Article
Environmental Sciences
Moustapha Harb, Ali Zarei-Baygi, Phillip Wang, Christelle BouNehme Sawaya, L. Daniel McCurry, B. Lauren Stadler, L. Adam Smith
Summary: This study investigated the transformation of antibiotics in anaerobic membrane bioreactor (AnMBR) and identified microbial communities that may facilitate the conversion of sulfamethoxazole and ampicillin. The relative activity of suspended biomass in the system shifted towards syntrophic groups during the experiment, showing notable differences from membrane biofilm communities. The high activity of specific methanogenic, syntrophic, and sulfate-reducing groups in membrane-attached biofilms likely contributes to the biotransformation of antibiotics.
ENVIRONMENTAL RESEARCH
(2021)
Article
Oncology
Bangwei Che, Wenjun Zhang, Wei Li, Kaifa Tang, Jingju Yin, Miao Liu, Shenghan Xu, Tao Huang, Ying Yu, Kunyuan Huang, Zheng Peng, Cheng Zha
Summary: This study explores the role and mechanism of the prostate microbiome in prostate cancer by analyzing genes. The findings indicate that microorganisms can regulate the tumor's immune microenvironment by influencing antigen presentation of immune cells and participate in various functional phenotypes such as tumor invasion, fat metabolism, sex hormone response, DNA repair, apoptosis, and immunoregulation. Furthermore, a prognostic model based on bacterial lipopolysaccharide-related genes can accurately predict progression-free survival in prostate cancer patients.
FRONTIERS IN ONCOLOGY
(2023)
Article
Genetics & Heredity
Chao Tang, Lingchen Deng, Qiang Luo, Guijun He
Summary: Atherosclerosis is the leading cause of death in individuals with cardiovascular and cerebrovascular diseases. Oxidative stress is closely related to the pathology of Atherosclerosis. This study aimed to identify genetic mechanisms, construct a diagnostic model, and investigate the immune microenvironment of Atherosclerosis.
FRONTIERS IN GENETICS
(2023)
Article
Engineering, Environmental
Xueru Deng, Yufeng Jiang, Min'an Zhang, Zhijiang Nan, Xinru Liang, Gang Wang
Summary: This study investigated the sorption properties and mechanisms of macrolides and beta-lactam antibiotics in loess soil using batch equilibrium experiments. The results showed that ERY is mainly adsorbed to loess soil by electrostatic sorption and cation exchange, while AMP depends on complexation, cationic bridging, and hydrogen bonding.
CHEMICAL ENGINEERING JOURNAL
(2022)
Article
Immunology
Ting Gong, Yongbin Liu, Zhiyuan Tian, Min Zhang, Hejun Gao, Zhiyong Peng, Shuang Yin, Chi Wai Cheung, Youtan Liu
Summary: This study developed a prognostic and diagnostic signature for sepsis related to endoplasmic reticulum (ER) stress using bioinformatics and machine learning algorithms. The results showed that the signature accurately predicted sepsis patients and may affect the progression of sepsis.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Ruoshu Duan, Kangli Ye, Yangni Li, Yujing Sun, Jiahong Zhu, Jingjing Ren
Summary: This study aimed to identify the core genes associated with heart failure (HF) and investigate their potential mechanisms in HF and lung cancer, including oxidative stress and immune responses. The signature genes ECM2, METTL7B, MNS1, and SFRP4 showed remarkable diagnostic performance in HF patients, and METTL7B may be involved in the co-occurrence of HF and lung cancer through affecting oxidative stress immune responses.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Neurosciences
Nikolaos P. Daskalakis, Changxin Xu, Heather N. Bader, Chris Chatzinakos, Peter Weber, Iouri Makotkine, Amy Lehrner, Linda M. Bierer, Elisabeth B. Binder, Rachel Yehuda
Summary: This study identified a set of glucocorticoid and immune-related genes associated with parental Holocaust exposure, with differential effects based on parental exposure-related factors.
