Selective Expansion of Tregs Using the IL-2 Cytokine Antibody Complex Does Not Reverse Established Alopecia Areata in C3H/HeJ Mice

Low-Dose IL-2 Therapy in Autoimmune and Rheumatic Diseases

(2021) Hanna Graßhoff et al.   Frontiers in Immunology

Blockade of IL-7 signaling suppresses inflammatory responses and reverses alopecia areata in C3H/HeJ mice

(2021) Zhenpeng Dai et al.   Science Advances

A Comprehensive Literature Review of JAK Inhibitors in Treatment of Alopecia Areata

(2021) Kerry-Ann L Dillon   Clinical Cosmetic and Investigational Dermatology

Low dose IL-2 for treating moderate to severe alopecia areata. A 52 weeks multicenter prospective placebo-controlled study assessing its impact on T regulatory cells and natural killer populations

(2020) Florence Le Duff et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

An IL-2 mutein engineered to promote expansion of regulatory T cells arrests ongoing autoimmunity in mice

(2020) Liliane Khoryati et al.   Science Immunology

Regulatory T cell adaptation in the intestine and skin

(2019) Natasha Whibley et al.   NATURE IMMUNOLOGY

JAK inhibitors and alopecia areata

(2019) Amos Gilhar et al.   LANCET

Alopecia areata patients show deficiency of FOXP3+CD39+ T regulatory cells and clonotypic restriction of Treg TCRβ-chain, which highlights the immunopathological aspect of the disease

(2019) Fatma N. Hamed et al.   PLoS One

TCB2, a new anti-human interleukin-2 antibody, facilitates heterodimeric IL-2 receptor signaling and improves anti-tumor immunity

(2019) Jun-Young Lee et al.   OncoImmunology

Mechanisms Underlying the Anti-inflammatory and Immunosuppressive Activity of Ruxolitinib

(2019) Elena Maria Elli et al.   Frontiers in Oncology

Frontiers in alopecia areata pathobiology research

(2019) Amos Gilhar et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Alopecia areata: a review of disease pathogenesis

(2018) F. Rajabi et al.   BRITISH JOURNAL OF DERMATOLOGY

Regulatory T cells in autoimmune skin diseases

(2018) Hideyuki Ujiie   EXPERIMENTAL DERMATOLOGY

Regulatory T cells in autoimmune disease

(2018) Margarita Dominguez-Villar et al.   NATURE IMMUNOLOGY

A human anti-IL-2 antibody that potentiates regulatory T cells by a structure-based mechanism

(2018) Eleonora Trotta et al.   NATURE MEDICINE

JAK Inhibitors for Treatment of Alopecia Areata

(2018) Eddy H.C. Wang et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

JAK inhibition as a therapeutic strategy for immune and inflammatory diseases

(2017) Daniella M. Schwartz et al.   NATURE REVIEWS DRUG DISCOVERY

Selective IL-2 Responsiveness of Regulatory T Cells Through Multiple Intrinsic Mechanisms Supports the Use of Low-Dose IL-2 Therapy in Type 1 Diabetes

(2015) Aixin Yu et al.   DIABETES

Antibodies to Interleukin-2 Elicit Selective T Cell Subset Potentiation through Distinct Conformational Mechanisms

(2015) Jamie B. Spangler et al.   IMMUNITY

Front-Line Memory T Cells Think Outside the T-box… Mostly

(2015) Christopher M. Snyder   IMMUNITY

T-box Transcription Factors Combine with the Cytokines TGF-β and IL-15 to Control Tissue-Resident Memory T Cell Fate

(2015) Laura K. Mackay et al.   IMMUNITY

Transfer of Alopecia Areata to C3H/HeJ Mice Using Cultured Lymph Node–Derived Cells

(2015) Eddy H.C. Wang et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Pharmacologic inhibition of JAK-STAT signaling promotes hair growth

(2015) S. Harel et al.   Science Advances

CD4+ T Cell Help Guides Formation of CD103+ Lung-Resident Memory CD8+ T Cells during Influenza Viral Infection

(2014) Brian J. Laidlaw et al.   IMMUNITY

Inhibiting Janus kinases to treat alopecia areata

(2014) Sherrie J Divito et al.   NATURE MEDICINE

Alopecia areata is driven by cytotoxic T lymphocytes and is reversed by JAK inhibition

(2014) Luzhou Xing et al.   NATURE MEDICINE

Effects of Low-Dose Recombinant Interleukin 2 to Promote T-Regulatory Cells in Alopecia Areata

(2014) Emeline Castela et al.   JAMA Dermatology

Ex vivo expanded autologous polyclonal regulatory T cells suppress inhibitor formation in hemophilia

(2014) Debalina Sarkar et al.   Molecular Therapy-Methods & Clinical Development

Impaired inhibitory function of circulating CD4+CD25+ regulatory T cells in alopecia areata

(2013) Bong Seok Shin et al.   JOURNAL OF DERMATOLOGICAL SCIENCE

Lifetime Incidence Risk of Alopecia Areata Estimated at 2.1% by Rochester Epidemiology Project, 1990–2009

(2013) Sultan A. Mirzoyev et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Interleukin-2/anti-interleukin-2 monoclonal antibody immune complex suppresses collagen-induced arthritis in mice by fortifying interleukin-2/STAT5 signalling pathways

(2012) Seon-Yeong Lee et al.   IMMUNOLOGY

Alopecia Areata

(2012) Amos Gilhar et al.   NEW ENGLAND JOURNAL OF MEDICINE

Selectively Expanding Subsets of T Cells in Mice by Injection of Interleukin-2/Antibody Complexes: Implications for Transplantation Tolerance

(2012) O. Boyman et al.   TRANSPLANTATION PROCEEDINGS

In vivo expansion of T reg cells with IL-2–mAb complexes: induction of resistance to EAE and long-term acceptance of islet allografts without immunosuppression

(2009) Kylie E. Webster et al.   JOURNAL OF EXPERIMENTAL MEDICINE