标题
Discovery and development of tumor glycolysis rate-limiting enzyme inhibitors
作者
关键词
Glycolysis, Inhibitor, Pyruvate kinase, Phosphofructokinase, Hexokinase
出版物
BIOORGANIC CHEMISTRY
Volume 112, Issue -, Pages 104891
出版商
Elsevier BV
发表日期
2021-04-08
DOI
10.1016/j.bioorg.2021.104891
参考文献
相关参考文献
注意：仅列出部分参考文献，下载原文获取全部文献信息。- Tannic Acid Promotes TRAIL-Induced Extrinsic Apoptosis by Regulating Mitochondrial ROS in Human Embryonic Carcinoma Cells
- (2020) Nipin Sp et al. Cells
- 3PO as a Selective Inhibitor of 6-Phosphofructo-2-Kinase/Fructose-2,6-Biphosphatase 3 in A375 Human Melanoma Cells
- (2020) KRZYSZTOF KOTOWSKI et al. ANTICANCER RESEARCH
- Inhibition of the STAT3 Signaling Pathway Contributes to the Anti-Melanoma Activities of Shikonin
- (2020) Hui-Hui Cao et al. Frontiers in Pharmacology
- Identification of Gliotoxin isolated from marine fungus as a new pyruvate kinase M2 inhibitor
- (2020) Wei Tang et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Shikonin Inhibits Cancer Through P21 Upregulation and Apoptosis Induction
- (2020) Fangfang Wang et al. Frontiers in Pharmacology
- Tumor Energy Metabolism and Potential of 3-Bromopyruvate as an Inhibitor of Aerobic Glycolysis: Implications in Tumor Treatment
- (2019) Tengjiao Fan et al. Cancers
- Long non-coding RNA PVT1 promotes tumor progression by regulating the miR-143/HK2 axis in gallbladder cancer
- (2019) Jianan Chen et al. Molecular Cancer
- Discover potential inhibitors for PFKFB3 using 3D-QSAR, virtual screening, molecular docking and molecular dynamics simulation
- (2019) Yinfeng Bao et al. JOURNAL OF RECEPTORS AND SIGNAL TRANSDUCTION
- Potent Cytotoxic Natural Flavonoids: The Limits of Perspective
- (2019) Akram Taleghani et al. CURRENT PHARMACEUTICAL DESIGN
- Synergistic effect of colistin combined with PFK-158 against colistin-resistant Enterobacteriaceae
- (2019) Youwen Zhang et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- The synergistic effect of PFK15 with metformin exerts anti-myeloma activity via PFKFB3
- (2019) Xinling Liu et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- PKM2 is the target of proanthocyanidin B2 during the inhibition of hepatocellular carcinoma
- (2019) Jiao Feng et al. JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
- Regulating the BCL2 Family to Improve Sensitivity to Microtubule Targeting Agents
- (2019) Robert H. Whitaker et al. Cells
- Beta‐elemene inhibits breast cancer metastasis through blocking pyruvate kinase M2 dimerization and nuclear translocation
- (2019) Yanhong Pan et al. JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
- β‐Elemene inhibits peritoneal metastasis of gastric cancer cells by modulating FAK/Claudin‐1 signaling
- (2019) Mingming Deng et al. PHYTOTHERAPY RESEARCH
- Development of Novel Irreversible Pyruvate Kinase M2 Inhibitors
- (2019) I-Shan Hsieh et al. JOURNAL OF MEDICINAL CHEMISTRY
- Pharmacological properties and derivatives of shikonin—A review in recent years
- (2019) Chuanjie Guo et al. PHARMACOLOGICAL RESEARCH
- Synthesis of novel methyl jasmonate derivatives and evaluation of their biological activity in various cancer cell lines
- (2019) Bilgesu Onur Sucu et al. BIOORGANIC CHEMISTRY
- Anti-inflammatory effects of flavonoids
- (2019) Soheila J. Maleki et al. FOOD CHEMISTRY
- Flavonoid GL-V9 induces apoptosis and inhibits glycolysis of breast cancer via disrupting GSK-3β-modulated mitochondrial binding of HKII
- (2019) Yongjian Guo et al. FREE RADICAL BIOLOGY AND MEDICINE
- Benserazide is a novel inhibitor targeting PKM2 for melanoma treatment