NEUROPSYCHOPHARMACOLOGY
(2021)
Review
Immunology
Guanzhou Zhou, Nana Zhang, Ke Meng, Fei Pan
Summary: This article discusses the interaction between gut microbiota and immune checkpoint inhibitor-related colitis, focusing on potential pathogenic mechanisms and interventions.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Wanchen Ning, Aneesha Acharya, Simin Li, Gerhard Schmalz, Shaohong Huang
Summary: This study identified pyroptosis-related genes and their immune characteristics in periodontitis. Three distinct pyroptosis-related clusters were also identified. The study highlights the importance of pyroptosis in the pathogenesis and immune regulation of periodontitis, and reveals functional heterogeneity in pyroptosis-related mechanisms.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Infectious Diseases
Binan Geng, Xingyu Huang, Yalun Wu, Qiaoning He, Shihui Yang
Summary: This study investigated antibiotic resistance genes in Z. mobilis using bioinformatic approaches and CRISPR/Cas12a-based genome-editing technology. Six ampicillin-resistant genes were identified, and mutant strains were constructed. The results showed that ZMO0103 played a key role in ampicillin resistance, and other ampicillin-resistant genes may have a synergetic effect with it. This study laid a foundation for further research on antibiotic resistance mechanisms.
Article
Genetics & Heredity
Yaxuan Wang, Haixia Zhu, Xiaolin Wang
Summary: This study reveals the crucial role of ER stress genes in the immunological milieu of BLCA, and identifies HSP90B1 as a potential prognostic biomarker and therapeutic target for cancer immunotherapy in BLCA.
FRONTIERS IN GENETICS
(2022)
Article
Biochemistry & Molecular Biology
Nandie Wu, Fangcen Liu, Ying Huang, Xinyu Su, Yaping Zhang, Lixia Yu, Baorui Liu
Summary: The high-risk group of gastric cancer patients showed higher clinical stage or grade and worse prognosis compared to the low-risk group. The low-risk group had higher levels of immunity and immune cell infiltration. Necroptosis was triggered by the TNF pathway in myeloid cells and the glycolysis pathway was altered. In vitro experiments demonstrated that necroptosis-related genes modulated cell function, including proliferation and migration, and the low-risk subgroup showed higher sensitivity to potential drugs. These findings contribute to a better understanding and improvement of treatment potential and prognosis in gastric cancer patients.
Article
Medicine, Research & Experimental
Jungang Liu, Xiaoliang Huang, Haizhou Liu, Chunyin Wei, Haiming Ru, Haiquan Qin, Hao Lai, Yongsheng Meng, Guo Wu, Weishun Xie, Xianwei Mo, Caroline H. Johnson, Yawei Zhang, Weizhong Tang
Summary: This study revealed that KRAS mutation in CRC is associated with suppressed immune pathways and immune infiltration, with increased Tregs and decreased M1 macrophages and activated CD4 memory T cells. An immune risk model was established to classify CRC patients with distinct clinical outcomes based on gene expression and immune cell abundance.
JOURNAL OF TRANSLATIONAL MEDICINE
(2021)
Article
Gastroenterology & Hepatology
Jun Sun, M. Nedim Ince, Clara Abraham, Terrence Barrett, Lisa A. Brenner, Yingzi Cong, Reza Dashti, Pradeep K. Dudeja, David Elliott, Thomas S. Griffith, Peter S. Heeger, Andrew Hoisington, Kaikobad Irani, Tae Kon Kim, Neeraj Kapur, Joseph Leventhal, Mansour Mohamadzadeh, Ece Mutlu, Rodney Newberry, Jonathan U. Peled, Israel Rubinstein, Salyka Sengsayadeth, Chen Sabrina Tan, Xiao-Di Tan, Eric Tkaczyk, Jason Wertheim, Zheng Jenny Zhang
Summary: This report summarizes a field-based meeting held by the United States Department of Veterans Affairs (VA), focusing on modulating the microbiome-immune axis in deployment-related chronic diseases of veterans. The meeting discussed various research areas, including interactions between microbiome and immune cells, intestinal inflammation and modification, microbiome-neuron-immunity interplay in mental and physical health, and microbiome-micronutrient-immune interactions during homeostasis and infectious diseases.
