Review
Biochemistry & Molecular Biology
J. R. Dev Arundhathi, Sandeep R. Mathur, Ajay Gogia, S. V. S. Deo, Purusottam Mohapatra, Chandra Prakash Prasad
Summary: Triple negative breast cancer (TNBC) has the worst prognosis among breast cancer subtypes and standard chemotherapy is the main treatment. Metabolic reprogramming, specifically altered glycolysis, plays a crucial role in TNBC progression, offering potential therapeutic targets.
MOLECULAR BIOLOGY REPORTS
(2021)
Article
Biochemistry & Molecular Biology
Xueyan Sun, Yijiao Peng, Jingduo Zhao, Zhizhong Xie, Xiaoyong Lei, Guotao Tang
Summary: Tumor cells primarily rely on aerobic glycolysis for energy, and inhibiting the three main rate-limiting enzymes in glycolysis is considered an important strategy for cancer treatment. The development of inhibitors targeting these enzymes is a focus of research for potential therapeutic interventions.
BIOORGANIC CHEMISTRY
(2021)
Review
Immunology
Chan Li, Fang-Yuan Liu, Ying Shen, Yuan Tian, Feng-Juan Han
Summary: This paper discusses the importance of glycolysis in cancer cells, particularly in ovarian cancer. Glycolysis plays a crucial role in promoting energy production and cancer progression. Understanding the relationship between glycolysis and related molecular mechanisms may provide new strategies for the treatment of ovarian cancer.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Microbiology
Yujie Qian, Yeyi Yang, Wenxiang Qing, Chunyun Li, Min Kong, Zhijuan Kang, Yuanbojiao Zuo, Jiping Wu, Meng Yu, Zuocheng Yang
Summary: The study found that CVB3 infection enhances glycolysis in cardiomyocytes, benefiting viral replication. Inhibiting glycolysis can effectively reduce CVB3 replication, while enhancing glycolysis significantly promotes viral replication. The expression of three key glycolytic enzymes increases in CVB3-infected cardiomyocytes.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Multidisciplinary Sciences
Panayotis Pachnis, Zheng Wu, Brandon Faubert, Alpaslan Tasdogan, Wen Gu, Spencer Shelton, Ashley Solmonson, Aparna D. Rao, Akash K. Kaushik, Thomas J. Rogers, Jessalyn M. Ubellacker, Collette A. LaVigne, Chendong Yang, Bookyung Ko, Vijayashree Ramesh, Jessica Sudderth, Lauren G. Zacharias, Misty S. Martin-Sandoval, Duyen Do, Thomas P. Mathews, Zhiyu Zhao, Prashant Mishra, Sean J. Morrison, Ralph J. DeBerardinis
Summary: ETC activity regulates TCA cycle metabolism and C-13 labeling in tumors, indicating the involvement of multiple nutrients.
Article
Biology
Oksana M. Sorochynska, Oksana V. Kuzniak, Maria M. Bayliak, Yulia V. Vasylyk, Kenneth B. Storey, Volodymyr I. Lushchak
Summary: The study compared the metabolic capabilities of skeletal hind limb muscles of one month old mice under restricted feeding (EODF) and ad libitum feeding (AL). Results showed lower concentrations of metabolic substrates in the muscles of EODF mice compared to AL mice.
Article
Cell Biology
Xiukun Hou, Xianle Shi, Wei Zhang, Dapeng Li, Linfei Hu, Jihong Yang, Jingzhu Zhao, Songfeng Wei, Xi Wei, Xianhui Ruan, Xiangqian Zheng, Ming Gao
Summary: High expression levels of LDHA in papillary thyroid carcinoma are associated with aggressive clinicopathological features and poor prognosis. LDHA promotes cancer cell migration, invasion, and proliferation, making it a potential therapeutic target.
CELL DEATH & DISEASE
(2021)
Review
Pharmacology & Pharmacy
Yuting Cui, Chuang Li, Feng Sang, Weiling Cao, Zhuo Qin, Peng Zhang
Summary: Glycolysis is a complex metabolic process, and cancer cells preferentially metabolize pyruvate to lactate to maintain a slightly acidic micro-environment. Natural products can exhibit anti-cancer properties by inhibiting glycolytic pathways.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Xiangling Ren, Xinyuan Huang, Qiong Wu, Longfei Tan, Changhui Fu, Yi Chen, Xianwei Meng
Summary: Metal organic frameworks were found to inhibit the activity of pyruvate kinase in tumor cells, with nanoscale ZIF-8 showing the ability to inhibit glycolysis. The inhibitory effect is attributed to the zinc ions in ZIF-8, which has an IC50 one percent of that of zinc ion. This novel enzyme inhibitor holds promise for cancer therapy.