- (2019) Youyou Zhou et al. INTERNATIONAL JOURNAL OF CANCER
- Physcion 8-O-β-glucopyranoside inhibits clear-cell renal cell carcinoma bydownregulating hexokinase II and inhibiting glycolysis
- (2018) Qiang Wang et al. BIOMEDICINE & PHARMACOTHERAPY
- Metformin in cancer
- (2018) Ritwika Mallik et al. DIABETES RESEARCH AND CLINICAL PRACTICE
- New natural inhibitors of hexokinase 2 (HK2): Steroids from Ganoderma sinense
- (2018) Fengyan Bao et al. FITOTERAPIA
- Jolkinolide B inhibits glycolysis by downregulating hexokinase 2 expression through inactivating the Akt/mTOR pathway in non-small cell lung cancer cells
- (2018) Xiang Gao et al. JOURNAL OF CELLULAR BIOCHEMISTRY
- Emerging role of lipid metabolism alterations in Cancer stem cells
- (2018) Mei Yi et al. JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
- PIM2-mediated phosphorylation of hexokinase 2 is critical for tumor growth and paclitaxel resistance in breast cancer
- (2018) Tingting Yang et al. ONCOGENE
- Lapachol inhibits glycolysis in cancer cells by targeting pyruvate kinase M2
- (2018) Mani Shankar Babu et al. PLoS One
- Remodeling the Tumor Microenvironment with Emerging Nanotherapeutics
- (2018) Qin Chen et al. TRENDS IN PHARMACOLOGICAL SCIENCES
- Design, synthesis and biological evaluation of 3′,4′,5′-trimethoxy flavonoid benzimidazole derivatives as potential anti-tumor agents
- (2018) Zhe Wang et al. MedChemComm
- Hexokinase-2 depletion inhibits glycolysis and induces oxidative phosphorylation in hepatocellular carcinoma and sensitizes to metformin
- (2018) Dannielle DeWaal et al. Nature Communications
- Role of PKM2 in directing the metabolic fate of glucose in cancer: a potential therapeutic target
- (2018) Gustav van Niekerk et al. CELLULAR ONCOLOGY
- Review of Metformin Use for Type 2 Diabetes Prevention
- (2018) Tannaz Moin et al. AMERICAN JOURNAL OF PREVENTIVE MEDICINE
- Amentoflavone suppresses hepatocellular carcinoma by repressing hexokinase 2 expression through inhibiting JAK2/STAT3 signaling
- (2018) Bo Liu et al. BIOMEDICINE & PHARMACOTHERAPY
- An Update on Patents Covering Agents That Interfere with the Cancer Glycolytic Cascade
- (2018) Serena Fortunato et al. ChemMedChem
- Tannic acid directly targets pyruvate kinase isoenzyme M2 to attenuate colon cancer cell proliferation
- (2018) Peng Yang et al. Food & Function
- Shikonin Inhibits Tumor Growth in Mice by Suppressing Pyruvate Kinase M2-mediated Aerobic Glycolysis
- (2018) Xiaoyue Zhao et al. Scientific Reports
- Targeting Pyruvate Kinase M2 and Hexokinase II, Pachymic Acid Impairs Glucose Metabolism and Induces Mitochondrial Apoptosis
- (2018) Guopeng Miao et al. BIOLOGICAL & PHARMACEUTICAL BULLETIN
- FS-7 inhibits MGC-803 cells growth in vitro and in vivo via down-regulating glycolysis
- (2018) Xiangping Deng et al. BIOMEDICINE & PHARMACOTHERAPY
- Synthesis of amide and sulfonamide substituted N-aryl 6-aminoquinoxalines as PFKFB3 inhibitors with improved physicochemical properties
- (2018) Nicolas Boutard et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Discovery and Structure-Activity Relationships of N -Aryl 6-Aminoquinoxalines as Potent PFKFB3 Kinase Inhibitors
- (2018) Nicolas Boutard et al. ChemMedChem
- Unlocking the potential of HK2 in cancer metabolism and therapeutics
- (2018) Sara N. Garcia et al. CURRENT MEDICINAL CHEMISTRY
- Effects of tumor metabolic microenvironment on regulatory T cells
- (2018) Yi-an Wang et al. Molecular Cancer
- 3‐Bromopyruvate as a potent anticancer therapy in honor and memory of the late Professor André Goffeau
- (2018) Young H. Ko et al. YEAST
