levels (30% and 45%) had negative effects on growth and humoral immunity in large yellow croakers.
Article
Fisheries
Yanzou Dong, Tian Xia, Manhan Yu, Ling Wang, Kai Song, Chunxiao Zhang, Kangle Lu
Summary: This study found that adding hydroxytyrosol to a high-fat diet can attenuate oxidative stress, inflammation, and cell apoptosis in blunt snout bream. Hydroxytyrosol reduces the production of reactive oxygen species, increases the activity of mitochondrial complexes, and promotes mitochondrial autophagy and biogenesis.