CHINESE CHEMICAL LETTERS
(2021)
Article
Neurosciences
Jingyi Li, Longmin Chen, Qixiong Qin, Danlei Wang, Jingwei Zhao, Hongling Gao, Xiao Yuan, Jing Zhang, Yuan Zou, Zhijuan Mao, Yongjie Xiong, Zhe Min, Manli Yan, Cong-yi Wang, Zheng Xue
Summary: In this study, the researchers investigated the changes in lactate metabolism in a Parkinson's disease model and found that the expression of HK2 and LDHA as well as lactate levels were significantly increased. They also found that lactate treatment induces apoptosis in neuronal cells, while the inhibition of HK2 suppresses lactate production and dopaminergic neuron apoptosis. Moreover, the HK2 inhibitor improves motor behavior in the Parkinson's disease model mice. Mechanistically, lactate increases AMPK activity and inhibits phosphorylation of Akt and mTOR.
NEUROBIOLOGY OF DISEASE
(2022)
Review
Chemistry, Multidisciplinary
Susan Wai Sum Leung, Yi Shi
Summary: Endothelial cells play a crucial role in regulating vascular tone and maintaining homeostasis. Cell metabolism, especially glycolysis, is essential for cell function and response to stimuli. Discussions on the role of glycolysis in cardiovascular disease may provide insights for future therapeutic strategies.
ACTA PHARMACOLOGICA SINICA
(2022)
Review
Fisheries
Ramya Kumar, Jiun-Yan Huang, Yen-Siong Ng, Cong-Yan Chen, Han-Ching Wang
Summary: For over three decades, infectious diseases have caused significant economic losses in the global shrimp industry, with white spot syndrome virus (WSSV) being one of the deadliest pathogens. WSSV modulates host metabolism by affecting glycolysis, TCA cycle, glutaminolysis, and lipid metabolism, with the PI3K-Akt-mTOR pathway playing a critical role in activating the WSSV-induced Warburg effect. Understanding these metabolic pathways and signaling mechanisms is crucial for developing effective anti-WSSV strategies.
REVIEWS IN AQUACULTURE
(2022)
Article
Pharmacology & Pharmacy
Min Kyoung Cho, Ling Jin, Jung Ho Han, Jung-Suk Jin, Se-Yun Cheon, Su Shin, Sung-Jin Bae, Jang-Kyung Park, Ki-Tae Ha
Summary: Endometriosis is a chronic inflammatory disorder with limited treatment options. However, recent studies have shown that Prunella vulgaris, a traditional herbal medicine with anti-estrogenic effects, may be a potential treatment for endometriosis. In this study, water-extracted Prunella vulgaris was found to alleviate endometriosis in mice by inducing apoptosis in endometrial cells through the regulation of aerobic glycolysis enzymes. These findings suggest that Prunella vulgaris may be a promising candidate for the prevention and treatment of endometriosis.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Qinfeng Li, Chao Li, Abdallah Elnwasany, Gaurav Sharma, Yu A. An, Guangyu Zhang, Waleed M. Elhelaly, Jun Lin, Yingchao Gong, Guihao Chen, Meihui Wang, Shangang Zhao, Chongshan Dai, Charles D. Smart, Juan Liu, Xiang Luo, Yingfeng Deng, Lin Tan, Shuang-Jie Lv, Shawn M. Davidson, Jason W. Locasale, Philip L. Lorenzi, Craig R. Malloy, Thomas G. Gillette, Matthew G. Vander Heiden, Philipp E. Scherer, Luke I. Szweda, Guosheng Fu, Zhao V. Wang
Summary: PKM1 plays a crucial role in maintaining a homeostatic response in the heart under hemodynamic stress, protecting against cardiac dysfunction and fibrosis caused by pressure overload. Furthermore, PKM1 is essential for enhancing glycolytic flux, mitochondrial respiration, and ATP production under pressure overload at a mechanistic level.
Article
Oncology
Veronica Bolanos-Suarez, Ana Alfaro, Ana Maria Espinosa, Ingrid Medina-Martinez, Eligia Juarez, Nicolas Villegas-Sepulveda, Marco Gudino-Zayas, America Gutierrez-Castro, Edgar Roman-Bassaure, Maria Eugenia Salinas-Nieves, Sergio Bruno-Munoz, Carlos Aranda, Oscar Flores-Herrera, Jaime Berumen
Summary: The expression of LDHA and PFKP genes in cervical cancer patients is associated with poor prognosis and increased risk of death. Regardless of FIGO stage, overexpression of LDHA and PFKP is associated with poor prognosis and increased risk of death in cervical cancer patients. Therefore, measuring these two markers can be useful for evaluating the clinical progression and death risk of cervical cancer.