- Discovery of novel naphthoquinone derivatives as inhibitors of the tumor cell specific M2 isoform of pyruvate kinase
- (2017) Xianling Ning et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- Tumor Microenvironment and Metabolism
- (2017) Li Yang INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Synthesis and antitumor activity of novel 2, 3-didithiocarbamate substituted naphthoquinones as inhibitors of pyruvate kinase M2 isoform
- (2017) Xianling Ning et al. JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY
- Benserazide, a dopadecarboxylase inhibitor, suppresses tumor growth by targeting hexokinase 2
- (2017) Wei Li et al. JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
- Chrysin inhibited tumor glycolysis and induced apoptosis in hepatocellular carcinoma by targeting hexokinase-2
- (2017) Dong Xu et al. JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
- Blockage of glycolysis by targeting PFKFB3 suppresses tumor growth and metastasis in head and neck squamous cell carcinoma
- (2017) Hui-Min Li et al. JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
- The anti-tumor effect of pachymic acid on osteosarcoma cells by inducing PTEN and Caspase 3/7-dependent apoptosis
- (2017) Huilong Wen et al. Journal of Natural Medicines
- ent-Abietane Lactones from Euphorbia
- (2017) Jia-Zhuo Lai et al. MINI-REVIEWS IN MEDICINAL CHEMISTRY
- Resveratrol and Brain Mitochondria: a Review
- (2017) Fernanda Rafaela Jardim et al. MOLECULAR NEUROBIOLOGY
- Co-treatment of breast cancer cells with pharmacologic doses of 2-deoxy-D-glucose and metformin: Starving tumors
- (2017) Ulrike Wokoun et al. ONCOLOGY REPORTS
- Metformin inhibits the development, and promotes the resensitization, of treatment-resistant breast cancer
- (2017) Gerald Davies et al. PLoS One
- Metformin – its potential anti-cancer and anti-aging effects
- (2017) Monika Podhorecka et al. Postepy Higieny I Medycyny Doswiadczalnej
- Antitumor activity of the pachymic acid in nasopharyngeal carcinoma cells
- (2017) Yan-Hua Zhang et al. ULTRASTRUCTURAL PATHOLOGY
- The molecular basis of targeting PFKFB3 as a therapeutic strategy against cancer
- (2017) Luo Lu et al. Oncotarget
- Anti-tumor effects of shikonin derivatives on human medullary thyroid carcinoma cells
- (2017) Carina Hasenoehrl et al. Endocrine Connections
- Directional modification of chrysin for exerting apoptosis and enhancing significantly anti-cancer effects of 10-hydroxy camptothecin
- (2016) Qin Tang et al. BIOMEDICINE & PHARMACOTHERAPY
- Inhibition of 6-phosphofructo-2-kinase (PFKFB3) suppresses glucose metabolism and the growth of HER2+ breast cancer
- (2016) Julie O’Neal et al. BREAST CANCER RESEARCH AND TREATMENT
- Inhibition of glycolytic enzyme hexokinase II (HK2) suppresses lung tumor growth
- (2016) Huanan Wang et al. Cancer Cell International
- Cyclosporine A sensitizes human non-small cell lung cancer cells to gefitinib through inhibition of STAT3
- (2016) Jiawei Shou et al. CANCER LETTERS
- Resveratrol inhibits Hexokinases II mediated glycolysis in non-small cell lung cancer via targeting Akt signaling pathway
- (2016) Wei Li et al. EXPERIMENTAL CELL RESEARCH
- TSC22D2 interacts with PKM2 and inhibits cell growth in colorectal cancer
- (2016) Fang Liang et al. INTERNATIONAL JOURNAL OF ONCOLOGY
- β-Elemene enhances the efficacy of gefitinib on glioblastoma multiforme cells through the inhibition of the EGFR signaling pathway
- (2016) Lin Mu et al. INTERNATIONAL JOURNAL OF ONCOLOGY
- Glycolysis Inhibitors for Anticancer Therapy: A Review of Recent Patents
- (2016) Huaming Sheng et al. Recent Patents on Anti-Cancer Drug Discovery
