Article
Immunology
Yuting Chen, Ye Wu, Lanlan Fang, Hui Zhao, Shenqian Xu, Zongwen Shuai, Haiyang Yu, Guoqi Cai, He-Qin Zhan, Faming Pan
Summary: The role of m6A modification in ankylosing spondylitis (AS) was investigated in this study. The researchers found that m6A modification was decreased in T cells of AS patients, and this abnormal modification was attributed to the downregulation of METTL14. METTL14 played a critical role in regulating autophagy activity and inflammation by targeting FOXO3a. These findings highlight the importance of m6A methylation mechanisms in the regulation of autophagy and inflammation, providing insights for the development of therapeutic strategies for AS.
CLINICAL IMMUNOLOGY
(2023)
Article
Immunology
Xiaoxue Bai, Yingjie Zhu, Jing Jie, Dan Li, Lei Song, Jingjing Luo
Summary: This study found that Maackiain, a natural compound from Sophora flavescens, protects against sepsis by reducing organ injury, inflammation, and oxidative stress. Maackiain activates the AMPK/Nrf2/HO-1 pathway, leading to its anti-inflammatory and antioxidant effects. Inhibition of this pathway abolishes the protective effects of Maackiain.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Pharmacology & Pharmacy
Xiaohang Zheng, Jianxin Qiu, Han Zhang, Ning Gao, Ting Jiang, Yuhang Gong, Weikang Zhang, Ze Li, Xingbing Feng, Zhenghua Hong
Summary: PD184352 is a small molecule inhibitor with potential anti-inflammatory and antioxidant activity. This study found that PD184352 has a protective effect against destabilized medial meniscus (DMM)-induced osteoarthritis (OA), showing higher Nrf2 expression and milder cartilage damage in the PD184352-treated group. In vitro experiments also showed that PD184352 suppressed IL-113-induced production of NO, iNOS, and PGE2, and attenuated pyroptosis. PD184352 treatment promoted antioxidant protein expression and reduced ROS accumulation by activating the Nrf2/HO-1 axis. The anti-inflammatory and antioxidant effects of PD184352 were partially dependent on Nrf2 activation. This study reveals the potential of PD184352 as an antioxidant and provides a new strategy for OA treatment.
BIOCHEMICAL PHARMACOLOGY
(2023)
Article
Environmental Sciences
Ehab A. M. El-Shoura, Maha A. A. Salem, Yasmine H. H. Ahmed, Lamiaa Khalaf Ahmed, Dalia Zaafar
Summary: This study investigated the protective effects of beta-sitosterol (BSS) and trimetazidine (TMZ) against hexavalent chromium (PD)-induced cardiotoxicity. The results showed that BSS and TMZ could reduce oxidative stress and pro-inflammatory cytokine levels, alleviating cardiac damage. The combination therapy may have potential for mitigating and preventing PD-induced cardiotoxicity at an early stage, but further clinical studies are needed to confirm these findings.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Rosalba Siracusa, Ramona D'Amico, Roberta Fusco, Daniela Impellizzeri, Alessio Filippo Peritore, Enrico Gugliandolo, Rosalia Crupi, Livia Interdonato, Marika Cordaro, Salvatore Cuzzocrea, Rosanna Di Paola
Summary: This study assessed the efficacy of acai berry in preventing damage caused by CYP. The results showed that acai berry could reduce inflammation, oxidative stress, and apoptosis in the bladder and testes, protecting these organs from CYP-induced changes.
Article
Chemistry, Medicinal
Eleonora Binatti, Gianni Zoccatelli, Francesca Zanoni, Giulia Dona, Federica Mainente, Roberto Chignola
Summary: The study demonstrates that astaxanthin-loaded microparticles are radiation-resistant, well-tolerated by J774A.1 macrophages, significantly reduce intracellular reactive oxygen species, and inhibit the release of active TGF beta. This indicates that micro-encapsulation of bioactive molecules is a promising strategy to specifically target phagocytic cells and modulate their functions.
Article
Biochemistry & Molecular Biology
Ramona D'Amico, Enrico Gugliandolo, Rosalba Siracusa, Marika Cordaro, Tiziana Genovese, Alessio Filippo Peritore, Rosalia Crupi, Livia Interdonato, Davide Di Paola, Salvatore Cuzzocrea, Roberta Fusco, Daniela Impellizzeri, Rosanna Di Paola
Summary: Exposure to endocrine disruptors (EDs) may worsen the progression of Parkinson's disease, leading to neuroinflammation and oxidative stress. Additionally, ED exposure can cause changes in behavior and cognition, with a more significant impact observed with exposure to herbicides.
