Aerosol Delivery of Lung Surfactant and Nasal CPAP in the Treatment of Neonatal Respiratory Distress Syndrome

Characterizing the Effects of Nasal Prong Interfaces on Aerosol Deposition in a Preterm Infant Nasal Model

(2022) Karl Bass et al.   AAPS PHARMSCITECH

Development and Characterization of Excipient Enhanced Growth (EEG) Surfactant Powder Formulations for Treating Neonatal Respiratory Distress Syndrome

(2021) Susan Boc et al.   AAPS PHARMSCITECH

Breath-Triggered Drug Release System for Preterm Neonates

(2021) Felix C. Wiegandt et al.   Pharmaceutics

Trial of aerosolised surfactant for preterm infants with respiratory distress syndrome

(2021) Luke Jardine et al.   Archives of Disease in Childhood-Fetal and Neonatal Edition

Changes in Use of Respiratory Support for Preterm Infants in the US, 2008-2018

(2021) L. Dupree Hatch et al.   JAMA Pediatrics

State-of-the-art review of the application and development of various methods of aerosol therapy

(2021) M. Matuszak et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Structural and functional stability of the sulfur-free surfactant protein B peptide mimic B-YL in synthetic surfactant lipids

(2021) Frans J. Walther et al.   BMC Pulmonary Medicine

Physiologic Effects of Instilled and Aerosolized Surfactant Using a Breath-Synchronized Nebulizer on Surfactant-Deficient Rabbits

(2021) Robert M. DiBlasi et al.   Pharmaceutics

Nebulized Poractant Alfa Reduces the Risk of Respiratory Failure at 72 Hours in Spontaneously Breathing Surfactant-Deficient Newborn Piglets

(2020) Carmen Rey-Santano et al.   CRITICAL CARE MEDICINE

Dose-Response Study on Surfactant Nebulization Therapy During Nasal Continuous Positive Airway Pressure Ventilation in Spontaneously Breathing Surfactant-Deficient Newborn Piglets

(2020) Carmen Rey-Santano et al.   Pediatric Critical Care Medicine

Extended Pharmacopeial Characterization of Surfactant Aerosols Generated by a Customized eFlow Neos Nebulizer Delivered through Neonatal Nasal Prongs

(2020) Federico Bianco et al.   Pharmaceutics

Synthetic Surfactant CHF5633 Compared with Poractant Alfa in the Treatment of Neonatal Respiratory Distress Syndrome: A Multicenter, Double-Blind, Randomized, Controlled Clinical Trial

(2020) Rangasamy Ramanathan et al.   JOURNAL OF PEDIATRICS

Impact of Body Position on Lung Deposition of Nebulized Surfactant in Newborn Piglets on Nasal Continuous Positive Airway Pressure

(2020) Doris Cunha-Goncalves et al.   Neonatology

Aerosolized Calfactant for Newborns With Respiratory Distress: A Randomized Trial

(2020) James J. Cummings et al.   PEDIATRICS

A first-in-human clinical study of a new SP-B and SP-C enriched synthetic surfactant (CHF5633) in preterm babies with respiratory distress syndrome: two-year outcomes

(2020) David G. Sweet et al.   Journal of Maternal-Fetal & Neonatal Medicine

Aerosolized Beractant in neonatal respiratory distress syndrome: A randomized fixed-dose parallel-arm phase II trial

(2020) Beena G. Sood et al.   PULMONARY PHARMACOLOGY & THERAPEUTICS

Advances in synthetic lung surfactant protein technology

(2019) Frans J. Walther et al.   Expert Review of Respiratory Medicine

Helical side chain chemistry of a peptoid‐based SP‐C analogue: Balancing structural rigidity and biomimicry

(2019) Nathan J. Brown et al.   BIOPOLYMERS

Less invasive surfactant administration (LISA): chances and limitations

(2019) Egbert Herting et al.   Archives of Disease in Childhood-Fetal and Neonatal Edition

Aerosolized surfactant in neonatal respiratory distress syndrome: Phase I study

(2019) Beena G. Sood et al.   EARLY HUMAN DEVELOPMENT

Deposition of Aerosolized Lucinactant in Nonhuman Primates

(2019) Timothy J. Gregory et al.   Journal of Aerosol Medicine and Pulmonary Drug Delivery

A novel delivery system for supraglottic atomization allows increased lung deposition rates of pulmonary surfactant in newborn piglets