- Discovery of a Novel 2,6-Disubstituted Glucosamine Series of Potent and Selective Hexokinase 2 Inhibitors
- (2016) Hong Lin et al. ACS Medicinal Chemistry Letters
- Addiction to Coupling of the Warburg Effect with Glutamine Catabolism in Cancer Cells
- (2016) Bradley Smith et al. Cell Reports
- PFK15, a Small Molecule Inhibitor of PFKFB3, Induces Cell Cycle Arrest, Apoptosis and Inhibits Invasion in Gastric Cancer
- (2016) Wei Zhu et al. PLoS One
- Interaction with Pyruvate Kinase M2 Destabilizes Tristetraprolin by Proteasome Degradation and Regulates Cell Proliferation in Breast Cancer
- (2016) Liangqian Huang et al. Scientific Reports
- Inhibitory and Activating Effects of Some Flavonoid Derivatives on Human Pyruvate Kinase Isoenzyme M2
- (2015) Sevki Adem et al. ARCHIV DER PHARMAZIE
- HK2/hexokinase-II integrates glycolysis and autophagy to confer cellular protection
- (2015) Valerie P Tan et al. Autophagy
- Pyruvate kinase M2 affects liver cancer cell behavior through up-regulation of HIF-1α and Bcl-xL in culture
- (2015) Tianfu Dong et al. BIOMEDICINE & PHARMACOTHERAPY
- Design and synthesis of novel 1,2,3-triazole–pyrimidine–urea hybrids as potential anticancer agents
- (2015) Li-Ying Ma et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Metabolic changes associated with tumor metastasis, part 2: Mitochondria, lipid and amino acid metabolism
- (2015) Paolo E. Porporato et al. CELLULAR AND MOLECULAR LIFE SCIENCES
- Metabolic changes associated with tumor metastasis, part 1: tumor pH, glycolysis and the pentose phosphate pathway
- (2015) Valéry L. Payen et al. CELLULAR AND MOLECULAR LIFE SCIENCES
- Tannic acid inhibits the Jak2/STAT3 pathway and induces G1/S arrest and mitochondrial apoptosis in YD-38 gingival cancer cells
- (2015) PRAMOD DARVIN et al. INTERNATIONAL JOURNAL OF ONCOLOGY
- Structure-Based Design of Potent and Selective Inhibitors of the Metabolic Kinase PFKFB3
- (2015) Scott Boyd et al. JOURNAL OF MEDICINAL CHEMISTRY
- Cryptotanshinone, a novel tumor angiogenesis inhibitor, destabilizes tumor necrosis factor-α mRNA via decreasing nuclear-cytoplasmic translocation of RNA-binding protein HuR
- (2015) Zhijie Zhu et al. MOLECULAR CARCINOGENESIS
- Metformin: Multi-faceted protection against cancer
- (2015) Sonia Del Barco et al. Oncotarget
- 3-Bromopyruvate induces apoptosis in breast cancer cells by downregulating Mcl-1 through the PI3K/Akt signaling pathway
- (2014) Zhe Liu et al. ANTI-CANCER DRUGS
- Targeting the Warburg Effect in cancer; relationships for 2-arylpyridazinones as inhibitors of the key glycolytic enzyme 6-phosphofructo-2-kinase/2,6-bisphosphatase 3 (PFKFB3)
- (2014) Darby G. Brooke et al. BIOORGANIC & MEDICINAL CHEMISTRY
- An update on therapeutic opportunities offered by cancer glycolytic metabolism
- (2014) Carlotta Granchi et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- 2-Deoxy-D-glucose targeting of glucose metabolism in cancer cells as a potential therapy
- (2014) Dongsheng Zhang et al. CANCER LETTERS
- Metformin: From Mechanisms of Action to Therapies
- (2014) Marc Foretz et al. Cell Metabolism
- Metformin, cancer and glucose metabolism
- (2014) Barbara Salani et al. ENDOCRINE-RELATED CANCER
- In Vitro Effects of Some Flavones on Human Pyruvate Kinase Isoenzyme M2
- (2014) Erdem Aslan et al. JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY
- 3-bromopyruvate inhibits glycolysis, depletes cellular glutathione, and compromises the viability of cultured primary rat astrocytes
- (2014) Eric Ehrke et al. JOURNAL OF NEUROSCIENCE RESEARCH
