β-elemene Isopropanolamine Derivative LXX-8250 Induces Apoptosis Through Impairing Autophagic Flux via PFKFB4 Repression in Melanoma Cells
出版年份 2022 全文链接
标题
β-elemene Isopropanolamine Derivative LXX-8250 Induces Apoptosis Through Impairing Autophagic Flux via PFKFB4 Repression in Melanoma Cells
作者
关键词
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出版物
Frontiers in Pharmacology
Volume 13, Issue -, Pages -
出版商
Frontiers Media SA
发表日期
2022-08-10
DOI
10.3389/fphar.2022.900973
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注意:仅列出部分参考文献,下载原文获取全部文献信息。- Cancer statistics, 2022
- (2022) Rebecca L. Siegel et al. CA-A CANCER JOURNAL FOR CLINICIANS
- Tumor Cell Glycolysis—At the Crossroad of Epithelial–Mesenchymal Transition and Autophagy
- (2022) Fabrizio Marcucci et al. Cells
- Melanoma Cell Resistance to Vemurafenib Modifies Inter-Cellular Communication Signals
- (2021) Claudio Tabolacci et al. Biomedicines
- PFKFB4 promotes lung adenocarcinoma progression via phosphorylating and activating transcriptional coactivator SRC-2
- (2021) Jiguang Meng et al. BMC Pulmonary Medicine
- Role of PFKFB3 and PFKFB4 in Cancer: Genetic Basis, Impact on Disease Development/Progression, and Potential as Therapeutic Targets
- (2021) Krzysztof Kotowski et al. Cancers
- Changing profiles of cancer burden worldwide and in China: a secondary analysis of the global cancer statistics 2020
- (2021) Wei Cao et al. CHINESE MEDICAL JOURNAL
- Bruceine A induces cell growth inhibition and apoptosis through PFKFB4/GSK3β signaling in pancreatic cancer
- (2021) Pengfei Zhang et al. PHARMACOLOGICAL RESEARCH
- E2F2 drives glioma progression via PI3K/AKT in a PFKFB4-dependent manner
- (2021) Longzhou Zhang et al. LIFE SCIENCES
- PELP1/SRC-3-dependent regulation of metabolic PFKFB kinases drives therapy resistant ER+ breast cancer
- (2021) Thu H. Truong et al. ONCOGENE
- PFKFB4 is overexpressed in clear-cell renal cell carcinoma promoting pentose phosphate pathway that mediates Sunitinib resistance
- (2021) Chenchen Feng et al. JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
- Colorectal cancer statistics, 2020
- (2020) Rebecca L. Siegel et al. CA-A CANCER JOURNAL FOR CLINICIANS
- β-Elemene Reverses the Resistance of p53-Deficient Colorectal Cancer Cells to 5-Fluorouracil by Inducing Pro-death Autophagy and Cyclin D3-Dependent Cycle Arrest
- (2020) Ruonan Zhang et al. Frontiers in Bioengineering and Biotechnology
- Hypoxia‐inducible hexokinase‐2 enhances anti‐apoptotic function via activating autophagy in multiple myeloma
- (2020) Sho Ikeda et al. CANCER SCIENCE
- WNT11-FZD7-DAAM1 signalling supports tumour initiating abilities and melanoma amoeboid invasion
- (2020) Irene Rodriguez-Hernandez et al. Nature Communications
- Click-Nucleic-Acid-Containing Codelivery System Inducing Collapse of Cellular Homeostasis for Tumor Therapy through Bidirectional Regulation of Autophagy and Glycolysis
- (2020) Qin Guo et al. ACS Applied Materials & Interfaces
- Lactate dehydrogenase A regulates autophagy and tamoxifen resistance in breast cancer
- (2019) Chandan Kanta Das et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
- Beta‐elemene inhibits breast cancer metastasis through blocking pyruvate kinase M2 dimerization and nuclear translocation
- (2019) Yanhong Pan et al. JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
- Cytotoxic effects of a sesquiterpene β-elemene on THP-1 leukemia cells is mediated via crosstalk between beclin-1 mediated autophagy and caspase-dependent apoptosis
- (2019) Ziyu Jiang et al. PROCESS BIOCHEMISTRY
- Topical treatments for skin cancer
- (2019) Jason K. Cullen et al. ADVANCED DRUG DELIVERY REVIEWS
- Erythrocyte–Cancer Hybrid Membrane Camouflaged Hollow Copper Sulfide Nanoparticles for Prolonged Circulation Life and Homotypic-Targeting Photothermal/Chemotherapy of Melanoma
