Functional changes of the gastric bypass microbiota reactivate thermogenic adipose tissue and systemic glucose control via intestinal FXR-TGR5 crosstalk in diet-induced obesity

Hypothalamic bile acid-TGR5 signaling protects from obesity

(2021) Ashley Castellanos-Jankiewicz et al.   Cell Metabolism

Gastric bypass surgery in a rat model alters the community structure and functional composition of the intestinal microbiota independently of weight loss

(2020) Sven-Bastiaan Haange et al.   Microbiome

A dysregulated bile acid-gut microbiota axis contributes to obesity susceptibility

(2020) Meilin Wei et al.   EBioMedicine

Farnesoid X receptor contributes to body weight-independent improvements in glycemic control after Roux-en-Y gastric bypass surgery in diet-induced obese mice

(2020) Kun Li et al.   Molecular Metabolism

Microbiota Depletion Impairs Thermogenesis of Brown Adipose Tissue and Browning of White Adipose Tissue

(2019) Baoguo Li et al.   Cell Reports

Donor metabolic characteristics drive effects of faecal microbiota transplantation on recipient insulin sensitivity, energy expenditure and intestinal transit time

(2019) Pieter de Groot et al.   GUT

Genetic determinants of gut microbiota composition and bile acid profiles in mice

(2019) Julia H. Kemis et al.   PLoS Genetics

Major microbiota dysbiosis in severe obesity: fate after bariatric surgery

(2018) Judith Aron-Wisnewsky et al.   GUT

Intestine farnesoid X receptor agonist and the gut microbiota activate G-protein bile acid receptor-1 signaling to improve metabolism

(2018) Preeti Pathak et al.   HEPATOLOGY

Bile acids in glucose metabolism in health and disease

(2018) Hagit Shapiro et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Targeting FXR and FGF19 to Treat Metabolic Diseases—Lessons Learned From Bariatric Surgery

(2018) Nadejda Bozadjieva et al.   DIABETES

Secretin-Activated Brown Fat Mediates Prandial Thermogenesis to Induce Satiation

(2018) Yongguo Li et al.   CELL

The PRIDE database and related tools and resources in 2019: improving support for quantification data

(2018) Yasset Perez-Riverol et al.   NUCLEIC ACIDS RESEARCH

Farnesoid X receptor induces Takeda G-protein receptor 5 cross-talk to regulate bile acid synthesis and hepatic metabolism

(2017) Preeti Pathak et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Transfer of dysbiotic gut microbiota has beneficial effects on host liver metabolism

(2017) Simon Nicolas et al.   Molecular Systems Biology

Cold-induced conversion of cholesterol to bile acids in mice shapes the gut microbiome and promotes adaptive thermogenesis

(2017) Anna Worthmann et al.   NATURE MEDICINE

Gut microbiome and serum metabolome alterations in obesity and after weight-loss intervention

(2017) Ruixin Liu et al.   NATURE MEDICINE

Bariatric Surgery versus Intensive Medical Therapy for Diabetes — 5-Year Outcomes

(2017) Philip R. Schauer et al.   NEW ENGLAND JOURNAL OF MEDICINE

Intestinal Crosstalk between Bile Acids and Microbiota and Its Impact on Host Metabolism

(2016) Annika Wahlström et al.   Cell Metabolism

Altered Microbiota Contributes to Reduced Diet-Induced Obesity upon Cold Exposure

(2016) Marika Ziętak et al.   Cell Metabolism

Alterations of Gut Microbiota After Roux-en-Y Gastric Bypass and Sleeve Gastrectomy in Sprague-Dawley Rats

(2016) Yikai Shao et al.   OBESITY SURGERY

Farnesoid X Receptor Signaling Shapes the Gut Microbiota and Controls Hepatic Lipid Metabolism

(2016) Limin Zhang et al.   mSystems

Gut Microbiota Orchestrates Energy Homeostasis during Cold

(2015) Claire Chevalier et al.   CELL

Roux-en-Y Gastric Bypass and Vertical Banded Gastroplasty Induce Long-Term Changes on the Human Gut Microbiome Contributing to Fat Mass Regulation