Article
Surgery
Tianzhu Tao, Bo Ye, Yuhai Xu, Yi Wang, Ying Zhu, Ye Tian
Summary: In this study, the protective effects of beta-patchoulene (beta-PAE) on hepatic ischemia-reperfusion (I/R) injury were investigated. The results demonstrated that beta-PAE could alleviate tissue damage and inflammation induced by hepatic I/R injury, and it exerted its effects by modulating the balance between Nrf2/HO-1 and NF-kappa B pathways.
JOURNAL OF SURGICAL RESEARCH
(2022)
Article
Pharmacology & Pharmacy
Jiaji Hu, Zhoujie Zhu, Hanglu Ying, Jie Yao, Huabin Ma, Long Li, Yufen Zhao
Summary: The study showed that OEA can protect mice from LPS/D-Gal-induced acute liver injury by inhibiting apoptosis, oxidative stress, and inflammation, with mechanisms possibly involving the Nrf-2/HO-1 and NLRP3 inflammasome signaling pathways.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Huaxin Li, Mengxue Zhang, Yuanyu Wang, Ke Gong, Tengteng Yan, Dandan Wang, Xianshe Meng, Xiaoxiao Yang, Yuanli Chen, Jihong Han, Yajun Duan, Shuang Zhang
Summary: This study demonstrates that Daidzein (DAI) can alleviate heart failure (HF) by regulating cardiac energy metabolism, improving cardiac function, reducing inflammation, oxidative stress, apoptosis, and fibrosis.
Article
Medicine, Research & Experimental
Shanshan Xu, Xiaoyi Zhang, Xinqi Wang, Huimin Xie, Feier Wang, Tingting Zhou, Lingxiang Yu, Shengqian Xu, Faming Pan
Summary: The study explores the association between the methylation level and transcript level of the FOXO3a gene with AS susceptibility. It is found that DNA methylation and transcription of FOXO3a may be related to AS susceptibility and have a crucial role in the diagnosis of AS.
CLINICAL AND EXPERIMENTAL MEDICINE
(2023)
Article
Medicine, Research & Experimental
Walied Abdo, Imer Haziri, Mohamed Dmerdash, Sulaiman Mohammed Alnasser, Ali Hakamy, Ehab Ali, Soha A. Soliman, Hanan H. Abd-Elhafeez, Ahmed M. Abd-Eldayem
Summary: The study demonstrated the potential beneficial effect of anatabine against asthma through anti-inflammatory and antioxidant mechanisms. Anatabine showed promise as a candidate for treating pulmonary asthma by reducing lung inflammation and enhancing antioxidant defenses.
Article
Biochemistry & Molecular Biology
Xiangyun Li, Jianbo Yu, Lirong Gong, Yuan Zhang, Shuan Dong, Jia Shi, Cui Li, Yuting Li, Yanfang Zhang, Haibo Li
Summary: Sepsis-induced acute lung injury leads to oxidative stress, inflammation, apoptosis, and changes in Golgi morphology. Activating the HO-1 pathway can alleviate Golgi stress and oxidative stress, providing a therapeutic target for treating acute lung injury.
FREE RADICAL BIOLOGY AND MEDICINE
(2021)
Article
Immunology
Reem S. Alruhaimi, Emad H. M. Hassanein, Mostafa K. Abd El-Aziz, Maisa Siddiq Abduh, Albandari Bin-Ammar, Emadeldin M. Kamel, Ayman M. Mahmoud
Summary: In this study, it was found that the melatonin receptor agonist agomelatine can protect against acute pancreatitis induced by cadmium by preventing inflammation, oxidative stress, and apoptosis, and by modulating the Nrf2/HO-1 pathway. Agomelatine enhanced the antioxidant capacity through the activation of the Nrf2/HO-1 pathway, while reducing inflammation and cellular damage.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Plant Sciences
Ying Chun Li, Jin Cheng Hao, Bo Shang, Cheng Zhao, Li Juan Wang, Kai Lin Yang, Xiao Zhou He, Qian Qian Tian, Zhao Liang Wang, Hui Ling Jing, Yang Li, Yan Jun Cao
Summary: The study evaluated the inhibitory effects of Aucubin (AU) on oxidative stress-induced cell injury in SH-SY5Y cells. Results showed that AU significantly increased cell viability, mitochondrial membrane potential, and decreased ROS generation. AU treatment also reduced inflammation and oxidative stress through various pathways such as NF-kappa B, Nrf2/HO-1, and MAPK.