- Targeting Microtubules by Natural Agents for Cancer Therapy
- (2014) E. Mukhtar et al. MOLECULAR CANCER THERAPEUTICS
- D-Glucosamine supplementation extends life span of nematodes and of ageing mice
- (2014) Sandra Weimer et al. Nature Communications
- A novel metformin derivative, HL010183, inhibits proliferation and invasion of triple-negative breast cancer cells
- (2013) Minsoo Koh et al. BIOORGANIC & MEDICINAL CHEMISTRY
- PKM2 Isoform-Specific Deletion Reveals a Differential Requirement for Pyruvate Kinase in Tumor Cells
- (2013) William J. Israelsen et al. CELL
- Direct inhibition of hexokinase activity by metformin at least partially impairs glucose metabolism and tumor growth in experimental breast cancer
- (2013) Cecilia Marini et al. CELL CYCLE
- Cellular and molecular mechanisms in cancer immune escape: a comprehensive review
- (2013) Alka Bhatia et al. Expert Review of Clinical Immunology
- Protein and ligand preparation: parameters, protocols, and influence on virtual screening enrichments
- (2013) G. Madhavi Sastry et al. JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN
- The Antioxidant Property of Pachymic Acid Improves Bone Disturbance against AH Plus–induced Inflammation in MC-3T3 E1 Cells
- (2013) Tae-Gun Kim et al. JOURNAL OF ENDODONTICS
- Antiglycolytic Therapy Combined with an Image-guided Minimally Invasive Delivery Strategy for the Treatment of Breast Cancer
- (2013) Manon Buijs et al. JOURNAL OF VASCULAR AND INTERVENTIONAL RADIOLOGY
- Antiangiogenic therapy improves the antitumor effect of adoptive cell immunotherapy by normalizing tumor vasculature
- (2013) Shujing Shi et al. MEDICAL ONCOLOGY
- Targeting 6-Phosphofructo-2-Kinase (PFKFB3) as a Therapeutic Strategy against Cancer
- (2013) B. F. Clem et al. MOLECULAR CANCER THERAPEUTICS
- Innate and adaptive immune cells in the tumor microenvironment
- (2013) Thomas F Gajewski et al. NATURE IMMUNOLOGY
- Microenvironmental regulation of tumor progression and metastasis
- (2013) Daniela F Quail et al. NATURE MEDICINE
- Pharmacological Properties of Shikonin – A Review of Literature since 2002
- (2013) Isabel Andújar et al. PLANTA MEDICA
- Chemistry and Biological Activities of Flavonoids: An Overview
- (2013) Shashank Kumar et al. TheScientificWorldJOURNAL
- Metformin Impairs Glucose Consumption and Survival in Calu-1 Cells by Direct Inhibition of Hexokinase-II
- (2013) Barbara Salani et al. Scientific Reports
- Acidic tumor microenvironment and pH-sensing G protein-coupled receptors
- (2013) Calvin R. Justus et al. Frontiers in Physiology
- Cyclosporine A inhibits breast cancer cell growth by downregulating the expression of pyruvate kinase subtype M2
- (2012) KAI JIANG et al. INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
- 3-bromopyruvate: Targets and outcomes
- (2012) Maria C. Shoshan JOURNAL OF BIOENERGETICS AND BIOMEMBRANES
- Tannic Acid Is a Natural β-Secretase Inhibitor That Prevents Cognitive Impairment and Mitigates Alzheimer-like Pathology in Transgenic Mice
- (2012) Takashi Mori et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Anti-inflammatory effect of pachymic acid promotes odontoblastic differentiation via HO-1 in dental pulp cells
- (2012) Y-H Lee et al. ORAL DISEASES
- Lanostane triterpenes from cultures of the Basidiomycete Ganoderma orbiforme BCC 22324
- (2012) Masahiko Isaka et al. PHYTOCHEMISTRY
- Novel EGFR inhibitors prepared by combination of dithiocarbamic acid esters and 4-anilinoquinazolines
- (2011) Ri-Dong Li et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Vitamin K3 and K5 are inhibitors of tumor pyruvate kinase M2