- (2018) Dongdong Wang et al. ACS Nano
- Metabolic enzyme PFKFB4 activates transcriptional coactivator SRC-3 to drive breast cancer
- (2018) Subhamoy Dasgupta et al. NATURE
- Autophagy-dependent cell death
- (2018) Donna Denton et al. CELL DEATH AND DIFFERENTIATION
- Antitumor effects of β-elemene via targeting the phosphorylation of insulin receptor
- (2018) Dawei Wu et al. ENDOCRINE-RELATED CANCER
- Novel hybrids of natural β -elemene bearing isopropanolamine moieties: Synthesis, enhanced anticancer profile, and improved aqueous solubility
- (2017) Jichao Chen et al. FITOTERAPIA
- Phosphoglycerate Kinase 1 Phosphorylates Beclin1 to Induce Autophagy
- (2017) Xu Qian et al. MOLECULAR CELL
- 6-Phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 is essential for p53-null cancer cells
- (2017) S Ros et al. ONCOGENE
- Autophagy inhibition overcomes multiple mechanisms of resistance to BRAF inhibition in brain tumors
- (2017) Jean M Mulcahy Levy et al. eLife
- Interplay of DNA methyltransferase 1 and EZH2 through inactivation of Stat3 contributes to β-elemene-inhibited growth of nasopharyngeal carcinoma cells
- (2017) JingJing Wu et al. Scientific Reports
- Roads to melanoma: Key pathways and emerging players in melanoma progression and oncogenic signaling
- (2016) Jasmina Paluncic et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
- State of the science on prevention and screening to reduce melanoma incidence and mortality: The time is now
- (2016) Mary K. Tripp et al. CA-A CANCER JOURNAL FOR CLINICIANS
- The discovery of vemurafenib for the treatment of BRAF-mutated metastatic melanoma
- (2016) Alex Kim et al. Expert Opinion on Drug Discovery
- Co-targeting hexokinase 2-mediated Warburg effect and ULK1-dependent autophagy suppresses tumor growth of PTEN- and TP53- deficiency-driven castration-resistant prostate cancer
- (2016) Lei Wang et al. EBioMedicine
- Inhibition of tumor growth by β-elemene through downregulation of the expression of uPA, uPAR, MMP-2, and MMP-9 in a murine intraocular melanoma model
- (2015) Hong Shi et al. MELANOMA RESEARCH
- Identification of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase as a novel autophagy regulator by high content shRNA screening
- (2015) A M Strohecker et al. ONCOGENE
- β-Elemene inhibits the metastasis of B16F10 melanoma cells by downregulation of the expression of uPA, uPAR, MMP-2, and MMP-9
- (2014) Hong Shi et al. MELANOMA RESEARCH
- Response of BRAF-Mutant Melanoma to BRAF Inhibition Is Mediated by a Network of Transcriptional Regulators of Glycolysis
- (2014) T. J. Parmenter et al. Cancer Discovery
- The cytotoxic effect of β-elemene against malignant glioma is enhanced by base-excision repair inhibitor methoxyamine
- (2013) Yongjian Zhu et al. JOURNAL OF NEURO-ONCOLOGY
- Functional Metabolic Screen Identifies 6-Phosphofructo-2-Kinase/Fructose-2,6-Biphosphatase 4 as an Important Regulator of Prostate Cancer Cell Survival
- (2012) Susana Ros et al. Cancer Discovery
- β-Elemene-induced autophagy protects human gastric cancer cells from undergoing apoptosis
- (2011) Jing Liu et al. BMC CANCER
- RNAi screening in glioma stem-like cells identifies PFKFB4 as a key molecule important for cancer cell survival
- (2011) V Goidts et al. ONCOGENE
- Beta-elemene inhibits melanoma growth and metastasis via suppressing vascular endothelial growth factor-mediated angiogenesis
- (2010) Wenxing Chen et al. CANCER CHEMOTHERAPY AND PHARMACOLOGY
- Methods in Mammalian Autophagy Research
- (2010) Noboru Mizushima et al. CELL
- Antineoplastic effect ofβ-elemene on prostate cancer cells and other types of solid tumour cells
- (2010) Qingdi Quentin Li et al. JOURNAL OF PHARMACY AND PHARMACOLOGY
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