(2015) Valentina Tremaroli et al.   Cell Metabolism

TGR5 is essential for bile acid-dependent cholangiocyte proliferation in vivo and in vitro

(2015) Maria Reich et al.   GUT

Intestinal FXR agonism promotes adipose tissue browning and reduces obesity and insulin resistance

(2015) Sungsoon Fang et al.   NATURE MEDICINE

Microbiota depletion promotes browning of white adipose tissue and reduces obesity

(2015) Nicolas Suárez-Zamorano et al.   NATURE MEDICINE

FGF 19 and Bile Acids Increase Following Roux-en-Y Gastric Bypass but Not After Medical Management in Patients with Type 2 Diabetes

(2015) Saachi Sachdev et al.   OBESITY SURGERY

Intestine-selective farnesoid X receptor inhibition improves obesity-related metabolic dysfunction

(2015) Changtao Jiang et al.   Nature Communications

The cross talk between microbiota and the immune system: metabolites take center stage

(2014) Hagit Shapiro et al.   CURRENT OPINION IN IMMUNOLOGY

The bile acid TGR5 membrane receptor: From basic research to clinical application

(2014) Henri Duboc et al.   DIGESTIVE AND LIVER DISEASE

Adenosine activates brown adipose tissue and recruits beige adipocytes via A2A receptors

(2014) Thorsten Gnad et al.   NATURE

FXR is a molecular target for the effects of vertical sleeve gastrectomy

(2014) Karen K. Ryan et al.   NATURE

Gut microbiota after gastric bypass in human obesity: increased richness and associations of bacterial genera with adipose tissue genes

(2013) Ling-Chun Kong et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Fibrosis and Adipose Tissue Dysfunction

(2013) Kai Sun et al.   Cell Metabolism

A Role for Fibroblast Growth Factor 19 and Bile Acids in Diabetes Remission After Roux-en-Y Gastric Bypass

(2013) G. S. Gerhard et al.   DIABETES CARE

Weight Loss Induced by Roux-en-Y Gastric Bypass But Not Laparoscopic Adjustable Gastric Banding Increases Circulating Bile Acids

(2013) Rohit Kohli et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Richness of human gut microbiome correlates with metabolic markers

(2013) Emmanuelle Le Chatelier et al.   NATURE

Conserved Shifts in the Gut Microbiota Due to Gastric Bypass Reduce Host Weight and Adiposity

(2013) A. P. Liou et al.   Science Translational Medicine

Mechanism of Fatty-Acid-Dependent UCP1 Uncoupling in Brown Fat Mitochondria

(2012) Andriy Fedorenko et al.   CELL

Metagenomic sequencing of the human gut microbiome before and after bariatric surgery in obese patients with type 2 diabetes: correlation with inflammatory and metabolic parameters

(2012) J Graessler et al.   PHARMACOGENOMICS JOURNAL

Alterations of Hormonally Active Fibroblast Growth Factors after Roux-en-Y Gastric Bypass Surgery

(2011) Peter L.M. Jansen et al.   DIGESTIVE DISEASES

Metabolic surgery profoundly influences gut microbial-host metabolic cross-talk

(2011) J. V. Li et al.   GUT

Differential Adaptation of Human Gut Microbiota to Bariatric Surgery-Induced Weight Loss: Links With Metabolic and Low-Grade Inflammation Markers

(2010) J.-P. Furet et al.   DIABETES

The Sequence Read Archive

(2010) R. Leinonen et al.   NUCLEIC ACIDS RESEARCH

TGR5-Mediated Bile Acid Sensing Controls Glucose Homeostasis

(2009) Charles Thomas et al.   Cell Metabolism

Nod2 is required for the regulation of commensal microbiota in the intestine

(2009) T. Petnicki-Ocwieja et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Human gut microbiota in obesity and after gastric bypass

(2009) H. Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A core gut microbiome in obese and lean twins

(2008) Peter J. Turnbaugh et al.   NATURE