- (2011) Jing Chen et al. CANCER LETTERS
- Hallmarks of Cancer: The Next Generation
- (2011) Douglas Hanahan et al. CELL
- Evaluation of Selected Flavonoids as Antiangiogenic, Anticancer, and Radical Scavenging Agents: An Experimental and In Silico Analysis
- (2011) Rajesh N. Gacche et al. CELL BIOCHEMISTRY AND BIOPHYSICS
- Shikonin and its analogs inhibit cancer cell glycolysis by targeting tumor pyruvate kinase-M2
- (2011) J Chen et al. ONCOGENE
- Structure-Based Development of Small Molecule PFKFB3 Inhibitors: A Framework for Potential Cancer Therapeutic Agents Targeting the Warburg Effect
- (2011) Minsuh Seo et al. PLoS One
- Shikonin inhibits the proliferation and induces the apoptosis of human HepG2 cells
- (2010) Nie Yingkun et al. CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY
- Beta-elemene inhibits melanoma growth and metastasis via suppressing vascular endothelial growth factor-mediated angiogenesis
- (2010) Wenxing Chen et al. CANCER CHEMOTHERAPY AND PHARMACOLOGY
- Pachymic acid stimulates glucose uptake through enhanced GLUT4 expression and translocation
- (2010) Yu-Chuan Huang et al. EUROPEAN JOURNAL OF PHARMACOLOGY
- Tumor vasculature as target for therapeutic intervention
- (2010) Marcel HAM Fens et al. EXPERT OPINION ON INVESTIGATIONAL DRUGS
- Human pyruvate kinase M2: A multifunctional protein
- (2010) Vibhor Gupta et al. PROTEIN SCIENCE
- Therapeutic strategies by modulating oxygen stress in cancer and inflammation
- (2009) Jun Fang et al. ADVANCED DRUG DELIVERY REVIEWS
- Identification of small molecule inhibitors of pyruvate kinase M2
- (2009) Matthew G. Vander Heiden et al. BIOCHEMICAL PHARMACOLOGY
- Synergistic anti-cancer effects of immunotoxin and cyclosporin in vitro and in vivo
- (2009) Y Andersson et al. BRITISH JOURNAL OF CANCER
- Cyclosporine A inhibits colorectal cancer proliferation probably by regulating expression levels of c-Myc, p21WAF1/CIP1 and proliferating cell nuclear antigen
- (2009) Takashige Masuo et al. CANCER LETTERS
- HIF-1α Modulates Energy Metabolism in Cancer Cells by Inducing Over-Expression of Specific Glycolytic Isoforms
- (2009) Alvaro Marin-Hernandez et al. MINI-REVIEWS IN MEDICINAL CHEMISTRY
- Pachymic acid inhibits cell growth and modulates arachidonic acid metabolism in nonsmall cell lung cancer A549 cells
- (2009) Hui Ling et al. MOLECULAR CARCINOGENESIS
- Tannins: Current knowledge of food sources, intake, bioavailability and biological effects
- (2009) José Serrano et al. MOLECULAR NUTRITION & FOOD RESEARCH
- Methyl jasmonate: A plant stress hormone as an anti-cancer drug
- (2009) Sharon Cohen et al. PHYTOCHEMISTRY
- Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation
- (2009) M. G. Vander Heiden et al. SCIENCE
- Glycolytic enzyme inhibitors in cancer treatment
- (2008) Roberto Scatena et al. EXPERT OPINION ON INVESTIGATIONAL DRUGS
- Small-molecule inhibition of 6-phosphofructo-2-kinase activity suppresses glycolytic flux and tumor growth
- (2008) B. Clem et al. MOLECULAR CANCER THERAPEUTICS
- The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth
- (2008) Heather R. Christofk et al. NATURE
- Methyl jasmonate binds to and detaches mitochondria-bound hexokinase
- (2008) N Goldin et al. ONCOGENE
- Apoptosis induction of oroxylin A in human cervical cancer HeLa cell line in vitro and in vivo
- (2008) Hua-Nan Li et al. TOXICOLOGY
Find Funding. Review Successful Grants.
Explore over 25,000 new funding opportunities and over 6,000,000 successful grants.
ExploreDiscover Peeref hubs
Discuss science. Find collaborators. Network.
Join a conversation