(2019) Anders Nord et al.   PEDIATRIC RESEARCH

Lung deposition of nebulized surfactant in newborn piglets: Nasal CPAP vs Nasal IPPV

(2019) Anders Nord et al.   PEDIATRIC PULMONOLOGY

Nebulised surfactant to reduce severity of respiratory distress: a blinded, parallel, randomised controlled trial

(2018) Stefan Minocchieri et al.   Archives of Disease in Childhood-Fetal and Neonatal Edition

Surfactant Need by Gestation for Very Preterm Babies Initiated on Early Nasal CPAP: A Danish Observational Multicentre Study of 6,628 Infants Born 2000-2013

(2017) Rikke Wiingreen et al.   Neonatology

Supraglottic Atomization of Surfactant in Spontaneously Breathing Lambs Receiving Continuous Positive Airway Pressure

(2017) Ilaria Milesi et al.   Pediatric Critical Care Medicine

How Should Aerosols Be Delivered During Invasive Mechanical Ventilation?

(2017) Rajiv Dhand   Respiratory Care

Stability of an amphipathic helix-hairpin surfactant peptide in liposomes

(2016) Alan J. Waring et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

In vitro and in vivo comparison between poractant alfa and the new generation synthetic surfactant CHF5633

(2016) Francesca Ricci et al.   PEDIATRIC RESEARCH

Evolution of surfactant therapy for respiratory distress syndrome: past, present and future

(2016) Smeeta Sardesai et al.   PEDIATRIC RESEARCH

Incidence and Outcome of CPAP Failure in Preterm Infants

(2016) P. A. Dargaville et al.   PEDIATRICS

Trends in Care Practices, Morbidity, and Mortality of Extremely Preterm Neonates, 1993-2012

(2015) Barbara J. Stoll et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Lung Deposition of Nebulized Surfactant in Newborn Piglets

(2015) Rikard Linner et al.   Neonatology

Surfactant proteins in pediatric interstitial lung disease

(2015) Matthias Griese et al.   PEDIATRIC RESEARCH

Nebulization of Poractant alfa via a vibrating membrane nebulizer in spontaneously breathing preterm lambs with binasal continuous positive pressure ventilation

(2015) Matthias C. Hütten et al.   PEDIATRIC RESEARCH

Noninvasive Respiratory Support

(2015) James J. Cummings et al.   PEDIATRICS

Clinical Controversies in Aerosol Therapy for Infants and Children

(2015) R. M. DiBlasi   Respiratory Care

Surfactant protein C peptides with salt-bridges (“ion-locks”) promote high surfactant activities by mimicking theα-helix and membrane topography of the native protein

(2014) Frans J. Walther et al.   PeerJ

Acute respiratory distress syndrome in children

(2013) David N. Cornfield   CURRENT OPINION IN PEDIATRICS

A Novel Continuous Powder Aerosolizer (CPA) for Inhalative Administration of Highly Concentrated Recombinant Surfactant Protein-C (rSP-C) Surfactant to Preterm Neonates

(2013) G. Pohlmann et al.   Journal of Aerosol Medicine and Pulmonary Drug Delivery

Vibrating Membrane Devices Deliver Aerosols More Efficient than Standard Devices: A Study in a Neonatal Upper Airway Model

(2012) Sybrich Tiemersma et al.   Journal of Aerosol Medicine and Pulmonary Drug Delivery

The non-intubated, spontaneously breathing, continuous positive airway pressure (CPAP) ventilated pre-term lamb: A unique animal model

(2012) D.K. Rahmel et al.   REPRODUCTIVE TOXICOLOGY

An Open Label, Pilot Study of Aerosurf® Combined with nCPAP to Prevent RDS in Preterm Neonates

(2010) Neil N. Finer et al.   Journal of Aerosol Medicine and Pulmonary Drug Delivery

Critical Structural and Functional Roles for the N-Terminal Insertion Sequence in Surfactant Protein B Analogs

(2010) Frans J. Walther et al.   PLoS One

Development of the Premature Infant Nose Throat-Model (PrINT-Model)—An Upper Airway Replica of a Premature Neonate for the Study of Aerosol Delivery

(2009) Stefan Minocchieri et al.   PEDIATRIC RESEARCH

Non-invasive ventilation of the preterm infant

(2008) Eduardo Bancalari et al.   EARLY HUMAN DEVELOPMENT