Article
Immunology
Zhi-Shuai Hou, Yuan-Ru Xin, Xiao-Dong Yang, Chu Zeng, Hong-Kui Zhao, Meng-Qun Liu, Mei-Zhao Zhang, Jeffrey G. Daniel, Ji-Fang Li, Hai-Shen Wen
Summary: Our study revealed that both asymptomatic and symptomatic rainbow trout showed activated immunomodulatory genes in the cytokine network, with downregulated glucocorticoid and mineralocorticoid receptors. Asymptomatic trout specifically activated complement- and TNF-associated immune defenses in response to Vibrio anguillarum infection. On the other hand, the complement and coagulation cascades, as well as steroid hormone homeostasis in symptomatic trout, were disturbed by V. anguillarum infection. The findings provide new insights into the regulatory mechanisms of stress and immune responses in rainbow trout.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Toxicology
Bokyeong Ryu, C-Yoon Kim, Hanseul Oh, Ukjin Kim, Jin Kim, Cho-Rok Jung, Byoung-Hee Lee, Seungki Lee, Seo-Na Chang, Ji Min Lee, Hyung-Min Chung, Jae-Hak Park
JOURNAL OF APPLIED TOXICOLOGY
(2018)
Article
Biochemistry & Molecular Biology
Loan Thi Thanh Nguyen, Ja Yeong Jang, Tae Yoon Kim, Nan Hee Yu, Ae Ran Park, Seungki Lee, Chang-Hwan Bae, Joo Hong Yeo, Jae-Seoun Hur, Hae Woong Park, Jin-Cheol Kim
PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY
(2018)
Article
Cell & Tissue Engineering
Goro Yoshizaki, Seungki Lee
STEM CELL RESEARCH
(2018)
Article
Biochemistry & Molecular Biology
Ki Hwan Moon, Xiaowei Zhao, Hui Xu, Jun Liu, Md A. Motaleb
MOLECULAR MICROBIOLOGY
(2018)
Article
Microbiology
Se Ra Lim, Do-Hun Lee, Seon Young Park, Seungki Lee, Hyo Yeon Kim, Moo-Seung Lee, Jung Ro Lee, Jee Eun Han, Hye Kwon Kim, Ji Hyung Kim
Article
Genetics & Heredity
Seungki Lee, Dae-Sung Lee, Jong Su Yoo, Ha Yeun Song
MITOCHONDRIAL DNA PART B-RESOURCES
(2020)
Article
Food Science & Technology
Sam Woong Kim, Yeon Jo Ha, Kyu Ho Bang, Seungki Lee, Joo-Hong Yeo, Hee-Sun Yang, Tae-Won Kim, Kyu Pil Lee, Woo Young Bang
Article
Microbiology
Ju Bin Yoon, Sungmin Hwang, Se-Won Baek, Seungki Lee, Woo Young Bang, Ki Hwan Moon
Article
Biochemistry & Molecular Biology
Seungki Lee, Woo Young Bang, Hee-Sun Yang, Dae-Sung Lee, Ha Yeun Song
Summary: This study reveals that there is no effective cryopreservation technique for fish eggs and embryos, but freezing germ cells and transplanting them to recipients could be an alternative solution for long-term preservation of piscine genetic resources. The method shows potential for practical conservation projects in other teleost fish species and masu salmon by successfully generating normal offspring with a balanced sex ratio.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Microbiology
Juvenal Lopez, Nguyen-Hung Le, Ki Hwan Moon, Dor Salomon, Eran Bosis, Mario F. Feldman
Summary: Competition among Gram-negative bacteria is often mediated by the type VI secretion system (T6SS), which delivers toxic effector proteins to adjacent bacteria. Tsi3 is a newly identified immunity protein that neutralizes the effects of the antibacterial effector Tse3. Despite predictions of enzymatic activity, Tsi3 homologs are unlikely to function as enzymes and rely on protein-protein interactions for immunity.
JOURNAL OF BACTERIOLOGY
(2021)
Article
Fisheries
Yunjeong Choe, Donghee Lee, Minji Seong, Ju Bin Yoon, Jun Hyeok Yang, Jin-Young Yang, Ki Hwan Moon, Ho Young Kang
Summary: The study identified a potential live vaccine candidate against E. piscicida infection in aquaculture, and found that Fap and Fdp proteins are crucial for flagella formation and motility, as well as for stimulating fish immune response.
JOURNAL OF FISH DISEASES
(2022)
Article
Microbiology
Se-Won Baek, Sungmin Hwang, Ho Young Kang, Woo Young Bang, Ki Hwan Moon
MICROBIOLOGY RESOURCE ANNOUNCEMENTS
(2020)